Homo sapiens

138 known processes

PTPN11

protein tyrosine phosphatase, non-receptor type 11

(Aliases: BPTP3,MGC14433,PTP-1D,CFC,PTP2C,NS1,SHP2,SH-PTP3,SH-PTP2)

PTPN11 biological process predictions


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Biological processGO term IDProcess sizeProbabilityFunc Analog Org
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691811.000
enzyme linked receptor protein signaling pathwayGO:00071673031.000
cellular response to endogenous stimulusGO:00714953360.999
positive regulation of map kinase activityGO:0043406800.996
Mouse
cellular response to oxygen containing compoundGO:19017012760.992
insulin receptor signaling pathwayGO:0008286230.992
regulation of tyrosine phosphorylation of stat3 proteinGO:0042516180.992
cellular response to peptide hormone stimulusGO:0071375560.991
response to insulinGO:0032868450.987
regulation of transferase activityGO:00513383550.986
Mouse
response to peptideGO:1901652650.983
response to growth factorGO:00708482050.981
Mouse Fly
cell developmentGO:00484683280.981
Mouse Fly
myeloid cell differentiationGO:00300991170.980
Mouse
mapk cascadeGO:00001652880.979
Human Mouse
positive regulation of glucose import in response to insulin stimulusGO:200127530.978
cellular response to peptideGO:1901653590.969
epithelium developmentGO:00604292270.967
Zebrafish Fly
tyrosine phosphorylation of stat proteinGO:0007260330.959
tyrosine phosphorylation of stat3 proteinGO:0042503200.953
cellular response to nitrogen compoundGO:19016991440.950
hemopoiesisGO:00300971800.950
Mouse
cellular ketone metabolic processGO:0042180800.948
cellular response to hormone stimulusGO:00328701250.945
regulation of protein kinase activityGO:00458592890.938
Mouse
response to cytokineGO:00340972320.929
response to peptide hormoneGO:0043434610.927
regulation of protein serine threonine kinase activityGO:00719001790.923
Mouse
positive regulation of protein phosphorylationGO:00019343130.923
Mouse
cell cell signalingGO:00072671550.918
Mouse
response to nitrogen compoundGO:19016981840.917
photoreceptor cell differentiationGO:004653020.915
Fly
regulation of phosphatidylinositol 3 kinase signalingGO:0014066350.913
Human
negative regulation of phosphate metabolic processGO:00459362670.912
Human
neuron projection regenerationGO:003110210.909
response to organonitrogen compoundGO:00102431560.909
positive regulation of mapk cascadeGO:00434101900.909
Mouse
jak stat cascadeGO:0007259460.907
regulation of cellular ketone metabolic processGO:0010565500.906
negative regulation of programmed cell deathGO:00430693210.906
Fly
regulation of cellular response to insulin stimulusGO:1900076170.904
mitotic cell cycleGO:00002783260.903
Human Mouse Fly
regulation of map kinase activityGO:00434051080.901
Mouse
interleukin 6 mediated signaling pathwayGO:007010270.900
regulation of insulin receptor signaling pathwayGO:0046626130.880
regulation of cell migrationGO:00303342890.865
cellular response to organonitrogen compoundGO:00714171240.864
positive regulation of protein kinase activityGO:00458601900.853
Mouse
phosphatidylinositol 3 kinase signalingGO:0014065480.842
Human
positive regulation of phosphorylationGO:00423273940.837
Mouse
response to hormoneGO:00097251750.833
positive regulation of tyrosine phosphorylation of stat3 proteinGO:0042517160.831
regulation of cell activationGO:00508651250.829
positive regulation of phosphatidylinositol 3 kinase signalingGO:0014068280.826
Human
cellular ion homeostasisGO:00068731680.821
regulation of kinase activityGO:00435493140.817
Mouse
cytokine mediated signaling pathwayGO:00192211090.816
activation of mapk activityGO:0000187450.815
Mouse
small gtpase mediated signal transductionGO:0007264780.807
cardiovascular system developmentGO:00723582620.805
regulation of interleukin 6 mediated signaling pathwayGO:007010330.804
cell activationGO:00017752130.795
neuron differentiationGO:00301821380.786
Mouse Fly
cellular amine metabolic processGO:0044106410.780
embryonic camera type eye formationGO:006090020.776
regulation of mapk cascadeGO:00434082620.771
Human Mouse
cellular response to growth factor stimulusGO:00713631970.769
Mouse Fly
positive regulation of cell proliferationGO:00082843010.756
Human
actin filament organizationGO:00070151280.748
positive regulation of immune system processGO:00026842830.741
regenerationGO:003109940.729
glucose import in response to insulin stimulusGO:004438140.718
anatomical structure formation involved in morphogenesisGO:00486462840.711
Mouse
signal transduction by phosphorylationGO:00230142970.704
Human Mouse
tissue morphogenesisGO:0048729960.702
Zebrafish Fly
behaviorGO:00076101120.699
positive regulation of kinase activityGO:00336742040.699
Mouse
actin filament based processGO:00300292240.699
female gamete generationGO:000729220.685
Fly
heart developmentGO:0007507950.685
regulation of erk1 and erk2 cascadeGO:0070372990.684
Human Mouse
immune responseGO:00069553070.684
prostate gland developmentGO:003085030.682
cellular amino acid metabolic processGO:00065201160.656
tripartite regional subdivisionGO:000735120.656
Fly
peptidyl tyrosine phosphorylationGO:00181081700.648
Human
regulation of anatomical structure morphogenesisGO:00226032860.636
Fly
negative regulation of apoptotic processGO:00430663160.634
Fly
vesicle mediated transportGO:00161923710.629
Fly
cellular response to insulin stimulusGO:0032869410.625
cellular response to cytokine stimulusGO:00713451810.625
positive regulation of jnk cascadeGO:0046330520.599
reproductive processGO:00224141060.595
response to oxygen containing compoundGO:19017003690.591
lipid localizationGO:00108761060.590
Mouse
determination of adult lifespanGO:000834020.590
morphogenesis of embryonic epitheliumGO:001633140.586
regulation of immune responseGO:00507762010.584
embryonic camera type eye developmentGO:003107620.565
anterior posterior axis specificationGO:000994820.558
Fly
circulatory system developmentGO:00723592620.551
activation of protein kinase activityGO:0032147900.540
Mouse
regulation of epithelial cell proliferationGO:00506781130.537
ion homeostasisGO:00508012300.535
response to biotic stimulusGO:00096072760.532
regulation of cellular amine metabolic processGO:0033238110.530
response to woundingGO:00096111680.529
tube morphogenesisGO:0035239950.527
Zebrafish
negative regulation of cell deathGO:00605483450.524
Zebrafish Fly
negative regulation of cell adhesionGO:0007162640.517
Mouse
epithelial cell developmentGO:0002064340.517
Fly
guanosine containing compound catabolic processGO:19010692390.510
cellular lipid metabolic processGO:00442553030.508
Mouse
regulation of erbb signaling pathwayGO:1901184270.499
associative learningGO:000830610.496
amine metabolic processGO:0009308440.494
multicellular organismal agingGO:001025930.488
cellular component morphogenesisGO:00329893140.480
Mouse
positive regulation of cellular amino acid metabolic processGO:004576430.467
segmentationGO:003528240.466
Fly
negative regulation of protein phosphorylationGO:00019331400.458
Human
tissue regenerationGO:004224630.453
growthGO:00400072020.452
Zebrafish Mouse
positive regulation of tyrosine phosphorylation of stat proteinGO:0042531280.438
cell morphogenesisGO:00009022960.435
Mouse
single organism reproductive processGO:0044702980.434
acylglycerol metabolic processGO:0006639270.424
Mouse
regulation of cellular amino acid metabolic processGO:000652160.421
cytosolic calcium ion homeostasisGO:0051480890.414
regulation of tyrosine phosphorylation of stat proteinGO:0042509300.409
cell projection organizationGO:00300302520.407
Mouse
negative regulation of cellular protein metabolic processGO:00322693530.406
Human
positive regulation of jak stat cascadeGO:0046427350.397
secretionGO:00469032540.397
Mouse
av node cell to bundle of his cell communicationGO:008606740.395
inositol lipid mediated signalingGO:0048017550.389
Human
regulation of peptidyl tyrosine phosphorylationGO:00507301080.380
Human
negative regulation of epidermal growth factor receptor signaling pathwayGO:0042059110.379
negative regulation of tyrosine phosphorylation of stat3 proteinGO:004251820.373
cellular extravasationGO:0045123210.369
osteoclast differentiationGO:0030316210.353
negative regulation of cell proliferationGO:00082852280.353
response to interleukin 6GO:0070741150.353
cellular homeostasisGO:00197251960.351
regulation of glucose import in response to insulin stimulusGO:200127340.341
single organism cellular localizationGO:19025803320.338
negative regulation of interleukin 6 mediated signaling pathwayGO:007010420.326
purine nucleoside catabolic processGO:00061523980.312
positive regulation of mesenchymal cell proliferationGO:000205320.311
negative regulation of phosphorylationGO:00423261740.308
Human
negative regulation of catalytic activityGO:00430863350.307
purine ribonucleoside metabolic processGO:00461284370.299
embryonic placenta developmentGO:000189210.297
organ morphogenesisGO:00098871470.294
Zebrafish Fly
cell growthGO:00160491600.294
motor neuron axon guidanceGO:000804520.286
regulation of growthGO:00400081650.284
Mouse
positive regulation of mitotic cell cycleGO:0045931600.282
Mouse
membrane organizationGO:00610242920.282
Fly
nervous system developmentGO:00073992930.281
wnt signaling pathwayGO:00160551560.279
neuron projection developmentGO:00311751060.275
Mouse
erbb signaling pathwayGO:0038127440.271
urogenital system developmentGO:0001655650.271
nucleoside phosphate catabolic processGO:19012924120.264
oogenesisGO:004847720.257
Fly
inactivation of mapk activityGO:000018850.256
negative regulation of cellular amino acid metabolic processGO:004576320.250
morphogenesis of an epitheliumGO:0002009600.248
Zebrafish Fly
cellular response to interleukin 6GO:0071354140.247
immune response regulating signaling pathwayGO:0002764970.247
positive regulation of immune responseGO:00507781590.246
epithelial cell proliferationGO:00506731280.242
prostate gland morphogenesisGO:006051210.241
axonogenesisGO:0007409310.236
Mouse
cell projection morphogenesisGO:00488581290.233
Mouse
response to uvGO:0009411730.233
carbohydrate transportGO:0008643370.231
regulation of cell motilityGO:20001452990.230
phosphatidylinositol metabolic processGO:0046488530.230
eye developmentGO:0001654420.229
Fly
cellular cation homeostasisGO:00300031630.227
embryo developmentGO:00097901230.227
Zebrafish Fly
negative regulation of cytokine mediated signaling pathwayGO:0001960220.226
negative regulation of phosphorus metabolic processGO:00105632670.222
Human
regulation of cell morphogenesisGO:00226041530.220
regulation of neurogenesisGO:0050767820.215
Fly
osteoblast differentiationGO:0001649920.213
erk1 and erk2 cascadeGO:00703711040.211
Human Mouse
cation transportGO:00068123310.209
brain developmentGO:0007420970.208
ras protein signal transductionGO:0007265730.204
axon regenerationGO:003110310.202
regulation of wnt signaling pathwayGO:00301111230.201
sensory organ developmentGO:0007423520.199
negative regulation of protein modification processGO:00314002000.198
Human
eye morphogenesisGO:0048592160.197
Fly
regulation of intracellular transportGO:00323861950.196
Mouse
ameboidal type cell migrationGO:00016671350.196
Fly
myeloid leukocyte differentiationGO:0002573600.196
response to oxidative stressGO:00069791210.195
multi multicellular organism processGO:0044706180.190
generation of neuronsGO:00486991520.189
Mouse Fly
blood vessel developmentGO:00015681720.187
small molecule catabolic processGO:0044282920.186
platelet derived growth factor receptor signaling pathwayGO:0048008140.185
Mouse
response to abiotic stimulusGO:00096283360.184
tube developmentGO:00352951250.182
Zebrafish
gastrulationGO:0007369510.182
Zebrafish
protein polymerizationGO:0051258710.182
neurogenesisGO:00220081690.182
Mouse Fly
triglyceride metabolic processGO:0006641230.181
Mouse
endocytosisGO:00068971590.180
Fly
renal system developmentGO:0072001630.178
ion transmembrane transportGO:00342203380.173
response to tumor necrosis factorGO:0034612760.173
immune system developmentGO:00025201950.172
Mouse
positive regulation of cellular component organizationGO:00511303760.171
cellular divalent inorganic cation homeostasisGO:00725031280.170
regulation of cell morphogenesis involved in differentiationGO:0010769830.169
regulation of system processGO:00440571010.167
Mouse
cellular chemical homeostasisGO:00550821800.167
negative regulation of mapk cascadeGO:0043409560.166
response to organic cyclic compoundGO:00140702040.165
negative regulation of epithelial cell proliferationGO:0050680480.163
negative regulation of cellular amine metabolic processGO:003323930.163
regulation of jak stat cascadeGO:0046425440.163
embryonic organ morphogenesisGO:0048562240.161
Zebrafish
anterior posterior axis specification embryoGO:000859520.160
Fly
cell cycle phase transitionGO:00447701730.159
Human
positive regulation of protein serine threonine kinase activityGO:00719021190.158
Mouse
interleukin 27 mediated signaling pathwayGO:007010610.158
wound healingGO:00420601150.156
neutral lipid metabolic processGO:0006638270.155
Mouse
digestive tract morphogenesisGO:0048546560.154
Zebrafish
purine ribonucleoside triphosphate metabolic processGO:00092054110.151
regulation of cell cycleGO:00517263930.146
Human Mouse
negative regulation of protein serine threonine kinase activityGO:0071901570.146
regulation of locomotionGO:00400123290.143
response to external biotic stimulusGO:00432072610.141
somitogenesisGO:000175620.140
positive regulation of leukocyte activationGO:0002696800.139
negative regulation of map kinase activityGO:0043407270.139
positive regulation of stress activated mapk cascadeGO:0032874600.139
oocyte developmentGO:004859910.139
positive regulation of developmental processGO:00510943140.138
regulation of anatomical structure sizeGO:00900661010.138
single organism membrane organizationGO:00448022680.138
negative regulation of jak stat cascadeGO:004642640.136
protein localization to organelleGO:00333652800.136
cellular carbohydrate metabolic processGO:0044262840.135
negative regulation of protein metabolic processGO:00512483910.135
Human
mammary gland developmentGO:0030879170.132
positive regulation of neuron projection developmentGO:0010976340.130
epithelial cell differentiationGO:00308551410.129
Fly
lens development in camera type eyeGO:000208820.128
negative regulation of protein kinase activityGO:0006469980.127
regulation of heart contractionGO:0008016500.127
steroid metabolic processGO:0008202940.127
response to reactive oxygen speciesGO:0000302610.127
positive regulation of transportGO:00510503360.123
antigen receptor mediated signaling pathwayGO:0050851380.123
negative regulation of transferase activityGO:00513481240.120
response to estrogenGO:0043627470.118
gland developmentGO:0048732480.118
inorganic ion transmembrane transportGO:00986602310.117
post embryonic developmentGO:000979120.117
regulation of organ formationGO:000315640.116
ciliary neurotrophic factor mediated signaling pathwayGO:007012050.114
positive regulation of tyrosine phosphorylation of stat5 proteinGO:0042523110.114
growth hormone receptor signaling pathwayGO:0060396100.114
cell junction organizationGO:0034330790.113
morphogenesis of a branching epitheliumGO:0061138200.110
type i interferon signaling pathwayGO:0060337110.109
positive regulation of transferase activityGO:00513472270.109
Mouse
sensory organ morphogenesisGO:0090596210.109
Fly
positive regulation of cell activationGO:0050867810.108
response to axon injuryGO:004867810.107
secretion by cellGO:00329402260.105
Mouse
negative regulation of wnt signaling pathwayGO:0030178690.105
regulation of jun kinase activityGO:0043506270.104
vascular endothelial growth factor receptor signaling pathwayGO:0048010190.104
neuroblast proliferationGO:000740540.102
embryonic morphogenesisGO:0048598850.101
Zebrafish
canonical wnt signaling pathwayGO:00600701160.099
divalent inorganic cation homeostasisGO:00725071360.099
regulation of mitosisGO:0007088630.099
tyrosine phosphorylation of stat5 proteinGO:0042506130.098
hematopoietic or lymphoid organ developmentGO:00485341860.098
Mouse
leukocyte activationGO:00453211640.096
negative regulation of tyrosine phosphorylation of stat proteinGO:004253220.096
reproductive structure developmentGO:0048608550.095
multicellular organism reproductionGO:0032504420.094
Mouse Fly
negative regulation of cellular carbohydrate metabolic processGO:0010677140.094
negative regulation of cell differentiationGO:00455961710.094
metal ion transportGO:00300012720.093
regulation of atrial cardiac muscle cell membrane depolarizationGO:006037160.092
response to lipidGO:00339932060.091
protein dephosphorylationGO:0006470810.091
mitotic cell cycle processGO:19030472860.089
Human
muscle cell differentiationGO:0042692630.089
regulation of cellular component movementGO:00512703340.089
positive regulation of neurogenesisGO:0050769490.089
actin cytoskeleton organizationGO:00300362070.088
stress activated mapk cascadeGO:0051403930.088
positive regulation of cell differentiationGO:00455972110.088
cellular metal ion homeostasisGO:00068751460.088
actin mediated cell contractionGO:0070252120.088
oxidation reduction processGO:00551143960.086
nuclear divisionGO:00002801280.084
negative regulation of intracellular signal transductionGO:19025321830.083
cell morphogenesis involved in differentiationGO:00009041440.082
Mouse
embryonic organ developmentGO:0048568360.082
Zebrafish
neuron developmentGO:00486661130.082
Mouse Fly
protein modification by small protein conjugationGO:00324463420.080
positive regulation of organelle organizationGO:00106381950.080
immune response activating cell surface receptor signaling pathwayGO:0002429450.080
camera type eye developmentGO:0043010250.079
regulation of tyrosine phosphorylation of stat1 proteinGO:0042510110.079
regulation of leukocyte activationGO:00026941150.079
cellular response to growth hormone stimulusGO:0071378100.079
agingGO:0007568660.078
negative regulation of peptidyl tyrosine phosphorylationGO:0050732200.078
Human
regulation of ventricular cardiac muscle cell membrane repolarizationGO:0060307100.078
cation homeostasisGO:00550801890.077
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781250.077
regulation of cytokine mediated signaling pathwayGO:0001959410.076
apoptotic signaling pathwayGO:00971902680.075
biological adhesionGO:00226103310.075
epithelium migrationGO:00901321190.074
Fly
cellular response to hydrogen peroxideGO:0070301370.074
purine nucleotide catabolic processGO:00061954050.073
rho protein signal transductionGO:0007266260.073
nucleoside catabolic processGO:00091644080.072
vasculature developmentGO:00019441810.071
lipid modificationGO:0030258840.070
response to light stimulusGO:0009416870.069
negative regulation of insulin receptor signaling pathwayGO:004662780.069
defense responseGO:00069523150.068
embryonic camera type eye morphogenesisGO:004859620.068
ectodermal placode formationGO:006078810.067
reproductive system developmentGO:0061458560.067
neural tube formationGO:000184130.066
cardiac muscle cell action potential involved in contractionGO:0086002210.066
regulation of epidermal growth factor activated receptor activityGO:0007176140.066
regulation of cellular component sizeGO:0032535820.065
negative regulation of phagocytosisGO:005076540.065
regulation of nuclear divisionGO:0051783650.065
positive regulation of stress activated protein kinase signaling cascadeGO:0070304610.065
cell divisionGO:00513011680.064
innate immune responseGO:00450871780.063
regulation of blood vessel sizeGO:0050880180.063
metal ion homeostasisGO:00550651690.063
protein targetingGO:00066051870.062
regulation of cell adhesionGO:00301551660.062
immune response activating signal transductionGO:0002757900.062
response to hydrogen peroxideGO:0042542400.062
purine ribonucleotide catabolic processGO:00091544040.061
stem cell differentiationGO:0048863930.060
response to other organismGO:00517072610.060
maintenance of locationGO:00512351120.059
cellular glucan metabolic processGO:0006073220.059
negative regulation of endothelial cell proliferationGO:0001937200.058
memoryGO:000761330.058
ribonucleoside triphosphate metabolic processGO:00091994120.058
neurological system processGO:00508771630.057
positive regulation of cell developmentGO:0010720920.057
peripheral nervous system developmentGO:000742220.057
muscle cell developmentGO:0055001290.056
regulation of receptor activityGO:0010469470.056
melanin metabolic processGO:000658210.056
ear developmentGO:0043583140.056
gastrulation with mouth forming secondGO:000170210.056
regulation of metal ion transportGO:00109591200.055
digestive system developmentGO:0055123750.054
Zebrafish
hydrogen peroxide catabolic processGO:0042744130.054
regulation of endothelial cell proliferationGO:0001936560.054
actin filament based movementGO:0030048170.054
protein maturationGO:00516042330.053
organelle fissionGO:00482851490.053
negative regulation of b cell receptor signaling pathwayGO:005085920.053
leukocyte migrationGO:00509001070.053
purine nucleoside triphosphate catabolic processGO:00091463920.053
epidermal growth factor receptor signaling pathwayGO:0007173390.052
Mouse Fly
humoral immune responseGO:0006959490.052
regulation of transmembrane transportGO:00347621390.052
negative regulation of kinase activityGO:00336731060.051
transmembrane transportGO:00550853990.051
cell morphogenesis involved in neuron differentiationGO:0048667440.050
Mouse
regulation of homeostatic processGO:00328441210.049
embryonic eye morphogenesisGO:004804820.049
lipid metabolic processGO:00066293810.049
Mouse
organ inductionGO:000175940.049
cellular response to dna damage stimulusGO:00069743790.048
Mouse
monocyte extravasationGO:003569610.048
positive regulation of lipid metabolic processGO:0045834500.048
proteolysis involved in cellular protein catabolic processGO:00516032440.047
fibroblast growth factor receptor signaling pathwayGO:0008543260.047
Fly
negative regulation of transportGO:00510511760.047
Mouse
endomembrane system organizationGO:00102561960.047
multicellular organismal homeostasisGO:0048871670.047
blood circulationGO:00080151130.047
regulation of ras protein signal transductionGO:00465781550.047
morphogenesis of a branching structureGO:0001763210.046
peptidyl tyrosine modificationGO:00182121700.046
Human
anatomical structure homeostasisGO:00602491000.046
regulation of tor signalingGO:0032006300.046
regulation of nucleotide metabolic processGO:00061402690.046
stem cell proliferationGO:0072089250.046
leukocyte differentiationGO:0002521980.046
neutrophil extravasationGO:007267220.045
oocyte differentiationGO:000999420.045
regulation of vascular endothelial growth factor receptor signaling pathwayGO:003094790.045
negative regulation of erk1 and erk2 cascadeGO:0070373140.045
oncostatin m mediated signaling pathwayGO:003816530.045
positive regulation of neuron differentiationGO:0045666400.044
regulation of glucose importGO:0046324210.044
ribonucleotide catabolic processGO:00092614050.044
embryo development ending in birth or egg hatchingGO:0009792340.044
Zebrafish
circadian sleep wake cycle processGO:002241020.044
protein autophosphorylationGO:00467771230.043
organ formationGO:004864530.043
long term memoryGO:000761620.043
tissue remodelingGO:0048771160.043
leukocyte proliferationGO:0070661740.043
regulation of neuron differentiationGO:0045664700.043
Fly
positive regulation of insulin receptor signaling pathwayGO:004662830.043
negative regulation of protein processingGO:00109551420.043
regulation of leukocyte proliferationGO:0070663670.042
developmental growthGO:0048589480.042
Zebrafish Mouse
positive regulation of proteolysisGO:00458621420.041
regulation of branching involved in salivary gland morphogenesis by mesenchymal epithelial signalingGO:006066510.041
glycerolipid metabolic processGO:00464861070.041
Mouse
response to transition metal nanoparticleGO:1990267290.040
regulation of ion homeostasisGO:2000021730.040
regionalizationGO:0003002290.040
Fly
positive regulation of nucleoside metabolic processGO:00459791860.039
adult behaviorGO:0030534180.039
intrinsic apoptotic signaling pathwayGO:00971931270.039
camera type eye morphogenesisGO:0048593120.039
chemical homeostasisGO:00488783060.038
Mouse
regulation of cellular carbohydrate metabolic processGO:0010675470.038
regulation of cell cycle g1 s phase transitionGO:1902806420.038
Human
negative regulation of type i interferon mediated signaling pathwayGO:006033940.038
stem cell developmentGO:0048864690.038
nucleoside triphosphate metabolic processGO:00091414220.038
negative regulation of vascular endothelial growth factor receptor signaling pathwayGO:003094830.037
regulation of cellular protein catabolic processGO:1903362960.037
receptor internalization involved in canonical wnt signaling pathwayGO:200028630.036
regulation of response to cytokine stimulusGO:0060759460.036
regulation of cell shapeGO:0008360480.036
striated muscle contractionGO:0006941520.036
positive regulation of dendrite morphogenesisGO:005077530.035
regulation of blood circulationGO:1903522590.035
regulation of nervous system developmentGO:0051960880.035
Fly
response to fibroblast growth factorGO:0071774390.035
Fly
regulation of reactive oxygen species metabolic processGO:2000377410.035
regulation of cell cycle processGO:00105642660.035
Human
regulation of insulin secretionGO:0050796330.034
Mouse
single organism behaviorGO:0044708280.034
response to testosteroneGO:003357410.034
dephosphorylationGO:00163112090.034
regulation of b cell receptor signaling pathwayGO:005085540.034
negative regulation of t cell receptor signaling pathwayGO:005086040.034
phosphatidylinositol mediated signalingGO:0048015550.033
Human
single organism carbohydrate metabolic processGO:00447231930.033
membrane depolarizationGO:0051899260.033
neuron projection morphogenesisGO:0048812500.033
Mouse
syncytium formation by plasma membrane fusionGO:000076820.033
cellular protein catabolic processGO:00442572610.033
pattern specification processGO:0007389430.033
Zebrafish Fly
regulation of leukocyte mediated immunityGO:0002703380.032
response to bacteriumGO:00096171440.032
developmental process involved in reproductionGO:0003006660.032
immune response regulating cell surface receptor signaling pathwayGO:0002768510.032
regulation of carbohydrate metabolic processGO:0006109540.032
negative regulation of protein maturationGO:19033181420.032
endoplasmic reticulum organizationGO:0007029200.032
regulation of response to external stimulusGO:00321012220.032
semaphorin plexin signaling pathwayGO:007152640.031
protein import into nucleusGO:00066061040.031
striated muscle cell developmentGO:0055002270.031
negative regulation of hydrogen peroxide mediated programmed cell deathGO:190129930.031
leukocyte chemotaxisGO:0030595760.031
positive regulation of cellular response to insulin stimulusGO:190007860.031
multicellular organismal signalingGO:0035637340.031
multi organism reproductive processGO:0044703540.031
Fly
lymphocyte differentiationGO:0030098350.031
regulation of epidermal growth factor receptor signaling pathwayGO:0042058270.031
regulation of multicellular organism growthGO:004001480.031
Mouse
protein processingGO:00164852260.030
regulation of endocytosisGO:0030100720.030
regulation of hormone levelsGO:00108171250.030
Mouse

PTPN11 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
acquired metabolic diseaseDOID:0060158580.395
carbohydrate metabolism diseaseDOID:0050013320.395
disease of metabolismDOID:00146672950.395
diabetes mellitusDOID:9351310.308
glucose metabolism diseaseDOID:4194320.308
type 2 diabetes mellitusDOID:9352280.280