Homo sapiens

80 known processes

HIST1H4I

histone cluster 1, H4i

(Aliases: HIST1H4C,HIST1H4B,HIST1H4A,HIST4H4,HIST1H4F,HIST1H4E,HIST1H4D,H4/m,HIST1H4J,H4M,HIST1H4H,H4FM,HIST1H4K,HIST1H4L,HIST2H4B,HIST2H4A)

HIST1H4I biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
dna replication dependent nucleosome assemblyGO:0006335320.572
negative regulation of megakaryocyte differentiationGO:0045653160.405
dna replication independent nucleosome assemblyGO:0006336270.377
dna replication independent nucleosome organizationGO:0034724270.368
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.330
Yeast
nucleosome assemblyGO:0006334500.260
chromatin assembly or disassemblyGO:0006333780.243
chromatin organizationGO:00063253510.239
chromatin assemblyGO:0031497610.238
dna replication dependent nucleosome organizationGO:0034723320.228
nucleosome organizationGO:0034728660.216
regulation of cell differentiationGO:00455953930.160
immune system developmentGO:00025201950.135
regulation of megakaryocyte differentiationGO:0045652220.128
negative regulation of developmental processGO:00510932470.120
protein dna complex assemblyGO:0065004640.119
regulation of hematopoietic progenitor cell differentiationGO:1901532240.109
hematopoietic or lymphoid organ developmentGO:00485341860.105
megakaryocyte differentiationGO:0030219250.095
cellular macromolecular complex assemblyGO:00346223240.088
negative regulation of cell differentiationGO:00455961710.087
dna conformation changeGO:00711031130.085
protein dna complex subunit organizationGO:0071824800.085
cellular response to dna damage stimulusGO:00069743790.082
myeloid cell differentiationGO:00300991170.082
post embryonic developmentGO:000979120.082
histone modificationGO:00165702510.074
Yeast
hemopoiesisGO:00300971800.074
extraocular skeletal muscle developmentGO:000207410.073
negative regulation of immune system processGO:00026831360.073
negative regulation of multicellular organismal processGO:00512413170.071
anatomical structure formation involved in morphogenesisGO:00486462840.067
Yeast
dna packagingGO:0006323770.067
dna repairGO:00062811980.064
regulation of myeloid cell differentiationGO:0045637810.062
histone lysine methylationGO:0034968500.062
Yeast
chromatin modificationGO:00165682980.059
Yeast
protein alkylationGO:0008213740.057
Yeast
hematopoietic progenitor cell differentiationGO:0002244380.056
rna processingGO:00063962550.055
macromolecule methylationGO:0043414970.055
Yeast
histone h3 k79 methylationGO:003472920.053
Yeast
segmentationGO:003528240.051
negative regulation of myeloid cell differentiationGO:0045638420.050
histone methylationGO:0016571600.049
Yeast
mrna metabolic processGO:00160711750.048
covalent chromatin modificationGO:00165692540.047
Yeast
negative regulation of hematopoietic progenitor cell differentiationGO:1901533180.046
protein methylationGO:0006479740.046
Yeast
cellular amino acid metabolic processGO:00065201160.044
amine metabolic processGO:0009308440.044
regulation of cellular amino acid metabolic processGO:000652160.042
cellular ketone metabolic processGO:0042180800.042
regulation of cellular amine metabolic processGO:0033238110.041
regulation of cell cycleGO:00517263930.039
determination of adult lifespanGO:000834020.039
multicellular organismal agingGO:001025930.039
cellular amine metabolic processGO:0044106410.039
regulation of cellular ketone metabolic processGO:0010565500.038
positive regulation of cellular amino acid metabolic processGO:004576430.038
cellular component disassemblyGO:0022411920.037
cellular macromolecule catabolic processGO:00442653800.037
negative regulation of cellular protein metabolic processGO:00322693530.037
cell cycle checkpointGO:00000751170.036
response to abiotic stimulusGO:00096283360.036
methylationGO:00322591060.036
Yeast
positive regulation of cellular component organizationGO:00511303760.035
regenerationGO:003109940.035
positive regulation of cellular amine metabolic processGO:003324070.034
positive regulation of transportGO:00510503360.033
mrna processingGO:00063971330.031
locomotory behaviorGO:000762610.031
mitotic cell cycleGO:00002783260.030
positive regulation of developmental processGO:00510943140.029
positive regulation of hydrolase activityGO:00513453310.029
cellular response to oxygen containing compoundGO:19017012760.029
ras protein signal transductionGO:0007265730.028
regulation of cell cycle processGO:00105642660.028
protein complex disassemblyGO:0043241520.028
cellular response to abiotic stimulusGO:00712141170.028
blastoderm segmentationGO:000735020.027
response to radiationGO:00093141510.027
cellular component morphogenesisGO:00329893140.027
regulation of proteolysisGO:00301622930.027
negative regulation of protein metabolic processGO:00512483910.027
organ formationGO:004864530.027
immune responseGO:00069553070.026
female gamete generationGO:000729220.026
positive regulation of cell differentiationGO:00455972110.026
negative regulation of cell cycleGO:00457861930.026
nerve developmentGO:002167540.026
oogenesisGO:004847720.025
growthGO:00400072020.025
negative regulation of cell deathGO:00605483450.025
regulation of mitotic cell cycleGO:00073461890.025
regulation of anatomical structure morphogenesisGO:00226032860.025
positive regulation of cell deathGO:00109422630.025
cytoplasmic transportGO:00164823790.025
cell developmentGO:00484683280.025
regulation of gene expression epigeneticGO:0040029730.024
Yeast
regulation of cellular component movementGO:00512703340.024
negative regulation of cellular component organizationGO:00511292350.024
positive regulation of apoptotic processGO:00430652460.024
cell morphogenesisGO:00009022960.024
positive regulation of programmed cell deathGO:00430682490.024
morphogenesis of embryonic epitheliumGO:001633140.024
small gtpase mediated signal transductionGO:0007264780.024
oxidation reduction processGO:00551143960.024
single organism cellular localizationGO:19025803320.024
protein catabolic processGO:00301633250.023
hindbrain developmentGO:003090230.023
response to uvGO:0009411730.023
motor neuron axon guidanceGO:000804520.023
epithelium developmentGO:00604292270.023
organonitrogen compound biosynthetic processGO:19015662000.023
negative regulation of programmed cell deathGO:00430693210.022
adult locomotory behaviorGO:000834410.022
response to oxygen containing compoundGO:19017003690.022
regulation of locomotionGO:00400123290.022
circulatory system developmentGO:00723592620.022
cellular response to radiationGO:0071478650.022
positive regulation of organelle organizationGO:00106381950.022
cellular protein catabolic processGO:00442572610.022
cellular response to endogenous stimulusGO:00714953360.022
positive regulation of catabolic processGO:00098963100.022
negative regulation of catalytic activityGO:00430863350.022
negative regulation of apoptotic processGO:00430663160.021
regulation of cell motilityGO:20001452990.021
neuromuscular junction developmentGO:000752830.021
negative regulation of phosphorus metabolic processGO:00105632670.021
regulation of response to external stimulusGO:00321012220.021
single organism membrane organizationGO:00448022680.021
cellular lipid metabolic processGO:00442553030.021
regulation of protein localizationGO:00328802960.021
enzyme linked receptor protein signaling pathwayGO:00071673030.021
cardiovascular system developmentGO:00723582620.021
neuron fate commitmentGO:004866320.020
protein maturationGO:00516042330.020
nervous system developmentGO:00073992930.020
negative regulation of cellular amine metabolic processGO:003323930.020
cell growthGO:00160491600.020
gene silencingGO:0016458490.020
Yeast
protein localization to organelleGO:00333652800.020
posttranscriptional regulation of gene expressionGO:00106082130.020
dna damage checkpointGO:0000077680.020
protein processingGO:00164852260.020
anterior posterior axis specificationGO:000994820.020
cell cycle phase transitionGO:00447701730.020
positive regulation of cell proliferationGO:00082843010.020
negative regulation of cell proliferationGO:00082852280.020
cell fate determinationGO:000170930.019
defense responseGO:00069523150.019
regulation of sequence specific dna binding transcription factor activityGO:00510902110.019
modification dependent macromolecule catabolic processGO:00436322120.019
spinal cord developmentGO:002151040.019
specification of organ identityGO:001009230.019
positive regulation of cellular catabolic processGO:00313312840.019
proteolysis involved in cellular protein catabolic processGO:00516032440.019
small molecule biosynthetic processGO:00442831570.019
lipid metabolic processGO:00066293810.019
system processGO:00030083490.019
negative regulation of cellular amino acid metabolic processGO:004576320.019
negative regulation of phosphate metabolic processGO:00459362670.019
organophosphate catabolic processGO:00464344300.019
negative regulation of intracellular signal transductionGO:19025321830.019
response to biotic stimulusGO:00096072760.018
mitochondrion organizationGO:00070051560.018
negative regulation of proteolysisGO:00458611320.018
lipid biosynthetic processGO:00086101770.018
apoptotic signaling pathwayGO:00971902680.018
modification dependent protein catabolic processGO:00199412090.018
regulation of growthGO:00400081650.018
macromolecular complex disassemblyGO:0032984600.018
thymus developmentGO:004853830.018
intracellular protein transportGO:00068862700.018
positive regulation of immune system processGO:00026842830.018
regulation of cell growthGO:00015581350.018
regulation of establishment of protein localizationGO:00702012420.018
vasculature developmentGO:00019441810.018
cellular response to uvGO:0034644320.018
metencephalon developmentGO:002203720.018
reactive oxygen species biosynthetic processGO:190340940.018
ribonucleoside catabolic processGO:00424544060.018
transmembrane transportGO:00550853990.017
regulation of protein transportGO:00512232130.017
reactive oxygen species metabolic processGO:0072593750.017
associative learningGO:000830610.017
nucleoside triphosphate metabolic processGO:00091414220.017
single organism reproductive processGO:0044702980.017
Yeast
somitogenesisGO:000175620.017
ribonucleoside triphosphate metabolic processGO:00091994120.017
membrane organizationGO:00610242920.017
tissue regenerationGO:004224630.017
memoryGO:000761330.017
response to lipidGO:00339932060.017
monocarboxylic acid metabolic processGO:00327871850.017
organophosphate biosynthetic processGO:00904071630.017
secretion by cellGO:00329402260.017
rho protein signal transductionGO:0007266260.017
regulation of cellular response to stressGO:00801352440.017
oocyte developmentGO:004859910.017
spermatid differentiationGO:004851540.017
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.017
carbohydrate derivative biosynthetic processGO:19011372070.017
positive regulation of protein phosphorylationGO:00019343130.017
ribonucleoside triphosphate catabolic processGO:00092033910.017
embryonic epithelial tube formationGO:000183840.017
negative regulation of protein modification processGO:00314002000.017
regulation of transferase activityGO:00513383550.017
protein modification by small protein conjugationGO:00324463420.017
peripheral nervous system developmentGO:000742220.017
cell differentiation in spinal cordGO:002151510.017
organ morphogenesisGO:00098871470.017
oocyte differentiationGO:000999420.017
positive regulation of phosphorylationGO:00423273940.016
response to external biotic stimulusGO:00432072610.016
establishment or maintenance of bipolar cell polarityGO:006124520.016
response to other organismGO:00517072610.016
biological adhesionGO:00226103310.016
regulation of cell migrationGO:00303342890.016
morphogenesis of a polarized epitheliumGO:000173830.016
negative regulation of gene expression epigeneticGO:0045814190.016
Yeast
reproductive processGO:00224141060.016
Yeast
chemical homeostasisGO:00488783060.016
purine nucleoside triphosphate metabolic processGO:00091444120.016
purine ribonucleoside metabolic processGO:00461284370.016
regulation of cellular component biogenesisGO:00440872810.016
mitotic cell cycle processGO:19030472860.016
tripartite regional subdivisionGO:000735120.016
cranial nerve developmentGO:002154540.016
regulation of secretion by cellGO:19035301770.016
epidermis morphogenesisGO:004873030.016
cardiac muscle cell contractionGO:008600340.016
regulation of secretionGO:00510461940.016
purine ribonucleoside triphosphate metabolic processGO:00092054110.016
anterior posterior axis specification embryoGO:000859520.016
regulation of protein catabolic processGO:00421761550.016
maintenance of locationGO:00512351120.016
regulation of purine nucleotide metabolic processGO:19005422640.016
establishment of protein localization to organelleGO:00725941720.016
regulation of gene silencingGO:0060968240.016
regulation of nucleotide metabolic processGO:00061402690.016
carbohydrate metabolic processGO:00059752070.016
negative regulation of organelle organizationGO:00106391260.016
heart formationGO:006091420.016
regulation of mapk cascadeGO:00434082620.016
compound eye developmentGO:004874910.016
regulation of apoptotic signaling pathwayGO:20012331750.015
epithelial cell differentiationGO:00308551410.015
cell morphogenesis involved in differentiationGO:00009041440.015
proteasomal protein catabolic processGO:00104981760.015
cellular response to light stimulusGO:0071482340.015
negative regulation of cell cycle processGO:00109481210.015
syncytium formation by plasma membrane fusionGO:000076820.015
purine containing compound catabolic processGO:00725234110.015
dephosphorylationGO:00163112090.015
carboxylic acid biosynthetic processGO:0046394970.015
central nervous system developmentGO:00074171230.015
somatic muscle developmentGO:000752510.015
mitotic cell cycle phase transitionGO:00447721620.015
regulation of cell developmentGO:00602841610.015
cerebellum developmentGO:002154920.015
spermatid developmentGO:000728640.015
ribonucleotide catabolic processGO:00092614050.015
response to light stimulusGO:0009416870.015
protein targetingGO:00066051870.015
blood vessel morphogenesisGO:00485141620.015
endomembrane system organizationGO:00102561960.015
ubiquitin dependent protein catabolic processGO:00065112060.015
actin filament based processGO:00300292240.015
ion homeostasisGO:00508012300.015
negative regulation of protein maturationGO:19033181420.015
glycosyl compound catabolic processGO:19016584130.015
astrocyte differentiationGO:004870840.015
regulation of kinase activityGO:00435493140.014
vesicle mediated transportGO:00161923710.014
innate immune responseGO:00450871780.014
purine nucleoside triphosphate catabolic processGO:00091463920.014
nucleoside phosphate catabolic processGO:19012924120.014
purine ribonucleotide catabolic processGO:00091544040.014
reactive nitrogen species metabolic processGO:200105730.014
regulation of mitotic cell cycle phase transitionGO:19019901180.014
response to axon injuryGO:004867810.014
cell adhesionGO:00071553250.014
mapk cascadeGO:00001652880.014
nucleotide catabolic processGO:00091664080.014
cell projection organizationGO:00300302520.014
negative regulation of phosphorylationGO:00423261740.014
regulation of reactive oxygen species metabolic processGO:2000377410.014
limbic system developmentGO:002176130.014
forebrain neuron differentiationGO:002187930.014
regulation of protein complex assemblyGO:00432541470.014
positive regulation of purine nucleotide metabolic processGO:19005442270.014
regulation of protein processingGO:00706131500.014
embryonic placenta developmentGO:000189210.014
pharynx developmentGO:006046510.014
regulation of chromosome organizationGO:00330441030.014
regulation of cell divisionGO:00513021160.014
neural tube formationGO:000184130.014
neurogenesisGO:00220081690.014
negative regulation of transportGO:00510511760.014
purine nucleoside catabolic processGO:00061523980.014
positive regulation of reactive oxygen species metabolic processGO:2000379240.014
microtubule based processGO:00070172100.014
regulation of meiotic cell cycleGO:005144540.014
protein ubiquitinationGO:00165673140.014
organic acid biosynthetic processGO:0016053970.014
regulation of cell morphogenesisGO:00226041530.014
fatty acid metabolic processGO:00066311150.014
single organism carbohydrate metabolic processGO:00447231930.014
positive regulation of cell cycleGO:00457871400.013
interspecies interaction between organismsGO:00444191560.013
negative regulation of protein processingGO:00109551420.013
matingGO:000761810.013
ventral spinal cord developmentGO:002151710.013
regulation of protein maturationGO:19033171500.013
regulation of protein kinase activityGO:00458592890.013
dna integrity checkpointGO:0031570710.013
regulation of reactive oxygen species biosynthetic processGO:190342630.013
forelimb morphogenesisGO:003513640.013
purine ribonucleoside catabolic processGO:00461303980.013
response to hormoneGO:00097251750.013
regulation of cytokine productionGO:00018172320.013
lens development in camera type eyeGO:000208820.013
protein localization to membraneGO:00726571600.013
regulation of synaptic plasticityGO:004816730.013
negative regulation of mitotic cell cycleGO:00459301020.013
positive regulation of cell migrationGO:00303351720.013
response to fungusGO:000962040.013
stem cell divisionGO:001714520.013
positive regulation of cellular component biogenesisGO:00440891580.013
secretionGO:00469032540.013
forebrain generation of neuronsGO:002187230.013
tube closureGO:006060630.013
hair follicle morphogenesisGO:003106920.013
signal transduction by phosphorylationGO:00230142970.013
regulation of intracellular transportGO:00323861950.013
menstrual cycle phaseGO:002260120.013
regulation of neural precursor cell proliferationGO:200017740.013
nitrogen compound transportGO:00717051910.013
ossificationGO:00015031210.013
anion transportGO:00068201610.013
sequestering of metal ionGO:0051238240.013
photoreceptor cell differentiationGO:004653020.013
purine nucleotide catabolic processGO:00061954050.013
cell divisionGO:00513011680.013
neurotransmitter secretionGO:000726940.013
response to nitrogen compoundGO:19016981840.013
regulation of cell cycle phase transitionGO:19019871260.013
neuron projection regenerationGO:003110210.013
peptidyl tyrosine modificationGO:00182121700.013
cellular response to cytokine stimulusGO:00713451810.013
regulation of organ formationGO:000315640.013
nucleoside catabolic processGO:00091644080.013
somatic stem cell maintenanceGO:003501940.013
primary neural tube formationGO:001402030.013
regulation of immune responseGO:00507762010.012
regulation of cellular protein catabolic processGO:1903362960.012
visual behaviorGO:000763220.012
embryonic forelimb morphogenesisGO:003511540.012
organelle fissionGO:00482851490.012
cytokine productionGO:00018162470.012
regulation of peptidase activityGO:00525471800.012
nucleoside triphosphate catabolic processGO:00091433940.012
nuclear transportGO:00511691790.012
regulation of dna metabolic processGO:00510521530.012
positive regulation of reactive oxygen species biosynthetic processGO:190342820.012
regulation of homeostatic processGO:00328441210.012
positive regulation of cellular component movementGO:00512721810.012
positive regulation of locomotionGO:00400171860.012
rna splicingGO:00083801310.012
regulation of glial cell differentiationGO:004568530.012
positive regulation of proteolysisGO:00458621420.012
negative regulation of transferase activityGO:00513481240.012
regulation of response to woundingGO:19030341010.012
positive regulation of protein transportGO:00512221350.012
positive regulation of protein kinase activityGO:00458601900.012
symbiosis encompassing mutualism through parasitismGO:00444031560.012
forebrain regionalizationGO:002187130.012
nucleocytoplasmic transportGO:00069131760.012
neural tube closureGO:000184330.012
regulation of purine nucleotide catabolic processGO:00331212050.012
sequestering of calcium ionGO:0051208170.012
negative regulation of gliogenesisGO:001401430.012
peptidyl lysine modificationGO:00182051440.012
rhythmic behaviorGO:000762220.012
multi organism cellular processGO:00447641560.012
tongue developmentGO:004358610.012
post embryonic organ developmentGO:004856910.012
wound healingGO:00420601150.012
divalent inorganic cation transportGO:00725111580.012
hematopoietic stem cell differentiationGO:006021840.012
guanosine containing compound metabolic processGO:19010682440.012
blood vessel developmentGO:00015681720.012
chromosome segregationGO:00070591140.012
head developmentGO:00603221080.012
sex determinationGO:000753030.012
positive regulation of cytokine productionGO:00018191670.012
generation of neuronsGO:00486991520.012
response to organic cyclic compoundGO:00140702040.011
actin cytoskeleton organizationGO:00300362070.011
establishment of planar polarityGO:000173630.011
defense response to other organismGO:00985421290.011
establishment or maintenance of apical basal cell polarityGO:003508820.011
axis elongationGO:000340140.011
epithelial cell proliferationGO:00506731280.011
gtp catabolic processGO:00061842370.011
positive regulation of nucleotide metabolic processGO:00459812300.011
regulation of mitosisGO:0007088630.011
lipid modificationGO:0030258840.011
inner ear morphogenesisGO:004247240.011
positive regulation of secretion by cellGO:19035321080.011
protein oligomerizationGO:00512591730.011
neural crest cell developmentGO:001403230.011
organelle assemblyGO:00709251760.011
neuroblast proliferationGO:000740540.011
response to cytokineGO:00340972320.011
microtubule cytoskeleton organizationGO:00002261760.011
gtp metabolic processGO:00460392390.011
circadian behaviorGO:004851220.011
establishment of tissue polarityGO:000716430.011
regulation of proteolysis involved in cellular protein catabolic processGO:1903050910.011
guanosine containing compound catabolic processGO:19010692390.011
sleepGO:003043120.011
nucleic acid phosphodiester bond hydrolysisGO:00903051020.011
purine ribonucleoside triphosphate catabolic processGO:00092073910.011
negative regulation of cellular catabolic processGO:0031330830.011
response to woundingGO:00096111680.011
mitotic nuclear divisionGO:00070671190.011
hindlimb morphogenesisGO:003513720.011
cellular protein complex assemblyGO:00436231880.011
negative regulation of catabolic processGO:00098951040.011
regulation of gtpase activityGO:00430871800.011
negative regulation of protein phosphorylationGO:00019331400.011
peptidyl tyrosine phosphorylationGO:00181081700.011
neuron differentiationGO:00301821380.011
axon regenerationGO:003110310.011
lipid catabolic processGO:0016042840.011
cell activationGO:00017752130.011
tissue morphogenesisGO:0048729960.011
regulation of cytoplasmic transportGO:19036491490.011
ion transmembrane transportGO:00342203380.011
embryo developmentGO:00097901230.011
negative regulation of interleukin 5 secretionGO:200066310.011
cell part morphogenesisGO:00329901370.011
mesodermal cell fate commitmentGO:000171020.011
muscle cell fate commitmentGO:004269340.011
regulation of heart growthGO:006042040.011
negative regulation of voltage gated calcium channel activityGO:190138640.011
negative regulation of cell cycle phase transitionGO:1901988890.011
regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032434710.011
regulation of nucleoside metabolic processGO:00091182090.011
regulation of cell adhesionGO:00301551660.011
rna interferenceGO:001624640.011
glycoprotein metabolic processGO:00091001100.011
myoblast fusionGO:000752010.010
positive regulation of neural precursor cell proliferationGO:200017920.010
chromatin silencingGO:0006342120.010
Yeast
blastocyst formationGO:000182530.010
protein homooligomerizationGO:00512601000.010
positive regulation of nucleoside metabolic processGO:00459791860.010
cardiac right ventricle morphogenesisGO:000321530.010
taxisGO:00423301570.010
cation transportGO:00068123310.010
positive regulation of cysteine type endopeptidase activityGO:2001056790.010
embryonic viscerocranium morphogenesisGO:004870310.010
nuclear divisionGO:00002801280.010
negative regulation of hydrolase activityGO:00513461820.010
regulation of protein secretionGO:0050708860.010
regulation of proteasomal protein catabolic processGO:0061136870.010
positive regulation of sequence specific dna binding transcription factor activityGO:00510911310.010
regulation of axon extension involved in axon guidanceGO:004884120.010
positive regulation of purine nucleotide catabolic processGO:00331231850.010
regulation of cytoskeleton organizationGO:00514931770.010
protein secretionGO:0009306980.010

HIST1H4I disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:00146672950.032
immune system diseaseDOID:29141550.023
inherited metabolic disorderDOID:6552420.021
sensory system diseaseDOID:00501552030.020
eye diseaseDOID:56141490.020
eye and adnexa diseaseDOID:14921500.020
nervous system diseaseDOID:8634310.020
central nervous system diseaseDOID:3311860.019
musculoskeletal system diseaseDOID:172230.017
disease of cellular proliferationDOID:145661740.017
organ system cancerDOID:00506861640.016
cancerDOID:1621670.016
hematopoietic system diseaseDOID:741000.015
retinal diseaseDOID:56791180.015
bone diseaseDOID:0080001880.014
connective tissue diseaseDOID:651090.014
neurodegenerative diseaseDOID:12891020.013
acquired metabolic diseaseDOID:0060158580.011