Homo sapiens

16 known processes

PARL

presenilin associated, rhomboid-like

(Aliases: PSARL1,PSENIP2,RHBDS1,PSARL)

PARL biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
post embryonic developmentGO:000979120.202
vesicle mediated transportGO:00161923710.102
multicellular organismal agingGO:001025930.099
female gamete generationGO:000729220.061
purine nucleoside monophosphate metabolic processGO:00091261860.057
cellular macromolecule catabolic processGO:00442653800.056
purine ribonucleoside metabolic processGO:00461284370.054
determination of adult lifespanGO:000834020.051
purine ribonucleoside triphosphate metabolic processGO:00092054110.051
nucleoside monophosphate metabolic processGO:00091231910.049
oogenesisGO:004847720.048
nucleoside triphosphate metabolic processGO:00091414220.047
lipid metabolic processGO:00066293810.044
membrane organizationGO:00610242920.041
Fly
purine nucleoside triphosphate metabolic processGO:00091444120.041
negative regulation of protein metabolic processGO:00512483910.041
protein maturationGO:00516042330.038
Fly
cellular ketone metabolic processGO:0042180800.036
purine ribonucleoside monophosphate metabolic processGO:00091671860.036
modification dependent macromolecule catabolic processGO:00436322120.035
ribonucleoside monophosphate metabolic processGO:00091611870.033
cellular lipid metabolic processGO:00442553030.033
negative regulation of cellular protein metabolic processGO:00322693530.032
cytoplasmic transportGO:00164823790.032
regulation of cellular amine metabolic processGO:0033238110.032
endocytosisGO:00068971590.031
regulation of cellular amino acid metabolic processGO:000652160.031
cellular amino acid metabolic processGO:00065201160.030
ribonucleoside triphosphate metabolic processGO:00091994120.030
cellular amine metabolic processGO:0044106410.030
amine metabolic processGO:0009308440.029
mitochondrion organizationGO:00070051560.029
Fly
neuromuscular junction developmentGO:000752830.028
negative regulation of cell proliferationGO:00082852280.028
positive regulation of cellular amino acid metabolic processGO:004576430.028
system processGO:00030083490.028
carbohydrate derivative biosynthetic processGO:19011372070.027
apoptotic signaling pathwayGO:00971902680.027
protein catabolic processGO:00301633250.027
monocarboxylic acid metabolic processGO:00327871850.026
regulation of proteolysisGO:00301622930.026
regulation of cellular ketone metabolic processGO:0010565500.026
mrna metabolic processGO:00160711750.025
positive regulation of catabolic processGO:00098963100.025
posttranscriptional regulation of gene expressionGO:00106082130.024
response to abiotic stimulusGO:00096283360.024
ubiquitin dependent protein catabolic processGO:00065112060.024
adult locomotory behaviorGO:000834410.024
single organism membrane organizationGO:00448022680.024
Fly
positive regulation of transportGO:00510503360.024
modification dependent protein catabolic processGO:00199412090.024
regulation of cell cycleGO:00517263930.024
regulation of cell cycle processGO:00105642660.024
regulation of cell differentiationGO:00455953930.024
cellular protein catabolic processGO:00442572610.024
regulation of nucleotide metabolic processGO:00061402690.024
negative regulation of cellular component organizationGO:00511292350.023
protein processingGO:00164852260.023
Fly
defense responseGO:00069523150.023
positive regulation of cellular component organizationGO:00511303760.023
mitotic cell cycle processGO:19030472860.022
cellular component morphogenesisGO:00329893140.022
positive regulation of cellular catabolic processGO:00313312840.022
negative regulation of multicellular organismal processGO:00512413170.022
mitotic cell cycleGO:00002783260.022
proteolysis involved in cellular protein catabolic processGO:00516032440.022
growthGO:00400072020.022
organonitrogen compound biosynthetic processGO:19015662000.022
negative regulation of programmed cell deathGO:00430693210.021
regulation of mitotic cell cycleGO:00073461890.021
nitrogen compound transportGO:00717051910.021
locomotory behaviorGO:000762610.021
embryo developmentGO:00097901230.020
regulation of translationGO:0006417890.020
regulation of protein kinase activityGO:00458592890.020
purine ribonucleoside triphosphate catabolic processGO:00092073910.020
cofactor metabolic processGO:0051186870.020
regulation of kinase activityGO:00435493140.020
negative regulation of catalytic activityGO:00430863350.020
cellular response to dna damage stimulusGO:00069743790.020
positive regulation of purine nucleotide metabolic processGO:19005442270.020
cell developmentGO:00484683280.020
positive regulation of cellular amine metabolic processGO:003324070.019
organophosphate biosynthetic processGO:00904071630.019
positive regulation of phosphorylationGO:00423273940.019
single organism cellular localizationGO:19025803320.018
microtubule based processGO:00070172100.018
positive regulation of nucleotide metabolic processGO:00459812300.018
cation homeostasisGO:00550801890.018
regulation of anatomical structure morphogenesisGO:00226032860.018
regulation of peptidase activityGO:00525471800.018
regulation of intracellular transportGO:00323861950.018
neurological system processGO:00508771630.018
regulation of purine nucleotide metabolic processGO:19005422640.018
negative regulation of cell differentiationGO:00455961710.018
regulation of nucleoside metabolic processGO:00091182090.018
immune responseGO:00069553070.017
glycosyl compound catabolic processGO:19016584130.017
negative regulation of intracellular signal transductionGO:19025321830.017
positive regulation of apoptotic processGO:00430652460.017
positive regulation of nucleoside metabolic processGO:00459791860.017
metal ion homeostasisGO:00550651690.017
cell morphogenesisGO:00009022960.017
protein localization to organelleGO:00333652800.017
ribonucleoside triphosphate catabolic processGO:00092033910.017
regulation of cellular response to stressGO:00801352440.017
intracellular protein transportGO:00068862700.017
maintenance of locationGO:00512351120.017
transmembrane transportGO:00550853990.017
rna processingGO:00063962550.017
negative regulation of phosphorus metabolic processGO:00105632670.017
regulation of transferase activityGO:00513383550.016
segmentationGO:003528240.016
innate immune responseGO:00450871780.016
reactive oxygen species metabolic processGO:0072593750.016
negative regulation of phosphate metabolic processGO:00459362670.016
regulation of intracellular protein transportGO:00331571230.016
protein modification by small protein conjugationGO:00324463420.016
cellular macromolecular complex assemblyGO:00346223240.016
negative regulation of apoptotic processGO:00430663160.016
nucleotide catabolic processGO:00091664080.016
chemical homeostasisGO:00488783060.016
negative regulation of cell deathGO:00605483450.016
oxidation reduction processGO:00551143960.016
positive regulation of hydrolase activityGO:00513453310.016
proteasomal protein catabolic processGO:00104981760.016
microtubule cytoskeleton organizationGO:00002261760.016
fatty acid metabolic processGO:00066311150.016
mitotic cell cycle phase transitionGO:00447721620.016
cell divisionGO:00513011680.016
positive regulation of cell deathGO:00109422630.016
regulation of growthGO:00400081650.016
response to cytokineGO:00340972320.016
protein targetingGO:00066051870.016
cellular ion homeostasisGO:00068731680.015
purine nucleoside catabolic processGO:00061523980.015
positive regulation of programmed cell deathGO:00430682490.015
organophosphate catabolic processGO:00464344300.015
receptor mediated endocytosisGO:0006898840.015
regulation of cellular component biogenesisGO:00440872810.015
nucleoside phosphate biosynthetic processGO:19012931090.015
cell cycle phase transitionGO:00447701730.015
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.015
ribonucleoside catabolic processGO:00424544060.015
ion homeostasisGO:00508012300.015
positive regulation of nucleotide catabolic processGO:00308131850.015
response to biotic stimulusGO:00096072760.015
negative regulation of protein processingGO:00109551420.015
regulation of protein maturationGO:19033171500.014
regenerationGO:003109940.014
oocyte differentiationGO:000999420.014
translationGO:00064121320.014
oocyte developmentGO:004859910.014
chromatin modificationGO:00165682980.014
cellular cation homeostasisGO:00300031630.014
negative regulation of protein modification processGO:00314002000.014
small gtpase mediated signal transductionGO:0007264780.014
negative regulation of developmental processGO:00510932470.014
purine nucleotide catabolic processGO:00061954050.014
nerve developmentGO:002167540.014
cell growthGO:00160491600.014
dephosphorylationGO:00163112090.014
regulation of cysteine type endopeptidase activityGO:20001161270.014
purine ribonucleotide catabolic processGO:00091544040.014
reproductive structure developmentGO:0048608550.013
multi organism cellular processGO:00447641560.013
cytokine productionGO:00018162470.013
histone modificationGO:00165702510.013
cell adhesionGO:00071553250.013
ribose phosphate biosynthetic processGO:0046390820.013
single organism carbohydrate metabolic processGO:00447231930.013
positive regulation of organelle organizationGO:00106381950.013
reproductive processGO:00224141060.013
regulation of establishment of protein localizationGO:00702012420.013
nucleoside phosphate catabolic processGO:19012924120.013
cellular chemical homeostasisGO:00550821800.013
ribonucleotide catabolic processGO:00092614050.013
protein ubiquitinationGO:00165673140.013
purine ribonucleoside catabolic processGO:00461303980.013
cellular metal ion homeostasisGO:00068751460.013
carbohydrate metabolic processGO:00059752070.013
regulation of multi organism processGO:00439001570.013
generation of precursor metabolites and energyGO:0006091680.013
regulation of apoptotic signaling pathwayGO:20012331750.013
response to oxygen containing compoundGO:19017003690.012
cellular homeostasisGO:00197251960.012
actin filament based processGO:00300292240.012
divalent inorganic cation homeostasisGO:00725071360.012
guanosine containing compound catabolic processGO:19010692390.012
response to other organismGO:00517072610.012
negative regulation of phosphorylationGO:00423261740.012
intrinsic apoptotic signaling pathwayGO:00971931270.012
regulation of reactive oxygen species biosynthetic processGO:190342630.012
purine ribonucleotide biosynthetic processGO:0009152790.012
regulation of protein processingGO:00706131500.012
reactive oxygen species biosynthetic processGO:190340940.012
regulation of cell morphogenesisGO:00226041530.012
negative regulation of proteolysisGO:00458611320.012
regulation of cytokine productionGO:00018172320.012
regulation of protein catabolic processGO:00421761550.012
macromolecule methylationGO:0043414970.012
mitotic nuclear divisionGO:00070671190.012
protein oligomerizationGO:00512591730.012
purine containing compound catabolic processGO:00725234110.012
regulation of protein transportGO:00512232130.012
purine nucleotide biosynthetic processGO:0006164840.012
ras protein signal transductionGO:0007265730.012
regulation of endopeptidase activityGO:00525481700.012
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.012
positive regulation of protein phosphorylationGO:00019343130.012
secretionGO:00469032540.012
cell part morphogenesisGO:00329901370.012
regulation of locomotionGO:00400123290.012
protein acylationGO:00435431380.011
negative regulation of hydrolase activityGO:00513461820.011
ribonucleotide biosynthetic processGO:0009260810.011
negative regulation of cell cycleGO:00457861930.011
regulation of protein localizationGO:00328802960.011
protein localization to membraneGO:00726571600.011
nucleocytoplasmic transportGO:00069131760.011
regulation of cellular component movementGO:00512703340.011
negative regulation of organelle organizationGO:00106391260.011
apoptotic mitochondrial changesGO:0008637570.011
negative regulation of protein maturationGO:19033181420.011
spermatid differentiationGO:004851540.011
regulation of viral processGO:00507921030.011
generation of neuronsGO:00486991520.011
positive regulation of immune system processGO:00026842830.011
negative regulation of cell cycle processGO:00109481210.011
ion transmembrane transportGO:00342203380.011
methylationGO:00322591060.011
positive regulation of proteolysisGO:00458621420.011
regulation of response to external stimulusGO:00321012220.011
engulfment of apoptotic cellGO:004365220.011
purine nucleoside triphosphate catabolic processGO:00091463920.011
nucleoside triphosphate catabolic processGO:00091433940.011
regulation of defense responseGO:00313471540.011
negative regulation of protein phosphorylationGO:00019331400.011
neuroblast proliferationGO:000740540.011
covalent chromatin modificationGO:00165692540.011
immune system developmentGO:00025201950.011
regulation of sequence specific dna binding transcription factor activityGO:00510902110.011
establishment of protein localization to organelleGO:00725941720.011
cell cell signalingGO:00072671550.011
gtp metabolic processGO:00460392390.011
nucleoside catabolic processGO:00091644080.011
hindbrain developmentGO:003090230.011
single organism reproductive processGO:0044702980.011
central nervous system developmentGO:00074171230.011
regulation of neural precursor cell proliferationGO:200017740.011
negative regulation of catabolic processGO:00098951040.011
atp metabolic processGO:00460341760.011
negative regulation of transferase activityGO:00513481240.011
organelle assemblyGO:00709251760.011
positive regulation of cell proliferationGO:00082843010.011
biological adhesionGO:00226103310.011
purine containing compound biosynthetic processGO:0072522880.010
cellular protein complex assemblyGO:00436231880.010
cell projection organizationGO:00300302520.010
protein importGO:00170381300.010
regulation of nucleotide catabolic processGO:00308112050.010
endomembrane system organizationGO:00102561960.010
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:00432811160.010
regulation of cytoplasmic transportGO:19036491490.010
organelle localizationGO:0051640840.010
protein modification by small protein removalGO:0070646920.010
regulation of cell cycle phase transitionGO:19019871260.010
positive regulation of immune responseGO:00507781590.010
positive regulation of sequence specific dna binding transcription factor activityGO:00510911310.010
citrate metabolic processGO:000610120.010
regulation of proteolysis involved in cellular protein catabolic processGO:1903050910.010
regulation of protein complex assemblyGO:00432541470.010
head developmentGO:00603221080.010
response to external biotic stimulusGO:00432072610.010
signal transduction by phosphorylationGO:00230142970.010
metal ion transportGO:00300012720.010
positive regulation of transferase activityGO:00513472270.010
chromatin organizationGO:00063253510.010

PARL disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
nervous system diseaseDOID:8634310.039
sensory system diseaseDOID:00501552030.039
eye and adnexa diseaseDOID:14921500.039
eye diseaseDOID:56141490.035
disease of metabolismDOID:00146672950.027
retinal diseaseDOID:56791180.022
cancerDOID:1621670.021
disease of cellular proliferationDOID:145661740.021
organ system cancerDOID:00506861640.020
retinal degenerationDOID:8466890.017
inherited metabolic disorderDOID:6552420.017
central nervous system diseaseDOID:3311860.012
musculoskeletal system diseaseDOID:172230.011