Homo sapiens

108 known processes

TLK2

tousled-like kinase 2

(Aliases: PKU-ALPHA,MGC44450)

TLK2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
chromatin modificationGO:00165682980.538
Fly
covalent chromatin modificationGO:00165692540.440
Fly
histone modificationGO:00165702510.431
Fly
macromolecule methylationGO:0043414970.251
Worm
positive regulation of phosphorylationGO:00423273940.230
Worm
internal protein amino acid acetylationGO:00064751010.206
positive regulation of cellular amine metabolic processGO:003324070.180
protein ubiquitinationGO:00165673140.174
regulation of cellular amine metabolic processGO:0033238110.170
regulation of cellular amino acid metabolic processGO:000652160.168
chromatin organizationGO:00063253510.156
post embryonic developmentGO:000979120.149
regulation of cell cycleGO:00517263930.148
Fly
histone acetylationGO:0016573930.148
cellular amino acid metabolic processGO:00065201160.146
cellular component morphogenesisGO:00329893140.140
Fly
chromatin assembly or disassemblyGO:0006333780.135
female gamete generationGO:000729220.135
cellular ketone metabolic processGO:0042180800.134
cellular macromolecule catabolic processGO:00442653800.133
methylationGO:00322591060.130
Worm
regulation of anatomical structure morphogenesisGO:00226032860.125
Fly
protein catabolic processGO:00301633250.121
oogenesisGO:004847720.120
regulation of cellular ketone metabolic processGO:0010565500.112
histone ubiquitinationGO:0016574310.111
cellular amine metabolic processGO:0044106410.110
cellular response to dna damage stimulusGO:00069743790.105
purine ribonucleoside triphosphate metabolic processGO:00092054110.099
protein modification by small protein conjugationGO:00324463420.096
positive regulation of cellular amino acid metabolic processGO:004576430.092
positive regulation of cellular component organizationGO:00511303760.090
positive regulation of transferase activityGO:00513472270.089
Worm
amine metabolic processGO:0009308440.084
positive regulation of developmental processGO:00510943140.083
Worm
proteolysis involved in cellular protein catabolic processGO:00516032440.082
peptidyl lysine modificationGO:00182051440.078
internal peptidyl lysine acetylationGO:0018393970.077
peptidyl lysine acetylationGO:00183941010.076
cell morphogenesisGO:00009022960.073
Fly
small gtpase mediated signal transductionGO:0007264780.073
dna conformation changeGO:00711031130.071
cellular protein catabolic processGO:00442572610.071
protein acetylationGO:00064731160.070
purine ribonucleoside catabolic processGO:00461303980.068
regulation of protein maturationGO:19033171500.067
cell developmentGO:00484683280.066
purine nucleoside triphosphate metabolic processGO:00091444120.065
embryo developmentGO:00097901230.063
Worm Fly
regulation of transferase activityGO:00513383550.060
Worm
multicellular organismal agingGO:001025930.059
protein acylationGO:00435431380.058
modification dependent protein catabolic processGO:00199412090.057
nucleoside phosphate catabolic processGO:19012924120.056
purine nucleotide catabolic processGO:00061954050.056
ribonucleotide catabolic processGO:00092614050.055
regulation of cell differentiationGO:00455953930.054
regulation of proteasomal protein catabolic processGO:0061136870.053
peptidyl serine phosphorylationGO:00181051010.053
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.052
positive regulation of protein kinase activityGO:00458601900.052
Worm
cell part morphogenesisGO:00329901370.051
purine nucleoside catabolic processGO:00061523980.050
vesicle mediated transportGO:00161923710.050
protein autophosphorylationGO:00467771230.049
Worm Fly
regulation of intracellular transportGO:00323861950.048
regulation of chromatin organizationGO:1902275560.048
intracellular protein transportGO:00068862700.048
Human
ribonucleoside triphosphate catabolic processGO:00092033910.047
nucleotide catabolic processGO:00091664080.047
growthGO:00400072020.046
Worm
positive regulation of protein phosphorylationGO:00019343130.046
Worm
nucleoside triphosphate metabolic processGO:00091414220.045
regulation of protein kinase activityGO:00458592890.044
Worm
mitotic cell cycleGO:00002783260.044
Fly
proteasomal protein catabolic processGO:00104981760.044
regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032434710.043
neuromuscular junction developmentGO:000752830.043
nervous system developmentGO:00073992930.043
response to biotic stimulusGO:00096072760.043
Fly
neurogenesisGO:00220081690.042
determination of adult lifespanGO:000834020.042
peptidyl serine modificationGO:00182091060.041
dna repairGO:00062811980.041
regulation of proteolysisGO:00301622930.041
mapk cascadeGO:00001652880.040
cell projection organizationGO:00300302520.040
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.040
negative regulation of cellular protein metabolic processGO:00322693530.039
nucleosome organizationGO:0034728660.039
nucleoside catabolic processGO:00091644080.038
ras protein signal transductionGO:0007265730.038
regulation of mapk cascadeGO:00434082620.038
negative regulation of phosphate metabolic processGO:00459362670.038
modification dependent macromolecule catabolic processGO:00436322120.038
immune responseGO:00069553070.038
Fly
rho protein signal transductionGO:0007266260.037
ribonucleoside triphosphate metabolic processGO:00091994120.037
negative regulation of cellular component organizationGO:00511292350.036
cellular response to abiotic stimulusGO:00712141170.035
purine containing compound catabolic processGO:00725234110.035
cell morphogenesis involved in differentiationGO:00009041440.035
regulation of protein processingGO:00706131500.035
circulatory system developmentGO:00723592620.035
neurological system processGO:00508771630.034
negative regulation of cell cycleGO:00457861930.034
glycosyl compound catabolic processGO:19016584130.034
cellular macromolecular complex assemblyGO:00346223240.034
regulation of cellular response to stressGO:00801352440.034
protein localization to organelleGO:00333652800.034
organophosphate catabolic processGO:00464344300.034
dephosphorylationGO:00163112090.033
neuroblast proliferationGO:000740540.033
neural tube formationGO:000184130.033
canonical wnt signaling pathwayGO:00600701160.033
biological adhesionGO:00226103310.033
Fly
purine ribonucleoside metabolic processGO:00461284370.033
response to abiotic stimulusGO:00096283360.032
locomotory behaviorGO:000762610.032
response to external biotic stimulusGO:00432072610.031
Fly
regulation of cell developmentGO:00602841610.031
cytoplasmic transportGO:00164823790.031
protein processingGO:00164852260.031
guanosine containing compound catabolic processGO:19010692390.030
regulation of proteolysis involved in cellular protein catabolic processGO:1903050910.030
negative regulation of protein metabolic processGO:00512483910.030
regulation of small gtpase mediated signal transductionGO:00510561560.030
positive regulation of cell differentiationGO:00455972110.030
spermatid differentiationGO:004851540.029
morphogenesis of embryonic epitheliumGO:001633140.029
negative regulation of proteolysisGO:00458611320.029
purine ribonucleotide catabolic processGO:00091544040.029
purine nucleoside triphosphate catabolic processGO:00091463920.029
nucleoside triphosphate catabolic processGO:00091433940.029
microtubule cytoskeleton organizationGO:00002261760.029
signal transduction by phosphorylationGO:00230142970.028
histone h3 acetylationGO:0043966450.028
regulation of bindingGO:00510981110.028
cell projection morphogenesisGO:00488581290.028
positive regulation of kinase activityGO:00336742040.028
Worm
negative regulation of proteasomal protein catabolic processGO:1901799320.028
segmentationGO:003528240.028
regulation of cell morphogenesisGO:00226041530.028
Fly
negative regulation of phosphorus metabolic processGO:00105632670.028
single organism membrane organizationGO:00448022680.027
epithelium developmentGO:00604292270.027
mrna metabolic processGO:00160711750.026
mitotic cell cycle processGO:19030472860.026
microtubule organizing center organizationGO:0031023620.026
negative regulation of hydrolase activityGO:00513461820.026
memoryGO:000761330.026
regulation of response to external stimulusGO:00321012220.026
regulation of nucleotide metabolic processGO:00061402690.026
regulation of kinase activityGO:00435493140.026
Worm
system processGO:00030083490.026
vasculature developmentGO:00019441810.025
generation of neuronsGO:00486991520.025
cell growthGO:00160491600.025
negative regulation of programmed cell deathGO:00430693210.025
protein methylationGO:0006479740.025
Worm
regulation of dna metabolic processGO:00510521530.024
positive regulation of cellular catabolic processGO:00313312840.024
organelle localizationGO:0051640840.024
anatomical structure formation involved in morphogenesisGO:00486462840.024
developmental growthGO:0048589480.024
Worm
neuron differentiationGO:00301821380.024
positive regulation of purine nucleotide metabolic processGO:19005442270.024
mitotic nuclear divisionGO:00070671190.024
chromatin assemblyGO:0031497610.024
regulation of cytoskeleton organizationGO:00514931770.024
dna replicationGO:00062601160.024
histone exchangeGO:004348630.023
nucleocytoplasmic transportGO:00069131760.023
ribonucleoside catabolic processGO:00424544060.023
cell cycle phase transitionGO:00447701730.023
hematopoietic or lymphoid organ developmentGO:00485341860.023
actin filament based processGO:00300292240.023
cell adhesionGO:00071553250.022
Fly
negative regulation of bindingGO:0051100570.022
actin cytoskeleton organizationGO:00300362070.022
regulation of ras protein signal transductionGO:00465781550.022
negative regulation of apoptotic processGO:00430663160.022
response to ionizing radiationGO:0010212650.022
neuron developmentGO:00486661130.021
cell cell signalingGO:00072671550.021
reproductive processGO:00224141060.021
regulation of nervous system developmentGO:0051960880.021
negative regulation of synaptic transmissionGO:005080520.021
transcription elongation from rna polymerase ii promoterGO:0006368180.021
mitotic cell cycle phase transitionGO:00447721620.021
neuron projection developmentGO:00311751060.021
protein maturationGO:00516042330.021
regulation of histone modificationGO:0031056470.021
protein alkylationGO:0008213740.020
Worm
regulation of growthGO:00400081650.020
Worm
positive regulation of transportGO:00510503360.020
single organism cellular localizationGO:19025803320.020
regulation of cellular component biogenesisGO:00440872810.020
negative regulation of cell differentiationGO:00455961710.020
regulation of purine nucleotide metabolic processGO:19005422640.019
negative regulation of cellular protein catabolic processGO:1903363380.019
negative regulation of protein modification processGO:00314002000.019
stem cell developmentGO:0048864690.019
spermatid developmentGO:000728640.019
positive regulation of organelle organizationGO:00106381950.019
negative regulation of organelle organizationGO:00106391260.019
regulation of anatomical structure sizeGO:00900661010.019
carbohydrate metabolic processGO:00059752070.019
negative regulation of cellular catabolic processGO:0031330830.018
regulation of dephosphorylationGO:0035303960.018
adult locomotory behaviorGO:000834410.018
response to other organismGO:00517072610.018
Fly
rna processingGO:00063962550.018
regulation of mitotic cell cycleGO:00073461890.018
regulation of establishment of protein localizationGO:00702012420.018
regulation of nucleocytoplasmic transportGO:0046822980.018
neural tube closureGO:000184330.018
glycoprotein biosynthetic processGO:0009101910.018
negative regulation of catabolic processGO:00098951040.018
positive regulation of hydrolase activityGO:00513453310.018
regulation of cell migrationGO:00303342890.018
nitrogen compound transportGO:00717051910.018
negative regulation of proteolysis involved in cellular protein catabolic processGO:1903051350.018
nuclear transportGO:00511691790.018
regulation of cellular component movementGO:00512703340.018
microtubule based processGO:00070172100.018
behaviorGO:00076101120.017
regulation of chromosome organizationGO:00330441030.017
stem cell differentiationGO:0048863930.017
stem cell divisionGO:001714520.017
organelle fissionGO:00482851490.017
negative regulation of protein maturationGO:19033181420.017
positive regulation of growthGO:0045927580.017
Worm
regulation of cytokine productionGO:00018172320.017
response to radiationGO:00093141510.017
establishment of protein localization to organelleGO:00725941720.017
cellular response to ionizing radiationGO:0071479320.017
cellular protein complex assemblyGO:00436231880.017
regulation of immune responseGO:00507762010.017
developmental growth involved in morphogenesisGO:0060560230.017
negative regulation of catalytic activityGO:00430863350.017
negative regulation of cellular amine metabolic processGO:003323930.017
regulation of wnt signaling pathwayGO:00301111230.017
heart developmentGO:0007507950.017
ubiquitin dependent protein catabolic processGO:00065112060.017
positive regulation of mapk cascadeGO:00434101900.017
regulation of purine nucleotide catabolic processGO:00331212050.017
tube closureGO:006060630.017
positive regulation of cytokine productionGO:00018191670.017
protein importGO:00170381300.016
gtp metabolic processGO:00460392390.016
membrane organizationGO:00610242920.016
positive regulation of programmed cell deathGO:00430682490.016
carbohydrate derivative biosynthetic processGO:19011372070.016
nuclear exportGO:0051168690.016
primary neural tube formationGO:001402030.016
regulation of cellular component sizeGO:0032535820.016
regulation of cell projection organizationGO:00313441070.016
purine ribonucleoside triphosphate catabolic processGO:00092073910.016
rna splicingGO:00083801310.016
anterior posterior axis specificationGO:000994820.016
regulation of defense responseGO:00313471540.016
central nervous system developmentGO:00074171230.016
negative regulation of protein catabolic processGO:0042177590.016
centrosome organizationGO:0051297580.016
regulation of nucleoside metabolic processGO:00091182090.015
protein glycosylationGO:0006486620.015
regulation of canonical wnt signaling pathwayGO:0060828880.015
cell cycle checkpointGO:00000751170.015
maintenance of locationGO:00512351120.015
lipid metabolic processGO:00066293810.015
cellular component disassemblyGO:0022411920.015
regulation of chromatin modificationGO:1903308510.015
regulation of cytoplasmic transportGO:19036491490.015
protein dephosphorylationGO:0006470810.015
agingGO:0007568660.015
regulation of axon guidanceGO:190266730.015
macromolecule glycosylationGO:0043413630.015
meiotic chromosome segregationGO:004513240.015
cytokine productionGO:00018162470.015
regulation of locomotionGO:00400123290.015
response to growth factorGO:00708482050.014
single organism reproductive processGO:0044702980.014
blood vessel morphogenesisGO:00485141620.014
organ morphogenesisGO:00098871470.014
dna packagingGO:0006323770.014
positive regulation of nucleoside metabolic processGO:00459791860.014
mitochondrion organizationGO:00070051560.014
rna splicing via transesterification reactions with bulged adenosine as nucleophileGO:0000377890.014
regulation of ras gtpase activityGO:00323181280.014
oocyte developmentGO:004859910.014
organelle assemblyGO:00709251760.014
regulation of nucleotide catabolic processGO:00308112050.014
negative regulation of cellular amino acid metabolic processGO:004576320.014
positive regulation of cell deathGO:00109422630.014
ribonucleoside monophosphate catabolic processGO:00091581580.014
regulation of cell growthGO:00015581350.014
autophagyGO:0006914880.014
single organism carbohydrate metabolic processGO:00447231930.013
atp catabolic processGO:00062001570.013
angiogenesisGO:00015251470.013
embryonic epithelial tube formationGO:000183840.013
cellular homeostasisGO:00197251960.013
intracellular receptor signaling pathwayGO:00305221040.013
activation of protein kinase activityGO:0032147900.013
regulation of neuron differentiationGO:0045664700.013
antimicrobial humoral responseGO:0019730260.013
Fly
negative regulation of phosphatase activityGO:0010923610.013
organophosphate biosynthetic processGO:00904071630.013
regulation of cell shapeGO:0008360480.013
Fly
regulation of cell morphogenesis involved in differentiationGO:0010769830.013
regulation of microtubule cytoskeleton organizationGO:0070507610.013
negative regulation of intracellular signal transductionGO:19025321830.013
negative regulation of dna metabolic processGO:0051053570.013
regulation of actin filament based processGO:00329701410.013
nucleoside monophosphate metabolic processGO:00091231910.013
regulation of protein transportGO:00512232130.013
negative regulation of developmental processGO:00510932470.013
blood vessel developmentGO:00015681720.013
neuron projection morphogenesisGO:0048812500.013
embryo development ending in birth or egg hatchingGO:0009792340.013
Worm
oocyte differentiationGO:000999420.013
chromatin remodelingGO:0006338550.013
regulation of cell motilityGO:20001452990.013
positive regulation of purine nucleotide catabolic processGO:00331231850.013
response to extracellular stimulusGO:0009991850.012
enzyme linked receptor protein signaling pathwayGO:00071673030.012
peripheral nervous system developmentGO:000742220.012
endocytosisGO:00068971590.012
regulation of mitotic cell cycle phase transitionGO:19019901180.012
chemotaxisGO:00069351570.012
engulfment of apoptotic cellGO:004365220.012
dna damage checkpointGO:0000077680.012
purine ribonucleoside monophosphate metabolic processGO:00091671860.012
response to oxygen containing compoundGO:19017003690.012
purine nucleoside monophosphate catabolic processGO:00091281580.012
rna splicing via transesterification reactionsGO:0000375900.012
head developmentGO:00603221080.012
reactive oxygen species metabolic processGO:0072593750.012
regulation of jak stat cascadeGO:0046425440.012
photoreceptor cell differentiationGO:004653020.012
cellular response to cytokine stimulusGO:00713451810.012
response to virusGO:00096151260.012
response to cytokineGO:00340972320.012
protein localization to nucleusGO:00345041360.012
negative regulation of cell cycle processGO:00109481210.012
regulation of phosphatase activityGO:0010921810.012
limbic system developmentGO:002176130.012
cellular response to external stimulusGO:00714961110.012
positive regulation of canonical wnt signaling pathwayGO:0090263330.012
embryonic placenta developmentGO:000189210.011
positive regulation of cell developmentGO:0010720920.011
male meiosisGO:000714010.011
hindbrain developmentGO:003090230.011
positive regulation of apoptotic processGO:00430652460.011
regulation of cell cycle processGO:00105642660.011
humoral immune responseGO:0006959490.011
Fly
epithelial cell differentiationGO:00308551410.011
cytokinesisGO:0000910960.011
regenerationGO:003109940.011
positive regulation of chromatin modificationGO:1903310300.011
axon extensionGO:0048675130.011
meiosis iGO:000712740.011
chemical homeostasisGO:00488783060.011
regulation of actin cytoskeleton organizationGO:00329561160.011
cellular chemical homeostasisGO:00550821800.011
dna integrity checkpointGO:0031570710.011
rhythmic behaviorGO:000762220.011
regulation of secretionGO:00510461940.011
protein polyubiquitinationGO:00002091100.011
double strand break repairGO:00063021010.011
regulation of protein catabolic processGO:00421761550.011
regulation of stress activated mapk cascadeGO:0032872840.011
endomembrane system organizationGO:00102561960.011
myeloid cell differentiationGO:00300991170.011
regulation of neurogenesisGO:0050767820.011
atp metabolic processGO:00460341760.011
peptidyl tyrosine phosphorylationGO:00181081700.011
defense responseGO:00069523150.010
positive regulation of immune system processGO:00026842830.010
immune system developmentGO:00025201950.010
protein targeting to nucleusGO:00447441040.010
nucleoside phosphate biosynthetic processGO:19012931090.010
posttranscriptional regulation of gene expressionGO:00106082130.010
guanosine containing compound metabolic processGO:19010682440.010
transmembrane transportGO:00550853990.010
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.010
developmental process involved in reproductionGO:0003006660.010
positive regulation of axon extensionGO:004577340.010
protein targetingGO:00066051870.010
regulation of microtubule based processGO:0032886740.010
gtp catabolic processGO:00061842370.010
cardiovascular system developmentGO:00723582620.010
positive regulation of nucleotide metabolic processGO:00459812300.010
regulation of neural precursor cell proliferationGO:200017740.010
blastoderm segmentationGO:000735020.010

TLK2 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of cellular proliferationDOID:145661740.013
cancerDOID:1621670.013
organ system cancerDOID:00506861640.012