Homo sapiens

61 known processes

HLA-E

major histocompatibility complex, class I, E

(Aliases: QA1,EA2.1,HLA-6.2,EA1.2,MHC,DKFZp686P19218)

HLA-E biological process predictions


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Biological processGO term IDProcess sizeProbabilityFunc Analog Org
detection of chemical stimulus involved in sensory perceptionGO:0050907331.000
Human
immune response inhibiting cell surface receptor signaling pathwayGO:000276741.000
Human
antigen processing and presentation via mhc class ibGO:000247531.000
positive regulation of natural killer cell mediated immunityGO:0002717121.000
detection of external biotic stimulusGO:0098581191.000
Human
detection of chemical stimulusGO:0009593551.000
Human
regulation of regulatory t cell differentiationGO:004558940.999
Human
positive regulation of t cell tolerance inductionGO:000266620.999
Human
sensory perception of tasteGO:0050909360.999
Human
regulation of dendritic cell differentiationGO:200119830.998
Human
regulation of natural killer cell mediated cytotoxicityGO:0042269160.998
positive regulation of regulatory t cell differentiationGO:004559130.998
Human
sensory perception of chemical stimulusGO:0007606380.996
Human
sensory perception of bitter tasteGO:0050913280.991
Human
negative regulation of natural killer cell mediated cytotoxicityGO:004595350.974
antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathwayGO:000248430.958
Human
antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway tap independentGO:000248630.952
Human
dendritic cell differentiationGO:0097028130.944
Human
tolerance inductionGO:000250760.932
Human
immune response inhibiting signal transductionGO:000276540.929
Human
positive regulation of cytokine productionGO:00018191670.929
Human
iron ion import into cellGO:009745920.927
Human
detection of biotic stimulusGO:0009595210.918
Human
antigen processing and presentation of peptide antigen via mhc class iGO:000247460.900
Human
negative regulation of cell proliferationGO:00082852280.899
Human
antigen processing and presentation of peptide antigen via mhc class ibGO:000242820.895
regulation of leukocyte mediated immunityGO:0002703380.886
positive regulation of lymphocyte differentiationGO:0045621130.883
Human
response to external biotic stimulusGO:00432072610.877
Human
negative regulation of t cell proliferationGO:004213080.872
Human
regulation of cell killingGO:0031341220.870
detection of stimulusGO:0051606850.861
Human
regulation of cytokine productionGO:00018172320.851
Human
response to other organismGO:00517072610.847
Human
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002824190.838
Human
positive regulation of immune responseGO:00507781590.833
antigen processing and presentation of endogenous antigenGO:001988370.828
negative regulation of lymphocyte mediated immunityGO:0002707120.823
retina homeostasisGO:0001895420.822
Human
regulation of t cell mediated cytotoxicityGO:000191480.821
Human
positive regulation of interleukin 12 productionGO:003273580.819
Human
immune effector processGO:00022521590.818
type i interferon signaling pathwayGO:0060337110.817
negative regulation of leukocyte mediated immunityGO:0002704140.811
detection of chemical stimulus involved in sensory perception of tasteGO:0050912310.799
Human
natural killer cell mediated immunityGO:0002228230.790
lymphocyte mediated immunityGO:0002449480.786
negative regulation of leukocyte activationGO:0002695260.785
Human
memory t cell activationGO:003570910.780
Human
response to bacteriumGO:00096171440.779
Human
symbiosis encompassing mutualism through parasitismGO:00444031560.779
regulation of adaptive immune responseGO:0002819330.768
Human
immune responseGO:00069553070.760
regulation of t cell proliferationGO:0042129420.747
Human
regulation of natural killer cell mediated immunityGO:0002715160.747
defense responseGO:00069523150.746
leukocyte activationGO:00453211640.740
Human
negative regulation of leukocyte differentiationGO:1902106240.726
Human
cytokine productionGO:00018162470.725
Human
innate immune responseGO:00450871780.724
regulation of innate immune responseGO:0045088970.718
positive regulation of innate immune responseGO:0045089790.714
inorganic cation import into cellGO:009865920.703
Human
natural killer cell mediated cytotoxicityGO:0042267230.701
positive regulation of tolerance inductionGO:000264520.694
Human
response to biotic stimulusGO:00096072760.689
Human
regulation of t cell activationGO:0050863770.685
Human
detection of bacteriumGO:0016045130.683
Human
negative regulation of immune responseGO:0050777400.677
regulation of interleukin 12 productionGO:0032655150.675
Human
multicellular organismal homeostasisGO:0048871670.670
Human
detection of other organismGO:0098543130.668
Human
positive regulation of immune system processGO:00026842830.662
regulation of immune responseGO:00507762010.660
positive regulation of leukocyte activationGO:0002696800.657
Human
positive regulation of t cell mediated immunityGO:0002711120.657
Human
transition metal ion transportGO:0000041230.648
Human
negative regulation of defense responseGO:0031348470.641
import into cellGO:009865720.636
Human
antigen processing and presentation of endogenous peptide antigen via mhc class iGO:001988550.636
Human
regulation of leukocyte activationGO:00026941150.627
Human
cell killingGO:0001906340.625
regulation of t cell tolerance inductionGO:000266440.620
Human
negative regulation of dendritic cell differentiationGO:200119920.600
Human
negative regulation of cell killingGO:003134250.596
positive regulation of interferon gamma productionGO:0032729260.592
Human
positive regulation of leukocyte differentiationGO:1902107370.587
Human
positive regulation of leukocyte mediated immunityGO:0002705240.580
positive regulation of adaptive immune responseGO:0002821210.568
Human
t cell tolerance inductionGO:000251740.567
Human
anatomical structure homeostasisGO:00602491000.556
Human
positive regulation of t cell activationGO:0050870540.553
Human
regulation of leukocyte proliferationGO:0070663670.539
Human
positive regulation of cell differentiationGO:00455972110.537
Human
tissue homeostasisGO:0001894630.521
Human
t cell activationGO:0042110990.506
Human
protection from natural killer cell mediated cytotoxicityGO:004227030.504
antigen processing and presentation of peptide antigenGO:0048002180.489
immune response regulating signaling pathwayGO:0002764970.489
Human
positive regulation of leukocyte mediated cytotoxicityGO:0001912160.485
Human
positive regulation of defense responseGO:0031349870.483
regulation of mononuclear cell proliferationGO:0032944650.482
Human
negative regulation of cell differentiationGO:00455961710.481
Human
negative regulation of developmental processGO:00510932470.480
Human
t cell differentiationGO:0030217290.479
Human
regulation of lymphocyte mediated immunityGO:0002706330.478
regulation of lymphocyte proliferationGO:0050670640.463
Human
metal ion transportGO:00300012720.462
Human
iron ion transportGO:0006826120.457
Human
lymphocyte proliferationGO:0046651700.454
Human
leukocyte proliferationGO:0070661740.446
Human
regulation of leukocyte mediated cytotoxicityGO:0001910190.435
mononuclear cell proliferationGO:0032943710.434
Human
positive regulation of memory t cell activationGO:200056810.433
Human
negative regulation of leukocyte mediated cytotoxicityGO:000191150.432
cell activationGO:00017752130.428
Human
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002822290.420
Human
biological adhesionGO:00226103310.415
Human
regulation of defense responseGO:00313471540.403
antigen processing and presentationGO:0019882330.393
interleukin 12 productionGO:0032615150.393
Human
leukocyte mediated cytotoxicityGO:0001909270.389
positive regulation of developmental processGO:00510943140.386
Human
cell adhesionGO:00071553250.385
Human
regulation of lymphocyte activationGO:00512491030.377
Human
adaptive immune responseGO:0002250490.375
Human
negative regulation of multicellular organismal processGO:00512413170.371
Human
negative regulation of immune effector processGO:0002698380.363
negative regulation of natural killer cell mediated immunityGO:000271650.361
regulation of tolerance inductionGO:000264340.349
Human
regulation of interferon gamma productionGO:0032649360.348
Human
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002460400.342
Human
leukocyte differentiationGO:0002521980.329
Human
regulation of t cell mediated immunityGO:0002709180.327
Human
positive regulation of cell killingGO:0031343190.327
Human
negative regulation of immune system processGO:00026831360.326
positive regulation of cell activationGO:0050867810.320
Human
hemopoiesisGO:00300971800.316
Human
regulation of cell differentiationGO:00455953930.307
Human
immune system developmentGO:00025201950.306
Human
response to interferon gammaGO:0034341390.304
detection of stimulus involved in sensory perceptionGO:0050906430.301
Human
regulation of cell activationGO:00508651250.300
Human
regulation of t cell differentiationGO:0045580190.296
Human
antigen processing and presentation of endogenous peptide antigen via mhc class ibGO:000247620.291
cation transportGO:00068123310.284
Human
interferon gamma productionGO:0032609390.272
Human
regulation of leukocyte differentiationGO:1902105610.257
Human
immune response regulating cell surface receptor signaling pathwayGO:0002768510.252
Human
neurological system processGO:00508771630.240
Human
regulation of lymphocyte differentiationGO:0045619220.223
Human
antigen processing and presentation of endogenous peptide antigenGO:000248360.223
positive regulation of t cell differentiationGO:0045582110.215
Human
lymphocyte activationGO:00466491330.212
Human
sensory perceptionGO:00076001030.211
Human
positive regulation of t cell mediated cytotoxicityGO:000191670.202
Human
negative regulation of cell activationGO:0050866330.202
Human
positive regulation of lymphocyte activationGO:0051251730.197
Human
leukocyte mediated immunityGO:0002443590.196
negative regulation of leukocyte proliferationGO:0070664160.176
Human
inorganic ion import into cellGO:009958720.176
Human
regulation of immune effector processGO:0002697910.176
hematopoietic or lymphoid organ developmentGO:00485341860.176
Human
t cell mediated immunityGO:0002456250.166
Human
negative regulation of mononuclear cell proliferationGO:0032945150.156
Human
lymphocyte differentiationGO:0030098350.154
Human
positive regulation of immune effector processGO:0002699400.150
negative regulation of lymphocyte proliferationGO:0050672150.146
Human
system processGO:00030083490.138
Human
viral life cycleGO:00190581320.138
viral processGO:00160321460.135
purine ribonucleoside metabolic processGO:00461284370.134
t cell mediated cytotoxicityGO:000191390.131
Human
positive regulation of lymphocyte mediated immunityGO:0002708230.123
negative regulation of t cell activationGO:0050868180.109
Human
negative regulation of innate immune responseGO:0045824180.095
regulation of symbiosis encompassing mutualism through parasitismGO:00439031090.092
regulation of cellular amino acid metabolic processGO:000652160.083
response to virusGO:00096151260.074
t cell proliferationGO:0042098450.071
Human
response to type i interferonGO:0034340140.070
negative regulation of lymphocyte activationGO:0051250240.065
Human
regulation of memory t cell activationGO:200056710.064
Human
post embryonic developmentGO:000979120.062
cytoplasmic transportGO:00164823790.060
negative regulation of cellular protein metabolic processGO:00322693530.059
interleukin 6 productionGO:0032635370.056
interaction with hostGO:0051701420.055
detection of chemical stimulus involved in sensory perception of bitter tasteGO:0001580280.054
Human
interleukin 13 biosynthetic processGO:004223110.050
entry into hostGO:0044409250.047
defense response to other organismGO:00985421290.046
regulation of apoptotic signaling pathwayGO:20012331750.046
cellular response to cytokine stimulusGO:00713451810.045
regulation of viral transcriptionGO:0046782340.045
entry into host cellGO:0030260250.045
cytokine mediated signaling pathwayGO:00192211090.041
positive regulation of i kappab kinase nf kappab signalingGO:00431231320.041
multi organism metabolic processGO:0044033410.041
positive regulation of interleukin 4 biosynthetic processGO:004540410.041
regulation of cell migrationGO:00303342890.037
defense response to virusGO:0051607710.037
negative regulation of viral entry into host cellGO:0046597120.036
viral transcriptionGO:0019083350.034
cell projection organizationGO:00300302520.034
regulatory t cell differentiationGO:004506650.033
Human
cellular response to oxidative stressGO:0034599850.032
regulation of angiogenesisGO:0045765920.032
purine containing compound catabolic processGO:00725234110.031
negative regulation of multi organism processGO:0043901920.031
mapk cascadeGO:00001652880.031
intracellular protein transportGO:00068862700.030
cellular response to interferon gammaGO:0071346240.029
response to organonitrogen compoundGO:00102431560.029
ribonucleotide catabolic processGO:00092614050.028
regulation of cell cycleGO:00517263930.027
t cell differentiation in thymusGO:003307740.027
secretion by cellGO:00329402260.027
viral gene expressionGO:0019080350.026
positive regulation of interleukin 13 productionGO:003273640.026
interspecies interaction between organismsGO:00444191560.025
regulation of viral genome replicationGO:0045069480.025
response to cytokineGO:00340972320.024
cellular response to type i interferonGO:0071357120.024
ossificationGO:00015031210.024
amine metabolic processGO:0009308440.023
multi organism cellular processGO:00447641560.022
cellular response to dna damage stimulusGO:00069743790.021
nucleoside catabolic processGO:00091644080.021
protein maturationGO:00516042330.021
osteoblast differentiationGO:0001649920.020
response to oxygen containing compoundGO:19017003690.020
negative regulation of viral processGO:0048525660.020
negative regulation of catalytic activityGO:00430863350.019
ribonucleoside triphosphate metabolic processGO:00091994120.019
regulation of secretionGO:00510461940.019
multicellular organismal agingGO:001025930.019
regulation of viral processGO:00507921030.019
blood vessel morphogenesisGO:00485141620.019
purine nucleoside monophosphate metabolic processGO:00091261860.019
cardiovascular system developmentGO:00723582620.019
nucleoside phosphate catabolic processGO:19012924120.018
regulation of protein localizationGO:00328802960.018
regulation of locomotionGO:00400123290.018
immune response activating signal transductionGO:0002757900.018
dna catabolic process exonucleolyticGO:0000738170.018
regulation of cellular component movementGO:00512703340.018
negative regulation of cell motilityGO:20001461040.018
determination of adult lifespanGO:000834020.018
negative regulation of intracellular signal transductionGO:19025321830.018
proteolysis involved in cellular protein catabolic processGO:00516032440.018
response to interferon betaGO:0035456110.018
negative regulation of cell migrationGO:00303361020.017
secretionGO:00469032540.017
maintenance of location in cellGO:0051651620.017
negative regulation of viral transcriptionGO:0032897230.017
cellular macromolecule catabolic processGO:00442653800.016
positive regulation of cellular catabolic processGO:00313312840.016
regulation of cellular ketone metabolic processGO:0010565500.016
epithelial cell proliferationGO:00506731280.016
purine nucleoside catabolic processGO:00061523980.016
rna catabolic processGO:0006401710.016
positive regulation of purine nucleotide metabolic processGO:19005442270.016
regulation of osteoblast differentiationGO:0045667380.016
entry into other organism involved in symbiotic interactionGO:0051828250.016
regulation of multi organism processGO:00439001570.015
positive regulation of ossificationGO:0045778320.015
purine ribonucleoside triphosphate metabolic processGO:00092054110.015
i kappab kinase nf kappab signalingGO:00072491660.015
signal transduction by phosphorylationGO:00230142970.014
ribonucleoside triphosphate catabolic processGO:00092033910.014
negative regulation of protein metabolic processGO:00512483910.014
purine ribonucleoside triphosphate catabolic processGO:00092073910.014
regulation of establishment of protein localizationGO:00702012420.014
negative regulation of transportGO:00510511760.014
viral entry into host cellGO:0046718240.014
interleukin 4 biosynthetic processGO:004209720.013
negative regulation of cell deathGO:00605483450.013
negative regulation of protein activation cascadeGO:200025870.013
regulation of cell motilityGO:20001452990.013
blastoderm segmentationGO:000735020.013
purine ribonucleotide catabolic processGO:00091544040.013
chemical homeostasisGO:00488783060.013
negative regulation of protein processingGO:00109551420.012
cellular amine metabolic processGO:0044106410.012
regulation of vasculature developmentGO:1901342970.012
negative regulation of phosphorus metabolic processGO:00105632670.012
regulation of purine nucleotide metabolic processGO:19005422640.012
negative regulation of locomotionGO:00400131180.012
positive regulation of programmed cell deathGO:00430682490.012
regulation of transferase activityGO:00513383550.012
nucleotide catabolic processGO:00091664080.012
movement in host environmentGO:0052126250.012
negative regulation of antigen processing and presentationGO:000257850.012
negative regulation of cellular component movementGO:00512711060.012
intracellular transport of viral protein in host cellGO:001906040.012
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.012
modification dependent protein catabolic processGO:00199412090.012
purine nucleotide catabolic processGO:00061954050.011
negative regulation of cell cycleGO:00457861930.011
regulation of protein maturationGO:19033171500.011
neuron developmentGO:00486661130.011
positive regulation of cell deathGO:00109422630.011
cellular response to oxygen containing compoundGO:19017012760.011
positive regulation of cellular amine metabolic processGO:003324070.011
circulatory system developmentGO:00723592620.011
positive regulation of apoptotic processGO:00430652460.011
apoptotic signaling pathwayGO:00971902680.011
negative regulation of phosphorylationGO:00423261740.011
regulation of viral entry into host cellGO:0046596170.011
protein localization to organelleGO:00333652800.011
negative regulation of protein modification processGO:00314002000.010
interleukin 13 productionGO:003261670.010
cellular amino acid metabolic processGO:00065201160.010
cellular protein catabolic processGO:00442572610.010
regulation of actin filament based processGO:00329701410.010
response to mechanical stimulusGO:0009612510.010
positive regulation of hydrolase activityGO:00513453310.010
prostate gland developmentGO:003085030.010
regulation of cellular amine metabolic processGO:0033238110.010
response to peptidoglycanGO:003249430.010

HLA-E disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
viral infectious diseaseDOID:934130.320
Human
disease by infectious agentDOID:0050117340.320
Human
acquired immunodeficiency syndromeDOID:635130.303
Human
human immunodeficiency virus infectious diseaseDOID:526130.303
Human
musculoskeletal system diseaseDOID:172230.200
immune system diseaseDOID:29141550.031
primary immunodeficiency diseaseDOID:612360.029
combined t cell and b cell immunodeficiencyDOID:628120.029
severe combined immunodeficiencyDOID:627100.029
connective tissue diseaseDOID:651090.013
skin diseaseDOID:37330.011
Human
integumentary system diseaseDOID:16430.011
Human