Homo sapiens

77 known processes

PRLR

prolactin receptor

(Aliases: hPRLrI)

PRLR biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
lipid metabolic processGO:00066293810.439
response to oxygen containing compoundGO:19017003690.421
Human
regulation of hormone levelsGO:00108171250.285
anion transportGO:00068201610.256
cellular response to endogenous stimulusGO:00714953360.244
Human Mouse
cellular ketone metabolic processGO:0042180800.229
cellular amino acid metabolic processGO:00065201160.195
monocarboxylic acid metabolic processGO:00327871850.188
regulation of cellular ketone metabolic processGO:0010565500.166
response to hormoneGO:00097251750.155
Human Mouse
cellular response to genisteinGO:007141210.153
estrogen catabolic processGO:000671110.150
cellular response to oxygen containing compoundGO:19017012760.148
Human
cellular lipid metabolic processGO:00442553030.142
organic anion transportGO:00157111030.134
transmembrane transportGO:00550853990.123
regulation of locomotionGO:00400123290.122
secretionGO:00469032540.118
Mouse
cellular amine metabolic processGO:0044106410.115
organic hydroxy compound metabolic processGO:19016151470.111
oxidation reduction processGO:00551143960.108
response to lipidGO:00339932060.107
Human
response to organonitrogen compoundGO:00102431560.104
Human
organonitrogen compound biosynthetic processGO:19015662000.095
chemical homeostasisGO:00488783060.095
cation transportGO:00068123310.094
response to nitrogen compoundGO:19016981840.093
Human
amine metabolic processGO:0009308440.091
post embryonic developmentGO:000979120.089
positive regulation of cellular amine metabolic processGO:003324070.089
response to organic cyclic compoundGO:00140702040.088
Human
nervous system developmentGO:00073992930.084
regulation of cellular amino acid metabolic processGO:000652160.084
regulation of cellular amine metabolic processGO:0033238110.083
positive regulation of phosphorylationGO:00423273940.081
neurological system processGO:00508771630.081
response to abiotic stimulusGO:00096283360.080
system processGO:00030083490.080
regulation of transferase activityGO:00513383550.078
negative regulation of multicellular organismal processGO:00512413170.077
ion transmembrane transportGO:00342203380.077
positive regulation of cellular amino acid metabolic processGO:004576430.077
regulation of transmission of nerve impulseGO:005196920.077
regulation of cell migrationGO:00303342890.077
carbohydrate metabolic processGO:00059752070.076
regulation of cell motilityGO:20001452990.075
regulation of cell differentiationGO:00455953930.074
Mouse
negative regulation of protein metabolic processGO:00512483910.071
growthGO:00400072020.068
Human Mouse
regulation of growthGO:00400081650.068
Human
single organism carbohydrate metabolic processGO:00447231930.067
lipid catabolic processGO:0016042840.064
positive regulation of cellular component organizationGO:00511303760.060
steroid metabolic processGO:0008202940.059
cell morphogenesisGO:00009022960.058
nucleoside catabolic processGO:00091644080.055
enzyme linked receptor protein signaling pathwayGO:00071673030.055
fatty acid metabolic processGO:00066311150.054
cell projection organizationGO:00300302520.054
regulation of secretion by cellGO:19035301770.053
cellular response to hydroxyisoflavoneGO:007141310.053
vesicle mediated transportGO:00161923710.052
Human
carboxylic acid transportGO:0046942630.051
organophosphate catabolic processGO:00464344300.050
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.050
secretion by cellGO:00329402260.050
lipid biosynthetic processGO:00086101770.050
positive regulation of cell proliferationGO:00082843010.050
cellular response to hormone stimulusGO:00328701250.048
Human Mouse
membrane organizationGO:00610242920.048
cell developmentGO:00484683280.048
anatomical structure formation involved in morphogenesisGO:00486462840.047
jak stat cascadeGO:0007259460.047
Mouse
regulation of cell cycleGO:00517263930.047
hormone metabolic processGO:0042445610.045
ion homeostasisGO:00508012300.045
positive regulation of transportGO:00510503360.045
positive regulation of immune system processGO:00026842830.045
small molecule biosynthetic processGO:00442831570.045
positive regulation of developmental processGO:00510943140.044
Human
glycosyl compound catabolic processGO:19016584130.044
response to extracellular stimulusGO:0009991850.044
inorganic ion transmembrane transportGO:00986602310.044
memoryGO:000761330.044
locomotory behaviorGO:000762610.043
morphogenesis of embryonic epitheliumGO:001633140.043
nitrogen compound transportGO:00717051910.043
regulation of anatomical structure morphogenesisGO:00226032860.043
cellular component morphogenesisGO:00329893140.043
cation homeostasisGO:00550801890.042
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.042
cellular chemical homeostasisGO:00550821800.042
negative regulation of transportGO:00510511760.041
vitamin e metabolic processGO:004236010.041
determination of adult lifespanGO:000834020.040
cellular homeostasisGO:00197251960.040
regulation of protein kinase activityGO:00458592890.040
nucleoside phosphate biosynthetic processGO:19012931090.040
nucleotide catabolic processGO:00091664080.040
purine nucleoside triphosphate metabolic processGO:00091444120.039
positive regulation of locomotionGO:00400171860.039
protein catabolic processGO:00301633250.039
apoptotic signaling pathwayGO:00971902680.039
nucleoside triphosphate metabolic processGO:00091414220.039
purine containing compound catabolic processGO:00725234110.039
alcohol metabolic processGO:00060661140.038
oogenesisGO:004847720.038
defense responseGO:00069523150.038
positive regulation of programmed cell deathGO:00430682490.038
negative regulation of cell deathGO:00605483450.038
ribonucleoside triphosphate catabolic processGO:00092033910.038
circulatory system processGO:00030131130.038
nucleoside phosphate catabolic processGO:19012924120.037
carbohydrate derivative biosynthetic processGO:19011372070.037
small gtpase mediated signal transductionGO:0007264780.037
blood vessel developmentGO:00015681720.037
regulation of lipid metabolic processGO:0019216960.037
negative regulation of catalytic activityGO:00430863350.037
purine nucleoside catabolic processGO:00061523980.037
purine nucleotide catabolic processGO:00061954050.037
regulation of cell growthGO:00015581350.037
purine nucleoside triphosphate catabolic processGO:00091463920.037
single organism membrane organizationGO:00448022680.037
regulation of cellular component movementGO:00512703340.037
purine ribonucleoside catabolic processGO:00461303980.037
purine ribonucleoside triphosphate catabolic processGO:00092073910.036
segmentationGO:003528240.036
positive regulation of protein phosphorylationGO:00019343130.036
ribonucleoside catabolic processGO:00424544060.036
regulation of kinase activityGO:00435493140.036
cardiovascular system developmentGO:00723582620.036
organophosphate biosynthetic processGO:00904071630.035
negative regulation of icosanoid secretionGO:003230420.035
negative regulation of apoptotic processGO:00430663160.035
multicellular organismal agingGO:001025930.035
central nervous system developmentGO:00074171230.035
positive regulation of catabolic processGO:00098963100.035
protein processingGO:00164852260.035
purine ribonucleotide biosynthetic processGO:0009152790.035
negative regulation of transmission of nerve impulseGO:005197010.035
positive regulation of transferase activityGO:00513472270.034
fatty acid omega oxidationGO:001043020.034
sensory perception of smellGO:000760820.034
nucleotide biosynthetic processGO:00091651090.034
epithelial cell differentiationGO:00308551410.034
Mouse
positive regulation of cellular catabolic processGO:00313312840.034
response to cytokineGO:00340972320.034
Mouse
regulation of purine nucleotide metabolic processGO:19005422640.034
generation of neuronsGO:00486991520.033
regulation of proteolysisGO:00301622930.033
metal ion transportGO:00300012720.033
actin filament based processGO:00300292240.033
positive regulation of acrosome reactionGO:200034440.033
response to inorganic substanceGO:00100351270.033
ribonucleotide catabolic processGO:00092614050.033
positive regulation of cell motilityGO:20001471770.033
positive regulation of purine nucleotide metabolic processGO:19005442270.033
organ morphogenesisGO:00098871470.033
nucleoside triphosphate catabolic processGO:00091433940.032
response to biotic stimulusGO:00096072760.032
negative regulation of phosphate metabolic processGO:00459362670.032
peripheral nervous system developmentGO:000742220.032
negative regulation of cell proliferationGO:00082852280.032
organic acid transportGO:0015849650.031
positive regulation of cell differentiationGO:00455972110.031
negative regulation of programmed cell deathGO:00430693210.031
female gamete generationGO:000729220.031
regulation of secretionGO:00510461940.031
purine ribonucleoside triphosphate metabolic processGO:00092054110.031
single organism cellular localizationGO:19025803320.031
purine ribonucleoside metabolic processGO:00461284370.031
regulation of cellular component biogenesisGO:00440872810.031
quinone catabolic processGO:190166220.031
response to peptideGO:1901652650.031
Human
ras protein signal transductionGO:0007265730.031
protein localization to membraneGO:00726571600.030
regulation of sequence specific dna binding transcription factor activityGO:00510902110.030
regulation of protein localizationGO:00328802960.030
response to drugGO:0042493810.030
monovalent inorganic cation transportGO:00156721280.030
positive regulation of cell migrationGO:00303351720.030
carboxylic acid catabolic processGO:0046395710.030
ribonucleoside triphosphate metabolic processGO:00091994120.030
cellular ion homeostasisGO:00068731680.030
cellular lipid catabolic processGO:0044242650.030
negative regulation of cellular protein metabolic processGO:00322693530.029
cellular response to nitrogen compoundGO:19016991440.029
Human
reactive oxygen species metabolic processGO:0072593750.029
peptidyl tyrosine modificationGO:00182121700.029
cytoplasmic transportGO:00164823790.028
negative regulation of phosphorus metabolic processGO:00105632670.028
neurogenesisGO:00220081690.028
hindbrain developmentGO:003090230.028
response to metal ionGO:0010038840.028
cellular response to external stimulusGO:00714961110.028
lung alveolus developmentGO:004828640.028
hemostasisGO:0007599760.027
negative regulation of hydrolase activityGO:00513461820.027
ribose phosphate biosynthetic processGO:0046390820.027
negative regulation of developmental processGO:00510932470.027
vitamin k catabolic processGO:004237720.027
regulation of acrosome reactionGO:006004640.027
phylloquinone metabolic processGO:004237420.027
circulatory system developmentGO:00723592620.027
cell cell signalingGO:00072671550.027
sulfur compound metabolic processGO:00067901010.027
regulation of nucleotide metabolic processGO:00061402690.027
biological adhesionGO:00226103310.026
Mouse
regulation of ion transportGO:00432691890.026
cellular response to organonitrogen compoundGO:00714171240.026
Human
regulation of body fluid levelsGO:0050878990.026
Mouse
icosanoid catabolic processGO:190152320.026
cell growthGO:00160491600.026
positive regulation of secretionGO:00510471160.026
response to nutrient levelsGO:0031667810.026
purine ribonucleotide catabolic processGO:00091544040.026
photoreceptor cell differentiationGO:004653020.026
neuromuscular junction developmentGO:000752830.026
somatic stem cell maintenanceGO:003501940.026
maintenance of locationGO:00512351120.026
oocyte differentiationGO:000999420.025
mapk cascadeGO:00001652880.025
lipid localizationGO:00108761060.025
positive regulation of cellular component movementGO:00512721810.025
blastoderm segmentationGO:000735020.025
oocyte developmentGO:004859910.025
protein maturationGO:00516042330.025
endomembrane system organizationGO:00102561960.025
menaquinone metabolic processGO:000923330.025
hematopoietic or lymphoid organ developmentGO:00485341860.025
response to oxygen levelsGO:00704821000.025
gtp catabolic processGO:00061842370.025
cellular metal ion homeostasisGO:00068751460.025
regulation of multi organism processGO:00439001570.025
small molecule catabolic processGO:0044282920.025
negative regulation of neurological system processGO:003164520.024
positive regulation of cellular component biogenesisGO:00440891580.024
neuron differentiationGO:00301821380.024
purine containing compound biosynthetic processGO:0072522880.024
somatic muscle developmentGO:000752510.024
regulation of mapk cascadeGO:00434082620.024
immune responseGO:00069553070.024
vasculature developmentGO:00019441810.024
response to other organismGO:00517072610.024
neuron developmentGO:00486661130.024
cellular macromolecular complex assemblyGO:00346223240.023
lipid transportGO:0006869900.023
behaviorGO:00076101120.023
lipid modificationGO:0030258840.023
cellular cation homeostasisGO:00300031630.023
regulation of cell cycle processGO:00105642660.023
metal ion homeostasisGO:00550651690.023
response to decreased oxygen levelsGO:0036293960.023
cation transmembrane transportGO:00986552380.023
cell morphogenesis involved in differentiationGO:00009041440.023
ribonucleotide biosynthetic processGO:0009260810.023
regulation of cytokine productionGO:00018172320.023
proteolysis involved in cellular protein catabolic processGO:00516032440.023
regenerationGO:003109940.023
cyclic purine nucleotide metabolic processGO:0052652600.023
positive regulation of nucleotide metabolic processGO:00459812300.023
negative regulation of phosphorylationGO:00423261740.023
negative regulation of cellular component organizationGO:00511292350.023
regulation of response to external stimulusGO:00321012220.022
response to acid chemicalGO:0001101660.022
immune system developmentGO:00025201950.022
long term memoryGO:000761620.022
response to alcoholGO:0097305640.022
Human
phylloquinone catabolic processGO:004237620.022
cellular protein catabolic processGO:00442572610.022
cellular macromolecule catabolic processGO:00442653800.022
cell fate determinationGO:000170930.022
cell part morphogenesisGO:00329901370.022
organic acid catabolic processGO:0016054710.022
regulation of apoptotic signaling pathwayGO:20012331750.022
developmental growthGO:0048589480.022
Human Mouse
negative regulation of protein modification processGO:00314002000.022
hemopoiesisGO:00300971800.021
intracellular protein transportGO:00068862700.021
renal system process involved in regulation of blood volumeGO:000197740.021
compound eye developmentGO:004874910.021
tube developmentGO:00352951250.021
organic acid biosynthetic processGO:0016053970.021
matingGO:000761810.021
regulation of establishment of protein localizationGO:00702012420.021
anion transmembrane transportGO:0098656760.021
atp metabolic processGO:00460341760.021
cell projection morphogenesisGO:00488581290.021
regulation of intracellular transportGO:00323861950.021
response to bacteriumGO:00096171440.021
amide transportGO:0042886760.021
cellular response to organic cyclic compoundGO:00714071270.021
regulation of reactive oxygen species metabolic processGO:2000377410.021
leukotriene catabolic processGO:003610020.021
divalent inorganic cation transportGO:00725111580.021
protein localization to organelleGO:00333652800.021
phospholipid metabolic processGO:0006644990.020
coagulationGO:0050817780.020
positive regulation of organelle organizationGO:00106381950.020
limbic system developmentGO:002176130.020
inner ear morphogenesisGO:004247240.020
positive regulation of synaptic transmissionGO:005080640.020
positive regulation of jak stat cascadeGO:0046427350.020
regulation of nucleoside metabolic processGO:00091182090.020
response to external biotic stimulusGO:00432072610.020
regulation of epithelial cell migrationGO:0010632930.020
protein oligomerizationGO:00512591730.020
gtp metabolic processGO:00460392390.020
blood coagulationGO:0007596760.020
gamma aminobutyric acid signaling pathwayGO:000721430.019
regulation of metal ion transportGO:00109591200.019
cofactor metabolic processGO:0051186870.019
circadian behaviorGO:004851220.019
reactive nitrogen species metabolic processGO:200105730.019
regulation of anatomical structure sizeGO:00900661010.019
divalent metal ion transportGO:00708381520.019
neuron projection developmentGO:00311751060.019
signal transduction by phosphorylationGO:00230142970.019
cellular response to lipidGO:00713961270.019
reactive oxygen species biosynthetic processGO:190340940.019
purine nucleoside monophosphate catabolic processGO:00091281580.019
positive regulation of hydrolase activityGO:00513453310.019
g protein coupled receptor signaling pathwayGO:00071862070.019
carboxylic acid biosynthetic processGO:0046394970.019
negative regulation of cell differentiationGO:00455961710.019
ribonucleoside monophosphate catabolic processGO:00091581580.019
metencephalon developmentGO:002203720.019
monosaccharide metabolic processGO:0005996740.019
neural crest cell developmentGO:001403230.019
single organism cell adhesionGO:00986021790.018
mitotic cell cycleGO:00002783260.018
cellular response to histamineGO:007142030.018
motor neuron axon guidanceGO:000804520.018
regulation of cell morphogenesisGO:00226041530.018
anterior posterior axis specification embryoGO:000859520.018
wound healingGO:00420601150.018
regulation of protein transportGO:00512232130.018
protein modification by small protein conjugationGO:00324463420.018
hormone secretionGO:0046879650.018
peptidyl tyrosine phosphorylationGO:00181081700.018
response to woundingGO:00096111680.018
cellular response to dna damage stimulusGO:00069743790.018
regulation of canonical wnt signaling pathwayGO:0060828880.018
regulation of cell developmentGO:00602841610.018
sensory perceptionGO:00076001030.018
response to hypoxiaGO:0001666960.018
regulation of nucleotide catabolic processGO:00308112050.018
regulation of jak stat cascadeGO:0046425440.018
rho protein signal transductionGO:0007266260.018
regulation of ras gtpase activityGO:00323181280.018
tissue migrationGO:00901301190.018
organ formationGO:004864530.018
dephosphorylationGO:00163112090.018
blood circulationGO:00080151130.017
positive regulation of cell deathGO:00109422630.017
cellular response to cytokine stimulusGO:00713451810.017
Mouse
monocarboxylic acid biosynthetic processGO:0072330670.017
posttranscriptional regulation of gene expressionGO:00106082130.017
regulation of protein processingGO:00706131500.017
cellular carbohydrate metabolic processGO:0044262840.017
visual behaviorGO:000763220.017
endocytosisGO:00068971590.017
Human
nucleoside monophosphate metabolic processGO:00091231910.017
innate immune responseGO:00450871780.017
cell adhesionGO:00071553250.017
Mouse
negative regulation of cell cycleGO:00457861930.017
regulation of feeding behaviorGO:006025930.017
rhythmic behaviorGO:000762220.017
hormone transportGO:0009914680.017
cell projection assemblyGO:00300311260.017
canonical wnt signaling pathwayGO:00600701160.017
regulation of reactive oxygen species biosynthetic processGO:190342630.017
negative regulation of protein processingGO:00109551420.017
regulation of response to woundingGO:19030341010.017
divalent inorganic cation homeostasisGO:00725071360.017
embryonic epithelial tube formationGO:000183840.017
wnt signaling pathwayGO:00160551560.017
cellular hormone metabolic processGO:0034754410.017
purine nucleoside monophosphate metabolic processGO:00091261860.017
cerebellum developmentGO:002154920.017
embryo developmentGO:00097901230.017
regulation of gtpase activityGO:00430871800.017
cellular protein complex assemblyGO:00436231880.016
head developmentGO:00603221080.016
regulation of gtp catabolic processGO:00331241800.016
positive regulation of immune responseGO:00507781590.016
atp catabolic processGO:00062001570.016
response to peptide hormoneGO:0043434610.016
Human
positive regulation of sequence specific dna binding transcription factor activityGO:00510911310.016
purine nucleotide biosynthetic processGO:0006164840.016
leukocyte activationGO:00453211640.016
sodium ion transportGO:0006814610.016
negative regulation of growthGO:0045926970.016
negative regulation of intracellular signal transductionGO:19025321830.016
cell substrate adhesionGO:00315891320.016
cellular response to extracellular stimulusGO:0031668720.016
epithelial cell migrationGO:00106311190.016
regulation of synaptic plasticityGO:004816730.016
positive regulation of ion transportGO:0043270870.016
endosomal transportGO:00161971290.016
ribonucleoside monophosphate metabolic processGO:00091611870.016
cyclic nucleotide metabolic processGO:0009187820.016
response to growth factorGO:00708482050.016
glycerophospholipid metabolic processGO:0006650840.016
nucleoside monophosphate catabolic processGO:00091251590.016
mitotic cell cycle processGO:19030472860.015
syncytium formation by plasma membrane fusionGO:000076820.015
regulation of cytoskeleton organizationGO:00514931770.015
plasma membrane organizationGO:00070091150.015
response to radiationGO:00093141510.015
regulation of endopeptidase activityGO:00525481700.015
epoxygenase p450 pathwayGO:001937330.015
stem cell developmentGO:0048864690.015
epithelial cell proliferationGO:00506731280.015
positive regulation of secretion by cellGO:19035321080.015
negative regulation of protein phosphorylationGO:00019331400.015
chemotaxisGO:00069351570.015
calcium ion transportGO:00068161470.015
positive regulation of organic acid transportGO:003289230.015
negative regulation of protein maturationGO:19033181420.015
reproductive processGO:00224141060.015
Mouse
cell type specific apoptotic processGO:00972851250.015
brain developmentGO:0007420970.015
cellular response to peptideGO:1901653590.015
Human
peptide secretionGO:0002790510.015
positive regulation of lipid metabolic processGO:0045834500.015
peptide hormone secretionGO:0030072500.015
regulation of wnt signaling pathwayGO:00301111230.015
microtubule based processGO:00070172100.015
negative regulation of cell growthGO:0030308830.015
purine ribonucleoside monophosphate catabolic processGO:00091691580.015
coenzyme metabolic processGO:0006732650.015
menaquinone catabolic processGO:004236120.015
nerve developmentGO:002167540.015
regulation of protein catabolic processGO:00421761550.015
digestive system developmentGO:0055123750.015
negative regulation of locomotionGO:00400131180.015
stem cell differentiationGO:0048863930.015
skeletal system developmentGO:0001501790.015
regulation of ras protein signal transductionGO:00465781550.015
regulation of protein complex assemblyGO:00432541470.015
positive regulation of kinase activityGO:00336742040.015
microtubule cytoskeleton organizationGO:00002261760.015
protein ubiquitinationGO:00165673140.015
regulation of purine nucleotide catabolic processGO:00331212050.015
cellular response to ammonium ionGO:007124240.015
regulation of vasculature developmentGO:1901342970.015
positive regulation of reactive oxygen species metabolic processGO:2000379240.015
regulation of coagulationGO:0050818440.015
positive regulation of vasoconstrictionGO:004590730.015
protein targetingGO:00066051870.015
camp biosynthetic processGO:0006171470.014
regulation of neural precursor cell proliferationGO:200017740.014
negative regulation of proteolysisGO:00458611320.014
response to axon injuryGO:004867810.014
neuroblast proliferationGO:000740540.014
potassium ion transportGO:0006813620.014
guanosine containing compound catabolic processGO:19010692390.014
positive regulation of nucleoside metabolic processGO:00459791860.014
positive regulation of gtpase activityGO:00435471660.014
cellular response to abiotic stimulusGO:00712141170.014
response to estrogenGO:0043627470.014
Human
negative regulation of ion transportGO:0043271390.014
inorganic cation transmembrane transportGO:00986621940.014
cytokine mediated signaling pathwayGO:00192211090.014
Mouse
regulation of bindingGO:00510981110.014
angiogenesisGO:00015251470.014
ubiquitin dependent protein catabolic processGO:00065112060.014
positive regulation of nucleotide catabolic processGO:00308131850.014
peptide transportGO:0015833740.014
regulation of peptide hormone secretionGO:0090276410.014
cell cycle phase transitionGO:00447701730.014
regulation of cellular response to stressGO:00801352440.014
positive regulation of ras gtpase activityGO:00323201170.014
multicellular organismal signalingGO:0035637340.014
regulation of cell adhesionGO:00301551660.014
Mouse
chromatin modificationGO:00165682980.014
signal releaseGO:0023061700.014
endothelial cell migrationGO:0043542860.014
single organism reproductive processGO:0044702980.014
Mouse
regulation of immune responseGO:00507762010.014
response to calcium ionGO:0051592460.014
positive regulation of peptidyl tyrosine phosphorylationGO:0050731850.013
purine ribonucleoside monophosphate metabolic processGO:00091671860.013

PRLR disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:00146672950.078
Human
inherited metabolic disorderDOID:6552420.045
Human
sensory system diseaseDOID:00501552030.029
nervous system diseaseDOID:8634310.029
disease of cellular proliferationDOID:145661740.025
cancerDOID:1621670.025
organ system cancerDOID:00506861640.018
acquired metabolic diseaseDOID:0060158580.017
central nervous system diseaseDOID:3311860.014