Homo sapiens

44 known processes

PDHA1

pyruvate dehydrogenase (lipoamide) alpha 1

(Aliases: PDHA,PDHCE1A,PHE1A)

PDHA1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
acetyl coa biosynthetic process from pyruvateGO:000608640.960
cofactor biosynthetic processGO:0051188310.929
oxidation reduction processGO:00551143960.909
acyl coa metabolic processGO:0006637230.830
citrate metabolic processGO:000610120.823
generation of precursor metabolites and energyGO:0006091680.802
sulfur compound biosynthetic processGO:0044272380.795
monocarboxylic acid metabolic processGO:00327871850.761
tricarboxylic acid cycleGO:000609940.737
cofactor metabolic processGO:0051186870.648
coenzyme metabolic processGO:0006732650.624
thioester metabolic processGO:0035383230.607
sulfur compound metabolic processGO:00067901010.574
coenzyme biosynthetic processGO:0009108240.573
acyl coa biosynthetic processGO:007161660.480
vesicle mediated transportGO:00161923710.468
Worm
determination of adult lifespanGO:000834020.464
Worm
glycerol metabolic processGO:000607140.461
thioester biosynthetic processGO:003538460.403
aspartate family amino acid catabolic processGO:000906850.399
multicellular organismal agingGO:001025930.356
Worm
regulation of peptidase activityGO:00525471800.347
tricarboxylic acid metabolic processGO:007235040.320
dicarboxylic acid catabolic processGO:004364990.293
post embryonic developmentGO:000979120.275
aspartate metabolic processGO:000653140.242
purine nucleoside monophosphate metabolic processGO:00091261860.175
acetyl coa biosynthetic processGO:000608560.170
cellular respirationGO:0045333210.169
energy derivation by oxidation of organic compoundsGO:0015980430.168
fatty acid metabolic processGO:00066311150.157
activation of cysteine type endopeptidase activity involved in apoptotic processGO:0006919490.154
positive regulation of peptidase activityGO:0010952880.142
pyruvate metabolic processGO:0006090260.124
receptor mediated endocytosisGO:0006898840.122
Worm
protein maturationGO:00516042330.116
mitochondrial membrane organizationGO:0007006400.113
cellular amino acid metabolic processGO:00065201160.113
protein processingGO:00164852260.112
small molecule catabolic processGO:0044282920.110
positive regulation of programmed cell deathGO:00430682490.110
positive regulation of cysteine type endopeptidase activityGO:2001056790.106
cell cell signalingGO:00072671550.100
positive regulation of hydrolase activityGO:00513453310.094
glutamate metabolic processGO:0006536100.093
embryo developmentGO:00097901230.088
Worm
dicarboxylic acid metabolic processGO:0043648290.087
aerobic respirationGO:000906070.087
purine nucleoside triphosphate metabolic processGO:00091444120.083
organic acid catabolic processGO:0016054710.083
small molecule biosynthetic processGO:00442831570.079
lipid metabolic processGO:00066293810.077
alditol metabolic processGO:001940050.074
organonitrogen compound biosynthetic processGO:19015662000.070
cellular ketone metabolic processGO:0042180800.069
positive regulation of proteolysisGO:00458621420.068
acetyl coa metabolic processGO:000608480.067
nucleotide biosynthetic processGO:00091651090.064
positive regulation of apoptotic processGO:00430652460.063
endocytosisGO:00068971590.063
Worm
activation of cysteine type endopeptidase activityGO:0097202570.062
mitochondrion organizationGO:00070051560.059
purine ribonucleoside triphosphate metabolic processGO:00092054110.056
zymogen activationGO:0031638700.056
nucleoside monophosphate metabolic processGO:00091231910.054
regulation of endopeptidase activityGO:00525481700.051
regulation of cysteine type endopeptidase activityGO:20001161270.051
single organism membrane organizationGO:00448022680.050
glutamine family amino acid metabolic processGO:0009064170.050
glutamate biosynthetic processGO:000653730.049
atp metabolic processGO:00460341760.048
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:00432811160.047
response to hormoneGO:00097251750.047
system processGO:00030083490.046
positive regulation of cell deathGO:00109422630.046
cellular amino acid biosynthetic processGO:0008652300.044
dicarboxylic acid biosynthetic processGO:004365040.044
cellular protein complex assemblyGO:00436231880.042
negative regulation of transportGO:00510511760.041
carbohydrate metabolic processGO:00059752070.041
defense responseGO:00069523150.041
cellular macromolecular complex assemblyGO:00346223240.041
microtubule cytoskeleton organizationGO:00002261760.040
sleepGO:003043120.039
adult locomotory behaviorGO:000834410.039
alpha amino acid metabolic processGO:1901605720.038
spermatid differentiationGO:004851540.037
alpha amino acid biosynthetic processGO:1901607230.036
neuromuscular junction developmentGO:000752830.036
regulation of membrane potentialGO:0042391950.035
nervous system developmentGO:00073992930.035
organic acid biosynthetic processGO:0016053970.034
nucleoside triphosphate metabolic processGO:00091414220.034
membrane organizationGO:00610242920.033
negative regulation of cell deathGO:00605483450.032
apoptotic mitochondrial changesGO:0008637570.031
microtubule based processGO:00070172100.031
embryo development ending in birth or egg hatchingGO:0009792340.031
Worm
cell developmentGO:00484683280.030
Worm
dna catabolic processGO:0006308490.029
cellular carbohydrate metabolic processGO:0044262840.029
response to endoplasmic reticulum stressGO:0034976490.029
regulation of proteolysisGO:00301622930.029
positive regulation of endopeptidase activityGO:0010950840.028
purine ribonucleoside metabolic processGO:00461284370.027
positive regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043280690.027
negative regulation of intracellular signal transductionGO:19025321830.027
cellular lipid metabolic processGO:00442553030.026
nucleoside catabolic processGO:00091644080.026
regulation of cellular ketone metabolic processGO:0010565500.026
locomotory behaviorGO:000762610.025
carboxylic acid biosynthetic processGO:0046394970.024
innate immune responseGO:00450871780.024
cellular response to oxygen containing compoundGO:19017012760.024
growthGO:00400072020.023
negative regulation of programmed cell deathGO:00430693210.023
chemical homeostasisGO:00488783060.023
cellular amino acid catabolic processGO:0009063310.023
response to oxidative stressGO:00069791210.022
carboxylic acid catabolic processGO:0046395710.022
cellular amine metabolic processGO:0044106410.021
ion homeostasisGO:00508012300.021
protein targetingGO:00066051870.021
organelle fusionGO:0048284360.021
organic hydroxy compound biosynthetic processGO:1901617710.020
purine ribonucleoside monophosphate metabolic processGO:00091671860.020
agingGO:0007568660.020
Worm
regulation of cellular amino acid metabolic processGO:000652160.020
nadh dehydrogenase complex assemblyGO:0010257160.020
ribonucleotide catabolic processGO:00092614050.020
regenerationGO:003109940.020
protein localization to organelleGO:00333652800.020
response to woundingGO:00096111680.019
purine ribonucleoside catabolic processGO:00461303980.019
response to abiotic stimulusGO:00096283360.019
cation transportGO:00068123310.019
segmentationGO:003528240.019
amine metabolic processGO:0009308440.018
tissue regenerationGO:004224630.018
central nervous system developmentGO:00074171230.018
behaviorGO:00076101120.018
negative regulation of multicellular organismal processGO:00512413170.018
wound healingGO:00420601150.018
reproductionGO:0000003630.018
Worm
regulation of response to external stimulusGO:00321012220.017
actin filament based processGO:00300292240.017
ribonucleoside triphosphate metabolic processGO:00091994120.017
regulation of cell adhesionGO:00301551660.017
biological adhesionGO:00226103310.017
atp synthesis coupled electron transportGO:004277340.017
female gamete generationGO:000729220.017
Worm
epithelium developmentGO:00604292270.016
spermatid developmentGO:000728640.016
response to nitrogen compoundGO:19016981840.016
organophosphate catabolic processGO:00464344300.016
reactive oxygen species metabolic processGO:0072593750.016
glutamine family amino acid biosynthetic processGO:000908450.016
dephosphorylationGO:00163112090.016
alpha amino acid catabolic processGO:1901606260.016
positive regulation of developmental processGO:00510943140.016
mitochondrial atp synthesis coupled electron transportGO:004277540.015
execution phase of apoptosisGO:0097194320.015
mitochondrial respiratory chain complex i biogenesisGO:0097031160.015
response to organic cyclic compoundGO:00140702040.015
regulation of intrinsic apoptotic signaling pathwayGO:2001242720.015
carbohydrate derivative biosynthetic processGO:19011372070.015
anatomical structure formation involved in morphogenesisGO:00486462840.015
nucleotide catabolic processGO:00091664080.015
generation of neuronsGO:00486991520.015
response to oxygen containing compoundGO:19017003690.015
maintenance of locationGO:00512351120.015
neuron differentiationGO:00301821380.014
regulation of cellular amine metabolic processGO:0033238110.014
apoptotic nuclear changesGO:0030262130.014
negative regulation of hydrolase activityGO:00513461820.014
cellular component morphogenesisGO:00329893140.014
purine ribonucleoside triphosphate catabolic processGO:00092073910.014
regulation of growthGO:00400081650.014
regulation of apoptotic signaling pathwayGO:20012331750.014
ribonucleoside catabolic processGO:00424544060.014
regulation of protein kinase activityGO:00458592890.014
mitochondrial respiratory chain complex assemblyGO:0033108230.014
negative regulation of catalytic activityGO:00430863350.014
immune system developmentGO:00025201950.014
nucleoside triphosphate catabolic processGO:00091433940.013
response to external biotic stimulusGO:00432072610.013
positive regulation of cellular amino acid metabolic processGO:004576430.013
apoptotic signaling pathwayGO:00971902680.013
intracellular receptor signaling pathwayGO:00305221040.013
cellular response to oxidative stressGO:0034599850.013
reactive oxygen species biosynthetic processGO:190340940.013
cellular response to endogenous stimulusGO:00714953360.013
secretion by cellGO:00329402260.013
response to organonitrogen compoundGO:00102431560.013
tissue homeostasisGO:0001894630.013
cellular response to nitrogen compoundGO:19016991440.013
organic hydroxy compound metabolic processGO:19016151470.013
cell adhesionGO:00071553250.012
response to hypoxiaGO:0001666960.012
receptor metabolic processGO:0043112810.012
cellular amide metabolic processGO:0043603690.012
muscle system processGO:0003012810.012
actin cytoskeleton organizationGO:00300362070.012
lipid oxidationGO:0034440330.012
purine ribonucleotide catabolic processGO:00091544040.012
mitochondrial transportGO:0006839600.012
oxidative phosphorylationGO:0006119100.012
response to lipidGO:00339932060.012
cellular response to hormone stimulusGO:00328701250.012
cellular response to organonitrogen compoundGO:00714171240.012
embryonic morphogenesisGO:0048598850.012
neurological system processGO:00508771630.012
oogenesisGO:004847720.012
Worm
regulation of kinase activityGO:00435493140.012
negative regulation of apoptotic signaling pathwayGO:2001234970.012
regulation of establishment of protein localizationGO:00702012420.012
intracellular protein transportGO:00068862700.011
establishment of protein localization to organelleGO:00725941720.011
negative regulation of protein modification processGO:00314002000.011
anterior posterior axis specificationGO:000994820.011
protein stabilizationGO:0050821640.011
cellular ion homeostasisGO:00068731680.011
ossificationGO:00015031210.011
alcohol biosynthetic processGO:0046165520.011
immune responseGO:00069553070.011
positive regulation of nucleoside metabolic processGO:00459791860.011
negative regulation of peptidase activityGO:0010466910.011
cytoplasmic transportGO:00164823790.011
negative regulation of transferase activityGO:00513481240.011
head developmentGO:00603221080.011
spinal cord developmentGO:002151040.011
neurogenesisGO:00220081690.011
cellular macromolecule catabolic processGO:00442653800.011
regulation of reactive oxygen species metabolic processGO:2000377410.011
regulation of cytokine productionGO:00018172320.011
circulatory system developmentGO:00723592620.010
single organism reproductive processGO:0044702980.010
Worm
glycosyl compound catabolic processGO:19016584130.010
synaptic transmissionGO:0007268610.010
cardiovascular system developmentGO:00723582620.010
signal peptide processingGO:000646530.010
regulation of nucleoside metabolic processGO:00091182090.010
protein acylationGO:00435431380.010
oxaloacetate metabolic processGO:000610710.010
regulation of defense responseGO:00313471540.010
response to biotic stimulusGO:00096072760.010
nitrogen compound transportGO:00717051910.010
developmental process involved in reproductionGO:0003006660.010
Worm
cell part morphogenesisGO:00329901370.010

PDHA1 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:00146672950.206
amino acid metabolic disorderDOID:9252500.197
inherited metabolic disorderDOID:6552420.197
central nervous system diseaseDOID:3311860.108
nervous system diseaseDOID:8634310.108
immune system diseaseDOID:29141550.035
neurodegenerative diseaseDOID:12891020.019
disease of cellular proliferationDOID:145661740.015
organ system cancerDOID:00506861640.015
cancerDOID:1621670.015
neuromuscular diseaseDOID:440380.014
neuropathyDOID:870520.014
leigh diseaseDOID:3652160.014
mitochondrial metabolism diseaseDOID:700290.014
carbohydrate metabolic disorderDOID:2978550.003