Homo sapiens

28 known processes

HMGCL

3-hydroxymethyl-3-methylglutaryl-CoA lyase

(Aliases: HL)

HMGCL biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular amino acid metabolic processGO:00065201160.618
organic acid catabolic processGO:0016054710.557
carboxylic acid catabolic processGO:0046395710.492
negative regulation of hepatocyte growth factor receptor signaling pathwayGO:190220310.472
negative regulation of cellular response to hepatocyte growth factor stimulusGO:200111310.466
regulation of cellular response to hepatocyte growth factor stimulusGO:200111210.337
positive regulation of vascular endothelial growth factor signaling pathwayGO:190074830.261
small molecule catabolic processGO:0044282920.241
fatty acid metabolic processGO:00066311150.229
lipid metabolic processGO:00066293810.210
oxidation reduction processGO:00551143960.206
cellular lipid metabolic processGO:00442553030.199
proteoglycan catabolic processGO:003016730.174
lipid modificationGO:0030258840.145
cellular ketone metabolic processGO:0042180800.119
monocarboxylic acid catabolic processGO:0072329370.110
proteolysis involved in cellular protein catabolic processGO:00516032440.096
regulation of cellular ketone metabolic processGO:0010565500.088
cellular macromolecule catabolic processGO:00442653800.086
lipid catabolic processGO:0016042840.085
fatty acid catabolic processGO:0009062290.083
amine metabolic processGO:0009308440.077
cellular protein catabolic processGO:00442572610.076
enzyme linked receptor protein signaling pathwayGO:00071673030.075
cellular amino acid catabolic processGO:0009063310.072
cofactor metabolic processGO:0051186870.072
Rat
regulation of cellular amino acid metabolic processGO:000652160.071
branched chain amino acid metabolic processGO:000908140.069
peptide metabolic processGO:0006518510.069
branched chain amino acid catabolic processGO:000908340.068
monocarboxylic acid metabolic processGO:00327871850.065
neuroblast proliferationGO:000740540.063
cellular lipid catabolic processGO:0044242650.059
single organism carbohydrate metabolic processGO:00447231930.059
cellular amine metabolic processGO:0044106410.058
regulation of cellular amine metabolic processGO:0033238110.058
lipid biosynthetic processGO:00086101770.054
glycoprotein metabolic processGO:00091001100.053
cellular response to growth factor stimulusGO:00713631970.052
negative regulation of multicellular organismal processGO:00512413170.051
cytoplasmic transportGO:00164823790.050
short chain fatty acid metabolic processGO:004645920.049
cellular response to endogenous stimulusGO:00714953360.049
modification dependent macromolecule catabolic processGO:00436322120.048
negative regulation of platelet aggregationGO:009033130.048
protein maturationGO:00516042330.047
regulation of vascular endothelial growth factor signaling pathwayGO:190074660.047
heart formationGO:006091420.047
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.046
fatty acid oxidationGO:0019395310.045
negative regulation of developmental processGO:00510932470.044
regulation of neural precursor cell proliferationGO:200017740.043
modification dependent protein catabolic processGO:00199412090.042
post embryonic developmentGO:000979120.042
organic acid biosynthetic processGO:0016053970.042
alcohol metabolic processGO:00060661140.042
positive regulation of cellular amine metabolic processGO:003324070.041
pancreatic a cell differentiationGO:000331010.041
ubiquitin dependent protein catabolic processGO:00065112060.041
negative regulation of hemostasisGO:1900047220.040
small molecule biosynthetic processGO:00442831570.039
protein processingGO:00164852260.039
positive regulation of cellular amino acid metabolic processGO:004576430.038
regulation of defense responseGO:00313471540.038
regulation of platelet aggregationGO:009033040.038
response to growth factorGO:00708482050.038
cellular amide metabolic processGO:0043603690.037
cellular modified amino acid metabolic processGO:0006575640.036
salivary gland morphogenesisGO:000743540.035
carbohydrate metabolic processGO:00059752070.034
negative regulation of cell differentiationGO:00455961710.034
glutathione metabolic processGO:0006749200.034
regulation of cell activationGO:00508651250.034
metanephric nephron tubule morphogenesisGO:007228210.033
organic hydroxy compound metabolic processGO:19016151470.033
negative regulation of homotypic cell cell adhesionGO:003411130.032
regulation of cell differentiationGO:00455953930.032
sulfur compound metabolic processGO:00067901010.031
Rat
lipid oxidationGO:0034440330.031
regulation of neuroblast proliferationGO:190269230.030
organonitrogen compound biosynthetic processGO:19015662000.030
multicellular organismal agingGO:001025930.030
positive regulation of transportGO:00510503360.030
defense responseGO:00069523150.029
monocarboxylic acid biosynthetic processGO:0072330670.029
single organism cellular localizationGO:19025803320.029
coenzyme metabolic processGO:0006732650.029
Rat
female gamete generationGO:000729220.029
hindbrain developmentGO:003090230.028
intracellular protein transportGO:00068862700.028
response to cytokineGO:00340972320.027
organophosphate biosynthetic processGO:00904071630.027
regulation of cellular response to growth factor stimulusGO:0090287760.026
nerve developmentGO:002167540.026
epithelium developmentGO:00604292270.026
protein oligomerizationGO:00512591730.026
thymus developmentGO:004853830.026
proteoglycan metabolic processGO:0006029290.026
negative regulation of protein metabolic processGO:00512483910.026
negative regulation of cell proliferationGO:00082852280.026
protein ubiquitinationGO:00165673140.025
oogenesisGO:004847720.025
cytokine productionGO:00018162470.025
cranial nerve developmentGO:002154540.024
positive regulation of neural precursor cell proliferationGO:200017920.024
cell activationGO:00017752130.024
astrocyte differentiationGO:004870840.023
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.023
adult locomotory behaviorGO:000834410.023
cofactor biosynthetic processGO:0051188310.023
skeletal system developmentGO:0001501790.023
negative regulation of cellular protein metabolic processGO:00322693530.023
protein catabolic processGO:00301633250.023
locomotory behaviorGO:000762610.022
s shaped body morphogenesisGO:007205040.022
calcium ion transportGO:00068161470.022
sex determinationGO:000753030.022
connective tissue developmentGO:0061448390.021
organ formationGO:004864530.021
pituitary gland developmentGO:002198320.021
neuroendocrine cell differentiationGO:006110120.021
carboxylic acid biosynthetic processGO:0046394970.021
neuron fate commitmentGO:004866320.021
neural crest cell developmentGO:001403230.021
proteasomal protein catabolic processGO:00104981760.021
response to decreased oxygen levelsGO:0036293960.021
fatty acid biosynthetic processGO:0006633460.021
mitotic cell cycle processGO:19030472860.020
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092900.020
regulation of anatomical structure morphogenesisGO:00226032860.020
neural tube patterningGO:002153220.020
cellular response to dna damage stimulusGO:00069743790.020
carbohydrate derivative biosynthetic processGO:19011372070.020
determination of adult lifespanGO:000834020.020
membrane organizationGO:00610242920.020
cellular response to cytokine stimulusGO:00713451810.019
nucleoside phosphate biosynthetic processGO:19012931090.019
negative regulation of reactive oxygen species metabolic processGO:2000378110.019
positive regulation of phosphorylationGO:00423273940.019
negative regulation of cellular amine metabolic processGO:003323930.019
cell adhesionGO:00071553250.019
cellular response to tumor necrosis factorGO:0071356630.019
positive regulation of immune system processGO:00026842830.018
regulation of cell cycleGO:00517263930.018
regulation of organ formationGO:000315640.018
secretionGO:00469032540.018
blastoderm segmentationGO:000735020.018
positive regulation of gliogenesisGO:001401540.018
negative regulation of glial cell proliferationGO:006025320.018
biological adhesionGO:00226103310.018
negative regulation of catalytic activityGO:00430863350.018
negative regulation of cell developmentGO:0010721480.018
dephosphorylationGO:00163112090.017
negative regulation of protein maturationGO:19033181420.017
inflammatory responseGO:0006954790.017
ventricular septum morphogenesisGO:006041230.017
segmentationGO:003528240.017
apoptotic signaling pathwayGO:00971902680.017
alpha amino acid catabolic processGO:1901606260.017
rostrocaudal neural tube patterningGO:002190310.017
protein localization to organelleGO:00333652800.017
response to hypoxiaGO:0001666960.017
negative regulation of cellular component organizationGO:00511292350.017
regulation of response to external stimulusGO:00321012220.017
immune responseGO:00069553070.017
regulation of protein transportGO:00512232130.016
protein modification by small protein conjugationGO:00324463420.016
coagulationGO:0050817780.016
metal ion transportGO:00300012720.016
regulation of reactive oxygen species metabolic processGO:2000377410.016
very long chain fatty acid metabolic processGO:0000038190.016
epithelial cell differentiationGO:00308551410.016
peripheral nervous system developmentGO:000742220.016
negative regulation of phosphate metabolic processGO:00459362670.016
pharyngeal system developmentGO:006003720.016
embryonic placenta developmentGO:000189210.016
negative regulation of intracellular signal transductionGO:19025321830.016
hepatocyte growth factor receptor signaling pathwayGO:004801280.016
regulation of glial cell differentiationGO:004568530.016
negative regulation of response to woundingGO:1903035470.016
negative regulation of response to external stimulusGO:0032102830.016
negative regulation of phosphorus metabolic processGO:00105632670.015
negative regulation of cellular amino acid metabolic processGO:004576320.015
regulation of protein localizationGO:00328802960.015
positive regulation of secretion by cellGO:19035321080.015
response to external biotic stimulusGO:00432072610.015
positive regulation of synaptic transmissionGO:005080640.015
nucleocytoplasmic transportGO:00069131760.015
single organism cell adhesionGO:00986021790.015
fatty acid beta oxidationGO:0006635220.015
regulation of secretionGO:00510461940.015
response to woundingGO:00096111680.015
positive regulation of neuroblast proliferationGO:000205220.015
positive regulation of secretionGO:00510471160.015
regulation of proteolysisGO:00301622930.015
cellular response to oxygen containing compoundGO:19017012760.015
protein acylationGO:00435431380.014
establishment of protein localization to organelleGO:00725941720.014
fatty acid beta oxidation using acyl coa dehydrogenaseGO:003353930.014
epithelial cell fate commitmentGO:007214830.014
secretion by cellGO:00329402260.014
cell fate determinationGO:000170930.014
regulation of mitotic cell cycleGO:00073461890.014
dna repairGO:00062811980.014
regulation of cellular component biogenesisGO:00440872810.014
regulation of cell cycle processGO:00105642660.014
negative regulation of immune system processGO:00026831360.014
protein targetingGO:00066051870.014
protein acetylationGO:00064731160.014
multi organism cellular processGO:00447641560.014
endothelium developmentGO:0003158330.014
peptidyl lysine modificationGO:00182051440.014
store operated calcium entryGO:000211530.014
negative regulation of cell adhesionGO:0007162640.014
response to tumor necrosis factorGO:0034612760.014
regulation of lipid metabolic processGO:0019216960.014
sensory perception of painGO:001923340.014
peptide catabolic processGO:0043171100.013
mitotic cell cycleGO:00002783260.013
memoryGO:000761330.013
regulation of protein maturationGO:19033171500.013
interspecies interaction between organismsGO:00444191560.013
histone modificationGO:00165702510.013
divalent inorganic cation transportGO:00725111580.013
regulation of multi organism processGO:00439001570.013
spermatid differentiationGO:004851540.013
regulation of hemostasisGO:1900046420.013
reactive oxygen species metabolic processGO:0072593750.013
regulation of cholesterol metabolic processGO:009018140.013
regulation of cellular response to stressGO:00801352440.013
regulation of mitosisGO:0007088630.013
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090100410.013
negative regulation of glial cell differentiationGO:004568610.013
hemopoiesisGO:00300971800.013
regulation of blood coagulationGO:0030193420.013
immune system developmentGO:00025201950.013
steroid metabolic processGO:0008202940.013
cell morphogenesisGO:00009022960.013
response to abiotic stimulusGO:00096283360.013
negative regulation of cell deathGO:00605483450.013
cellular response to hepatocyte growth factor stimulusGO:003572960.013
cell projection organizationGO:00300302520.013
negative regulation of nervous system developmentGO:0051961280.013
negative regulation of protein processingGO:00109551420.013
regulation of response to woundingGO:19030341010.013
hair cell differentiationGO:003531520.013
spermatid developmentGO:000728640.012
nuclear importGO:00511701060.012
negative regulation of wound healingGO:0061045250.012
hexose metabolic processGO:0019318550.012
coenzyme a metabolic processGO:001593660.012
innate immune responseGO:00450871780.012
oocyte developmentGO:004859910.012
negative regulation of protein modification processGO:00314002000.012
multicellular organismal metabolic processGO:0044236340.012
symbiosis encompassing mutualism through parasitismGO:00444031560.012
regulation of glial cell proliferationGO:006025140.012
protein targeting to nucleusGO:00447441040.012
ribonucleoside bisphosphate metabolic processGO:003387570.012
hematopoietic or lymphoid organ developmentGO:00485341860.012
regulation of endothelial tube morphogenesisGO:190150910.012
cell matrix adhesionGO:0007160850.012
purine containing compound catabolic processGO:00725234110.012
metanephric nephron epithelium developmentGO:007224340.012
multi organism membrane organizationGO:0044803120.012
regulation of cell adhesionGO:00301551660.012
positive regulation of cell differentiationGO:00455972110.012
negative regulation of cell cycleGO:00457861930.012
positive regulation of developmental processGO:00510943140.012
regulation of symbiosis encompassing mutualism through parasitismGO:00439031090.012
regulation of calcium ion transportGO:0051924790.012
response to other organismGO:00517072610.012
glycosylationGO:0070085710.012
protein homooligomerizationGO:00512601000.012
nuclear transportGO:00511691790.012
alpha amino acid metabolic processGO:1901605720.012
reactive nitrogen species metabolic processGO:200105730.012
coenzyme biosynthetic processGO:0009108240.011
regulation of protein processingGO:00706131500.011
regulation of cellular response to vascular endothelial growth factor stimulusGO:190254770.011
compound eye developmentGO:004874910.011
hemostasisGO:0007599760.011
nitrogen compound transportGO:00717051910.011
negative regulation of cellular catabolic processGO:0031330830.011
cell cell signalingGO:00072671550.011
peptidyl tyrosine phosphorylationGO:00181081700.011
positive regulation of cellular component organizationGO:00511303760.011
regulation of inflammatory responseGO:0050727460.011
regulation of viral processGO:00507921030.011
regulation of cell cell adhesionGO:0022407570.011
regulation of secretion by cellGO:19035301770.011
regulation of wound healingGO:0061041560.011
negative regulation of blood coagulationGO:0030195220.011
regulation of cell developmentGO:00602841610.011
response to oxygen containing compoundGO:19017003690.011
Rat
negative regulation of cell activationGO:0050866330.011
monosaccharide metabolic processGO:0005996740.011
regulation of cytokine productionGO:00018172320.011
cellular carbohydrate metabolic processGO:0044262840.011
maintenance of locationGO:00512351120.011
organelle fissionGO:00482851490.011
vascular endothelial growth factor productionGO:0010573150.011
reactive oxygen species biosynthetic processGO:190340940.011
negative regulation of phosphorylationGO:00423261740.011
positive regulation of programmed cell deathGO:00430682490.011
response to bacteriumGO:00096171440.011
cellular chemical homeostasisGO:00550821800.011
negative regulation of stem cell proliferationGO:200064730.011
positive regulation of apoptotic processGO:00430652460.010
regulation of establishment of protein localizationGO:00702012420.010
protein localization to nucleusGO:00345041360.010
cellular response to interleukin 1GO:0071347350.010
ras protein signal transductionGO:0007265730.010
neuromuscular junction developmentGO:000752830.010
positive regulation of protein phosphorylationGO:00019343130.010
cell part morphogenesisGO:00329901370.010
positive regulation of cell deathGO:00109422630.010
negative regulation of programmed cell deathGO:00430693210.010
positive regulation of leukocyte activationGO:0002696800.010
meiosis iGO:000712740.010
golgi vesicle transportGO:0048193800.010
positive regulation of organelle organizationGO:00106381950.010
protein tetramerizationGO:0051262470.010
divalent metal ion transportGO:00708381520.010
endosome transport via multivesicular body sorting pathwayGO:003250930.010
viral life cycleGO:00190581320.010
chemical homeostasisGO:00488783060.010
regulation of body fluid levelsGO:0050878990.010
response to axon injuryGO:004867810.010
cell substrate adhesionGO:00315891320.010
cellular response to nutrient levelsGO:0031669690.010

HMGCL disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
inherited metabolic disorderDOID:6552420.243
disease of metabolismDOID:00146672950.243
amino acid metabolic disorderDOID:9252500.056
carbohydrate metabolic disorderDOID:2978550.027
organ system cancerDOID:00506861640.022
cancerDOID:1621670.022
disease of cellular proliferationDOID:145661740.022
central nervous system diseaseDOID:3311860.019
nervous system diseaseDOID:8634310.019
sensory system diseaseDOID:00501552030.017
eye diseaseDOID:56141490.017
eye and adnexa diseaseDOID:14921500.017
neurodegenerative diseaseDOID:12891020.014
musculoskeletal system diseaseDOID:172230.013
cardiovascular system diseaseDOID:12871060.011
urinary system diseaseDOID:18400.011
muscular diseaseDOID:00800001140.011
myopathyDOID:4231040.011
muscle tissue diseaseDOID:661130.011
connective tissue diseaseDOID:651090.011
organic acidemiaDOID:0060159140.011
retinal diseaseDOID:56791180.010