Homo sapiens

215 known processes

IRS1

insulin receptor substrate 1

(Aliases: HIRS-1)

IRS1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.999
enzyme linked receptor protein signaling pathwayGO:00071673030.996
regulation of glycogen metabolic processGO:0070873150.996
cellular lipid metabolic processGO:00442553030.996
lipid metabolic processGO:00066293810.993
asymmetric stem cell divisionGO:009872210.992
Fly
regulation of glycogen biosynthetic processGO:0005979140.989
positive regulation of steroid hormone biosynthetic processGO:009003120.986
cellular response to phGO:007146790.984
single organism carbohydrate metabolic processGO:00447231930.978
carbohydrate metabolic processGO:00059752070.976
positive regulation of glycogen biosynthetic processGO:0045725100.973
phosphatidylinositol mediated signalingGO:0048015550.967
phosphatidylinositol 3 phosphate biosynthetic processGO:003609230.964
cellular glucan metabolic processGO:0006073220.963
cellular polysaccharide biosynthetic processGO:0033692210.960
stem cell divisionGO:001714520.956
Fly
positive regulation of glucose import in response to insulin stimulusGO:200127530.953
regulation of cellular ketone metabolic processGO:0010565500.951
positive regulation of lipid metabolic processGO:0045834500.951
activation of mapk activityGO:0000187450.948
associative learningGO:000830610.943
Fly
positive regulation of map kinase activityGO:0043406800.937
cellular response to endogenous stimulusGO:00714953360.934
energy reserve metabolic processGO:0006112220.923
regulation of cell migrationGO:00303342890.922
Mouse
positive regulation of glucose metabolic processGO:0010907120.920
monosaccharide metabolic processGO:0005996740.918
glucan biosynthetic processGO:0009250160.911
carbohydrate transportGO:0008643370.904
phosphatidylinositol 3 kinase signalingGO:0014065480.885
multicellular organismal agingGO:001025930.882
Fly
monocarboxylic acid metabolic processGO:00327871850.881
glucan metabolic processGO:0044042220.875
lipid biosynthetic processGO:00086101770.855
negative regulation of programmed cell deathGO:00430693210.852
regulation of locomotionGO:00400123290.850
Mouse
cellular amino acid metabolic processGO:00065201160.847
circadian sleep wake cycleGO:004274520.847
positive regulation of locomotionGO:00400171860.844
Mouse
fibroblast apoptotic processGO:004434680.840
female gamete generationGO:000729220.835
Fly
glucose metabolic processGO:0006006450.833
polysaccharide biosynthetic processGO:0000271270.823
positive regulation of cell proliferationGO:00082843010.822
Mouse
cellular response to alkaline phGO:007146910.819
inositol lipid mediated signalingGO:0048017550.819
regulation of glucose metabolic processGO:0010906280.819
glycerolipid biosynthetic processGO:0045017510.817
mitotic cell cycleGO:00002783260.812
negative regulation of cell deathGO:00605483450.812
positive regulation of secretion by cellGO:19035321080.804
Rat
regulation of cellular carbohydrate metabolic processGO:0010675470.803
response to peptideGO:1901652650.802
regulation of cellular amine metabolic processGO:0033238110.799
cellular polysaccharide metabolic processGO:0044264270.782
positive regulation of kinase activityGO:00336742040.780
Mouse Rat
cellular amine metabolic processGO:0044106410.778
post embryonic developmentGO:000979120.777
regulation of cellular component movementGO:00512703340.774
Mouse
insulin like growth factor receptor signaling pathwayGO:0048009130.773
circulatory system developmentGO:00723592620.773
positive regulation of cellular response to insulin stimulusGO:190007860.769
positive regulation of transportGO:00510503360.760
growthGO:00400072020.754
Fly
cellular response to insulin stimulusGO:0032869410.752
regulation of glucan biosynthetic processGO:0010962140.742
cellular response to hormone stimulusGO:00328701250.740
regulation of glucose importGO:0046324210.736
positive regulation of phosphorylationGO:00423273940.734
Mouse Rat
regulation of growthGO:00400081650.730
Fly
positive regulation of glycogen metabolic processGO:0070875100.727
blastoderm segmentationGO:000735020.726
cellular carbohydrate biosynthetic processGO:0034637210.717
regulation of lipid metabolic processGO:0019216960.708
regulation of cell motilityGO:20001452990.705
Mouse
regulation of kinase activityGO:00435493140.701
Mouse Rat
chemical homeostasisGO:00488783060.690
positive regulation of organelle organizationGO:00106381950.690
g protein coupled receptor signaling pathwayGO:00071862070.682
response to cocaineGO:004222010.681
negative regulation of apoptotic processGO:00430663160.679
determination of adult lifespanGO:000834020.677
Fly
behaviorGO:00076101120.668
Fly
glycerolipid metabolic processGO:00464861070.664
Mouse Rat
ion transmembrane transportGO:00342203380.652
Human
regulation of glucose import in response to insulin stimulusGO:200127340.647
positive regulation of protein phosphorylationGO:00019343130.645
circadian sleep wake cycle processGO:002241020.643
glycogen metabolic processGO:0005977220.639
cellular response to organonitrogen compoundGO:00714171240.637
phosphatidylinositol metabolic processGO:0046488530.633
Mouse Rat
monosaccharide transportGO:0015749320.626
regulation of protein localizationGO:00328802960.617
positive regulation of protein kinase activityGO:00458601900.617
negative regulation of transportGO:00510511760.616
cellular response to nitrogen compoundGO:19016991440.612
glycogen biosynthetic processGO:0005978160.609
cell developmentGO:00484683280.602
Fly
regulation of protein kinase activityGO:00458592890.596
regulation of transferase activityGO:00513383550.592
Mouse Rat
positive regulation of muscle cell apoptotic processGO:001066140.592
regulation of ion transmembrane transportGO:00347651320.582
Human
cellular response to oxygen containing compoundGO:19017012760.581
inactivation of mapkk activityGO:005138910.576
response to organonitrogen compoundGO:00102431560.571
matingGO:000761810.552
hexose metabolic processGO:0019318550.549
positive regulation of mapk cascadeGO:00434101900.548
oxidation reduction processGO:00551143960.548
cellular carbohydrate metabolic processGO:0044262840.539
regulation of cellular amino acid metabolic processGO:000652160.534
photoreceptor cell differentiationGO:004653020.517
cellular ketone metabolic processGO:0042180800.515
regulation of tyrosine phosphorylation of stat3 proteinGO:0042516180.507
organophosphate biosynthetic processGO:00904071630.503
immune responseGO:00069553070.492
Fly
regulation of feeding behaviorGO:006025930.491
positive regulation of phosphatidylinositol 3 kinase signalingGO:0014068280.490
positive regulation of cell divisionGO:0051781590.490
response to oxygen containing compoundGO:19017003690.487
regulation of cell differentiationGO:00455953930.486
regulation of carbohydrate metabolic processGO:0006109540.475
positive regulation of cell migrationGO:00303351720.473
Mouse
cortisol secretionGO:004340040.471
phospholipid metabolic processGO:0006644990.467
Mouse Rat
cell activationGO:00017752130.463
response to hormoneGO:00097251750.459
response to insulinGO:0032868450.457
lipid localizationGO:00108761060.453
Human
regulation of jnk cascadeGO:0046328730.450
smooth muscle cell proliferationGO:0048659280.442
regulation of tor signalingGO:0032006300.436
ribonucleotide catabolic processGO:00092614050.433
regulation of mitosisGO:0007088630.432
regulation of cell developmentGO:00602841610.428
regulation of erk1 and erk2 cascadeGO:0070372990.427
positive regulation of protein kinase b signalingGO:0051897420.425
cell morphogenesisGO:00009022960.423
Fly
regulation of cellular response to insulin stimulusGO:1900076170.417
epithelium developmentGO:00604292270.417
negative regulation of tyrosine phosphorylation of stat3 proteinGO:004251820.413
negative regulation of phosphate metabolic processGO:00459362670.411
embryonic viscerocranium morphogenesisGO:004870310.410
cell differentiation in spinal cordGO:002151510.409
fatty acid metabolic processGO:00066311150.409
peptidyl tyrosine phosphorylationGO:00181081700.409
cell type specific apoptotic processGO:00972851250.409
positive regulation of endothelial cell migrationGO:0010595390.405
regenerationGO:003109940.402
cellular component morphogenesisGO:00329893140.401
Fly
positive regulation of transferase activityGO:00513472270.401
Mouse Rat
positive regulation of mitotic cell cycleGO:0045931600.399
response to abiotic stimulusGO:00096283360.396
Fly
response to growth factorGO:00708482050.395
protein autophosphorylationGO:00467771230.386
positive regulation of cellular amine metabolic processGO:003324070.385
oogenesisGO:004847720.385
Fly
negative regulation of circadian sleep wake cycle sleepGO:004232110.384
cellular response to abiotic stimulusGO:00712141170.376
positive regulation of cellular component movementGO:00512721810.376
Mouse
cell divisionGO:00513011680.372
Fly
positive regulation of insulin like growth factor receptor signaling pathwayGO:004356840.367
nuclear transportGO:00511691790.366
sulfur compound metabolic processGO:00067901010.365
response to testosteroneGO:003357410.362
syncytium formation by plasma membrane fusionGO:000076820.360
response to interleukin 15GO:007067260.357
generation of neuronsGO:00486991520.355
positive regulation of respiratory burstGO:006026750.355
negative regulation of glycogen biosynthetic processGO:004571930.355
neuron remodelingGO:001632220.353
cellular response to peptideGO:1901653590.352
protein heterotetramerizationGO:005129030.348
cellular response to peptide hormone stimulusGO:0071375560.348
regulation of protein serine threonine kinase activityGO:00719001790.346
response to phGO:0009268120.345
striated muscle cell apoptotic processGO:001065830.343
energy derivation by oxidation of organic compoundsGO:0015980430.341
polysaccharide metabolic processGO:0005976330.331
digestive system developmentGO:0055123750.328
positive regulation of catabolic processGO:00098963100.322
neuron differentiationGO:00301821380.321
response to alkaline phGO:001044620.321
regulation of response to external stimulusGO:00321012220.320
glycerophospholipid metabolic processGO:0006650840.319
Mouse Rat
response to nitrogen compoundGO:19016981840.316
regulation of phosphatidylinositol 3 kinase signalingGO:0014066350.315
rho protein signal transductionGO:0007266260.313
regulation of cellular component biogenesisGO:00440872810.311
regulation of polysaccharide metabolic processGO:0032881210.309
regulation of glucose transportGO:0010827230.309
carbohydrate biosynthetic processGO:0016051420.308
embryonic camera type eye developmentGO:003107620.307
positive regulation of cell motilityGO:20001471770.304
Mouse
regulation of reactive oxygen species biosynthetic processGO:190342630.302
activation of protein kinase activityGO:0032147900.297
modulation by virus of host morphology or physiologyGO:0019048100.297
regulation of establishment of protein localizationGO:00702012420.293
regulation of reactive oxygen species metabolic processGO:2000377410.291
female gonad developmentGO:0008585100.289
regulation of map kinase activityGO:00434051080.289
response to manganese ionGO:001004220.287
response to peptide hormoneGO:0043434610.285
response to metal ionGO:0010038840.283
regulation of natural killer cell differentiationGO:003282320.282
somatic stem cell divisionGO:004810310.280
protein localization to organelleGO:00333652800.278
Mouse
generation of precursor metabolites and energyGO:0006091680.275
reactive oxygen species biosynthetic processGO:190340940.273
lymphocyte activationGO:00466491330.272
maintenance of locationGO:00512351120.272
regulation of mitotic cell cycleGO:00073461890.270
regulation of secretion by cellGO:19035301770.266
negative regulation of cellular carbohydrate metabolic processGO:0010677140.265
regulation of mapk cascadeGO:00434082620.260
positive regulation of cellular amino acid metabolic processGO:004576430.259
regulation of generation of precursor metabolites and energyGO:0043467270.259
positive regulation of protein serine threonine kinase activityGO:00719021190.257
neurotrophin trk receptor signaling pathwayGO:004801140.257
circadian sleep wake cycle sleepGO:005080220.254
transformation of host cell by virusGO:001908720.252
regulation of activin receptor signaling pathwayGO:0032925140.250
Fly
regulation of multicellular organism growthGO:004001480.248
Fly
regulation of circadian sleep wake cycle sleepGO:004518720.247
negative regulation of protein modification processGO:00314002000.247
nuclear divisionGO:00002801280.245
regulation of lymphocyte proliferationGO:0050670640.244
tyrosine phosphorylation of stat proteinGO:0007260330.244
amine metabolic processGO:0009308440.241
cytokine mediated signaling pathwayGO:00192211090.241
regulation of behaviorGO:0050795820.240
mammary gland developmentGO:0030879170.238
Mouse
neuron projection regenerationGO:003110210.237
response to oxidative stressGO:00069791210.236
axon regenerationGO:003110310.234
positive regulation of cell activationGO:0050867810.234
sex determinationGO:000753030.233
negative regulation of protein phosphorylationGO:00019331400.233
interleukin 6 mediated signaling pathwayGO:007010270.232
regulation of nucleocytoplasmic transportGO:0046822980.231
positive regulation of stress activated protein kinase signaling cascadeGO:0070304610.230
circadian behaviorGO:004851220.230
regulation of glucocorticoid secretionGO:200084940.225
stress activated mapk cascadeGO:0051403930.225
myoblast fusionGO:000752010.225
pyruvate metabolic processGO:0006090260.224
glucose transportGO:0015758300.223
positive regulation of hormone biosynthetic processGO:004688640.222
prostate gland morphogenesisGO:006051210.222
tyrosine phosphorylation of stat5 proteinGO:0042506130.221
regulation of tyrosine phosphorylation of stat proteinGO:0042509300.219
negative regulation of circadian rhythmGO:004275410.218
regulation of autophagyGO:0010506520.216
carbohydrate catabolic processGO:0016052360.216
cardiovascular system developmentGO:00723582620.216
steroid metabolic processGO:0008202940.215
positive regulation of cell cycleGO:00457871400.214
glycerophospholipid biosynthetic processGO:0046474400.213
regulation of intracellular protein transportGO:00331571230.213
positive regulation of peptidyl serine phosphorylationGO:0033138420.212
positive regulation of organ growthGO:004662220.210
regulation of cardiac muscle cell apoptotic processGO:001066530.210
positive regulation of sequence specific dna binding transcription factor activityGO:00510911310.208
vascular endothelial growth factor receptor signaling pathwayGO:0048010190.207
glucocorticoid secretionGO:003593340.207
single organism reproductive processGO:0044702980.206
Fly
tyrosine phosphorylation of stat3 proteinGO:0042503200.205
glucose importGO:0046323240.202
spinal cord developmentGO:002151040.201
negative regulation of protein metabolic processGO:00512483910.201
ventral spinal cord developmentGO:002151710.199
positive regulation of insulin secretionGO:0032024100.199
negative regulation of feeding behaviorGO:200025210.197
cellular response to starvationGO:0009267580.196
leukocyte activationGO:00453211640.195
reactive nitrogen species metabolic processGO:200105730.195
regulation of peptide hormone secretionGO:0090276410.194
negative regulation of catalytic activityGO:00430863350.193
regulation of vascular endothelial growth factor receptor signaling pathwayGO:003094790.193
positive regulation of tyrosine phosphorylation of stat5 proteinGO:0042523110.192
reactive oxygen species metabolic processGO:0072593750.192
positive regulation of smooth muscle cell proliferationGO:0048661140.192
negative regulation of phosphorylationGO:00423261740.192
mitotic nuclear divisionGO:00070671190.191
regulation of insulin receptor signaling pathwayGO:0046626130.191
Rat
somatic muscle developmentGO:000752510.189
viral processGO:00160321460.189
cellular response to growth factor stimulusGO:00713631970.189
phosphatidylinositol biosynthetic processGO:0006661250.187
rhythmic behaviorGO:000762220.185
response to oxygen levelsGO:00704821000.185
Fly
protein localization to nucleusGO:00345041360.184
Mouse
inner ear morphogenesisGO:004247240.183
regulation of nuclear divisionGO:0051783650.182
phospholipid biosynthetic processGO:0008654440.181
tube developmentGO:00352951250.180
insulin receptor signaling pathwayGO:0008286230.179
regulation of circadian sleep wake cycleGO:004274920.179
negative regulation of wnt signaling pathwayGO:0030178690.178
cell cell signalingGO:00072671550.178
regulation of leukocyte proliferationGO:0070663670.178
positive regulation of mitosisGO:0045840250.177
intracellular protein transportGO:00068862700.177
regulation of protein targetingGO:1903533910.175
negative regulation of secretionGO:0051048580.174
cardiac muscle cell apoptotic processGO:001065930.173
b cell activationGO:0042113330.171
mononuclear cell proliferationGO:0032943710.171
regulation of response to reactive oxygen speciesGO:1901031120.171
positive regulation of jnk cascadeGO:0046330520.171
cellular response to external stimulusGO:00714961110.170
peptide secretionGO:0002790510.169
mitotic cell cycle processGO:19030472860.169
vesicle mediated transportGO:00161923710.169
semicircular canal morphogenesisGO:004875210.168
regulation of polysaccharide biosynthetic processGO:0032885200.167
negative regulation of cell differentiationGO:00455961710.167
protein kinase b signalingGO:0043491690.164
Mouse
sleepGO:003043120.164
immune effector processGO:00022521590.163
neurogenesisGO:00220081690.163
locomotory behaviorGO:000762610.162
regulation of cell cycleGO:00517263930.162
biological adhesionGO:00226103310.162
activation of protein kinase b activityGO:0032148140.160
positive regulation of tyrosine phosphorylation of stat3 proteinGO:0042517160.159
male sex differentiationGO:0046661250.159
response to cytokineGO:00340972320.158
regulation of neuron differentiationGO:0045664700.158
positive regulation of leukocyte activationGO:0002696800.157
regulation of stress activated mapk cascadeGO:0032872840.155
regulation of cell cycle processGO:00105642660.155
taxisGO:00423301570.154
developmental growthGO:0048589480.152
Fly
cellular response to dna damage stimulusGO:00069743790.152
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092900.152
Fly
positive regulation of apoptotic processGO:00430652460.150
intracellular receptor signaling pathwayGO:00305221040.150
activin receptor signaling pathwayGO:0032924240.150
Fly
tor signalingGO:0031929390.149
positive regulation of cell cycle processGO:00900681060.148
reproductive processGO:00224141060.148
Fly
regulation of smooth muscle cell proliferationGO:0048660280.147
negative regulation of carbohydrate metabolic processGO:0045912200.147
positive regulation of glucose transportGO:0010828170.146
organelle fissionGO:00482851490.145
cell growthGO:00160491600.145
Fly
digestive tract developmentGO:0048565750.144
negative regulation of peptidyl tyrosine phosphorylationGO:0050732200.144
cellular response to nutrient levelsGO:0031669690.143
regulation of protein transportGO:00512232130.143
osteoblast differentiationGO:0001649920.143
response to decreased oxygen levelsGO:0036293960.143
Fly
cell migration involved in gastrulationGO:004207410.141
positive regulation of fatty acid beta oxidationGO:003200050.141
regulation of autophagic vacuole assemblyGO:200078560.140
positive regulation of cardiac muscle cell apoptotic processGO:001066610.140
regulation of cell divisionGO:00513021160.140
response to lipidGO:00339932060.139
inorganic ion transmembrane transportGO:00986602310.139
positive regulation of tyrosine phosphorylation of stat proteinGO:0042531280.139
negative regulation of cell proliferationGO:00082852280.139
regulation of striated muscle cell apoptotic processGO:001066230.137
regulation of response to oxidative stressGO:1902882260.137
interspecies interaction between organismsGO:00444191560.137
leukocyte differentiationGO:0002521980.134
cell projection morphogenesisGO:00488581290.133
regulation of lipid catabolic processGO:0050994230.132
regulation of wnt signaling pathwayGO:00301111230.131
epidermis developmentGO:0008544590.130
response to uvGO:0009411730.130
anatomical structure formation involved in morphogenesisGO:00486462840.129
regulation of hormone secretionGO:0046883570.129
regulation of chemotaxisGO:0050920740.128
regulation of carbohydrate biosynthetic processGO:0043255270.127
positive regulation of glycolytic processGO:004582140.126
glycosyl compound catabolic processGO:19016584130.126
small molecule catabolic processGO:0044282920.126
positive regulation of cell differentiationGO:00455972110.125
regulation of respiratory burstGO:006026380.125
positive regulation of lymphocyte activationGO:0051251730.125
gland developmentGO:0048732480.125
Mouse
regulation of cellular response to stressGO:00801352440.123
monocarboxylic acid catabolic processGO:0072329370.122
modification of morphology or physiology of other organismGO:0035821430.122
wnt signaling pathwayGO:00160551560.121
nervous system developmentGO:00073992930.121
regulation of hydrogen peroxide metabolic processGO:001031060.121
negative regulation of type i interferon mediated signaling pathwayGO:006033940.120
single organism behaviorGO:0044708280.120
Fly
nucleocytoplasmic transportGO:00069131760.119
respiratory burstGO:0045730120.118
negative regulation of cellular protein metabolic processGO:00322693530.118
myeloid cell differentiationGO:00300991170.115
hexose transportGO:0008645300.115
positive regulation of striated muscle cell apoptotic processGO:001066310.115
regulation of dna metabolic processGO:00510521530.114
organic anion transportGO:00157111030.114
Human
neuron developmentGO:00486661130.114
jnk cascadeGO:0007254800.113
regulation of cytokinesisGO:0032465450.112
cellular ion homeostasisGO:00068731680.112
hormone secretionGO:0046879650.112
multi organism cellular processGO:00447641560.112
anion transportGO:00068201610.112
Human
positive regulation of epithelial cell proliferationGO:0050679650.110
chemotaxisGO:00069351570.109
response to axon injuryGO:004867810.109
regulation of system processGO:00440571010.107
muscle cell apoptotic processGO:0010657110.105
glucose import in response to insulin stimulusGO:004438140.105
positive regulation of immune responseGO:00507781590.104
Fly
positive regulation of multicellular organism growthGO:004001860.104
Fly
protein oligomerizationGO:00512591730.103
Rat
regulation of vacuole organizationGO:004408880.103
epithelial cell differentiationGO:00308551410.103
ameboidal type cell migrationGO:00016671350.102
cellular lipid catabolic processGO:0044242650.102
response to organic cyclic compoundGO:00140702040.102
Rat
regulation of tyrosine phosphorylation of stat5 proteinGO:0042522120.102
regulation of neuron projection developmentGO:0010975570.101
negative regulation of secretion by cellGO:1903531520.101
regulation of interleukin 6 mediated signaling pathwayGO:007010330.101
cellular response to growth hormone stimulusGO:0071378100.100
positive regulation of reactive oxygen species biosynthetic processGO:190342820.100
agingGO:0007568660.100
Fly
endothelial cell migrationGO:0043542860.099
negative regulation of tyrosine phosphorylation of stat proteinGO:004253220.098
negative regulation of protein transportGO:0051224750.098
mapk cascadeGO:00001652880.097
regulation of ion transportGO:00432691890.096
Human
epithelial cell proliferationGO:00506731280.096
neutral lipid metabolic processGO:0006638270.095
regulation of hormone levelsGO:00108171250.095
negative regulation of developmental processGO:00510932470.094
regulation of dna replicationGO:0006275680.094
dna replicationGO:00062601160.094
negative regulation of lipid transportGO:0032369180.094
Human
leukocyte proliferationGO:0070661740.093
muscle cell migrationGO:0014812190.092
macromolecule methylationGO:0043414970.092
memoryGO:000761330.092
hematopoietic or lymphoid organ developmentGO:00485341860.091
symbiosis encompassing mutualism through parasitismGO:00444031560.091
muscle cell differentiationGO:0042692630.091
epithelial cell migrationGO:00106311190.091
skin developmentGO:0043588760.091
cellular response to molecule of bacterial originGO:0071219620.090
regulation of protein kinase b signalingGO:0051896610.090
regulation of endothelial cell migrationGO:0010594670.089
response to inorganic substanceGO:00100351270.089
regulation of sequence specific dna binding transcription factor activityGO:00510902110.088
embryonic morphogenesisGO:0048598850.088
response to light stimulusGO:0009416870.088
anatomical structure homeostasisGO:00602491000.088
Fly
single organism carbohydrate catabolic processGO:0044724330.087
erk1 and erk2 cascadeGO:00703711040.087
wound healingGO:00420601150.087
response to nutrient levelsGO:0031667810.086
Fly
prostate gland developmentGO:003085030.086
negative regulation of transferase activityGO:00513481240.085
ion homeostasisGO:00508012300.085
acylglycerol metabolic processGO:0006639270.085
hormone mediated signaling pathwayGO:0009755220.085
negative regulation of cell sizeGO:004579230.083
regulation of immune responseGO:00507762010.083
Fly
regulation of ossificationGO:0030278580.083
regulation of fatty acid beta oxidationGO:003199880.082
dephosphorylationGO:00163112090.082
negative regulation of insulin secretionGO:004667690.082
regulation of peptidyl tyrosine phosphorylationGO:00507301080.082
actin filament based processGO:00300292240.082
genetic imprintingGO:007151410.081
regulation of protein localization to nucleusGO:1900180850.081
regulation of tyrosine phosphorylation of stat1 proteinGO:0042510110.081
negative regulation of insulin receptor signaling pathwayGO:004662780.081
Rat
ribonucleoside triphosphate catabolic processGO:00092033910.080
protein targetingGO:00066051870.080
inactivation of mapk activityGO:000018850.080
natural killer cell differentiationGO:000177920.079
muscle structure developmentGO:0061061980.079
regulation of cytokine productionGO:00018172320.079
negative regulation of anoikisGO:2000811150.079
positive regulation of nuclear divisionGO:0051785270.078

IRS1 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
hyperinsulinemic hypoglycemiaDOID:1331770.997
disease of metabolismDOID:00146672950.997
carbohydrate metabolic disorderDOID:2978550.997
inherited metabolic disorderDOID:6552420.997
diabetes mellitusDOID:9351310.297
type 2 diabetes mellitusDOID:9352280.297
carbohydrate metabolism diseaseDOID:0050013320.297
glucose metabolism diseaseDOID:4194320.297
acquired metabolic diseaseDOID:0060158580.297
cancerDOID:1621670.241
disease of cellular proliferationDOID:145661740.241
organ system cancerDOID:00506861640.241
reproductive organ cancerDOID:193230.213
gastrointestinal system cancerDOID:3119520.164