Homo sapiens

162 known processes

MDFIC

MyoD family inhibitor domain containing

(Aliases: HIC)

MDFIC biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular ketone metabolic processGO:0042180800.091
regulation of cellular amine metabolic processGO:0033238110.087
post embryonic developmentGO:000979120.086
regulation of cellular amino acid metabolic processGO:000652160.079
regulation of cellular ketone metabolic processGO:0010565500.075
cellular amino acid metabolic processGO:00065201160.072
regulation of cell differentiationGO:00455953930.070
cellular amine metabolic processGO:0044106410.069
amine metabolic processGO:0009308440.068
response to oxygen containing compoundGO:19017003690.056
organophosphate catabolic processGO:00464344300.052
cell developmentGO:00484683280.051
positive regulation of cellular amine metabolic processGO:003324070.050
glycosyl compound catabolic processGO:19016584130.049
positive regulation of phosphorylationGO:00423273940.049
nucleoside triphosphate metabolic processGO:00091414220.047
purine ribonucleoside metabolic processGO:00461284370.045
negative regulation of protein metabolic processGO:00512483910.044
regulation of transferase activityGO:00513383550.044
ribonucleoside triphosphate metabolic processGO:00091994120.043
purine nucleotide catabolic processGO:00061954050.043
purine ribonucleotide catabolic processGO:00091544040.042
nucleoside catabolic processGO:00091644080.042
positive regulation of cellular amino acid metabolic processGO:004576430.041
regulation of proteolysisGO:00301622930.041
memoryGO:000761330.041
nucleoside phosphate catabolic processGO:19012924120.041
gtp catabolic processGO:00061842370.041
system processGO:00030083490.040
multicellular organismal agingGO:001025930.040
negative regulation of catalytic activityGO:00430863350.039
purine ribonucleoside triphosphate metabolic processGO:00092054110.039
negative regulation of cell deathGO:00605483450.039
nucleotide catabolic processGO:00091664080.039
positive regulation of cellular component organizationGO:00511303760.038
purine nucleoside triphosphate metabolic processGO:00091444120.038
nucleoside triphosphate catabolic processGO:00091433940.038
enzyme linked receptor protein signaling pathwayGO:00071673030.038
positive regulation of developmental processGO:00510943140.038
cellular component morphogenesisGO:00329893140.037
ribonucleoside triphosphate catabolic processGO:00092033910.037
purine containing compound catabolic processGO:00725234110.037
negative regulation of cellular protein metabolic processGO:00322693530.036
ribonucleotide catabolic processGO:00092614050.036
regulation of locomotionGO:00400123290.036
female gamete generationGO:000729220.036
circulatory system developmentGO:00723592620.036
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.035
purine ribonucleoside catabolic processGO:00461303980.035
oogenesisGO:004847720.035
cardiovascular system developmentGO:00723582620.034
purine ribonucleoside triphosphate catabolic processGO:00092073910.034
immune responseGO:00069553070.034
ribonucleoside catabolic processGO:00424544060.034
purine nucleoside catabolic processGO:00061523980.034
epithelium developmentGO:00604292270.034
determination of adult lifespanGO:000834020.034
segmentationGO:003528240.033
negative regulation of cell proliferationGO:00082852280.033
negative regulation of apoptotic processGO:00430663160.033
small gtpase mediated signal transductionGO:0007264780.033
regulation of cell motilityGO:20001452990.033
locomotory behaviorGO:000762610.033
inorganic ion transmembrane transportGO:00986602310.032
cell morphogenesisGO:00009022960.032
positive regulation of catabolic processGO:00098963100.032
regulation of cell cycleGO:00517263930.032
regulation of cell migrationGO:00303342890.032
cellular macromolecule catabolic processGO:00442653800.031
purine nucleoside triphosphate catabolic processGO:00091463920.031
positive regulation of hydrolase activityGO:00513453310.031
cell projection organizationGO:00300302520.030
defense responseGO:00069523150.030
regulation of kinase activityGO:00435493140.030
negative regulation of phosphate metabolic processGO:00459362670.029
ras protein signal transductionGO:0007265730.029
cytoplasmic transportGO:00164823790.029
Mouse
biological adhesionGO:00226103310.029
negative regulation of cellular amine metabolic processGO:003323930.029
regulation of protein kinase activityGO:00458592890.029
positive regulation of nucleotide metabolic processGO:00459812300.029
negative regulation of programmed cell deathGO:00430693210.029
positive regulation of programmed cell deathGO:00430682490.028
negative regulation of developmental processGO:00510932470.028
positive regulation of cell differentiationGO:00455972110.028
positive regulation of cell proliferationGO:00082843010.028
positive regulation of cellular catabolic processGO:00313312840.028
negative regulation of multicellular organismal processGO:00512413170.028
regulation of cellular component movementGO:00512703340.027
guanosine containing compound metabolic processGO:19010682440.027
positive regulation of cell deathGO:00109422630.027
positive regulation of apoptotic processGO:00430652460.027
guanosine containing compound catabolic processGO:19010692390.027
response to abiotic stimulusGO:00096283360.027
cellular response to oxygen containing compoundGO:19017012760.026
cell adhesionGO:00071553250.026
regulation of protein localizationGO:00328802960.026
Mouse
regulation of endopeptidase activityGO:00525481700.026
organ formationGO:004864530.026
response to external biotic stimulusGO:00432072610.026
regulation of anatomical structure morphogenesisGO:00226032860.026
gtp metabolic processGO:00460392390.026
cation transmembrane transportGO:00986552380.026
cytokine productionGO:00018162470.025
regulation of nucleotide metabolic processGO:00061402690.025
vesicle mediated transportGO:00161923710.025
regenerationGO:003109940.025
covalent chromatin modificationGO:00165692540.025
neuromuscular junction developmentGO:000752830.025
membrane organizationGO:00610242920.025
regulation of purine nucleotide metabolic processGO:19005422640.025
protein catabolic processGO:00301633250.025
positive regulation of purine nucleotide metabolic processGO:19005442270.025
negative regulation of cellular amino acid metabolic processGO:004576320.025
cation transportGO:00068123310.025
protein processingGO:00164852260.025
cell morphogenesis involved in differentiationGO:00009041440.025
negative regulation of hydrolase activityGO:00513461820.025
positive regulation of immune system processGO:00026842830.024
protein maturationGO:00516042330.024
leukocyte activationGO:00453211640.024
mapk cascadeGO:00001652880.024
cellular response to dna damage stimulusGO:00069743790.024
angiogenesisGO:00015251470.024
actin filament based processGO:00300292240.024
epithelial cell differentiationGO:00308551410.024
ion homeostasisGO:00508012300.024
metal ion transportGO:00300012720.024
transmembrane transportGO:00550853990.024
signal transduction by phosphorylationGO:00230142970.023
proteolysis involved in cellular protein catabolic processGO:00516032440.023
mitotic cell cycleGO:00002783260.023
negative regulation of phosphorus metabolic processGO:00105632670.023
nervous system developmentGO:00073992930.023
negative regulation of cellular component organizationGO:00511292350.023
lipid metabolic processGO:00066293810.023
blood vessel developmentGO:00015681720.023
response to lipidGO:00339932060.023
regulation of cell cycle processGO:00105642660.023
cellular protein catabolic processGO:00442572610.023
negative regulation of protein modification processGO:00314002000.023
response to biotic stimulusGO:00096072760.023
rho protein signal transductionGO:0007266260.022
positive regulation of protein phosphorylationGO:00019343130.022
anatomical structure formation involved in morphogenesisGO:00486462840.022
response to other organismGO:00517072610.022
innate immune responseGO:00450871780.022
ion transmembrane transportGO:00342203380.022
chromatin organizationGO:00063253510.022
regulation of immune responseGO:00507762010.022
single organism cellular localizationGO:19025803320.022
Mouse
carbohydrate derivative biosynthetic processGO:19011372070.022
maintenance of locationGO:00512351120.022
apoptotic signaling pathwayGO:00971902680.022
regulation of mapk cascadeGO:00434082620.022
regulation of nucleoside metabolic processGO:00091182090.022
regulation of peptidase activityGO:00525471800.021
response to growth factorGO:00708482050.021
regulation of cell developmentGO:00602841610.021
negative regulation of cell cycleGO:00457861930.021
cellular lipid metabolic processGO:00442553030.021
blastoderm segmentationGO:000735020.021
cellular response to endogenous stimulusGO:00714953360.020
regulation of establishment of protein localizationGO:00702012420.020
Mouse
wnt signaling pathwayGO:00160551560.020
protein localization to organelleGO:00333652800.020
Mouse
histone modificationGO:00165702510.020
regulation of response to external stimulusGO:00321012220.020
positive regulation of transportGO:00510503360.020
single organism membrane organizationGO:00448022680.020
regulation of protein transportGO:00512232130.020
Mouse
regulation of cellular component biogenesisGO:00440872810.020
cell cycle phase transitionGO:00447701730.020
morphogenesis of embryonic epitheliumGO:001633140.020
vasculature developmentGO:00019441810.020
immune system developmentGO:00025201950.020
inner ear morphogenesisGO:004247240.020
positive regulation of nucleoside metabolic processGO:00459791860.020
cell activationGO:00017752130.020
oocyte developmentGO:004859910.020
carbohydrate metabolic processGO:00059752070.020
organonitrogen compound biosynthetic processGO:19015662000.020
dephosphorylationGO:00163112090.019
response to organic cyclic compoundGO:00140702040.019
chromatin modificationGO:00165682980.019
growthGO:00400072020.019
mitotic cell cycle processGO:19030472860.019
blood vessel morphogenesisGO:00485141620.019
rhythmic behaviorGO:000762220.019
regulation of gtp catabolic processGO:00331241800.019
intracellular protein transportGO:00068862700.019
Mouse
negative regulation of phosphorylationGO:00423261740.019
inorganic cation transmembrane transportGO:00986621940.018
regulation of purine nucleotide catabolic processGO:00331212050.018
negative regulation of cell differentiationGO:00455961710.018
response to hormoneGO:00097251750.018
motor neuron axon guidanceGO:000804520.018
peptidyl tyrosine phosphorylationGO:00181081700.018
circadian behaviorGO:004851220.018
small molecule biosynthetic processGO:00442831570.018
chemical homeostasisGO:00488783060.018
ubiquitin dependent protein catabolic processGO:00065112060.018
epithelial cell proliferationGO:00506731280.018
positive regulation of purine nucleotide catabolic processGO:00331231850.018
negative regulation of protein phosphorylationGO:00019331400.018
generation of neuronsGO:00486991520.018
secretionGO:00469032540.018
cation homeostasisGO:00550801890.017
regulation of cellular response to stressGO:00801352440.017
lipid biosynthetic processGO:00086101770.017
lymphocyte activationGO:00466491330.017
response to woundingGO:00096111680.017
single organism carbohydrate metabolic processGO:00447231930.017
positive regulation of proteolysisGO:00458621420.017
positive regulation of nucleotide catabolic processGO:00308131850.017
oocyte differentiationGO:000999420.017
response to nitrogen compoundGO:19016981840.017
single organismal cell cell adhesionGO:00163371480.017
modification dependent macromolecule catabolic processGO:00436322120.017
regulation of cytokine productionGO:00018172320.017
regulation of protein catabolic processGO:00421761550.017
single organism cell adhesionGO:00986021790.017
cell growthGO:00160491600.017
cell fate determinationGO:000170930.017
anion transportGO:00068201610.017
long term memoryGO:000761620.017
nitrogen compound transportGO:00717051910.017
reactive nitrogen species metabolic processGO:200105730.016
neuron differentiationGO:00301821380.016
peripheral nervous system developmentGO:000742220.016
syncytium formation by plasma membrane fusionGO:000076820.016
regulation of nucleotide catabolic processGO:00308112050.016
proteasomal protein catabolic processGO:00104981760.016
positive regulation of cytokine productionGO:00018191670.016
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.016
compound eye developmentGO:004874910.016
immune effector processGO:00022521590.016
regulation of gtpase activityGO:00430871800.016
peptidyl tyrosine modificationGO:00182121700.016
regulation of sequence specific dna binding transcription factor activityGO:00510902110.016
neurological system processGO:00508771630.016
positive regulation of protein kinase activityGO:00458601900.016
nerve developmentGO:002167540.016
regulation of apoptotic signaling pathwayGO:20012331750.016
nucleocytoplasmic transportGO:00069131760.016
Mouse
regulation of defense responseGO:00313471540.016
reactive oxygen species metabolic processGO:0072593750.016
cellular macromolecular complex assemblyGO:00346223240.016
neuroblast proliferationGO:000740540.016
negative regulation of transferase activityGO:00513481240.016
mitotic cell cycle phase transitionGO:00447721620.016
cellular homeostasisGO:00197251960.016
reactive oxygen species biosynthetic processGO:190340940.016
positive regulation of mapk cascadeGO:00434101900.016
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.016
cellular chemical homeostasisGO:00550821800.015
secretion by cellGO:00329402260.015
negative regulation of protein maturationGO:19033181420.015
regulation of growthGO:00400081650.015
anterior posterior axis specificationGO:000994820.015
regulation of secretionGO:00510461940.015
response to virusGO:00096151260.015
neural tube formationGO:000184130.015
positive regulation of gtpase activityGO:00435471660.015
regulation of protein serine threonine kinase activityGO:00719001790.015
regulation of cell projection organizationGO:00313441070.015
matingGO:000761810.015
ossificationGO:00015031210.015
hemopoiesisGO:00300971800.015
modification dependent protein catabolic processGO:00199412090.015
neuron projection developmentGO:00311751060.015
hindbrain developmentGO:003090230.015
embryonic epithelial tube formationGO:000183840.015
regulation of reactive oxygen species biosynthetic processGO:190342630.015
negative regulation of protein processingGO:00109551420.015
adult locomotory behaviorGO:000834410.015
tissue regenerationGO:004224630.015
negative regulation of intracellular signal transductionGO:19025321830.015
protein oligomerizationGO:00512591730.015
positive regulation of kinase activityGO:00336742040.015
neuron developmentGO:00486661130.015
cellular ion homeostasisGO:00068731680.015
protein ubiquitinationGO:00165673140.015
positive regulation of organelle organizationGO:00106381950.015
regulation of i kappab kinase nf kappab signalingGO:00431221620.015
positive regulation of gtp catabolic processGO:00331261660.014
regulation of mitotic cell cycleGO:00073461890.014
cellular response to nitrogen compoundGO:19016991440.014
regulation of cell activationGO:00508651250.014
activation of immune responseGO:00022531140.014
regulation of cell morphogenesisGO:00226041530.014
hematopoietic or lymphoid organ developmentGO:00485341860.014
positive regulation of immune responseGO:00507781590.014
cardiac muscle cell contractionGO:008600340.014
organophosphate biosynthetic processGO:00904071630.014
stem cell divisionGO:001714520.014
regulation of secretion by cellGO:19035301770.014
cellular response to cytokine stimulusGO:00713451810.014
protein localization to membraneGO:00726571600.014
response to cytokineGO:00340972320.014
cellular response to hormone stimulusGO:00328701250.014
endomembrane system organizationGO:00102561960.014
neurogenesisGO:00220081690.014
divalent inorganic cation transportGO:00725111580.014
cellular protein complex assemblyGO:00436231880.014
spermatid differentiationGO:004851540.014
organelle assemblyGO:00709251760.014
regulation of ras protein signal transductionGO:00465781550.014
negative regulation of kinase activityGO:00336731060.014
i kappab kinase nf kappab signalingGO:00072491660.014
chemotaxisGO:00069351570.014
regulation of neural precursor cell proliferationGO:200017740.014
protein acylationGO:00435431380.014
viral processGO:00160321460.014
regulation of protein maturationGO:19033171500.014
regulation of wnt signaling pathwayGO:00301111230.014
spermatid developmentGO:000728640.014
response to organonitrogen compoundGO:00102431560.014
negative regulation of transportGO:00510511760.014
Mouse
regulation of cysteine type endopeptidase activityGO:20001161270.014
negative regulation of cellular component movementGO:00512711060.014
behaviorGO:00076101120.014
regulation of cytoplasmic transportGO:19036491490.014
Mouse
specification of organ identityGO:001009230.014
regulation of cell adhesionGO:00301551660.014
oxidation reduction processGO:00551143960.014
g protein coupled receptor signaling pathwayGO:00071862070.014
regulation of nervous system developmentGO:0051960880.014
negative regulation of immune system processGO:00026831360.014
negative regulation of proteolysisGO:00458611320.014
neural crest cell developmentGO:001403230.014
tripartite regional subdivisionGO:000735120.013
anterior posterior axis specification embryoGO:000859520.013
tissue morphogenesisGO:0048729960.013
positive regulation of transferase activityGO:00513472270.013
regulation of small gtpase mediated signal transductionGO:00510561560.013
negative regulation of locomotionGO:00400131180.013
actin cytoskeleton organizationGO:00300362070.013
associative learningGO:000830610.013
lipid localizationGO:00108761060.013
calcium ion transportGO:00068161470.013
cellular response to organonitrogen compoundGO:00714171240.013
regulation of protein processingGO:00706131500.013
cellular response to lipidGO:00713961270.013
response to fungusGO:000962040.013
regulation of dna metabolic processGO:00510521530.013
regulation of synaptic plasticityGO:004816730.013
negative regulation of protein kinase activityGO:0006469980.013
osteoblast differentiationGO:0001649920.013
morphogenesis of a polarized epitheliumGO:000173830.013
purine ribonucleoside monophosphate metabolic processGO:00091671860.013
negative regulation of cell migrationGO:00303361020.013
cell part morphogenesisGO:00329901370.013
primary neural tube formationGO:001402030.013
metal ion homeostasisGO:00550651690.013
somitogenesisGO:000175620.013
cellular response to abiotic stimulusGO:00712141170.013
myoblast fusionGO:000752010.013
cellular response to glucocorticoid stimulusGO:007138540.013
response to bacteriumGO:00096171440.013
cell substrate adhesionGO:00315891320.013
positive regulation of locomotionGO:00400171860.013
regulation of homeostatic processGO:00328441210.013
positive regulation of cellular component movementGO:00512721810.013
cell projection morphogenesisGO:00488581290.013
ribonucleoside monophosphate metabolic processGO:00091611870.013
cell projection assemblyGO:00300311260.013
regulation of cytoskeleton organizationGO:00514931770.013
positive regulation of sequence specific dna binding transcription factor activityGO:00510911310.013
sequestering of metal ionGO:0051238240.013
regulation of ras gtpase activityGO:00323181280.013
post embryonic organ developmentGO:004856910.013
divalent metal ion transportGO:00708381520.013
alcohol metabolic processGO:00060661140.012
regulation of reactive oxygen species metabolic processGO:2000377410.012
atp metabolic processGO:00460341760.012
calcium ion transmembrane transportGO:0070588760.012
positive regulation of cellular component biogenesisGO:00440891580.012
protein modification by small protein conjugationGO:00324463420.012
salivary gland morphogenesisGO:000743540.012
sex determinationGO:000753030.012
retina vasculature morphogenesis in camera type eyeGO:006129930.012
regulation of multi organism processGO:00439001570.012
limbic system developmentGO:002176130.012
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:00432811160.012
cellular cation homeostasisGO:00300031630.012
regulation of lymphocyte activationGO:00512491030.012
spinal cord developmentGO:002151040.012
t cell differentiation in thymusGO:003307740.012
ameboidal type cell migrationGO:00016671350.012
nucleoside monophosphate metabolic processGO:00091231910.012
defense response to other organismGO:00985421290.012
thymus developmentGO:004853830.012
wound healingGO:00420601150.012
response to radiationGO:00093141510.012
divalent inorganic cation homeostasisGO:00725071360.012
purine nucleoside monophosphate metabolic processGO:00091261860.012
regulation of peptidyl tyrosine phosphorylationGO:00507301080.012
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781250.012
muscle cell fate commitmentGO:004269340.012
monocarboxylic acid metabolic processGO:00327871850.012
positive regulation of secretion by cellGO:19035321080.012
response to inorganic substanceGO:00100351270.012
metencephalon developmentGO:002203720.012
rna processingGO:00063962550.012
circulatory system processGO:00030131130.012
organic acid biosynthetic processGO:0016053970.012
regulation of leukocyte activationGO:00026941150.012
neurotransmitter secretionGO:000726940.012
immune response regulating signaling pathwayGO:0002764970.012
response to axon injuryGO:004867810.012
regulation of ion transportGO:00432691890.012
positive regulation of reactive oxygen species biosynthetic processGO:190342820.012
positive regulation of cell cycleGO:00457871400.012
positive regulation of ras gtpase activityGO:00323201170.012
lens development in camera type eyeGO:000208820.012
cellular response to growth factor stimulusGO:00713631970.012
immune response activating signal transductionGO:0002757900.012
patterning of blood vesselsGO:000156920.012
glycoprotein metabolic processGO:00091001100.012
lung alveolus developmentGO:004828640.012
forebrain generation of neuronsGO:002187230.012
protein targetingGO:00066051870.012
Mouse
photoreceptor cell differentiationGO:004653020.012
regulation of vesicle mediated transportGO:00606271300.012
glycoprotein biosynthetic processGO:0009101910.012
regulation of cell cycle phase transitionGO:19019871260.012
microtubule based processGO:00070172100.012
reproductive processGO:00224141060.012
cellular response to organic cyclic compoundGO:00714071270.012
morphogenesis of an epitheliumGO:0002009600.011
posttranscriptional regulation of gene expressionGO:00106082130.011
regulation of cell growthGO:00015581350.011
cell divisionGO:00513011680.011
regulation of cellular protein catabolic processGO:1903362960.011
regulation of intracellular transportGO:00323861950.011
Mouse
positive regulation of cell migrationGO:00303351720.011
symbiosis encompassing mutualism through parasitismGO:00444031560.011
ectoderm developmentGO:000739830.011
positive regulation of cell developmentGO:0010720920.011
neural tube closureGO:000184330.011
interspecies interaction between organismsGO:00444191560.011
t cell activationGO:0042110990.011
positive regulation of cell motilityGO:20001471770.011
somatic stem cell divisionGO:004810310.011
protein autophosphorylationGO:00467771230.011
regulation of mitotic cell cycle phase transitionGO:19019901180.011
carboxylic acid biosynthetic processGO:0046394970.011
regulation of actin filament based processGO:00329701410.011
response to oxidative stressGO:00069791210.011
negative regulation of organelle organizationGO:00106391260.011
positive regulation of secretionGO:00510471160.011
meiotic chromosome segregationGO:004513240.011
positive regulation of synaptic transmissionGO:005080640.011
embryo developmentGO:00097901230.011
sequestering of calcium ionGO:0051208170.011
negative regulation of endopeptidase activityGO:0010951840.011
establishment of planar polarityGO:000173630.011
nuclear transportGO:00511691790.011
Mouse
protein localization to nucleusGO:00345041360.011
Mouse
neuron projection regenerationGO:003110210.011
regulation of epithelial cell migrationGO:0010632930.011
regulation of meiotic cell cycleGO:005144540.011
actin filament based movementGO:0030048170.011
cellular response to transforming growth factor beta stimulusGO:0071560940.011
regulation of cardiac muscle tissue growthGO:005502140.011
regulation of bindingGO:00510981110.011
establishment of protein localization to membraneGO:00901501210.011
calcium ion homeostasisGO:00550741220.011
purine ribonucleoside monophosphate catabolic processGO:00091691580.011
single organism reproductive processGO:0044702980.011
positive regulation of cell activationGO:0050867810.011
establishment of tissue polarityGO:000716430.011

MDFIC disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
musculoskeletal system diseaseDOID:172230.035
nervous system diseaseDOID:8634310.028
sensory system diseaseDOID:00501552030.028
disease of metabolismDOID:00146672950.027
eye diseaseDOID:56141490.020
eye and adnexa diseaseDOID:14921500.020
inherited metabolic disorderDOID:6552420.017
connective tissue diseaseDOID:651090.017
central nervous system diseaseDOID:3311860.016
disease of cellular proliferationDOID:145661740.016
cancerDOID:1621670.016
organ system cancerDOID:00506861640.014
bone diseaseDOID:0080001880.014
muscular diseaseDOID:00800001140.014
muscle tissue diseaseDOID:661130.014
immune system diseaseDOID:29141550.014
myopathyDOID:4231040.012
retinal diseaseDOID:56791180.012
neurodegenerative diseaseDOID:12891020.011
cardiovascular system diseaseDOID:12871060.011