IMP: Integrative Multi-species Prediction

Homo sapiens

32 known processes

HIBADH

3-hydroxyisobutyrate dehydrogenase

(Aliases: NS5ATP1,MGC40361)

HGNC: 4907
Ensembl: ENSG00000106049
Entrez: 11112
HPRD: 12238
MIM: 608475
UniProtKB: A0A024RA75
UniProtKB: P31937

Process Predictions
Disease Predictions

HIBADH biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
oxidation reduction process	GO:0055114	396	0.472
organic acid catabolic process	GO:0016054	71	0.347
carboxylic acid catabolic process	GO:0046395	71	0.262
small molecule catabolic process	GO:0044282	92	0.172
cellular lipid metabolic process	GO:0044255	303	0.163
cellular amino acid metabolic process	GO:0006520	116	0.154
lipid metabolic process	GO:0006629	381	0.134
cellular ketone metabolic process	GO:0042180	80	0.119
fatty acid metabolic process	GO:0006631	115	0.087
lipid oxidation	GO:0034440	33	0.079
peroxisome organization	GO:0007031	28	0.078
post embryonic development	GO:0009791	2	0.075
cellular amino acid catabolic process	GO:0009063	31	0.074
monocarboxylic acid metabolic process	GO:0032787	185	0.062
cellular lipid catabolic process	GO:0044242	65	0.060
mitochondrion organization	GO:0007005	156	0.060
ribonucleoside triphosphate metabolic process	GO:0009199	412	0.058
regulation of cellular ketone metabolic process	GO:0010565	50	0.058
determination of adult lifespan	GO:0008340	2	0.056
transmembrane transport	GO:0055085	399	0.056
ribonucleoside monophosphate metabolic process	GO:0009161	187	0.055
purine ribonucleoside metabolic process	GO:0046128	437	0.050
branched chain amino acid metabolic process	GO:0009081	4	0.048
multicellular organismal aging	GO:0010259	3	0.046
nucleoside triphosphate metabolic process	GO:0009141	422	0.044
protein homooligomerization	GO:0051260	100	0.044
membrane organization	GO:0061024	292	0.044
purine nucleoside triphosphate metabolic process	GO:0009144	412	0.044
lipid modification	GO:0030258	84	0.041
purine ribonucleoside triphosphate metabolic process	GO:0009205	411	0.040
cytoplasmic transport	GO:0016482	379	0.039
carboxylic acid biosynthetic process	GO:0046394	97	0.039
nucleoside monophosphate metabolic process	GO:0009123	191	0.039
fatty acid catabolic process	GO:0009062	29	0.039
single organism cellular localization	GO:1902580	332	0.038
response to oxygen containing compound	GO:1901700	369	0.036
purine nucleoside monophosphate metabolic process	GO:0009126	186	0.034
single organism membrane organization	GO:0044802	268	0.032
lipid catabolic process	GO:0016042	84	0.030
positive regulation of hydrolase activity	GO:0051345	331	0.030
amine metabolic process	GO:0009308	44	0.029
small molecule biosynthetic process	GO:0044283	157	0.029
lipid biosynthetic process	GO:0008610	177	0.029
organic hydroxy compound metabolic process	GO:1901615	147	0.029
coenzyme metabolic process	GO:0006732	65	0.029
protein localization to organelle	GO:0033365	280	0.028
guanosine containing compound metabolic process	GO:1901068	244	0.028
fatty acid oxidation	GO:0019395	31	0.028
intracellular protein transport	GO:0006886	270	0.027
protein localization to membrane	GO:0072657	160	0.027
response to hormone	GO:0009725	175	0.027
negative regulation of protein metabolic process	GO:0051248	391	0.026
negative regulation of catalytic activity	GO:0043086	335	0.026
atp metabolic process	GO:0046034	176	0.026
glycosyl compound catabolic process	GO:1901658	413	0.026
protein oligomerization	GO:0051259	173	0.026
regulation of cellular amino acid metabolic process	GO:0006521	6	0.026
cellular amine metabolic process	GO:0044106	41	0.025
purine ribonucleoside monophosphate metabolic process	GO:0009167	186	0.025
regulation of proteolysis	GO:0030162	293	0.025
negative regulation of cellular protein metabolic process	GO:0032269	353	0.025
ion transmembrane transport	GO:0034220	338	0.024
anion transport	GO:0006820	161	0.023
single organism carbohydrate metabolic process	GO:0044723	193	0.023
cellular macromolecule catabolic process	GO:0044265	380	0.023
regulation of cellular amine metabolic process	GO:0033238	11	0.023
protein processing	GO:0016485	226	0.023
ribonucleoside catabolic process	GO:0042454	406	0.023
carbohydrate metabolic process	GO:0005975	207	0.023
cofactor metabolic process	GO:0051186	87	0.023
organic hydroxy compound biosynthetic process	GO:1901617	71	0.022
regulation of transferase activity	GO:0051338	355	0.022
purine ribonucleoside catabolic process	GO:0046130	398	0.022
vesicle mediated transport	GO:0016192	371	0.021
purine ribonucleoside triphosphate catabolic process	GO:0009207	391	0.021
organophosphate biosynthetic process	GO:0090407	163	0.020
purine nucleotide catabolic process	GO:0006195	405	0.020
purine ribonucleotide catabolic process	GO:0009154	404	0.020
organic acid biosynthetic process	GO:0016053	97	0.020
protein maturation	GO:0051604	233	0.020
purine containing compound catabolic process	GO:0072523	411	0.020
regulation of hormone levels	GO:0010817	125	0.020
nucleoside phosphate biosynthetic process	GO:1901293	109	0.020
negative regulation of transferase activity	GO:0051348	124	0.020
organophosphate catabolic process	GO:0046434	430	0.020
oogenesis	GO:0048477	2	0.019
secretion by cell	GO:0032940	226	0.019
response to abiotic stimulus	GO:0009628	336	0.019
nucleoside triphosphate catabolic process	GO:0009143	394	0.019
defense response	GO:0006952	315	0.019
response to lipid	GO:0033993	206	0.019
regulation of endopeptidase activity	GO:0052548	170	0.019
gtp metabolic process	GO:0046039	239	0.019
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.019
establishment of protein localization to organelle	GO:0072594	172	0.018
protein targeting	GO:0006605	187	0.018
negative regulation of phosphorus metabolic process	GO:0010563	267	0.018
chemical homeostasis	GO:0048878	306	0.018
locomotory behavior	GO:0007626	1	0.018
monocarboxylic acid biosynthetic process	GO:0072330	67	0.018
memory	GO:0007613	3	0.017
ribonucleotide catabolic process	GO:0009261	405	0.017
nucleotide catabolic process	GO:0009166	408	0.017
positive regulation of cellular amine metabolic process	GO:0033240	7	0.017
reactive oxygen species metabolic process	GO:0072593	75	0.017
response to nitrogen compound	GO:1901698	184	0.017
positive regulation of catabolic process	GO:0009896	310	0.017
innate immune response	GO:0045087	178	0.017
purine nucleoside catabolic process	GO:0006152	398	0.017
cellular response to dna damage stimulus	GO:0006974	379	0.016
regulation of secretion	GO:0051046	194	0.016
negative regulation of transport	GO:0051051	176	0.016
alcohol metabolic process	GO:0006066	114	0.016
monocarboxylic acid catabolic process	GO:0072329	37	0.016
response to external biotic stimulus	GO:0043207	261	0.016
segmentation	GO:0035282	4	0.016
positive regulation of transport	GO:0051050	336	0.016
endocytosis	GO:0006897	159	0.016
cellular protein catabolic process	GO:0044257	261	0.016
regulation of peptidase activity	GO:0052547	180	0.016
organonitrogen compound biosynthetic process	GO:1901566	200	0.016
intracellular protein transmembrane transport	GO:0065002	24	0.016
protein catabolic process	GO:0030163	325	0.016
immune response	GO:0006955	307	0.016
negative regulation of phosphate metabolic process	GO:0045936	267	0.016
positive regulation of programmed cell death	GO:0043068	249	0.016
sulfur compound metabolic process	GO:0006790	101	0.016
secretion	GO:0046903	254	0.016
nucleoside catabolic process	GO:0009164	408	0.016
cellular component morphogenesis	GO:0032989	314	0.015
response to oxidative stress	GO:0006979	121	0.015
ribonucleoside triphosphate catabolic process	GO:0009203	391	0.015
establishment of protein localization to membrane	GO:0090150	121	0.015
regulation of anatomical structure morphogenesis	GO:0022603	286	0.015
nucleotide biosynthetic process	GO:0009165	109	0.015
ras protein signal transduction	GO:0007265	73	0.015
negative regulation of cellular amine metabolic process	GO:0033239	3	0.015
nucleoside phosphate catabolic process	GO:1901292	412	0.015
maintenance of location	GO:0051235	112	0.015
response to organonitrogen compound	GO:0010243	156	0.015
metal ion transport	GO:0030001	272	0.014
response to other organism	GO:0051707	261	0.014
protein import	GO:0017038	130	0.014
regulation of secretion by cell	GO:1903530	177	0.014
negative regulation of cell death	GO:0060548	345	0.014
endomembrane system organization	GO:0010256	196	0.014
ion homeostasis	GO:0050801	230	0.014
regulation of kinase activity	GO:0043549	314	0.014
purine nucleoside triphosphate catabolic process	GO:0009146	392	0.014
response to inorganic substance	GO:0010035	127	0.014
carbohydrate derivative biosynthetic process	GO:1901137	207	0.014
small gtpase mediated signal transduction	GO:0007264	78	0.014
nervous system development	GO:0007399	293	0.014
cellular response to oxygen containing compound	GO:1901701	276	0.014
intracellular protein transmembrane import	GO:0044743	23	0.014
neuromuscular junction development	GO:0007528	3	0.014
inorganic ion transmembrane transport	GO:0098660	231	0.014
regulation of cysteine type endopeptidase activity	GO:2000116	127	0.013
negative regulation of cellular amino acid metabolic process	GO:0045763	2	0.013
regulation of sequence specific dna binding transcription factor activity	GO:0051090	211	0.013
regulation of lipid metabolic process	GO:0019216	96	0.013
female gamete generation	GO:0007292	2	0.013
spermatid differentiation	GO:0048515	4	0.013
reactive oxygen species biosynthetic process	GO:1903409	4	0.013
response to activity	GO:0014823	0	0.013
cation homeostasis	GO:0055080	189	0.013
response to biotic stimulus	GO:0009607	276	0.013
positive regulation of proteolysis	GO:0045862	142	0.013
regulation of intracellular transport	GO:0032386	195	0.013
response to nutrient levels	GO:0031667	81	0.013
negative regulation of phosphorylation	GO:0042326	174	0.013
system process	GO:0003008	349	0.013
positive regulation of cellular component organization	GO:0051130	376	0.013
anion transmembrane transport	GO:0098656	76	0.013
guanosine containing compound catabolic process	GO:1901069	239	0.013
negative regulation of programmed cell death	GO:0043069	321	0.012
positive regulation of cellular catabolic process	GO:0031331	284	0.012
response to bacterium	GO:0009617	144	0.012
blastoderm segmentation	GO:0007350	2	0.012
regulation of hormone secretion	GO:0046883	57	0.012
reactive nitrogen species metabolic process	GO:2001057	3	0.012
fatty acid beta oxidation	GO:0006635	22	0.012
regulation of protein localization	GO:0032880	296	0.012
cellular modified amino acid metabolic process	GO:0006575	64	0.012
regulation of protein maturation	GO:1903317	150	0.012
negative regulation of protein processing	GO:0010955	142	0.012
cellular response to endogenous stimulus	GO:0071495	336	0.012
nitrogen compound transport	GO:0071705	191	0.012
biological adhesion	GO:0022610	331	0.012
negative regulation of hydrolase activity	GO:0051346	182	0.012
negative regulation of cellular component organization	GO:0051129	235	0.012
negative regulation of protein modification process	GO:0031400	200	0.012
regulation of protein kinase activity	GO:0045859	289	0.012
response to extracellular stimulus	GO:0009991	85	0.012
glycerolipid metabolic process	GO:0046486	107	0.012
proteolysis involved in cellular protein catabolic process	GO:0051603	244	0.012
adult locomotory behavior	GO:0008344	1	0.012
neurogenesis	GO:0022008	169	0.011
cation transport	GO:0006812	331	0.011
lipid localization	GO:0010876	106	0.011
spermatid development	GO:0007286	4	0.011
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	116	0.011
posttranscriptional regulation of gene expression	GO:0010608	213	0.011
regulation of response to external stimulus	GO:0032101	222	0.011
cellular macromolecular complex assembly	GO:0034622	324	0.011
regulation of reactive oxygen species biosynthetic process	GO:1903426	3	0.011
regeneration	GO:0031099	4	0.011
positive regulation of peptidase activity	GO:0010952	88	0.011
regulation of establishment of protein localization	GO:0070201	242	0.011
negative regulation of apoptotic process	GO:0043066	316	0.011
organic anion transport	GO:0015711	103	0.011
cytokine production	GO:0001816	247	0.011
positive regulation of cell death	GO:0010942	263	0.011
proteasomal protein catabolic process	GO:0010498	176	0.011
apoptotic signaling pathway	GO:0097190	268	0.011
positive regulation of purine nucleotide metabolic process	GO:1900544	227	0.011
cell projection organization	GO:0030030	252	0.011
cellular cation homeostasis	GO:0030003	163	0.011
regulation of protein transport	GO:0051223	213	0.011
regulation of cell differentiation	GO:0045595	393	0.011
regulation of cellular response to stress	GO:0080135	244	0.011
tube closure	GO:0060606	3	0.011
regulation of cytokine production	GO:0001817	232	0.010
regulation of nucleoside metabolic process	GO:0009118	209	0.010
positive regulation of apoptotic process	GO:0043065	246	0.010
cellular homeostasis	GO:0019725	196	0.010
alcohol biosynthetic process	GO:0046165	52	0.010
response to organic cyclic compound	GO:0014070	204	0.010
cellular ion homeostasis	GO:0006873	168	0.010
monosaccharide metabolic process	GO:0005996	74	0.010
regulation of nucleotide metabolic process	GO:0006140	269	0.010
rho protein signal transduction	GO:0007266	26	0.010
protein tetramerization	GO:0051262	47	0.010
gtp catabolic process	GO:0006184	237	0.010
ossification	GO:0001503	121	0.010
cellular amide metabolic process	GO:0043603	69	0.010
neurological system process	GO:0050877	163	0.010
regulation of protein processing	GO:0070613	150	0.010

HIBADH disease predictions

Disease	DO term ID	Size	Probability
amino acid metabolic disorder	DOID:9252	50	0.154
inherited metabolic disorder	DOID:655	242	0.154
disease of metabolism	DOID:0014667	295	0.154
disease of cellular proliferation	DOID:14566	174	0.020
organic acidemia	DOID:0060159	14	0.020
sensory system disease	DOID:0050155	203	0.020
nervous system disease	DOID:863	431	0.020
carbohydrate metabolic disorder	DOID:2978	55	0.017
organ system cancer	DOID:0050686	164	0.017
cancer	DOID:162	167	0.017
eye and adnexa disease	DOID:1492	150	0.015
hyperinsulinemic hypoglycemia	DOID:13317	7	0.014
eye disease	DOID:5614	149	0.013
central nervous system disease	DOID:331	186	0.013
musculoskeletal system disease	DOID:17	223	0.013
immune system disease	DOID:2914	155	0.011
cardiovascular system disease	DOID:1287	106	0.011

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