Homo sapiens

105 known processes

UBE2B

ubiquitin-conjugating enzyme E2B (RAD6 homolog)

(Aliases: E2-17kDa,RAD6B,UBC2,HR6B,HHR6B)

UBE2B biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
protein modification by small protein conjugationGO:00324463420.994
regulation of tor signalingGO:0032006300.989
cellular macromolecule catabolic processGO:00442653800.988
modification dependent protein catabolic processGO:00199412090.987
protein ubiquitinationGO:00165673140.985
modification dependent macromolecule catabolic processGO:00436322120.966
histone ubiquitinationGO:0016574310.957
histone h2a ubiquitinationGO:0033522170.939
ubiquitin dependent protein catabolic processGO:00065112060.918
sensory perception of smellGO:000760820.869
protein catabolic processGO:00301633250.859
tor signalingGO:0031929390.811
protein k48 linked ubiquitinationGO:0070936380.743
cellular response to amino acid stimulusGO:0071230120.723
response to leucineGO:004320120.715
histone modificationGO:00165702510.682
cellular protein catabolic processGO:00442572610.638
protein polyubiquitinationGO:00002091100.626
response to oxygen containing compoundGO:19017003690.585
Rat
negative regulation of camp mediated signalingGO:004395140.562
covalent chromatin modificationGO:00165692540.535
response to organonitrogen compoundGO:00102431560.505
Rat
chromatin organizationGO:00063253510.472
response to nitrogen compoundGO:19016981840.429
Rat
response to amino acidGO:0043200140.401
proteolysis involved in cellular protein catabolic processGO:00516032440.366
cellular response to oxygen containing compoundGO:19017012760.366
Rat
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.333
sensory perception of chemical stimulusGO:0007606380.333
cellular response to endogenous stimulusGO:00714953360.331
Rat
negative regulation of apoptotic signaling pathwayGO:2001234970.302
Fly
post embryonic developmentGO:000979120.289
Worm
negative regulation of intracellular signal transductionGO:19025321830.251
cellular response to organonitrogen compoundGO:00714171240.248
Rat
dna damage checkpointGO:0000077680.241
Yeast
protein monoubiquitinationGO:0006513390.239
negative regulation of catalytic activityGO:00430863350.200
cellular response to acid chemicalGO:0071229440.197
dna integrity checkpointGO:0031570710.184
Yeast
regulation of cellular response to stressGO:00801352440.165
Fly
nitrogen compound transportGO:00717051910.161
Yeast
response to radiationGO:00093141510.159
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.157
protein autoubiquitinationGO:0051865370.153
positive regulation of cell proliferationGO:00082843010.151
Human
chromatin modificationGO:00165682980.145
wnt signaling pathwayGO:00160551560.142
Mouse
posttranscriptional regulation of gene expressionGO:00106082130.142
negative regulation of tor signalingGO:0032007110.132
positive regulation of cellular catabolic processGO:00313312840.130
Fly
neurological system processGO:00508771630.129
negative regulation of cell proliferationGO:00082852280.125
sensory perceptionGO:00076001030.122
limbic system developmentGO:002176130.121
regulation of purine nucleotide metabolic processGO:19005422640.119
regulation of protein stabilityGO:0031647870.117
protein ubiquitination involved in ubiquitin dependent protein catabolic processGO:0042787370.110
Yeast Fly
regulation of protein modification by small protein conjugation or removalGO:19033201070.109
response to acid chemicalGO:0001101660.108
negative regulation of gene expression epigeneticGO:0045814190.107
Yeast Mouse
negative regulation of multicellular organismal processGO:00512413170.105
negative regulation of protein metabolic processGO:00512483910.103
Mouse
regulation of cell cycleGO:00517263930.102
Yeast Mouse
dna recombinationGO:0006310770.094
Yeast Mouse
meiosis iGO:000712740.094
Yeast Mouse
cellular response to nitrogen compoundGO:19016991440.090
Rat
canonical wnt signaling pathwayGO:00600701160.089
Mouse
g1 dna damage checkpointGO:0044783180.087
Yeast
response to uvGO:0009411730.084
regulation of protein kinase activityGO:00458592890.083
regulation of proteolysisGO:00301622930.082
Fly
organelle fissionGO:00482851490.078
Yeast Mouse
proteasomal protein catabolic processGO:00104981760.076
recombinational repairGO:0000725500.074
Yeast
purine ribonucleoside metabolic processGO:00461284370.073
Yeast
negative regulation of cell cycleGO:00457861930.073
Yeast
er associated ubiquitin dependent protein catabolic processGO:0030433310.072
Yeast
system processGO:00030083490.071
response to abiotic stimulusGO:00096283360.070
negative regulation of cell deathGO:00605483450.069
Mouse Fly
double strand break repair via homologous recombinationGO:0000724500.067
Yeast
second messenger mediated signalingGO:0019932780.066
negative regulation of apoptotic processGO:00430663160.064
Mouse Fly
hindbrain developmentGO:003090230.062
cellular response to growth factor stimulusGO:00713631970.061
gtp metabolic processGO:00460392390.060
regulation of cellular protein catabolic processGO:1903362960.059
Fly
small gtpase mediated signal transductionGO:0007264780.059
negative regulation of cellular protein metabolic processGO:00322693530.058
Mouse
regulation of proteasomal protein catabolic processGO:0061136870.057
Fly
regulation of protein catabolic processGO:00421761550.057
Fly
positive regulation of proteolysisGO:00458621420.056
Fly
regulation of cellular ketone metabolic processGO:0010565500.056
regulation of neurotransmitter secretionGO:004692830.056
defense responseGO:00069523150.055
positive regulation of cellular protein catabolic processGO:1903364370.055
Fly
organophosphate catabolic processGO:00464344300.053
Yeast
regulation of apoptotic signaling pathwayGO:20012331750.053
Fly
regulation of transferase activityGO:00513383550.053
positive regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032436300.053
Fly
regulation of gtpase activityGO:00430871800.052
cellular macromolecular complex assemblyGO:00346223240.052
negative regulation of cellular component organizationGO:00511292350.052
Mouse
cell cycle checkpointGO:00000751170.052
Yeast
negative regulation of programmed cell deathGO:00430693210.051
Mouse Fly
regulation of nucleotide metabolic processGO:00061402690.051
regulation of cell cycle processGO:00105642660.050
Yeast Mouse
double strand break repairGO:00063021010.050
Yeast
apoptotic signaling pathwayGO:00971902680.048
Fly
regulation of kinase activityGO:00435493140.047
mitotic cell cycle processGO:19030472860.047
Yeast Fly
regulation of gtp catabolic processGO:00331241800.047
chromatin silencingGO:0006342120.047
Yeast Mouse
regulation of endopeptidase activityGO:00525481700.046
regulation of protein maturationGO:19033171500.046
peptide transportGO:0015833740.045
Yeast
dna repairGO:00062811980.045
protein deubiquitinationGO:0016579790.044
nucleoside phosphate catabolic processGO:19012924120.044
Yeast
response to drugGO:0042493810.044
negative regulation of protein modification processGO:00314002000.043
Mouse
cellular response to dna damage stimulusGO:00069743790.043
positive regulation of proteasomal protein catabolic processGO:1901800350.043
Fly
negative regulation of phosphorus metabolic processGO:00105632670.042
Mouse
regulation of synaptic plasticityGO:004816730.042
cellular response to organic cyclic compoundGO:00714071270.041
ribonucleoside triphosphate metabolic processGO:00091994120.041
Yeast
immune effector processGO:00022521590.040
regulation of dna metabolic processGO:00510521530.039
Mouse
determination of adult lifespanGO:000834020.039
mitotic cell cycle phase transitionGO:00447721620.039
Yeast
guanosine containing compound metabolic processGO:19010682440.039
multicellular organismal agingGO:001025930.038
i kappab kinase nf kappab signalingGO:00072491660.038
regulation of establishment of protein localizationGO:00702012420.038
neurotransmitter secretionGO:000726940.038
regulation of cell cycle phase transitionGO:19019871260.036
Yeast
dna damage response signal transduction by p53 class mediatorGO:0030330440.036
Fly
cellular amino acid metabolic processGO:00065201160.035
purine nucleotide catabolic processGO:00061954050.035
Yeast
intracellular protein transportGO:00068862700.035
anatomical structure homeostasisGO:00602491000.034
Yeast
negative regulation of cell cycle processGO:00109481210.033
Yeast
purine ribonucleotide catabolic processGO:00091544040.033
Yeast
purine nucleoside triphosphate metabolic processGO:00091444120.033
Yeast
regulation of mitotic cell cycleGO:00073461890.032
Yeast
cerebellum developmentGO:002154920.032
negative regulation of response to external stimulusGO:0032102830.032
negative regulation of proteolysisGO:00458611320.032
regulation of cellular component movementGO:00512703340.031
signal transduction in response to dna damageGO:0042770570.031
Fly
mrna processingGO:00063971330.031
negative regulation of phosphorylationGO:00423261740.030
Mouse
vesicle mediated transportGO:00161923710.030
Fly
gtp catabolic processGO:00061842370.030
positive regulation of transportGO:00510503360.029
regulation of protein ubiquitinationGO:0031396950.029
mapk cascadeGO:00001652880.029
fibroblast proliferationGO:0048144330.029
glycosyl compound catabolic processGO:19016584130.029
Yeast
regulation of protein localizationGO:00328802960.028
amine metabolic processGO:0009308440.028
regulation of microtubule cytoskeleton organizationGO:0070507610.028
positive regulation of purine nucleotide metabolic processGO:19005442270.028
regulation of stress activated protein kinase signaling cascadeGO:0070302850.028
lipid metabolic processGO:00066293810.027
regulation of fibroblast proliferationGO:0048145320.027
single organism reproductive processGO:0044702980.027
Mouse
protein stabilizationGO:0050821640.026
oogenesisGO:004847720.026
response to metal ionGO:0010038840.026
protein localization to nucleusGO:00345041360.026
regulation of nucleotide catabolic processGO:00308112050.026
cell adhesionGO:00071553250.026
hippocampus developmentGO:002176610.026
regulation of ubiquitin protein transferase activityGO:0051438280.025
response to inorganic substanceGO:00100351270.025
negative regulation of hydrolase activityGO:00513461820.025
positive regulation of phosphorylationGO:00423273940.025
embryo developmentGO:00097901230.025
Mouse
regulation of cellular amino acid metabolic processGO:000652160.025
secretion by cellGO:00329402260.025
rna processingGO:00063962550.025
nucleotide catabolic processGO:00091664080.024
Yeast
positive regulation of gtp catabolic processGO:00331261660.024
positive regulation of cellular component organizationGO:00511303760.024
Mouse
chromosome segregationGO:00070591140.024
response to light stimulusGO:0009416870.024
cell cycle phase transitionGO:00447701730.024
Yeast
negative regulation of phosphate metabolic processGO:00459362670.024
Mouse
anatomical structure formation involved in morphogenesisGO:00486462840.024
Mouse
protein targetingGO:00066051870.024
regulation of i kappab kinase nf kappab signalingGO:00431221620.023
organic acid biosynthetic processGO:0016053970.023
microtubule based processGO:00070172100.023
Mouse Fly
organic hydroxy compound metabolic processGO:19016151470.023
establishment of protein localization to organelleGO:00725941720.023
positive regulation of catabolic processGO:00098963100.023
Fly
protein maturationGO:00516042330.022
scf dependent proteasomal ubiquitin dependent protein catabolic processGO:0031146150.022
cytokine productionGO:00018162470.022
positive regulation of secretionGO:00510471160.022
reproductive processGO:00224141060.022
Mouse
jnk cascadeGO:0007254800.022
synaptic vesicle exocytosisGO:001607930.022
cellular ketone metabolic processGO:0042180800.022
response to lithium ionGO:001022620.022
protein localization to organelleGO:00333652800.022
regulation of mitotic cell cycle phase transitionGO:19019901180.022
Yeast
cellular response to abiotic stimulusGO:00712141170.022
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781250.022
regulation of synaptic vesicle exocytosisGO:200030020.021
regulation of gene expression epigeneticGO:0040029730.021
Yeast Mouse
positive regulation of protein ubiquitinationGO:0031398530.021
negative regulation of immune system processGO:00026831360.021
positive regulation of protein kinase activityGO:00458601900.021
negative regulation of developmental processGO:00510932470.021
chemical homeostasisGO:00488783060.021
negative regulation of kinase activityGO:00336731060.021
stress activated mapk cascadeGO:0051403930.021
positive regulation of transferase activityGO:00513472270.021
biological adhesionGO:00226103310.021
enzyme linked receptor protein signaling pathwayGO:00071673030.021
regulation of peptidase activityGO:00525471800.021
signal transduction by phosphorylationGO:00230142970.021
cation transportGO:00068123310.021
negative regulation of protein maturationGO:19033181420.020
negative regulation of multi organism processGO:0043901920.020
positive regulation of wnt signaling pathwayGO:0030177540.020
regulation of secretionGO:00510461940.020
methylationGO:00322591060.020
establishment of nucleus localizationGO:004002310.020
response to hormoneGO:00097251750.020
Rat
negative regulation of cellular component movementGO:00512711060.020
regulation of protein transportGO:00512232130.020
response to external biotic stimulusGO:00432072610.020
regulation of g1 s transition of mitotic cell cycleGO:2000045400.020
Yeast
regulation of intracellular transportGO:00323861950.020
endocytic recyclingGO:0032456120.020
Fly
cytoplasmic transportGO:00164823790.020
viral processGO:00160321460.020
immune system developmentGO:00025201950.019
positive regulation of intracellular transportGO:00323881040.019
negative regulation of cellular amino acid metabolic processGO:004576320.019
regulation of purine nucleotide catabolic processGO:00331212050.019
negative regulation of cysteine type endopeptidase activityGO:2000117480.019
negative regulation of response to dna damage stimulusGO:2001021330.019
Fly
regulation of cellular amine metabolic processGO:0033238110.019
positive regulation of kinase activityGO:00336742040.019
negative regulation of cell cycle g1 s phase transitionGO:1902807290.019
Yeast
positive regulation of hydrolase activityGO:00513453310.019
single organism cell adhesionGO:00986021790.018
regulation of nucleoside metabolic processGO:00091182090.018
peptidyl tyrosine dephosphorylationGO:0035335360.018
protein processingGO:00164852260.018
monovalent inorganic cation transportGO:00156721280.018
positive regulation of protein phosphorylationGO:00019343130.018
cellular component morphogenesisGO:00329893140.018
Mouse
female gamete generationGO:000729220.018
guanosine containing compound catabolic processGO:19010692390.018
protein k63 linked ubiquitinationGO:0070534310.018
receptor metabolic processGO:0043112810.018
protein k11 linked ubiquitinationGO:0070979240.018
telomere maintenance via recombinationGO:000072240.018
Yeast
nucleoside triphosphate metabolic processGO:00091414220.018
Yeast
purine containing compound catabolic processGO:00725234110.018
Yeast
negative regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043154460.017
regulation of response to external stimulusGO:00321012220.017
regulation of cysteine type endopeptidase activityGO:20001161270.017
ribonucleoprotein complex biogenesisGO:00226131160.017
negative regulation of defense responseGO:0031348470.017
cell morphogenesisGO:00009022960.017
Mouse
cellular response to radiationGO:0071478650.017
regulation of microtubule based processGO:0032886740.017
purine ribonucleoside catabolic processGO:00461303980.017
Yeast
purine nucleoside triphosphate catabolic processGO:00091463920.017
Yeast
regulation of endosome sizeGO:005103630.017
gene silencingGO:0016458490.017
Yeast Mouse
regulation of jnk cascadeGO:0046328730.017
ribonucleoside triphosphate catabolic processGO:00092033910.017
Yeast
response to transforming growth factor betaGO:0071559940.017
autophagic cell deathGO:004810230.017
synaptic vesicle recyclingGO:003646530.016
negative regulation of mitotic cell cycle phase transitionGO:1901991850.016
Yeast
inner ear morphogenesisGO:004247240.016
protein modification by small protein removalGO:0070646920.016
negative regulation of transferase activityGO:00513481240.016
regulation of cytoskeleton organizationGO:00514931770.016
ribonucleotide catabolic processGO:00092614050.016
Yeast
regulation of cytoplasmic transportGO:19036491490.016
protein dephosphorylationGO:0006470810.016
mrna metabolic processGO:00160711750.016
negative regulation of protein transportGO:0051224750.016
regulation of intrinsic apoptotic signaling pathwayGO:2001242720.016
Fly
regulation of peptide transportGO:0090087620.015
Yeast
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:00432811160.015
male meiosisGO:000714010.015
response to other organismGO:00517072610.015
small molecule biosynthetic processGO:00442831570.015
ion homeostasisGO:00508012300.015
response to organic cyclic compoundGO:00140702040.015
negative regulation of growthGO:0045926970.015
mitotic cell cycleGO:00002783260.015
Yeast Fly
negative regulation of peptidase activityGO:0010466910.015
sequestering of metal ionGO:0051238240.015
cellular ion homeostasisGO:00068731680.015
interspecies interaction between organismsGO:00444191560.015
epithelial cell proliferationGO:00506731280.015
regulation of anatomical structure sizeGO:00900661010.015
epithelial tube branching involved in lung morphogenesisGO:006044140.014
cation homeostasisGO:00550801890.014
regulation of synaptic vesicle transportGO:190280330.014
regulation of cell cycle g1 s phase transitionGO:1902806420.014
Yeast
carboxylic acid biosynthetic processGO:0046394970.014
defense response to bacteriumGO:0042742630.014
purine nucleoside catabolic processGO:00061523980.014
Yeast
positive regulation of nucleotide catabolic processGO:00308131850.014
negative regulation of cellular amine metabolic processGO:003323930.014
nucleoside catabolic processGO:00091644080.014
Yeast
multi organism cellular processGO:00447641560.014
regulation of cell migrationGO:00303342890.014
ribonucleoside catabolic processGO:00424544060.014
Yeast
extrinsic apoptotic signaling pathwayGO:00971911190.014
dephosphorylationGO:00163112090.014
negative regulation of endopeptidase activityGO:0010951840.014
defense response to other organismGO:00985421290.013
myeloid cell differentiationGO:00300991170.013
positive regulation of programmed cell deathGO:00430682490.013
nucleoside triphosphate catabolic processGO:00091433940.013
Yeast
cellular response to toxic substanceGO:009723740.013
metal ion transportGO:00300012720.013
monocarboxylic acid biosynthetic processGO:0072330670.013
single organism carbohydrate metabolic processGO:00447231930.013
establishment of organelle localizationGO:0051656590.013
centrosome cycleGO:0007098320.013
Fly
cellular amine metabolic processGO:0044106410.013
response to virusGO:00096151260.013
metal ion homeostasisGO:00550651690.013
regulation of growthGO:00400081650.013
mitotic dna integrity checkpointGO:0044774300.013
Yeast
regulation of ligase activityGO:0051340290.013
cellular response to oxidative stressGO:0034599850.013
nucleic acid phosphodiester bond hydrolysisGO:00903051020.013
Yeast
cellular response to lipidGO:00713961270.013
reproductionGO:0000003630.013
Yeast Mouse Worm
cell projection assemblyGO:00300311260.013
Mouse
regulation of cell motilityGO:20001452990.013
segmentationGO:003528240.013
cellular chemical homeostasisGO:00550821800.013
regulation of wnt signaling pathwayGO:00301111230.013
regulation of homeostatic processGO:00328441210.013
ras protein signal transductionGO:0007265730.013
autophagyGO:0006914880.013
Fly
regulation of cytokine productionGO:00018172320.012
intrinsic apoptotic signaling pathway in response to dna damageGO:0008630500.012
Fly
positive regulation of proteolysis involved in cellular protein catabolic processGO:1903052350.012
Fly
microtubule organizing center organizationGO:0031023620.012
Fly
cellular response to transforming growth factor beta stimulusGO:0071560940.012
regulation of secretion by cellGO:19035301770.012
regulation of anatomical structure morphogenesisGO:00226032860.012
metencephalon developmentGO:002203720.012
transforming growth factor beta receptor signaling pathwayGO:0007179760.012
endosomal transportGO:00161971290.012
Fly
negative regulation of transportGO:00510511760.011
regulation of cellular response to growth factor stimulusGO:0090287760.011
prostate gland developmentGO:003085030.011
negative regulation of protein processingGO:00109551420.011
cellular response to glucocorticoid stimulusGO:007138540.011
secretionGO:00469032540.011
p38mapk cascadeGO:003806690.011
telomere maintenanceGO:0000723320.011
Yeast
interleukin 8 productionGO:0032637510.011
regulation of microtubule polymerizationGO:0031113120.011
positive regulation of nucleoside metabolic processGO:00459791860.011
regulation of cellular component biogenesisGO:00440872810.011
anterior posterior axis specificationGO:000994820.011
protein methylationGO:0006479740.011
fibroblast growth factor receptor signaling pathwayGO:0008543260.011
response to peptideGO:1901652650.011
Rat
locomotory behaviorGO:000762610.011
calcium ion homeostasisGO:00550741220.011
brain morphogenesisGO:004885410.011
spermatid differentiationGO:004851540.011
Mouse
cellular cation homeostasisGO:00300031630.011
regulation of multi organism processGO:00439001570.011
hair follicle morphogenesisGO:003106920.011
defense response to virusGO:0051607710.010
response to endoplasmic reticulum stressGO:0034976490.010
negative regulation of protein kinase activityGO:0006469980.010
g1 s transition of mitotic cell cycleGO:0000082780.010
Yeast
intracellular receptor signaling pathwayGO:00305221040.010
regulation of mapk cascadeGO:00434082620.010
negative regulation of epithelial cell proliferationGO:0050680480.010

UBE2B disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
intellectual disabilityDOID:1059130.099
Human
developmental disorder of mental healthDOID:0060037290.099
Human
specific developmental disorderDOID:0060038190.099
Human
disease of mental healthDOID:150700.099
Human
organ system cancerDOID:00506861640.033
disease of cellular proliferationDOID:145661740.033
cancerDOID:1621670.033
neurodegenerative diseaseDOID:12891020.023
central nervous system diseaseDOID:3311860.023
nervous system diseaseDOID:8634310.023
muscular diseaseDOID:00800001140.023
muscle tissue diseaseDOID:661130.023
musculoskeletal system diseaseDOID:172230.023
retinal degenerationDOID:8466890.015
sensory system diseaseDOID:00501552030.015
eye diseaseDOID:56141490.015
eye and adnexa diseaseDOID:14921500.015
retinal diseaseDOID:56791180.015
brain diseaseDOID:936730.014
immune system diseaseDOID:29141550.012
hematopoietic system diseaseDOID:741000.012