Homo sapiens

18 known processes

TOP3A

topoisomerase (DNA) III alpha

(Aliases: TOP3)

TOP3A biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
regulation of telomere maintenance via telomeraseGO:003221060.792
negative regulation of telomere maintenance via telomeraseGO:003221150.543
positive regulation of telomere maintenanceGO:003220640.430
double strand break repair via single strand annealingGO:004500240.368
telomere maintenance via telomere lengtheningGO:001083390.357
anatomical structure homeostasisGO:00602491000.304
telomere maintenanceGO:0000723320.290
telomere maintenance via telomeraseGO:000700480.289
dna replicationGO:00062601160.240
protein localization to chromosome telomeric regionGO:007019860.236
regulation of transferase activityGO:00513383550.178
meiotic chromosome separationGO:005130730.172
negative regulation of t cell apoptotic processGO:007023340.171
replication fork processingGO:0031297130.165
chromatin modificationGO:00165682980.157
negative regulation of telomere maintenanceGO:003220590.148
cellular macromolecule catabolic processGO:00442653800.125
protein oligomerizationGO:00512591730.112
organelle fissionGO:00482851490.110
negative regulation of thymocyte apoptotic processGO:007024410.110
regulation of telomere maintenanceGO:0032204130.109
chromosome separationGO:0051304230.107
regulation of mitosisGO:0007088630.102
cellular response to dna damage stimulusGO:00069743790.102
Fly
regulation of cell cycleGO:00517263930.100
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.100
replicative cell agingGO:000130230.096
hemopoiesisGO:00300971800.096
regulation of mitotic cell cycle phase transitionGO:19019901180.096
protein catabolic processGO:00301633250.096
response to dietary excessGO:000202120.088
determination of adult lifespanGO:000834020.087
multicellular organismal agingGO:001025930.082
cell cycle checkpointGO:00000751170.082
chromatin organizationGO:00063253510.079
modification dependent protein catabolic processGO:00199412090.078
cell cycle phase transitionGO:00447701730.078
ubiquitin dependent protein catabolic processGO:00065112060.078
telomere cappingGO:001623350.077
negative regulation of cell cycleGO:00457861930.077
nuclear divisionGO:00002801280.076
regulation of cell divisionGO:00513021160.075
telomere organizationGO:0032200330.073
cellular protein catabolic processGO:00442572610.072
negative regulation of apoptotic processGO:00430663160.072
hematopoietic or lymphoid organ developmentGO:00485341860.072
regulation of dna replicationGO:0006275680.071
negative regulation of cell cycle processGO:00109481210.070
chemical homeostasisGO:00488783060.070
reciprocal dna recombinationGO:003582540.068
mitotic cell cycle processGO:19030472860.067
ribonucleoside triphosphate catabolic processGO:00092033910.067
chromosome segregationGO:00070591140.066
microtubule polymerizationGO:0046785180.065
regulation of kinase activityGO:00435493140.065
negative regulation of protein maturationGO:19033181420.063
positive regulation of cell deathGO:00109422630.062
regulation of microtubule based processGO:0032886740.061
negative regulation of cell deathGO:00605483450.059
positive regulation of cytoskeleton organizationGO:0051495830.058
protein localization to organelleGO:00333652800.057
cell divisionGO:00513011680.056
mitotic cell cycle phase transitionGO:00447721620.056
dna dependent dna replicationGO:0006261440.056
purine nucleoside triphosphate metabolic processGO:00091444120.055
proteolysis involved in cellular protein catabolic processGO:00516032440.053
positive regulation of t cell proliferationGO:0042102330.053
purine ribonucleoside triphosphate catabolic processGO:00092073910.051
meiotic chromosome segregationGO:004513240.049
regulation of proteasomal protein catabolic processGO:0061136870.049
positive regulation of dna metabolic processGO:0051054730.049
intracellular protein transportGO:00068862700.049
negative regulation of mitotic cell cycleGO:00459301020.048
dna geometric changeGO:0032392320.048
negative regulation of telomerase activityGO:005197460.047
negative regulation of protein metabolic processGO:00512483910.046
regulation of cell cycle phase transitionGO:19019871260.046
positive regulation of cell proliferationGO:00082843010.046
positive regulation of protein polymerizationGO:0032273450.046
cellular amino acid metabolic processGO:00065201160.044
regulation of microtubule polymerizationGO:0031113120.044
regulation of proteolysisGO:00301622930.044
positive regulation of organelle organizationGO:00106381950.043
positive regulation of chromosome organizationGO:2001252410.043
negative regulation of programmed cell deathGO:00430693210.043
negative regulation of cellular protein metabolic processGO:00322693530.042
protein maturationGO:00516042330.042
purine ribonucleotide catabolic processGO:00091544040.041
proteasomal protein catabolic processGO:00104981760.041
mitotic cell cycleGO:00002783260.041
ribonucleoside triphosphate metabolic processGO:00091994120.040
cell developmentGO:00484683280.039
cell type specific apoptotic processGO:00972851250.039
regulation of proteolysis involved in cellular protein catabolic processGO:1903050910.038
regulation of microtubule cytoskeleton organizationGO:0070507610.038
negative regulation of mitotic cell cycle phase transitionGO:1901991850.038
negative regulation of chromosome organizationGO:2001251480.038
modification dependent macromolecule catabolic processGO:00436322120.037
negative regulation of cellular catabolic processGO:0031330830.037
nucleoside phosphate catabolic processGO:19012924120.037
positive regulation of protein complex assemblyGO:0031334860.037
growthGO:00400072020.037
Fly
mitotic cell cycle checkpointGO:0007093680.036
regulation of cellular ketone metabolic processGO:0010565500.036
positive regulation of cellular component organizationGO:00511303760.036
protein homooligomerizationGO:00512601000.036
regulation of cytoskeleton organizationGO:00514931770.035
negative regulation of developmental processGO:00510932470.035
regulation of protein catabolic processGO:00421761550.035
positive regulation of hydrolase activityGO:00513453310.035
cellular macromolecular complex assemblyGO:00346223240.035
regulation of protein maturationGO:19033171500.035
positive regulation of cell cycle processGO:00900681060.035
cellular amine metabolic processGO:0044106410.035
regulation of protein serine threonine kinase activityGO:00719001790.035
negative regulation of organelle organizationGO:00106391260.035
regenerationGO:003109940.034
Fly
protein processingGO:00164852260.034
regulation of mitotic cell cycleGO:00073461890.034
sister chromatid segregationGO:0000819540.034
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic processGO:0031145250.034
positive regulation of apoptotic processGO:00430652460.034
amine metabolic processGO:0009308440.034
mitotic nuclear divisionGO:00070671190.033
cellular response to organic cyclic compoundGO:00714071270.033
protein targetingGO:00066051870.033
positive regulation of programmed cell deathGO:00430682490.033
regulation of cell cycle processGO:00105642660.033
nucleotide catabolic processGO:00091664080.033
covalent chromatin modificationGO:00165692540.032
response to extracellular stimulusGO:0009991850.032
regulation of protein kinase activityGO:00458592890.032
purine nucleotide catabolic processGO:00061954050.032
purine ribonucleoside metabolic processGO:00461284370.032
negative regulation of protein processingGO:00109551420.032
negative regulation of proteasomal protein catabolic processGO:1901799320.032
purine ribonucleoside triphosphate metabolic processGO:00092054110.032
negative regulation of homeostatic processGO:0032845590.032
regulation of cellular amine metabolic processGO:0033238110.031
stem cell developmentGO:0048864690.031
positive regulation of immune system processGO:00026842830.031
leukocyte apoptotic processGO:0071887310.030
negative regulation of protein catabolic processGO:0042177590.030
positive regulation of mitosisGO:0045840250.030
regulation of cellular response to stressGO:00801352440.030
negative regulation of transferase activityGO:00513481240.030
regulation of cellular amino acid metabolic processGO:000652160.029
regulation of cell differentiationGO:00455953930.029
regulation of dna metabolic processGO:00510521530.029
behaviorGO:00076101120.028
microtubule based processGO:00070172100.028
metaphase anaphase transition of cell cycleGO:0044784210.028
regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032434710.028
regulation of cellular protein catabolic processGO:1903362960.028
cellular protein complex assemblyGO:00436231880.028
dephosphorylationGO:00163112090.027
regulation of mitotic metaphase anaphase transitionGO:0030071260.027
purine containing compound catabolic processGO:00725234110.027
cellular response to organonitrogen compoundGO:00714171240.027
negative regulation of cell cycle phase transitionGO:1901988890.027
regulation of cellular component biogenesisGO:00440872810.027
negative regulation of proteolysisGO:00458611320.026
regulation of cyclin dependent protein serine threonine kinase activityGO:0000079360.026
cellular response to nitrogen compoundGO:19016991440.026
negative regulation of glycoprotein metabolic processGO:190301980.026
microtubule polymerization or depolymerizationGO:0031109370.026
organophosphate catabolic processGO:00464344300.026
histone methylationGO:0016571600.025
male meiosisGO:000714010.025
oocyte developmentGO:004859910.025
regulation of leukocyte activationGO:00026941150.025
purine nucleoside monophosphate metabolic processGO:00091261860.025
cellular ketone metabolic processGO:0042180800.025
segmentationGO:003528240.024
negative regulation of cell differentiationGO:00455961710.024
positive regulation of cell activationGO:0050867810.024
glycosyl compound catabolic processGO:19016584130.024
protein localization to chromosomeGO:0034502300.024
cellular component disassemblyGO:0022411920.024
purine ribonucleoside monophosphate catabolic processGO:00091691580.023
glycoprotein metabolic processGO:00091001100.023
purine nucleoside monophosphate catabolic processGO:00091281580.023
negative regulation of catalytic activityGO:00430863350.023
cellular response to abiotic stimulusGO:00712141170.023
dna biosynthetic processGO:0071897400.023
reciprocal meiotic recombinationGO:000713140.023
positive regulation of leukocyte proliferationGO:0070665480.023
regulation of homeostatic processGO:00328441210.022
regulation of protein processingGO:00706131500.022
agingGO:0007568660.022
cellular response to endogenous stimulusGO:00714953360.022
cytoplasmic transportGO:00164823790.022
vesicle mediated transportGO:00161923710.022
methylationGO:00322591060.022
ribonucleotide catabolic processGO:00092614050.022
epidermis morphogenesisGO:004873030.022
neuromuscular junction developmentGO:000752830.022
single organism carbohydrate metabolic processGO:00447231930.021
oocyte differentiationGO:000999420.021
positive regulation of cellular amino acid metabolic processGO:004576430.021
regulation of t cell activationGO:0050863770.021
rna processingGO:00063962550.021
response to organic cyclic compoundGO:00140702040.021
negative regulation of cell divisionGO:0051782310.021
protein ubiquitinationGO:00165673140.021
metaphase anaphase transition of mitotic cell cycleGO:0007091210.020
immune system developmentGO:00025201950.020
positive regulation of cellular catabolic processGO:00313312840.020
positive regulation of leukocyte activationGO:0002696800.020
protein polymerizationGO:0051258710.020
hindlimb morphogenesisGO:003513720.020
t cell activationGO:0042110990.020
negative regulation of cellular component organizationGO:00511292350.020
histone modificationGO:00165702510.020
cellular response to oxygen containing compoundGO:19017012760.020
telomere maintenance in response to dna damageGO:004324730.020
spermatid differentiationGO:004851540.020
cell activationGO:00017752130.020
single organism membrane organizationGO:00448022680.019
regulation of nuclear divisionGO:0051783650.019
purine nucleoside catabolic processGO:00061523980.019
regulation of mitotic sister chromatid segregationGO:0033047270.019
regulation of mitotic sister chromatid separationGO:0010965270.019
locomotory behaviorGO:000762610.019
hindbrain developmentGO:003090230.019
mitochondrion organizationGO:00070051560.019
Fly
regulation of microtubule polymerization or depolymerizationGO:0031110270.019
negative regulation of cellular protein catabolic processGO:1903363380.019
response to inorganic substanceGO:00100351270.019
atp metabolic processGO:00460341760.019
glucose homeostasisGO:0042593310.018
cellular response to inorganic substanceGO:0071241450.018
negative regulation of transportGO:00510511760.018
negative regulation of catabolic processGO:00098951040.018
regulation of growthGO:00400081650.018
nucleoside catabolic processGO:00091644080.018
positive regulation of phosphorylationGO:00423273940.018
oogenesisGO:004847720.018
post embryonic developmentGO:000979120.018
purine nucleoside triphosphate catabolic processGO:00091463920.018
single organism cellular localizationGO:19025803320.018
positive regulation of cellular component biogenesisGO:00440891580.018
meiosis iGO:000712740.017
response to oxygen containing compoundGO:19017003690.017
positive regulation of cellular amine metabolic processGO:003324070.017
positive regulation of transferase activityGO:00513472270.017
response to organonitrogen compoundGO:00102431560.017
cell fate determinationGO:000170930.017
regulation of protein localizationGO:00328802960.017
regulation of chromosome organizationGO:00330441030.017
mitotic sister chromatid separationGO:0051306180.017
regulation of bindingGO:00510981110.017
ribonucleoside catabolic processGO:00424544060.017
nucleic acid phosphodiester bond hydrolysisGO:00903051020.017
regulation of dna biosynthetic processGO:2000278180.017
positive regulation of cell divisionGO:0051781590.017
lymphocyte proliferationGO:0046651700.017
compound eye developmentGO:004874910.017
negative regulation of dna replicationGO:0008156290.017
protein methylationGO:0006479740.017
purine ribonucleoside monophosphate metabolic processGO:00091671860.017
nitrogen compound transportGO:00717051910.016
regulation of protein transportGO:00512232130.016
lymphocyte activationGO:00466491330.016
memoryGO:000761330.016
protein dna complex subunit organizationGO:0071824800.016
stem cell differentiationGO:0048863930.016
microtubule cytoskeleton organizationGO:00002261760.016
regulation of t cell proliferationGO:0042129420.016
apoptotic signaling pathwayGO:00971902680.016
regulation of mononuclear cell proliferationGO:0032944650.016
negative regulation of mitosisGO:0045839240.016
cellular response to radiationGO:0071478650.016
regulation of response to dna damage stimulusGO:2001020940.016
mrna metabolic processGO:00160711750.016
negative regulation of dna metabolic processGO:0051053570.016
rna dependent dna replicationGO:0006278160.016
maintenance of locationGO:00512351120.016
embryo developmentGO:00097901230.016
positive regulation of nuclear divisionGO:0051785270.016
regulation of cell activationGO:00508651250.016
positive regulation of mitotic cell cycleGO:0045931600.016
female gamete generationGO:000729220.015
positive regulation of lymphocyte activationGO:0051251730.015
cell cycle g2 m phase transitionGO:0044839430.015
regulation of sister chromatid segregationGO:0033045270.015
dna synthesis involved in dna repairGO:000073160.015
protein modification by small protein conjugationGO:00324463420.015
regulation of cytoplasmic transportGO:19036491490.015
carbohydrate derivative biosynthetic processGO:19011372070.015
purine ribonucleoside catabolic processGO:00461303980.015
regulation of protein polymerizationGO:0032271630.015
negative regulation of lymphocyte apoptotic processGO:007022980.015
anterior posterior axis specificationGO:000994820.015
protein localization to nucleusGO:00345041360.015
endocytosisGO:00068971590.015
nucleoside monophosphate metabolic processGO:00091231910.015
g1 s transition of mitotic cell cycleGO:0000082780.015
spindle assembly checkpointGO:0071173170.015
nervous system developmentGO:00073992930.014
actin filament based processGO:00300292240.014
mitotic sister chromatid segregationGO:0000070530.014
regulation of establishment of protein localizationGO:00702012420.014
regulation of protein complex assemblyGO:00432541470.014
protein import into nucleusGO:00066061040.014
negative regulation of cellular amino acid metabolic processGO:004576320.014
negative regulation of mitotic metaphase anaphase transitionGO:0045841170.014
positive regulation of mononuclear cell proliferationGO:0032946470.014
dna conformation changeGO:00711031130.014
ion transmembrane transportGO:00342203380.014
mononuclear cell proliferationGO:0032943710.014
regulation of lymphocyte proliferationGO:0050670640.014
cell adhesionGO:00071553250.014
cation transportGO:00068123310.014
base excision repairGO:0006284210.014
macromolecule glycosylationGO:0043413630.014
positive regulation of alpha beta t cell proliferationGO:004664150.014
nucleoside triphosphate metabolic processGO:00091414220.014
spindle checkpointGO:0031577260.014
response to nutrient levelsGO:0031667810.014
lipid metabolic processGO:00066293810.014
morphogenesis of embryonic epitheliumGO:001633140.014
defense responseGO:00069523150.014
small molecule catabolic processGO:0044282920.014
regulation of lymphocyte activationGO:00512491030.014
negative regulation of cellular amine metabolic processGO:003323930.014
alcohol metabolic processGO:00060661140.014
rna splicingGO:00083801310.014
cellular lipid metabolic processGO:00442553030.013
peptidyl lysine modificationGO:00182051440.013
regulation of apoptotic signaling pathwayGO:20012331750.013
ribonucleoside monophosphate metabolic processGO:00091611870.013
adult locomotory behaviorGO:000834410.013
carbohydrate metabolic processGO:00059752070.013
regulation of intracellular transportGO:00323861950.013
biological adhesionGO:00226103310.013
pharyngeal system developmentGO:006003720.013
regulation of cellular carbohydrate metabolic processGO:0010675470.013
dna dependent dna replication maintenance of fidelityGO:0045005140.013
organic hydroxy compound metabolic processGO:19016151470.013
cell morphogenesisGO:00009022960.013
regulation of chromosome segregationGO:0051983440.013
regulation of neural precursor cell proliferationGO:200017740.013
establishment of protein localization to organelleGO:00725941720.013
regulation of metaphase anaphase transition of cell cycleGO:1902099260.013
negative regulation of leukocyte apoptotic processGO:2000107160.012
signal transduction by phosphorylationGO:00230142970.012
t cell differentiationGO:0030217290.012
membrane organizationGO:00610242920.012
positive regulation of t cell activationGO:0050870540.012
positive regulation of lymphocyte proliferationGO:0050671460.012
negative regulation of phosphate metabolic processGO:00459362670.012
regulation of leukocyte proliferationGO:0070663670.012
protein importGO:00170381300.012
blastoderm segmentationGO:000735020.012
rna interferenceGO:001624640.012
regulation of alpha beta t cell activationGO:0046634130.012
neurogenesisGO:00220081690.012
regulation of t cell apoptotic processGO:007023280.012
protein glycosylationGO:0006486620.012
positive regulation of catabolic processGO:00098963100.012
response to tumor necrosis factorGO:0034612760.012
carbohydrate homeostasisGO:0033500310.012
carboxylic acid biosynthetic processGO:0046394970.012
spermatid developmentGO:000728640.012
negative regulation of cell proliferationGO:00082852280.011
negative regulation of synaptic transmissionGO:005080520.011
response to external biotic stimulusGO:00432072610.011
peripheral nervous system developmentGO:000742220.011
negative regulation of proteolysis involved in cellular protein catabolic processGO:1903051350.011
atp catabolic processGO:00062001570.011
reactive nitrogen species metabolic processGO:200105730.011
protein acetylationGO:00064731160.011
cellular component morphogenesisGO:00329893140.011
transmembrane transportGO:00550853990.011
positive regulation of cell cycleGO:00457871400.011
positive regulation of cell fate commitmentGO:001045520.011
nucleocytoplasmic transportGO:00069131760.011
neurotransmitter secretionGO:000726940.011
positive regulation of developmental processGO:00510943140.011
embryonic hindlimb morphogenesisGO:003511620.011
cell growthGO:00160491600.011
positive regulation of nucleoside metabolic processGO:00459791860.011
mrna splicing via spliceosomeGO:0000398890.011
small gtpase mediated signal transductionGO:0007264780.011
t cell proliferationGO:0042098450.011
anatomical structure formation involved in morphogenesisGO:00486462840.011
negative regulation of epithelial cell proliferationGO:0050680480.011
small molecule biosynthetic processGO:00442831570.011
regulation of anatomical structure morphogenesisGO:00226032860.010
negative regulation of protein transportGO:0051224750.010
secretionGO:00469032540.010
negative regulation of phosphorus metabolic processGO:00105632670.010
leukocyte proliferationGO:0070661740.010
regulation of synaptic plasticityGO:004816730.010
innate immune responseGO:00450871780.010
leukocyte differentiationGO:0002521980.010
cellular response to ionizing radiationGO:0071479320.010
sex determinationGO:000753030.010
negative regulation of multicellular organismal processGO:00512413170.010
positive regulation of protein catabolic processGO:0045732750.010
nuclear transportGO:00511691790.010
regulation of phosphatase activityGO:0010921810.010
dna duplex unwindingGO:0032508300.010

TOP3A disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
hematopoietic system diseaseDOID:741000.236
bone marrow diseaseDOID:4961310.236
immune system diseaseDOID:29141550.236
fanconi s anemiaDOID:13636160.038
aplastic anemiaDOID:12449300.038
anemiaDOID:2355550.038
congenital hypoplastic anemiaDOID:1342260.038
musculoskeletal system diseaseDOID:172230.028
disease of cellular proliferationDOID:145661740.019
disease of metabolismDOID:00146672950.019
nervous system diseaseDOID:8634310.018
central nervous system diseaseDOID:3311860.018
brain diseaseDOID:936730.018
organ system cancerDOID:00506861640.016
cancerDOID:1621670.016
inherited metabolic disorderDOID:6552420.014
sensory system diseaseDOID:00501552030.013
eye and adnexa diseaseDOID:14921500.013
eye diseaseDOID:56141490.013
connective tissue diseaseDOID:651090.012
muscle tissue diseaseDOID:661130.010
muscular diseaseDOID:00800001140.010
retinal diseaseDOID:56791180.010