Homo sapiens

313 known processes

PLK1

polo-like kinase 1

(Aliases: STPK13,PLK)

PLK1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
regulation of cell cycleGO:00517263931.000
regulation of mitotic cell cycleGO:00073461890.998
mitotic cell cycle processGO:19030472860.996
mitotic sister chromatid segregationGO:0000070530.988
modification dependent macromolecule catabolic processGO:00436322120.986
mitotic cell cycleGO:00002783260.984
organelle fissionGO:00482851490.981
meiotic chromosome segregationGO:004513240.975
Yeast Worm
modification dependent protein catabolic processGO:00199412090.968
mitotic nuclear divisionGO:00070671190.968
spindle assemblyGO:0051225290.967
Yeast Fly
nuclear divisionGO:00002801280.958
ubiquitin dependent protein catabolic processGO:00065112060.958
dna integrity checkpointGO:0031570710.949
mitotic cell cycle phase transitionGO:00447721620.947
sister chromatid segregationGO:0000819540.939
cell cycle phase transitionGO:00447701730.933
proteasomal protein catabolic processGO:00104981760.931
regulation of mitotic metaphase anaphase transitionGO:0030071260.910
cellular response to dna damage stimulusGO:00069743790.910
negative regulation of cell cycle phase transitionGO:1901988890.896
negative regulation of mitotic cell cycleGO:00459301020.891
dna repairGO:00062811980.890
proteolysis involved in cellular protein catabolic processGO:00516032440.889
mitotic cell cycle checkpointGO:0007093680.886
regulation of cell cycle processGO:00105642660.885
double strand break repairGO:00063021010.882
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.862
regulation of proteasomal protein catabolic processGO:0061136870.855
post embryonic developmentGO:000979120.855
Worm
regulation of mitotic cell cycle phase transitionGO:19019901180.851
positive regulation of mitotic cell cycleGO:0045931600.844
microtubule cytoskeleton organizationGO:00002261760.818
negative regulation of cell cycleGO:00457861930.811
male meiosisGO:000714010.802
Fly
cellular macromolecule catabolic processGO:00442653800.792
positive regulation of cell divisionGO:0051781590.764
regulation of proteolysisGO:00301622930.761
negative regulation of cell cycle processGO:00109481210.744
positive regulation of cell cycleGO:00457871400.714
chromosome segregationGO:00070591140.712
positive regulation of mitosisGO:0045840250.701
regulation of cell cycle phase transitionGO:19019871260.698
cellular protein catabolic processGO:00442572610.697
protein catabolic processGO:00301633250.659
regulation of cell diameterGO:006030510.653
cytokinesisGO:0000910960.649
spindle organizationGO:0007051530.647
Human Yeast Worm Fly
mitotic dna integrity checkpointGO:0044774300.639
positive regulation of cellular protein catabolic processGO:1903364370.637
g2 m transition of mitotic cell cycleGO:0000086410.623
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.621
positive regulation of proteolysisGO:00458621420.614
protein ubiquitinationGO:00165673140.613
regulation of cellular protein catabolic processGO:1903362960.591
endomembrane system organizationGO:00102561960.579
Human Worm
histone serine phosphorylationGO:003540440.573
regulation of mitosisGO:0007088630.569
positive regulation of catabolic processGO:00098963100.562
regulation of proteolysis involved in cellular protein catabolic processGO:1903050910.560
cell cycle checkpointGO:00000751170.545
regulation of chromosome segregationGO:0051983440.542
chromosome separationGO:0051304230.533
dna damage checkpointGO:0000077680.517
response to radiationGO:00093141510.515
Human
protein localization to organelleGO:00333652800.510
regulation of cell divisionGO:00513021160.498
positive regulation of cellular catabolic processGO:00313312840.493
positive regulation of mitotic sister chromatid separationGO:190197060.480
oocyte maturationGO:000155610.479
negative regulation of programmed cell deathGO:00430693210.450
metaphase anaphase transition of cell cycleGO:0044784210.438
female gamete generationGO:000729220.436
Worm Fly
positive regulation of cell cycle processGO:00900681060.434
regulation of mitotic sister chromatid segregationGO:0033047270.420
mitotic dna damage checkpointGO:0044773280.398
mitotic cytokinesisGO:0000281190.390
cell developmentGO:00484683280.387
Worm Fly
protein maturationGO:00516042330.379
cell cycle g2 m phase transitionGO:0044839430.367
cell divisionGO:00513011680.367
peptidyl serine modificationGO:00182091060.361
positive regulation of protein catabolic processGO:0045732750.335
microtubule based processGO:00070172100.318
negative regulation of cellular component organizationGO:00511292350.310
centrosome organizationGO:0051297580.298
tube morphogenesisGO:0035239950.291
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic processGO:0031145250.290
maintenance of protein locationGO:0045185570.289
negative regulation of mitotic cell cycle phase transitionGO:1901991850.289
regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032434710.288
positive regulation of exit from mitosisGO:003153620.281
centrosome cycleGO:0007098320.276
Human Worm
nucleus localizationGO:005164710.270
Fly
positive regulation of cellular component organizationGO:00511303760.260
mitotic spindle organizationGO:0007052270.251
Human Worm Fly
positive regulation of cell differentiationGO:00455972110.249
cyclin catabolic processGO:000805460.238
spindle checkpointGO:0031577260.233
protein modification by small protein conjugationGO:00324463420.226
intrinsic apoptotic signaling pathwayGO:00971931270.214
cell cell signalingGO:00072671550.205
negative regulation of cell deathGO:00605483450.203
positive regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032436300.201
regulation of cytoskeleton organizationGO:00514931770.199
Human Yeast
regulation of nuclear divisionGO:0051783650.198
positive regulation of protein phosphorylationGO:00019343130.198
spindle assembly checkpointGO:0071173170.193
attachment of spindle microtubules to kinetochoreGO:0008608170.193
purine ribonucleoside triphosphate metabolic processGO:00092054110.189
determination of adult lifespanGO:000834020.188
negative regulation of protein processingGO:00109551420.182
negative regulation of chromosome organizationGO:2001251480.182
negative regulation of cellular catabolic processGO:0031330830.171
positive regulation of proteolysis involved in cellular protein catabolic processGO:1903052350.156
positive regulation of organelle organizationGO:00106381950.155
maintenance of locationGO:00512351120.153
single organism cellular localizationGO:19025803320.152
protein localization to chromosomeGO:0034502300.150
positive regulation of phosphorylationGO:00423273940.147
mitotic sister chromatid separationGO:0051306180.147
negative regulation of apoptotic processGO:00430663160.144
negative regulation of protein metabolic processGO:00512483910.143
apoptotic signaling pathwayGO:00971902680.141
histone modificationGO:00165702510.137
cytoskeleton dependent cytokinesisGO:0061640220.136
microtubule anchoringGO:0034453240.136
ribonucleoside triphosphate metabolic processGO:00091994120.135
regulation of kinase activityGO:00435493140.134
protein oligomerizationGO:00512591730.133
regulation of cellular amine metabolic processGO:0033238110.132
dna damage response signal transduction by p53 class mediatorGO:0030330440.132
cell cycle g1 s phase transitionGO:0044843800.131
Human
regulation of mitotic sister chromatid separationGO:0010965270.129
maintenance of protein location in cellGO:0032507560.128
positive regulation of ligase activityGO:0051351190.124
nucleus organizationGO:0006997280.123
Worm Fly
protein k11 linked ubiquitinationGO:0070979240.119
organelle assemblyGO:00709251760.116
Human Yeast Fly
regulation of cell developmentGO:00602841610.115
Fly
regulation of endopeptidase activityGO:00525481700.115
cellular homeostasisGO:00197251960.115
signal transduction by p53 class mediatorGO:0072331720.114
regulation of cellular response to stressGO:00801352440.113
negative regulation of phosphorylationGO:00423261740.107
covalent chromatin modificationGO:00165692540.107
double strand break repair via single strand annealingGO:004500240.106
dna replicationGO:00062601160.104
response to abiotic stimulusGO:00096283360.103
Human
positive regulation of hydrolase activityGO:00513453310.103
regulation of microtubule cytoskeleton organizationGO:0070507610.101
Human Yeast
cellular component disassemblyGO:0022411920.101
Human Yeast Worm
sister chromatid cohesionGO:0007062240.099
positive regulation of cellular component biogenesisGO:00440891580.097
meiotic cell cycleGO:0051321130.095
Yeast Rat Worm Fly
positive regulation of chromosome segregationGO:005198490.093
regulation of transferase activityGO:00513383550.092
negative regulation of multicellular organismal processGO:00512413170.091
Fly
positive regulation of chromosome organizationGO:2001252410.091
guanosine containing compound catabolic processGO:19010692390.085
single organism reproductive processGO:0044702980.082
Worm Fly
embryo developmentGO:00097901230.082
Worm Fly
positive regulation of apoptotic signaling pathwayGO:2001235700.081
gtp catabolic processGO:00061842370.081
ras protein signal transductionGO:0007265730.080
protein polyubiquitinationGO:00002091100.078
microtubule organizing center organizationGO:0031023620.078
regulation of metaphase anaphase transition of cell cycleGO:1902099260.078
negative regulation of protein catabolic processGO:0042177590.078
histone phosphorylationGO:0016572160.077
protein k48 linked ubiquitinationGO:0070936380.077
protein polymerizationGO:0051258710.076
Fly
purine nucleoside triphosphate catabolic processGO:00091463920.076
establishment of nucleus localizationGO:004002310.075
Fly
ribonucleoside catabolic processGO:00424544060.074
membrane organizationGO:00610242920.072
Worm
protein processingGO:00164852260.071
positive regulation of proteasomal protein catabolic processGO:1901800350.070
positive regulation of mitotic cell cycle phase transitionGO:1901992190.069
negative regulation of cellular protein metabolic processGO:00322693530.068
negative regulation of phosphorus metabolic processGO:00105632670.067
positive regulation of transferase activityGO:00513472270.067
establishment of organelle localizationGO:0051656590.067
Fly
positive regulation of metaphase anaphase transition of cell cycleGO:190210160.067
negative regulation of organelle organizationGO:00106391260.066
positive regulation of nuclear divisionGO:0051785270.066
regulation of meiotic cell cycleGO:005144540.065
Worm
cellular component morphogenesisGO:00329893140.065
agingGO:0007568660.064
regulation of protein localizationGO:00328802960.062
Human
actin filament based processGO:00300292240.061
Fly
microtubule nucleationGO:000702060.060
Fly
regulation of protein modification by small protein conjugation or removalGO:19033201070.060
negative regulation of catabolic processGO:00098951040.058
regulation of protein ubiquitinationGO:0031396950.058
positive regulation of kinase activityGO:00336742040.058
dephosphorylationGO:00163112090.058
regulation of response to dna damage stimulusGO:2001020940.058
spindle assembly involved in mitosisGO:0090307120.057
regulation of protein kinase activityGO:00458592890.056
meiosis iGO:000712740.055
Yeast Worm
epithelium developmentGO:00604292270.055
Fly
regulation of cysteine type endopeptidase activityGO:20001161270.054
nucleoside triphosphate metabolic processGO:00091414220.054
signal transduction in response to dna damageGO:0042770570.052
positive regulation of protein kinase activityGO:00458601900.052
positive regulation of cysteine type endopeptidase activityGO:2001056790.052
negative regulation of transportGO:00510511760.052
regulation of nucleoside metabolic processGO:00091182090.051
nucleoside phosphate catabolic processGO:19012924120.051
cell agingGO:0007569520.050
nervous system developmentGO:00073992930.050
Fly
regulation of chromosome organizationGO:00330441030.049
regulation of cellular ketone metabolic processGO:0010565500.049
regulation of cytoplasmic transportGO:19036491490.048
centrosome separationGO:005129930.047
regulation of intrinsic apoptotic signaling pathwayGO:2001242720.046
negative regulation of protein phosphorylationGO:00019331400.046
generation of neuronsGO:00486991520.046
Fly
negative regulation of transferase activityGO:00513481240.046
positive regulation of ubiquitin protein transferase activityGO:0051443180.045
nucleotide catabolic processGO:00091664080.045
single organism membrane organizationGO:00448022680.045
Worm
embryo development ending in birth or egg hatchingGO:0009792340.044
Worm
microtubule cytoskeleton organization involved in mitosisGO:1902850150.044
recombinational repairGO:0000725500.044
glomerular epithelial cell developmentGO:007231030.043
intrinsic apoptotic signaling pathway by p53 class mediatorGO:0072332370.043
multicellular organismal agingGO:001025930.042
regulation of dna repairGO:0006282470.042
centrosome duplicationGO:0051298280.041
Human
guanosine containing compound metabolic processGO:19010682440.041
anatomical structure homeostasisGO:00602491000.041
oocyte developmentGO:004859910.040
signal transduction by phosphorylationGO:00230142970.040
negative regulation of cell proliferationGO:00082852280.040
Fly
organelle localizationGO:0051640840.039
Fly
negative regulation of proteolysis involved in cellular protein catabolic processGO:1903051350.039
oocyte differentiationGO:000999420.039
Fly
regulation of protein catabolic processGO:00421761550.038
nucleoside triphosphate catabolic processGO:00091433940.038
anatomical structure formation involved in morphogenesisGO:00486462840.037
cytoplasmic transportGO:00164823790.037
regulation of dna metabolic processGO:00510521530.036
protein autophosphorylationGO:00467771230.036
cell morphogenesisGO:00009022960.035
myosin filament assemblyGO:003103420.035
positive regulation of ubiquitin protein ligase activity involved in mitotic cell cycleGO:005143720.034
negative regulation of developmental processGO:00510932470.034
Fly
positive regulation of developmental processGO:00510943140.034
nucleoside catabolic processGO:00091644080.034
response to fungusGO:000962040.033
negative regulation of protein maturationGO:19033181420.032
maintenance of location in cellGO:0051651620.032
negative regulation of proteolysisGO:00458611320.032
neuron developmentGO:00486661130.032
purine nucleoside catabolic processGO:00061523980.032
purine ribonucleoside metabolic processGO:00461284370.032
dna damage response signal transduction resulting in transcriptionGO:0042772120.032
peptidyl serine phosphorylationGO:00181051010.032
regulation of nervous system developmentGO:0051960880.031
Fly
mapk cascadeGO:00001652880.031
negative regulation of chromosome segregationGO:0051985180.031
positive regulation of purine nucleotide metabolic processGO:19005442270.031
ribonucleoside triphosphate catabolic processGO:00092033910.030
cellular response to cytokine stimulusGO:00713451810.029
activation of cysteine type endopeptidase activity involved in apoptotic processGO:0006919490.029
small gtpase mediated signal transductionGO:0007264780.029
response to nitrogen compoundGO:19016981840.029
double strand break repair via homologous recombinationGO:0000724500.028
regulation of cell agingGO:0090342180.028
exit from mitosisGO:0010458100.028
negative regulation of phosphate metabolic processGO:00459362670.028
organophosphate catabolic processGO:00464344300.028
spermatogenesisGO:0007283220.028
Fly
regulation of cytokinesisGO:0032465450.027
Human
multi organism reproductive processGO:0044703540.027
Worm Fly
negative regulation of mitotic metaphase anaphase transitionGO:0045841170.027
nuclear migrationGO:000709710.027
Fly
meiotic nuclear divisionGO:0007126100.027
Yeast Rat Worm Fly
cellular response to radiationGO:0071478650.026
endocytosisGO:00068971590.026
Fly
regulation of peptidase activityGO:00525471800.026
peptidyl threonine phosphorylationGO:0018107410.026
regulation of dephosphorylationGO:0035303960.026
regulation of cell cycle arrestGO:0071156360.026
vesicle mediated transportGO:00161923710.026
Fly
response to oxygen containing compoundGO:19017003690.025
Human
regenerationGO:003109940.025
cellular protein complex assemblyGO:00436231880.025
Fly
cellular ketone metabolic processGO:0042180800.025
multicellular organismal reproductive processGO:0048609400.025
Worm Fly
negative regulation of kinase activityGO:00336731060.025
regulation of anatomical structure sizeGO:00900661010.024
negative regulation of catalytic activityGO:00430863350.024
zymogen activationGO:0031638700.023
regulation of sister chromatid segregationGO:0033045270.023
cell type specific apoptotic processGO:00972851250.023
g2 dna damage checkpointGO:0031572260.023
enzyme linked receptor protein signaling pathwayGO:00071673030.023
regulation of protein processingGO:00706131500.023
positive regulation of mitotic metaphase anaphase transitionGO:004584260.023
dna damage response signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0006978110.022
positive regulation of nucleotide metabolic processGO:00459812300.022
positive regulation of sequence specific dna binding transcription factor activityGO:00510911310.022
negative regulation of protein modification processGO:00314002000.022
spermatid differentiationGO:004851540.022
establishment or maintenance of cell polarityGO:0007163310.022
activation of cysteine type endopeptidase activityGO:0097202570.021
dna catabolic processGO:0006308490.021
positive regulation of peptidase activityGO:0010952880.021
nuclear transportGO:00511691790.021
epithelial cell proliferationGO:00506731280.020
negative regulation of cell divisionGO:0051782310.020
regulation of spindle organizationGO:0090224100.020
cell projection organizationGO:00300302520.020
male gamete generationGO:0048232220.020
Fly
myosin filament organizationGO:003103320.020
non recombinational repairGO:0000726140.019
establishment or maintenance of microtubule cytoskeleton polarityGO:003095120.019
oogenesisGO:004847720.019
Worm Fly
regulation of cellular component biogenesisGO:00440872810.019
Human
dna catabolic process exonucleolyticGO:0000738170.019
erk1 and erk2 cascadeGO:00703711040.019
establishment of cell polarityGO:0030010220.019
cellular response to abiotic stimulusGO:00712141170.019
striated muscle myosin thick filament assemblyGO:007168820.019
metaphase anaphase transition of mitotic cell cycleGO:0007091210.019
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:00432811160.018
lipid localizationGO:00108761060.018
cellular response to organic cyclic compoundGO:00714071270.017
muscle organ developmentGO:0007517560.017
histone acetylationGO:0016573930.017
positive regulation of nucleotide catabolic processGO:00308131850.017
regulation of histone modificationGO:0031056470.017
nucleotide excision repair dna incisionGO:003368370.017
chemotaxisGO:00069351570.017
regulation of cell cycle g1 s phase transitionGO:1902806420.017
regulation of ligase activityGO:0051340290.017
telomere maintenanceGO:0000723320.017
chromatin modificationGO:00165682980.016
purine containing compound catabolic processGO:00725234110.016
protein import into nucleusGO:00066061040.016
gtp metabolic processGO:00460392390.016
dna recombinationGO:0006310770.016
Yeast
regulation of cell adhesionGO:00301551660.016
negative regulation of protein transportGO:0051224750.016
negative regulation of cell sizeGO:004579230.016
tube developmentGO:00352951250.016
Fly
positive regulation of cardiac muscle cell proliferationGO:006004520.016
dna duplex unwindingGO:0032508300.016
positive regulation of cellular amine metabolic processGO:003324070.016
protein targetingGO:00066051870.015
dna geometric changeGO:0032392320.015
cellular amino acid metabolic processGO:00065201160.015
positive regulation of purine nucleotide catabolic processGO:00331231850.015
positive regulation of programmed cell deathGO:00430682490.015
negative regulation of mitosisGO:0045839240.015
vesicle organizationGO:0016050620.015
g1 s transition of mitotic cell cycleGO:0000082780.015
Human
posttranscriptional regulation of gene expressionGO:00106082130.015
regulation of purine nucleotide catabolic processGO:00331212050.015
negative regulation of cysteine type endopeptidase activityGO:2000117480.015
regulation of protein maturationGO:19033171500.015
response to uvGO:0009411730.015
activation of protein kinase activityGO:0032147900.014
digestive system developmentGO:0055123750.014
actin cytoskeleton organizationGO:00300362070.014
Fly
ribonucleotide catabolic processGO:00092614050.014
positive regulation of protein ubiquitinationGO:0031398530.014
regulation of canonical wnt signaling pathwayGO:0060828880.014
protein sumoylationGO:0016925250.014
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.014
regulation of protein serine threonine kinase activityGO:00719001790.014
intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediatorGO:0042771230.014
regulation of ubiquitin protein transferase activityGO:0051438280.014
neuron differentiationGO:00301821380.014
blood vessel morphogenesisGO:00485141620.014
positive regulation of endopeptidase activityGO:0010950840.014
cellular response to endogenous stimulusGO:00714953360.013
response to ionizing radiationGO:0010212650.013
immune responseGO:00069553070.013
ameboidal type cell migrationGO:00016671350.013
negative regulation of dna metabolic processGO:0051053570.013
negative regulation of protein kinase activityGO:0006469980.013
reproductive processGO:00224141060.013
Worm Fly
gland developmentGO:0048732480.013
positive regulation of apoptotic processGO:00430652460.013
regulation of homeostatic processGO:00328441210.013
negative regulation of neurogenesisGO:0050768260.012
Fly
regulation of protein bindingGO:0043393660.012
sexual reproductionGO:0019953370.012
Worm Fly
positive regulation of dna metabolic processGO:0051054730.012
cytokinetic processGO:0032506120.012
Fly
negative regulation of peptidase activityGO:0010466910.012
positive regulation of cell developmentGO:0010720920.012
regulation of synaptic plasticityGO:004816730.012
regulation of cytokine mediated signaling pathwayGO:0001959410.012
receptor mediated endocytosisGO:0006898840.012
taxisGO:00423301570.012
organ morphogenesisGO:00098871470.012
positive regulation of immune responseGO:00507781590.012
neuronal stem cell maintenanceGO:009715050.012
regulation of protein dephosphorylationGO:0035304180.011
purine nucleoside triphosphate metabolic processGO:00091444120.011
protein k63 linked ubiquitinationGO:0070534310.011
regulation of gtp catabolic processGO:00331241800.011
single organism nuclear importGO:19025931040.011
positive regulation of cell deathGO:00109422630.011
intracellular protein transportGO:00068862700.011
Human
response to organonitrogen compoundGO:00102431560.011
cell part morphogenesisGO:00329901370.011
chromatin organizationGO:00063253510.011
protein tetramerizationGO:0051262470.011
regulation of microtubule based processGO:0032886740.011
Human Yeast
purine ribonucleoside catabolic processGO:00461303980.011
regulation of centrosome cycleGO:0046605150.011
Human
positive regulation of cytokinesisGO:0032467290.011
response to biotic stimulusGO:00096072760.011
negative regulation of metaphase anaphase transition of cell cycleGO:1902100170.010
response to oxygen levelsGO:00704821000.010
Human
sex differentiationGO:0007548450.010
Worm
negative regulation of hydrolase activityGO:00513461820.010
positive regulation of protein complex assemblyGO:0031334860.010
negative regulation of dephosphorylationGO:0035305630.010
protein homotetramerizationGO:0051289280.010
response to oxidative stressGO:00069791210.010
Human

PLK1 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
thoracic cancerDOID:5093210.136
cancerDOID:1621670.136
disease of cellular proliferationDOID:145661740.136
organ system cancerDOID:00506861640.136
hematopoietic system diseaseDOID:741000.053
immune system diseaseDOID:29141550.053
bone marrow diseaseDOID:4961310.053
gastrointestinal system cancerDOID:3119520.044
breast cancerDOID:1612210.026