Homo sapiens

9 known processes

PSMB8

proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)

(Aliases: D6S216E,D6S216,LMP7,MGC1491,PSMB5i,RING10)

PSMB8 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
proteasomal ubiquitin independent protein catabolic processGO:001049930.998
Yeast
antigen processing and presentationGO:0019882330.958
Mouse
proteolysis involved in cellular protein catabolic processGO:00516032440.777
Yeast
viral processGO:00160321460.616
protein catabolic processGO:00301633250.608
Yeast
multi organism localizationGO:1902579140.596
symbiosis encompassing mutualism through parasitismGO:00444031560.588
cellular protein catabolic processGO:00442572610.498
Yeast
defense response to other organismGO:00985421290.492
modification dependent protein catabolic processGO:00199412090.489
Yeast
ubiquitin dependent protein catabolic processGO:00065112060.488
Yeast
antigen processing and presentation via mhc class ibGO:000247530.470
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.451
Yeast
immune effector processGO:00022521590.448
regulation of immune responseGO:00507762010.359
regulation of natural killer cell mediated cytotoxicityGO:0042269160.344
negative regulation of defense responseGO:0031348470.344
mononuclear cell proliferationGO:0032943710.315
antigen processing and presentation of exogenous antigenGO:001988440.306
antigen processing and presentation of peptide antigenGO:0048002180.287
immune responseGO:00069553070.285
leukocyte mediated immunityGO:0002443590.282
sensory perception of chemical stimulusGO:0007606380.268
cellular macromolecule catabolic processGO:00442653800.262
Yeast
positive regulation of peptidase activityGO:0010952880.251
transport of virusGO:0046794140.240
multi organism transportGO:0044766140.219
negative regulation of natural killer cell mediated cytotoxicityGO:004595350.215
response to external biotic stimulusGO:00432072610.204
regulation of symbiosis encompassing mutualism through parasitismGO:00439031090.195
response to other organismGO:00517072610.183
regulation of proteasomal protein catabolic processGO:0061136870.182
modification dependent macromolecule catabolic processGO:00436322120.179
Yeast
negative regulation of intracellular transport of viral materialGO:190125320.177
regulation of proteolysis involved in cellular protein catabolic processGO:1903050910.176
regulation of proteolysisGO:00301622930.174
interspecies interaction between organismsGO:00444191560.174
defense responseGO:00069523150.147
peptide transportGO:0015833740.144
negative regulation of immune responseGO:0050777400.143
intracellular transport of viral protein in host cellGO:001906040.136
negative regulation of immune system processGO:00026831360.136
isg15 protein conjugationGO:003202050.133
natural killer cell mediated cytotoxicityGO:0042267230.131
viral life cycleGO:00190581320.120
positive regulation of endopeptidase activityGO:0010950840.119
antigen processing and presentation of peptide antigen via mhc class iGO:000247460.106
regulation of fas signaling pathwayGO:190204420.103
leukocyte mediated cytotoxicityGO:0001909270.102
t cell proliferationGO:0042098450.100
positive regulation of leukocyte activationGO:0002696800.099
proteasomal protein catabolic processGO:00104981760.097
Yeast
chemical homeostasisGO:00488783060.091
regulation of cellular protein catabolic processGO:1903362960.090
positive regulation of immune effector processGO:0002699400.087
purine nucleotide catabolic processGO:00061954050.086
intracellular protein transportGO:00068862700.081
nucleoside triphosphate catabolic processGO:00091433940.081
regulation of interferon gamma productionGO:0032649360.078
positive regulation of leukocyte mediated immunityGO:0002705240.078
intracellular transport of virusGO:0075733140.078
positive regulation of i kappab kinase nf kappab signalingGO:00431231320.074
purine ribonucleoside monophosphate catabolic processGO:00091691580.073
regulation of peptidase activityGO:00525471800.072
cellular response to cytokine stimulusGO:00713451810.069
purine nucleoside catabolic processGO:00061523980.068
multi organism intracellular transportGO:1902583140.066
multi organism metabolic processGO:0044033410.065
regulation of transferase activityGO:00513383550.064
positive regulation of secretionGO:00510471160.064
t cell activationGO:0042110990.064
negative regulation of apoptotic signaling pathwayGO:2001234970.062
regulation of natural killer cell mediated immunityGO:0002715160.061
positive regulation of immune system processGO:00026842830.061
regulation of multi organism processGO:00439001570.061
regulation of t cell mediated immunityGO:0002709180.060
regulation of adaptive immune responseGO:0002819330.059
positive regulation of developmental processGO:00510943140.058
regulation of apoptotic signaling pathwayGO:20012331750.057
positive regulation of hydrolase activityGO:00513453310.056
innate immune responseGO:00450871780.054
purine ribonucleotide catabolic processGO:00091544040.054
nucleotide catabolic processGO:00091664080.051
positive regulation of leukocyte mediated cytotoxicityGO:0001912160.050
antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathwayGO:000248430.050
lymphocyte mediated immunityGO:0002449480.050
cell activationGO:00017752130.050
extrinsic apoptotic signaling pathwayGO:00971911190.050
cellular component morphogenesisGO:00329893140.049
positive regulation of cell activationGO:0050867810.048
negative regulation of extrinsic apoptotic signaling pathwayGO:2001237520.047
antigen processing and presentation of endogenous peptide antigenGO:000248360.046
negative regulation of cell deathGO:00605483450.046
regulation of leukocyte mediated immunityGO:0002703380.045
protection from natural killer cell mediated cytotoxicityGO:004227030.045
regulation by virus of viral protein levels in host cellGO:004671940.044
regulation of extrinsic apoptotic signaling pathwayGO:2001236850.043
regulation of protein catabolic processGO:00421761550.041
amide transportGO:0042886760.041
multi organism cellular processGO:00447641560.041
regulation of cell killingGO:0031341220.041
negative regulation of leukocyte mediated immunityGO:0002704140.040
apoptotic signaling pathwayGO:00971902680.039
negative regulation of kinase activityGO:00336731060.039
purine containing compound catabolic processGO:00725234110.039
lymphocyte proliferationGO:0046651700.039
negative regulation of viral transcriptionGO:0032897230.039
movement in environment of other organism involved in symbiotic interactionGO:0052192250.039
regulation of defense responseGO:00313471540.039
response to biotic stimulusGO:00096072760.039
regulation of innate immune responseGO:0045088970.038
nucleoside monophosphate metabolic processGO:00091231910.037
purine nucleoside monophosphate metabolic processGO:00091261860.037
negative regulation of cell migrationGO:00303361020.037
leukocyte activationGO:00453211640.037
positive regulation of adaptive immune responseGO:0002821210.036
cytoplasmic transportGO:00164823790.035
immune response activating signal transductionGO:0002757900.034
regulation of endopeptidase activityGO:00525481700.034
regulation of leukocyte activationGO:00026941150.034
regulation of circadian sleep wake cycleGO:004274920.034
leukocyte proliferationGO:0070661740.033
purine ribonucleoside monophosphate metabolic processGO:00091671860.033
negative regulation of lymphocyte mediated immunityGO:0002707120.032
positive regulation of t cell mediated immunityGO:0002711120.032
cell killingGO:0001906340.032
regulation of cellular component movementGO:00512703340.032
natural killer cell mediated immunityGO:0002228230.032
positive regulation of proteolysisGO:00458621420.031
secretionGO:00469032540.030
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002824190.029
nitrogen compound transportGO:00717051910.027
inorganic ion transmembrane transportGO:00986602310.026
immune response regulating cell surface receptor signaling pathwayGO:0002768510.026
purine ribonucleoside triphosphate metabolic processGO:00092054110.024
nucleoside phosphate biosynthetic processGO:19012931090.024
interaction with hostGO:0051701420.024
purine nucleoside triphosphate metabolic processGO:00091444120.024
regenerationGO:003109940.024
cation transportGO:00068123310.023
negative regulation of cell motilityGO:20001461040.023
cell morphogenesisGO:00009022960.023
oogenesisGO:004847720.023
purine ribonucleoside catabolic processGO:00461303980.022
positive regulation of cell differentiationGO:00455972110.022
regulation of leukocyte proliferationGO:0070663670.022
dna damage response signal transduction by p53 class mediatorGO:0030330440.021
intracellular protein transport in other organism involved in symbiotic interactionGO:005170840.021
regulation of mononuclear cell proliferationGO:0032944650.021
detection of chemical stimulusGO:0009593550.021
regulation of regulatory t cell differentiationGO:004558940.021
regulation of interleukin 10 secretionGO:200117940.020
regulation of antigen processing and presentation of peptide antigenGO:000258340.019
regulation of cytoskeleton organizationGO:00514931770.019
regulation of viral processGO:00507921030.019
blastocyst developmentGO:000182430.019
negative regulation of viral processGO:0048525660.019
positive regulation of protein secretionGO:0050714600.018
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002822290.018
cd8 positive alpha beta t cell activationGO:003603730.018
regulation of t cell activationGO:0050863770.018
regulation of establishment of protein localizationGO:00702012420.018
negative regulation of leukocyte mediated cytotoxicityGO:000191150.018
positive regulation of production of molecular mediator of immune responseGO:0002702110.018
positive regulation of lymphocyte activationGO:0051251730.018
negative regulation of innate immune responseGO:0045824180.018
system processGO:00030083490.017
symbiont intracellular protein transport in hostGO:003058140.017
extracellular transportGO:000685840.016
positive regulation of secretion by cellGO:19035321080.016
positive regulation of activated t cell proliferationGO:0042104110.016
response to bacteriumGO:00096171440.016
regulation of lymphocyte mediated immunityGO:0002706330.016
negative regulation of catalytic activityGO:00430863350.016
regulation of cell migrationGO:00303342890.016
regulation of actin filament based processGO:00329701410.016
ribonucleoside catabolic processGO:00424544060.015
antigen processing and presentation of endogenous peptide antigen via mhc class ibGO:000247620.015
cellular response to external stimulusGO:00714961110.015
cellular ketone metabolic processGO:0042180800.015
regulation of cell motilityGO:20001452990.015
inflammatory response to antigenic stimulusGO:000243740.015
negative regulation of posttranscriptional gene silencingGO:006014930.015
regulation of cell activationGO:00508651250.014
positive regulation of antigen processing and presentationGO:000257910.014
lymphocyte activationGO:00466491330.014
regulation of secretionGO:00510461940.014
purine ribonucleoside triphosphate catabolic processGO:00092073910.013
regulation of cell cycle phase transitionGO:19019871260.013
negative regulation of phosphorus metabolic processGO:00105632670.013
regulation of cellular component biogenesisGO:00440872810.013
organophosphate catabolic processGO:00464344300.013
guanosine containing compound catabolic processGO:19010692390.013
positive regulation of cytokine secretionGO:0050715420.013
positive regulation of protein complex assemblyGO:0031334860.013
posttranscriptional regulation of gene expressionGO:00106082130.013
syncytium formation by plasma membrane fusionGO:000076820.013
negative regulation of programmed cell deathGO:00430693210.013
positive regulation of cellular component organizationGO:00511303760.012
regulation of t cell differentiationGO:0045580190.012
positive regulation of mononuclear cell proliferationGO:0032946470.012
regulation of ligase activityGO:0051340290.012
adenosine to inosine editingGO:000638230.012
mitotic spindle elongationGO:000002240.012
Fly
spermatid differentiationGO:004851540.012
cellular homeostasisGO:00197251960.012
cation transmembrane transportGO:00986552380.012
positive regulation of protein transportGO:00512221350.012
ribonucleotide catabolic processGO:00092614050.012
regulation of secretion by cellGO:19035301770.011
divalent metal ion transportGO:00708381520.011
regulation of interleukin 10 productionGO:0032653160.011
negative regulation of phosphate metabolic processGO:00459362670.011
purine nucleoside triphosphate catabolic processGO:00091463920.011
regulation of type i interferon productionGO:0032479260.011
secretion by cellGO:00329402260.011
regulation of cellular component sizeGO:0032535820.011
negative regulation of apoptotic processGO:00430663160.011
antigen processing and presentation of peptide antigen via mhc class ibGO:000242820.011
activation of innate immune responseGO:0002218550.011
arp2 3 complex mediated actin nucleationGO:0034314170.010
sensory organ developmentGO:0007423520.010
spermatid developmentGO:000728640.010
negative regulation of protein kinase activityGO:0006469980.010
purine nucleotide biosynthetic processGO:0006164840.010
negative regulation of protein phosphorylationGO:00019331400.010
positive regulation of immune responseGO:00507781590.010
purine ribonucleoside metabolic processGO:00461284370.010
positive regulation of cellular component biogenesisGO:00440891580.010
positive regulation of transportGO:00510503360.010
negative regulation of developmental processGO:00510932470.010

PSMB8 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
immune system diseaseDOID:29141550.588
primary immunodeficiency diseaseDOID:612360.522
severe combined immunodeficiencyDOID:627100.353
combined t cell and b cell immunodeficiencyDOID:628120.353
cancerDOID:1621670.022
organ system cancerDOID:00506861640.022
disease of cellular proliferationDOID:145661740.022
musculoskeletal system diseaseDOID:172230.012