Homo sapiens

7 known processes

UBA1

ubiquitin-like modifier activating enzyme 1

(Aliases: UBE1,UBE1X,POC20,UBA1A,GXP1,A1S9,A1S9T,SMAX2,AMCX1,MGC4781,A1ST)

UBA1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
protein ubiquitinationGO:00165673140.993
Yeast Mouse Worm Fly
protein polyubiquitinationGO:00002091100.942
ubiquitin dependent protein catabolic processGO:00065112060.916
protein modification by small protein conjugationGO:00324463420.903
Yeast Mouse Worm Fly
covalent chromatin modificationGO:00165692540.777
protein monoubiquitinationGO:0006513390.769
histone modificationGO:00165702510.761
mitotic cell cycle processGO:19030472860.761
protein k48 linked ubiquitinationGO:0070936380.739
cell cycle phase transitionGO:00447701730.737
proteolysis involved in cellular protein catabolic processGO:00516032440.725
proteasomal protein catabolic processGO:00104981760.721
mitotic cell cycleGO:00002783260.700
chromatin modificationGO:00165682980.636
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.564
mitotic cell cycle phase transitionGO:00447721620.540
modification dependent macromolecule catabolic processGO:00436322120.532
negative regulation of cell cycleGO:00457861930.529
protein catabolic processGO:00301633250.513
regulation of protein ubiquitinationGO:0031396950.497
cellular protein catabolic processGO:00442572610.434
modification dependent protein catabolic processGO:00199412090.405
positive regulation of protein modification by small protein conjugation or removalGO:1903322610.403
regulation of cell cycleGO:00517263930.403
negative regulation of apoptotic processGO:00430663160.399
mitotic cell cycle checkpointGO:0007093680.387
cellular macromolecule catabolic processGO:00442653800.342
regulation of mitotic cell cycle phase transitionGO:19019901180.342
protein sumoylationGO:0016925250.333
compound eye developmentGO:004874910.333
negative regulation of cell cycle phase transitionGO:1901988890.315
negative regulation of mitotic cell cycleGO:00459301020.282
histone ubiquitinationGO:0016574310.279
regulation of innate immune responseGO:0045088970.273
protein k11 linked ubiquitinationGO:0070979240.269
protein k63 linked ubiquitinationGO:0070534310.269
negative regulation of mitotic cell cycle phase transitionGO:1901991850.252
regulation of cell cycle phase transitionGO:19019871260.239
response to external biotic stimulusGO:00432072610.223
dna damage checkpointGO:0000077680.210
regulation of mitotic cell cycleGO:00073461890.209
dna integrity checkpointGO:0031570710.207
immune responseGO:00069553070.207
post embryonic developmentGO:000979120.207
Worm Fly
regulation of proteolysis involved in cellular protein catabolic processGO:1903050910.206
regulation of intracellular steroid hormone receptor signaling pathwayGO:0033143320.203
cellular macromolecular complex assemblyGO:00346223240.185
mitotic dna damage checkpointGO:0044773280.183
locomotory behaviorGO:000762610.180
cell cycle checkpointGO:00000751170.178
negative regulation of programmed cell deathGO:00430693210.176
epithelium developmentGO:00604292270.171
metal ion transportGO:00300012720.168
response to hormoneGO:00097251750.167
cellular response to dna damage stimulusGO:00069743790.164
posttranscriptional regulation of gene expressionGO:00106082130.162
intracellular receptor signaling pathwayGO:00305221040.158
regulation of protein modification by small protein conjugation or removalGO:19033201070.157
chromatin organizationGO:00063253510.150
cation transportGO:00068123310.146
response to other organismGO:00517072610.145
intracellular steroid hormone receptor signaling pathwayGO:0030518610.144
protein ubiquitination involved in ubiquitin dependent protein catabolic processGO:0042787370.135
skin developmentGO:0043588760.132
g2 dna damage checkpointGO:0031572260.132
negative regulation of cellular protein metabolic processGO:00322693530.125
regulation of proteasomal protein catabolic processGO:0061136870.119
histone monoubiquitinationGO:0010390200.114
regulation of cellular ketone metabolic processGO:0010565500.113
innate immune responseGO:00450871780.110
regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032434710.109
dna conformation changeGO:00711031130.106
adult locomotory behaviorGO:000834410.104
regulation of camp mediated signalingGO:0043949130.103
cellular protein complex assemblyGO:00436231880.102
regulation of protein catabolic processGO:00421761550.101
positive regulation of innate immune responseGO:0045089790.097
regulation of cellular protein catabolic processGO:1903362960.095
positive regulation of membrane potentialGO:004583820.095
neurogenesisGO:00220081690.095
Zebrafish Fly
regulation of defense responseGO:00313471540.093
cyclic nucleotide mediated signalingGO:0019935260.093
nervous system developmentGO:00073992930.092
Zebrafish Fly
mitotic dna integrity checkpointGO:0044774300.091
system processGO:00030083490.091
Worm
oogenesisGO:004847720.087
Worm
maintenance of locationGO:00512351120.087
Fly
monovalent inorganic cation transportGO:00156721280.087
regulation of androgen receptor signaling pathwayGO:0060765180.086
regulation of cell cycle processGO:00105642660.085
positive regulation of immune system processGO:00026842830.085
cytoplasmic transportGO:00164823790.083
negative regulation of protein metabolic processGO:00512483910.083
vesicle mediated transportGO:00161923710.082
Worm
negative regulation of cell deathGO:00605483450.081
single organism cellular localizationGO:19025803320.080
rna processingGO:00063962550.078
positive regulation of defense responseGO:0031349870.075
androgen receptor signaling pathwayGO:0030521340.075
dna packagingGO:0006323770.073
regulation of protein sumoylationGO:0033233130.071
camp mediated signalingGO:0019933230.070
segmentationGO:003528240.069
protein localization to organelleGO:00333652800.068
ncrna metabolic processGO:00346601080.064
regulation of secretion by cellGO:19035301770.063
sodium ion transportGO:0006814610.063
organelle assemblyGO:00709251760.060
regulation of transmembrane transporter activityGO:0022898740.060
cellular homeostasisGO:00197251960.060
female gamete generationGO:000729220.059
Worm
negative regulation of cell cycle processGO:00109481210.057
negative regulation of protein modification processGO:00314002000.057
regulation of metal ion transportGO:00109591200.057
ncrna processingGO:0034470830.056
regulation of transferase activityGO:00513383550.054
positive regulation of immune responseGO:00507781590.054
wnt signaling pathwayGO:00160551560.053
lipid metabolic processGO:00066293810.053
lipid localizationGO:00108761060.051
Fly
chromosome segregationGO:00070591140.050
cellular ketone metabolic processGO:0042180800.049
defense response to bacteriumGO:0042742630.049
mitotic g2 m transition checkpointGO:004481890.047
organelle fissionGO:00482851490.047
somitogenesisGO:000175620.046
cell developmentGO:00484683280.045
Zebrafish Worm Fly
peptide transportGO:0015833740.045
regulation of proteolysisGO:00301622930.044
organ morphogenesisGO:00098871470.044
blood coagulationGO:0007596760.044
defense response to other organismGO:00985421290.044
ribonucleoprotein complex biogenesisGO:00226131160.044
canonical wnt signaling pathwayGO:00600701160.043
positive regulation of cellular catabolic processGO:00313312840.043
chemical homeostasisGO:00488783060.042
positive regulation of protein ubiquitinationGO:0031398530.041
nucleoside triphosphate catabolic processGO:00091433940.041
cell projection organizationGO:00300302520.041
Zebrafish
hair cycleGO:0042633280.041
response to biotic stimulusGO:00096072760.041
single organism membrane organizationGO:00448022680.040
epithelial cell differentiationGO:00308551410.039
regulation of ion transmembrane transportGO:00347651320.039
potassium ion transmembrane transportGO:0071805600.039
blastoderm segmentationGO:000735020.039
protein stabilizationGO:0050821640.039
defense responseGO:00069523150.039
positive regulation of organelle organizationGO:00106381950.038
glycosyl compound catabolic processGO:19016584130.038
distal tubule developmentGO:007201740.038
regulation of secretionGO:00510461940.037
tube developmentGO:00352951250.037
determination of adult lifespanGO:000834020.037
cellular component morphogenesisGO:00329893140.036
Zebrafish
negative regulation of camp mediated signalingGO:004395140.035
inorganic ion transmembrane transportGO:00986602310.035
cellular response to endogenous stimulusGO:00714953360.034
protein autoubiquitinationGO:0051865370.033
regulation of translationGO:0006417890.033
protein acylationGO:00435431380.033
negative regulation of intracellular steroid hormone receptor signaling pathwayGO:0033144180.032
actin filament based processGO:00300292240.032
trna processingGO:0008033230.031
positive regulation of transportGO:00510503360.031
mitotic nuclear divisionGO:00070671190.031
response to oxygen containing compoundGO:19017003690.031
ion homeostasisGO:00508012300.030
tube morphogenesisGO:0035239950.030
embryo developmentGO:00097901230.029
Worm
cell activationGO:00017752130.029
cell adhesionGO:00071553250.029
second messenger mediated signalingGO:0019932780.029
negative regulation of protein ubiquitinationGO:0031397350.029
neuron projection developmentGO:00311751060.029
Zebrafish
cell cycle g1 s phase transitionGO:0044843800.028
oocyte differentiationGO:000999420.028
defense response to gram negative bacteriumGO:0050829140.027
response to decreased oxygen levelsGO:0036293960.027
regulation of transporter activityGO:0032409820.027
cellular potassium ion transportGO:0071804600.027
nuclear divisionGO:00002801280.027
negative regulation of cellular component movementGO:00512711060.026
oocyte developmentGO:004859910.026
adenylate cyclase inhibiting g protein coupled receptor signaling pathwayGO:0007193220.026
peripheral nervous system developmentGO:000742220.026
regulation of locomotionGO:00400123290.026
response to bacteriumGO:00096171440.026
microtubule based processGO:00070172100.026
regulation of small gtpase mediated signal transductionGO:00510561560.026
Fly
regulation of cytoplasmic transportGO:19036491490.026
anterior posterior axis specificationGO:000994820.026
protein deubiquitinationGO:0016579790.026
carbohydrate metabolic processGO:00059752070.025
protein k33 linked ubiquitinationGO:199039010.025
actin cytoskeleton organizationGO:00300362070.025
hemostasisGO:0007599760.024
purine nucleotide catabolic processGO:00061954050.024
gtp catabolic processGO:00061842370.024
multicellular organismal agingGO:001025930.024
positive regulation of hydrolase activityGO:00513453310.024
regulation of cytokinesisGO:0032465450.024
internal protein amino acid acetylationGO:00064751010.024
visual behaviorGO:000763220.024
memoryGO:000761330.023
secretion by cellGO:00329402260.023
chromosome condensationGO:0030261150.023
regulation of ion transmembrane transporter activityGO:0032412720.023
mitotic g2 dna damage checkpointGO:000709570.023
positive regulation of transferase activityGO:00513472270.023
monocarboxylic acid metabolic processGO:00327871850.023
transforming growth factor beta receptor signaling pathwayGO:0007179760.023
endosomal transportGO:00161971290.023
negative regulation of protein modification by small protein conjugation or removalGO:1903321410.022
regulation of cellular amino acid metabolic processGO:000652160.022
regulation of transmembrane transportGO:00347621390.022
regulation of protein stabilityGO:0031647870.022
protein localization to membraneGO:00726571600.022
response to abiotic stimulusGO:00096283360.022
purine containing compound catabolic processGO:00725234110.022
purine nucleoside triphosphate catabolic processGO:00091463920.021
nitrogen compound transportGO:00717051910.021
regulation of homeostatic processGO:00328441210.021
spindle organizationGO:0007051530.021
renal sodium ion absorptionGO:007029420.020
regulation of cellular response to stressGO:00801352440.020
adenylate cyclase modulating g protein coupled receptor signaling pathwayGO:0007188430.020
regulation of growthGO:00400081650.020
Fly
multi organism reproductive processGO:0044703540.020
Worm
tripartite regional subdivisionGO:000735120.020
ribonucleoside triphosphate metabolic processGO:00091994120.020
circulatory system developmentGO:00723592620.019
regulation of ion transportGO:00432691890.019
osteoblast differentiationGO:0001649920.019
nucleoside triphosphate metabolic processGO:00091414220.019
secretionGO:00469032540.019
translationGO:00064121320.019
cellular amine metabolic processGO:0044106410.019
interspecies interaction between organismsGO:00444191560.019
establishment of protein localization to organelleGO:00725941720.019
enzyme linked receptor protein signaling pathwayGO:00071673030.019
chromosome passenger complex localization to spindle midzoneGO:003585310.019
regulation of response to external stimulusGO:00321012220.019
peptidyl lysine acetylationGO:00183941010.018
positive regulation of cellular component movementGO:00512721810.018
coenzyme metabolic processGO:0006732650.018
circadian behaviorGO:004851220.018
symbiosis encompassing mutualism through parasitismGO:00444031560.018
positive regulation of proteolysisGO:00458621420.018
regulation of establishment of protein localizationGO:00702012420.018
protein acetylationGO:00064731160.018
motor neuron axon guidanceGO:000804520.018
nucleocytoplasmic transportGO:00069131760.018
endomembrane system organizationGO:00102561960.018
membrane organizationGO:00610242920.018
negative regulation of protein catabolic processGO:0042177590.018
purine ribonucleoside metabolic processGO:00461284370.018
copii vesicle coatingGO:004820820.018
ribonucleotide biosynthetic processGO:0009260810.017
regulation of vesicle mediated transportGO:00606271300.017
response to endoplasmic reticulum stressGO:0034976490.017
homotypic cell cell adhesionGO:0034109470.017
regulation of peptide transportGO:0090087620.017
t cell differentiation in thymusGO:003307740.017
transmembrane transportGO:00550853990.017
renal sodium ion transportGO:000309620.017
hematopoietic or lymphoid organ developmentGO:00485341860.017
ribonucleoprotein complex subunit organizationGO:0071826810.017
positive regulation of fibroblast growth factor receptor signaling pathwayGO:004574330.017
cation transmembrane transportGO:00986552380.017
membrane buddingGO:0006900280.017
immune system developmentGO:00025201950.016
internal peptidyl lysine acetylationGO:0018393970.016
organelle localizationGO:0051640840.016
single organismal cell cell adhesionGO:00163371480.016
single organism carbohydrate metabolic processGO:00447231930.016
negative regulation of ion transportGO:0043271390.016
peptidyl lysine modificationGO:00182051440.016
neurological system processGO:00508771630.016
Worm
negative regulation of phosphate metabolic processGO:00459362670.016
neuron developmentGO:00486661130.016
Zebrafish Fly
leukocyte activationGO:00453211640.015
positive regulation of catabolic processGO:00098963100.015
positive regulation of cell proliferationGO:00082843010.015
growth hormone secretionGO:003025240.015
purine ribonucleoside monophosphate metabolic processGO:00091671860.015
hormone secretionGO:0046879650.015
central nervous system developmentGO:00074171230.015
Fly
cell type specific apoptotic processGO:00972851250.015
amide transportGO:0042886760.015
negative regulation of ion transmembrane transportGO:0034766260.015
platelet activationGO:0030168440.015
regionalizationGO:0003002290.015
metencephalon developmentGO:002203720.015
head developmentGO:00603221080.014
Fly
regulation of purine nucleotide catabolic processGO:00331212050.014
cerebellum developmentGO:002154920.014
establishment of planar polarityGO:000173630.014
negative regulation of intracellular signal transductionGO:19025321830.014
regulation of potassium ion transmembrane transportGO:1901379200.014
regulation of jak stat cascadeGO:0046425440.014
regulation of nucleoside metabolic processGO:00091182090.014
spermatid differentiationGO:004851540.014
regulation of wnt signaling pathwayGO:00301111230.014
cell fate determinationGO:000170930.014
cellular response to growth factor stimulusGO:00713631970.014
lymphocyte homeostasisGO:000226040.014
neuron differentiationGO:00301821380.013
Zebrafish Fly
ribonucleoside catabolic processGO:00424544060.013
growthGO:00400072020.013
Worm Fly
regulation of ligase activityGO:0051340290.013
rhythmic behaviorGO:000762220.013
eye developmentGO:0001654420.013
regulation of protein processingGO:00706131500.013
negative regulation of multicellular organismal processGO:00512413170.013
negative regulation of cellular catabolic processGO:0031330830.013
positive regulation of gtpase activityGO:00435471660.013
negative regulation of catabolic processGO:00098951040.013
response to hypoxiaGO:0001666960.013
regulation of protein complex assemblyGO:00432541470.013
negative regulation of proteolysisGO:00458611320.013
single organism cell adhesionGO:00986021790.013
platelet aggregationGO:0070527320.013
nucleoside phosphate biosynthetic processGO:19012931090.013
regulation of nucleocytoplasmic transportGO:0046822980.013
exocytosisGO:0006887710.013
response to growth factorGO:00708482050.013
guanosine containing compound catabolic processGO:19010692390.013
negative regulation of voltage gated calcium channel activityGO:190138640.013
regulation of multi organism processGO:00439001570.013
hindbrain developmentGO:003090230.013
regulation of response to dna damage stimulusGO:2001020940.013
sensory perception of chemical stimulusGO:0007606380.013
regulation of canonical wnt signaling pathwayGO:0060828880.013
cell projection morphogenesisGO:00488581290.012
Zebrafish
response to cytokineGO:00340972320.012
mitochondrion organizationGO:00070051560.012
g1 s transition of mitotic cell cycleGO:0000082780.012
regulation of ras protein signal transductionGO:00465781550.012
Fly
purine nucleoside triphosphate metabolic processGO:00091444120.012
histone methylationGO:0016571600.012
protein maturationGO:00516042330.012
gene silencingGO:0016458490.012
anatomical structure formation involved in morphogenesisGO:00486462840.012
mitochondrial respiratory chain complex assemblyGO:0033108230.012
negative regulation of organelle organizationGO:00106391260.012
amine metabolic processGO:0009308440.012
positive regulation of proteolysis involved in cellular protein catabolic processGO:1903052350.012
neural tube formationGO:000184130.012
positive regulation of protein sumoylationGO:003323570.012
regulation of immune effector processGO:0002697910.012
response to nitrogen compoundGO:19016981840.012
cell junction assemblyGO:0034329670.012
positive regulation of proteasomal protein catabolic processGO:1901800350.012
regulation of immune responseGO:00507762010.012
apoptotic signaling pathwayGO:00971902680.012
lymphocyte activationGO:00466491330.012
somatic diversification of immunoglobulins involved in immune responseGO:000220830.012
t cell activationGO:0042110990.012
regulation of hormone levelsGO:00108171250.012
response to woundingGO:00096111680.012
regulation of nervous system developmentGO:0051960880.012
distal tubule morphogenesisGO:007215630.011
regulation of intracellular transportGO:00323861950.011
positive regulation of ubiquitin protein transferase activityGO:0051443180.011
regulation of dna metabolic processGO:00510521530.011
negative regulation of locomotionGO:00400131180.011
cell morphogenesisGO:00009022960.011
Zebrafish
mrna metabolic processGO:00160711750.011
dna repairGO:00062811980.011
protein autophosphorylationGO:00467771230.011
histone acetylationGO:0016573930.011
response to drugGO:0042493810.011
cellular response to lipidGO:00713961270.011
ribonucleoprotein complex assemblyGO:0022618780.011
viral processGO:00160321460.011
cell divisionGO:00513011680.011
negative regulation of phosphorylationGO:00423261740.011
negative regulation of transmembrane transportGO:0034763290.011
cell junction organizationGO:0034330790.011
regulation of protein localizationGO:00328802960.011
long term memoryGO:000761620.011
cellular response to hypoxiaGO:0071456510.011
jak stat cascadeGO:0007259460.011
positive regulation of secretion by cellGO:19035321080.011
reproductionGO:0000003630.011
Worm
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781250.011
positive regulation of nucleotide metabolic processGO:00459812300.011
myosin filament assemblyGO:003103420.011
neuron deathGO:0070997650.011
mitotic spindle organizationGO:0007052270.011
nuclear transportGO:00511691790.011
immune effector processGO:00022521590.010
toll signaling pathwayGO:000806320.010
coagulationGO:0050817780.010
spermatid developmentGO:000728640.010
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.010
er associated ubiquitin dependent protein catabolic processGO:0030433310.010
nucleoside catabolic processGO:00091644080.010
regulation of cellular response to growth factor stimulusGO:0090287760.010
intracellular mrna localizationGO:000829810.010
potassium ion transportGO:0006813620.010
ribonucleoside monophosphate metabolic processGO:00091611870.010
regulation of cellular component movementGO:00512703340.010

UBA1 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
urinary system diseaseDOID:18400.035
kidney diseaseDOID:557360.035
nervous system diseaseDOID:8634310.025
sensory system diseaseDOID:00501552030.025
nonsyndromic deafnessDOID:0050563500.025
auditory system diseaseDOID:2742530.025
central nervous system diseaseDOID:3311860.020
specific developmental disorderDOID:0060038190.020
disease of mental healthDOID:150700.020
intellectual disabilityDOID:1059130.020
developmental disorder of mental healthDOID:0060037290.020
disease of cellular proliferationDOID:145661740.013
neuromuscular diseaseDOID:440380.010
neuropathyDOID:870520.010
charcot marie tooth diseaseDOID:10595330.010
immune system diseaseDOID:29141550.010