Homo sapiens

68 known processes

CDK4

cyclin-dependent kinase 4

(Aliases: PSK-J3,CMM3,MGC14458)

CDK4 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
negative regulation of cell cycleGO:00457861930.995
cellular response to dna damage stimulusGO:00069743790.977
negative regulation of apoptotic processGO:00430663160.965
growthGO:00400072020.948
Fly
mitotic cell cycleGO:00002783260.941
negative regulation of programmed cell deathGO:00430693210.937
regulation of cell cycleGO:00517263930.867
mitotic cell cycle phase transitionGO:00447721620.851
negative regulation of cell deathGO:00605483450.846
type b pancreatic cell developmentGO:000332340.845
Human
regulation of cell growthGO:00015581350.820
negative regulation of cellular protein metabolic processGO:00322693530.815
negative regulation of cell proliferationGO:00082852280.813
Human
protein maturationGO:00516042330.807
regulation of cellular response to stressGO:00801352440.798
Human
regulation of growthGO:00400081650.781
glandular epithelial cell developmentGO:000206850.768
Human
cell cycle phase transitionGO:00447701730.753
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.750
protein processingGO:00164852260.748
regulation of cell cycle arrestGO:0071156360.745
cell adhesionGO:00071553250.736
Human
positive regulation of cell deathGO:00109422630.728
regulation of epithelial cell proliferationGO:00506781130.726
Human
negative regulation of mitotic cell cycleGO:00459301020.723
enteroendocrine cell differentiationGO:003588360.709
Human
positive regulation of cellular amine metabolic processGO:003324070.676
cell cycle g2 m phase transitionGO:0044839430.657
negative regulation of cell growthGO:0030308830.636
regulation of cyclin dependent protein serine threonine kinase activityGO:0000079360.607
regulation of response to dna damage stimulusGO:2001020940.606
negative regulation of developmental processGO:00510932470.598
Human
regulation of kinase activityGO:00435493140.596
regulation of cell cycle processGO:00105642660.577
negative regulation of multicellular organismal processGO:00512413170.556
Human
regulation of transferase activityGO:00513383550.540
regulation of protein kinase activityGO:00458592890.527
g1 s transition of mitotic cell cycleGO:0000082780.508
nuclear divisionGO:00002801280.491
Worm
negative regulation of phosphorylationGO:00423261740.474
negative regulation of cell cycle phase transitionGO:1901988890.440
negative regulation of phosphorus metabolic processGO:00105632670.438
epithelial cell proliferationGO:00506731280.422
Human
post embryonic developmentGO:000979120.420
Worm
cell substrate adhesionGO:00315891320.420
Human
negative regulation of protein serine threonine kinase activityGO:0071901570.406
response to light stimulusGO:0009416870.396
apoptotic signaling pathwayGO:00971902680.383
cellular response to oxygen containing compoundGO:19017012760.383
embryo development ending in birth or egg hatchingGO:0009792340.381
Worm
cell cycle arrestGO:0007050710.379
jak stat cascadeGO:0007259460.370
Fly
negative regulation of catalytic activityGO:00430863350.369
negative regulation of growthGO:0045926970.341
nucleotide biosynthetic processGO:00091651090.335
oogenesisGO:004847720.334
negative regulation of phosphate metabolic processGO:00459362670.326
negative regulation of protein phosphorylationGO:00019331400.296
covalent chromatin modificationGO:00165692540.295
response to organonitrogen compoundGO:00102431560.295
positive regulation of g2 m transition of mitotic cell cycleGO:001097180.293
dna repairGO:00062811980.292
embryo developmentGO:00097901230.290
Worm Fly
positive regulation of cell cycleGO:00457871400.286
cellular component morphogenesisGO:00329893140.286
regulation of protein serine threonine kinase activityGO:00719001790.284
dna dependent dna replicationGO:0006261440.283
cellular macromolecular complex assemblyGO:00346223240.277
dna integrity checkpointGO:0031570710.274
negative regulation of myeloid cell differentiationGO:0045638420.264
Human
negative regulation of epithelial cell proliferationGO:0050680480.263
Human
dna replicationGO:00062601160.252
organ morphogenesisGO:00098871470.242
single organism reproductive processGO:0044702980.242
Worm
cell growthGO:00160491600.241
Fly
response to radiationGO:00093141510.238
cell cycle g1 s phase transitionGO:0044843800.234
female gamete generationGO:000729220.233
blastocyst developmentGO:000182430.231
chemical homeostasisGO:00488783060.229
regulation of cellular protein catabolic processGO:1903362960.223
regulation of cellular amino acid metabolic processGO:000652160.221
protein ubiquitinationGO:00165673140.218
hemopoiesisGO:00300971800.218
Human
cell agingGO:0007569520.216
Human
regulation of mitotic cell cycleGO:00073461890.208
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:00432811160.196
positive regulation of apoptotic processGO:00430652460.195
system processGO:00030083490.182
cell dedifferentiationGO:004369710.180
Human
intrinsic apoptotic signaling pathwayGO:00971931270.180
cation transportGO:00068123310.179
cellular amino acid metabolic processGO:00065201160.174
negative regulation of kinase activityGO:00336731060.173
positive regulation of transportGO:00510503360.166
mitochondrion organizationGO:00070051560.163
Fly
determination of adult lifespanGO:000834020.161
cell type specific apoptotic processGO:00972851250.158
response to abiotic stimulusGO:00096283360.156
response to endoplasmic reticulum stressGO:0034976490.155
epithelium developmentGO:00604292270.153
Human
nervous system developmentGO:00073992930.152
Human
negative regulation of protein metabolic processGO:00512483910.150
hematopoietic or lymphoid organ developmentGO:00485341860.145
Human
regulation of g2 m transition of mitotic cell cycleGO:0010389200.144
positive regulation of transferase activityGO:00513472270.144
type b pancreatic cell differentiationGO:000330950.142
Human
response to cytokineGO:00340972320.139
regulation of dna metabolic processGO:00510521530.138
regulation of cell cycle phase transitionGO:19019871260.138
negative regulation of organelle organizationGO:00106391260.137
response to inorganic substanceGO:00100351270.136
positive regulation of cell cycle processGO:00900681060.133
regulation of protein processingGO:00706131500.131
peptidyl tyrosine phosphorylationGO:00181081700.131
positive regulation of cellular amino acid metabolic processGO:004576430.130
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781250.130
mitotic cell cycle checkpointGO:0007093680.129
cellular ketone metabolic processGO:0042180800.128
negative regulation of cellular component organizationGO:00511292350.126
response to metal ionGO:0010038840.123
sensory perceptionGO:00076001030.121
positive regulation of developmental processGO:00510943140.120
cell developmentGO:00484683280.120
Human
stem cell differentiationGO:0048863930.120
response to nitrogen compoundGO:19016981840.119
macromolecule methylationGO:0043414970.119
nuclear transportGO:00511691790.118
dna packagingGO:0006323770.116
regulation of peptidase activityGO:00525471800.115
camera type eye developmentGO:0043010250.114
response to other organismGO:00517072610.110
Human
organelle assemblyGO:00709251760.110
reproductive processGO:00224141060.104
Worm
negative regulation of cell cycle processGO:00109481210.104
dna damage checkpointGO:0000077680.104
dephosphorylationGO:00163112090.101
hematopoietic progenitor cell differentiationGO:0002244380.100
negative regulation of immune system processGO:00026831360.099
Human
mitotic cell cycle processGO:19030472860.095
cellular macromolecule catabolic processGO:00442653800.093
mitotic dna damage checkpointGO:0044773280.091
negative regulation of transferase activityGO:00513481240.091
agingGO:0007568660.088
Human
reproductive structure developmentGO:0048608550.087
Worm
positive regulation of dna metabolic processGO:0051054730.087
peptidyl serine phosphorylationGO:00181051010.087
cell activationGO:00017752130.084
cellular response to endogenous stimulusGO:00714953360.084
regulation of mapk cascadeGO:00434082620.083
regulation of bindingGO:00510981110.083
positive regulation of catabolic processGO:00098963100.083
negative regulation of cell differentiationGO:00455961710.082
Human
posttranscriptional regulation of gene expressionGO:00106082130.082
negative regulation of mitotic cell cycle phase transitionGO:1901991850.082
nucleoside triphosphate metabolic processGO:00091414220.081
rna processingGO:00063962550.081
negative regulation of cell cycle arrestGO:0071157120.081
positive regulation of response to dna damage stimulusGO:2001022430.080
regulation of protein ubiquitinationGO:0031396950.079
regulation of proteolysisGO:00301622930.078
positive regulation of cell cycle g2 m phase transitionGO:190275180.076
cellular response to cytokine stimulusGO:00713451810.074
positive regulation of protein phosphorylationGO:00019343130.073
positive regulation of cell proliferationGO:00082843010.072
positive regulation of programmed cell deathGO:00430682490.071
epithelial cell differentiationGO:00308551410.070
Human
cell divisionGO:00513011680.069
protein catabolic processGO:00301633250.069
organonitrogen compound biosynthetic processGO:19015662000.066
negative regulation of protein kinase activityGO:0006469980.065
response to external biotic stimulusGO:00432072610.065
Human
monovalent inorganic cation transportGO:00156721280.064
eye developmentGO:0001654420.063
response to drugGO:0042493810.061
ribonucleoside triphosphate metabolic processGO:00091994120.060
cellular lipid metabolic processGO:00442553030.060
positive regulation of hydrolase activityGO:00513453310.060
immune effector processGO:00022521590.059
immune responseGO:00069553070.057
biological adhesionGO:00226103310.056
Human
regulation of cell cycle g1 s phase transitionGO:1902806420.055
Worm
cellular response to insulin stimulusGO:0032869410.055
organophosphate biosynthetic processGO:00904071630.055
ribose phosphate biosynthetic processGO:0046390820.055
regulation of proteolysis involved in cellular protein catabolic processGO:1903050910.054
regulation of sequence specific dna binding transcription factor activityGO:00510902110.054
protein autophosphorylationGO:00467771230.054
regulation of cell agingGO:0090342180.054
Human
response to peptide hormoneGO:0043434610.053
positive regulation of cellular component organizationGO:00511303760.052
regulation of gtpase activityGO:00430871800.052
cellular response to nitrogen compoundGO:19016991440.052
metal ion transportGO:00300012720.050
regulation of nucleotide metabolic processGO:00061402690.049
regulation of mitotic cell cycle phase transitionGO:19019901180.048
regulation of cell adhesionGO:00301551660.047
Human
protein localization to organelleGO:00333652800.047
protein dna complex subunit organizationGO:0071824800.047
regulation of cellular amine metabolic processGO:0033238110.046
cellular response to hypoxiaGO:0071456510.044
regulation of mammary gland epithelial cell proliferationGO:003359960.044
nucleocytoplasmic transportGO:00069131760.044
autophagic cell deathGO:004810230.043
regulation of translationGO:0006417890.043
mononuclear cell proliferationGO:0032943710.043
regulation of cell substrate adhesionGO:0010810680.043
Human
amine metabolic processGO:0009308440.043
negative regulation of protein modification processGO:00314002000.043
activation of cysteine type endopeptidase activity involved in apoptotic processGO:0006919490.042
response to uvGO:0009411730.041
dna modificationGO:0006304270.040
dna demethylationGO:0080111120.040
cytoplasmic transportGO:00164823790.040
multicellular organismal agingGO:001025930.039
negative regulation of protein processingGO:00109551420.039
positive regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043280690.039
regulation of locomotionGO:00400123290.039
tube developmentGO:00352951250.038
regulation of endopeptidase activityGO:00525481700.037
translationGO:00064121320.037
reproductionGO:0000003630.035
Worm
cell morphogenesisGO:00009022960.034
positive regulation of cell substrate adhesionGO:0010811370.034
Human
viral processGO:00160321460.033
neurological system processGO:00508771630.033
mitotic dna integrity checkpointGO:0044774300.033
vesicle mediated transportGO:00161923710.033
regenerationGO:003109940.033
response to insulinGO:0032868450.032
multi organism reproductive processGO:0044703540.032
t cell activationGO:0042110990.032
positive regulation of organelle organizationGO:00106381950.032
regulation of cell differentiationGO:00455953930.032
Human
cell cycle checkpointGO:00000751170.031
cellular response to abiotic stimulusGO:00712141170.031
cellular amine metabolic processGO:0044106410.031
response to hormoneGO:00097251750.030
endoplasmic reticulum unfolded protein responseGO:0030968160.030
purine containing compound biosynthetic processGO:0072522880.030
positive regulation of cellular catabolic processGO:00313312840.030
peptidyl serine modificationGO:00182091060.030
ion homeostasisGO:00508012300.029
regulation of purine nucleotide metabolic processGO:19005422640.029
segmentationGO:003528240.028
Fly
response to nutrient levelsGO:0031667810.027
response to acid chemicalGO:0001101660.027
regulation of protein catabolic processGO:00421761550.027
negative regulation of intracellular signal transductionGO:19025321830.027
signal transduction by p53 class mediatorGO:0072331720.027
response to organic cyclic compoundGO:00140702040.027
cellular protein complex assemblyGO:00436231880.027
immune system developmentGO:00025201950.027
Human
mitotic nuclear divisionGO:00070671190.026
Worm
lymphocyte activationGO:00466491330.026
oxidation reduction processGO:00551143960.026
regulation of apoptotic signaling pathwayGO:20012331750.026
regulation of nucleoside metabolic processGO:00091182090.026
regulation of fibroblast proliferationGO:0048145320.026
leukocyte proliferationGO:0070661740.025
neuron apoptotic processGO:0051402390.025
multi organism cellular processGO:00447641560.025
blastoderm segmentationGO:000735020.024
Fly
muscle cell differentiationGO:0042692630.024
single organism carbohydrate metabolic processGO:00447231930.024
g2 m transition of mitotic cell cycleGO:0000086410.024
regulation of purine nucleotide catabolic processGO:00331212050.024
cellular response to hormone stimulusGO:00328701250.024
mammary gland morphogenesisGO:006044320.024
negative regulation of dephosphorylationGO:0035305630.024
carbohydrate derivative biosynthetic processGO:19011372070.023
intrinsic apoptotic signaling pathway in response to dna damageGO:0008630500.023
lymphocyte proliferationGO:0046651700.023
regulation of multi organism processGO:00439001570.023
mammary gland developmentGO:0030879170.023
regulation of protein modification by small protein conjugation or removalGO:19033201070.023
regulation of meiotic cell cycleGO:005144540.022
organelle fissionGO:00482851490.022
Worm
mammary gland epithelium developmentGO:0061180100.022
morphogenesis of an epitheliumGO:0002009600.022
negative regulation of cell cycle g1 s phase transitionGO:1902807290.022
positive regulation of peptidyl tyrosine phosphorylationGO:0050731850.022
negative regulation of cellular senescenceGO:200077350.021
Human
chordate embryonic developmentGO:0043009340.021
negative regulation of hydrolase activityGO:00513461820.021
cellular modified amino acid metabolic processGO:0006575640.021
negative regulation of cellular catabolic processGO:0031330830.021
regulation of dephosphorylationGO:0035303960.020
multicellular organism reproductionGO:0032504420.020
blood circulationGO:00080151130.020
positive regulation of purine nucleotide metabolic processGO:19005442270.020
epithelial tube morphogenesisGO:0060562380.020
t cell differentiation in thymusGO:003307740.019
response to oxygen containing compoundGO:19017003690.019
reproductive system developmentGO:0061458560.019
Worm
regulation of cell developmentGO:00602841610.019
cell matrix adhesionGO:0007160850.019
Human
regulation of myeloid cell differentiationGO:0045637810.019
Human
dna dealkylationGO:0035510130.019
leukocyte activationGO:00453211640.019
ribonucleotide biosynthetic processGO:0009260810.019
secretion by cellGO:00329402260.019
negative regulation of response to dna damage stimulusGO:2001021330.019
regulation of secretionGO:00510461940.018
purine ribonucleoside monophosphate biosynthetic processGO:0009168160.018
regulation of cellular ketone metabolic processGO:0010565500.018
response to extracellular stimulusGO:0009991850.018
endocytosisGO:00068971590.018
cell projection organizationGO:00300302520.018
pattern specification processGO:0007389430.018
Fly
cellular response to peptideGO:1901653590.017
negative regulation of apoptotic signaling pathwayGO:2001234970.017
regulation of defense responseGO:00313471540.017
eye morphogenesisGO:0048592160.017
regulation of mitosisGO:0007088630.017
defense responseGO:00069523150.017
response to transforming growth factor betaGO:0071559940.017
protein modification by small protein conjugationGO:00324463420.017
viral life cycleGO:00190581320.016
response to growth factorGO:00708482050.016
notch signaling pathwayGO:0007219310.016
gliogenesisGO:0042063210.016
Human
positive regulation of endopeptidase activityGO:0010950840.016
regulation of leukocyte differentiationGO:1902105610.016
regulation of nucleotide catabolic processGO:00308112050.016
response to magnesium ionGO:003202630.016
gland developmentGO:0048732480.015
myosin filament assemblyGO:003103420.015
myosin filament organizationGO:003103320.015
energy derivation by oxidation of organic compoundsGO:0015980430.015
secretionGO:00469032540.015
regulation of nervous system developmentGO:0051960880.015
regulation of t cell activationGO:0050863770.015
response to campGO:0051591250.015
regulation of cell divisionGO:00513021160.015
regulation of ubiquitin protein transferase activityGO:0051438280.015
cellular response to peptide hormone stimulusGO:0071375560.014
regulation of cellular component movementGO:00512703340.014
hematopoietic stem cell differentiationGO:006021840.014
nitrogen compound transportGO:00717051910.014
demethylationGO:0070988370.014
single organism cellular localizationGO:19025803320.014
negative regulation of peptidase activityGO:0010466910.014
transmembrane transportGO:00550853990.014
ncrna processingGO:0034470830.014
response to peptideGO:1901652650.014
generation of precursor metabolites and energyGO:0006091680.014
positive regulation of proteolysisGO:00458621420.013
b cell proliferationGO:0042100220.013
neuron deathGO:0070997650.013
positive regulation of mitotic cell cycle phase transitionGO:1901992190.013
leukocyte apoptotic processGO:0071887310.013
regulation of protein maturationGO:19033171500.013
dna damage response signal transduction by p53 class mediatorGO:0030330440.013
ion transmembrane transportGO:00342203380.013
tissue morphogenesisGO:0048729960.013
regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic processGO:200005870.012
mapk cascadeGO:00001652880.012
cellular chemical homeostasisGO:00550821800.012
negative regulation of neuron deathGO:1901215320.012
negative regulation of proteolysisGO:00458611320.012
alpha amino acid metabolic processGO:1901605720.012
negative regulation of leukocyte differentiationGO:1902106240.012
development of primary sexual characteristicsGO:0045137350.012
Worm
regulation of neuron deathGO:1901214560.012
nucleoside phosphate biosynthetic processGO:19012931090.012
cardiovascular system developmentGO:00723582620.012
developmental growthGO:0048589480.011
cellular response to organonitrogen compoundGO:00714171240.011
negative regulation of cysteine type endopeptidase activityGO:2000117480.011
generation of neuronsGO:00486991520.011
microtubule based processGO:00070172100.011
ras protein signal transductionGO:0007265730.011
regulation of mitotic cell cycle spindle assembly checkpointGO:009026680.011
cellular response to radiationGO:0071478650.011
response to alcoholGO:0097305640.011
cellular response to decreased oxygen levelsGO:0036294510.011
neuromuscular junction developmentGO:000752830.011
small gtpase mediated signal transductionGO:0007264780.011
regulation of stress activated protein kinase signaling cascadeGO:0070302850.011
gtp catabolic processGO:00061842370.011
regulation of g1 s transition of mitotic cell cycleGO:2000045400.011
Worm
cell part morphogenesisGO:00329901370.011
regulation of generation of precursor metabolites and energyGO:0043467270.011
signal transduction by phosphorylationGO:00230142970.011
protein targetingGO:00066051870.011
developmental process involved in reproductionGO:0003006660.010
Worm
positive regulation of phosphorylationGO:00423273940.010
negative regulation of endopeptidase activityGO:0010951840.010

CDK4 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
organ system cancerDOID:00506861640.057
cancerDOID:1621670.057
disease of cellular proliferationDOID:145661740.057