Homo sapiens

196 known processes

ALS2

amyotrophic lateral sclerosis 2 (juvenile)

(Aliases: KIAA1563,FLJ31851,MGC87187,ALSJ,IAHSP,ALS2CR6,PLSJ)

ALS2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
gtp catabolic processGO:00061842370.155
purine ribonucleoside triphosphate catabolic processGO:00092073910.152
membrane organizationGO:00610242920.149
ribonucleoside triphosphate metabolic processGO:00091994120.145
purine containing compound catabolic processGO:00725234110.127
single organism membrane organizationGO:00448022680.125
guanosine containing compound metabolic processGO:19010682440.109
single organism cellular localizationGO:19025803320.108
positive regulation of purine nucleotide catabolic processGO:00331231850.106
ras protein signal transductionGO:0007265730.103
Rat
cell developmentGO:00484683280.096
purine ribonucleoside triphosphate metabolic processGO:00092054110.094
purine nucleoside catabolic processGO:00061523980.092
rab protein signal transductionGO:003248240.089
cytoplasmic transportGO:00164823790.089
regulation of purine nucleotide metabolic processGO:19005422640.084
post embryonic developmentGO:000979120.084
purine ribonucleoside metabolic processGO:00461284370.083
female gamete generationGO:000729220.083
purine nucleotide catabolic processGO:00061954050.082
regulation of nucleoside metabolic processGO:00091182090.079
purine ribonucleotide catabolic processGO:00091544040.079
multicellular organismal agingGO:001025930.078
positive regulation of gtpase activityGO:00435471660.077
positive regulation of gtp catabolic processGO:00331261660.076
ion transmembrane transportGO:00342203380.075
nucleoside phosphate catabolic processGO:19012924120.075
positive regulation of ras gtpase activityGO:00323201170.074
determination of adult lifespanGO:000834020.073
positive regulation of rab gtpase activityGO:0032851390.073
positive regulation of nucleotide metabolic processGO:00459812300.070
transmembrane transportGO:00550853990.068
anterior posterior axis specificationGO:000994820.065
regulation of cell cycleGO:00517263930.063
small gtpase mediated signal transductionGO:0007264780.063
Rat
positive regulation of nucleotide catabolic processGO:00308131850.063
regulation of nucleotide metabolic processGO:00061402690.063
gtp metabolic processGO:00460392390.063
guanosine containing compound catabolic processGO:19010692390.062
regulation of cellular amino acid metabolic processGO:000652160.062
regulation of gtp catabolic processGO:00331241800.060
positive regulation of cellular catabolic processGO:00313312840.060
chemical homeostasisGO:00488783060.060
positive regulation of catabolic processGO:00098963100.060
regulation of purine nucleotide catabolic processGO:00331212050.059
regulation of nucleotide catabolic processGO:00308112050.059
organophosphate catabolic processGO:00464344300.058
regulation of rab protein signal transductionGO:0032483390.058
protein catabolic processGO:00301633250.057
hindbrain developmentGO:003090230.057
oogenesisGO:004847720.055
photoreceptor cell differentiationGO:004653020.055
organelle fissionGO:00482851490.052
regulation of gtpase activityGO:00430871800.052
regulation of small gtpase mediated signal transductionGO:00510561560.050
purine nucleoside triphosphate metabolic processGO:00091444120.049
protein localization to membraneGO:00726571600.049
regulation of cellular ketone metabolic processGO:0010565500.049
negative regulation of phosphorus metabolic processGO:00105632670.049
intracellular protein transportGO:00068862700.048
protein ubiquitinationGO:00165673140.047
dephosphorylationGO:00163112090.047
ion homeostasisGO:00508012300.046
nucleoside catabolic processGO:00091644080.045
regulation of neurotransmitter secretionGO:004692830.045
positive regulation of purine nucleotide metabolic processGO:19005442270.045
regulation of ras protein signal transductionGO:00465781550.045
cellular component morphogenesisGO:00329893140.044
regulation of protein kinase activityGO:00458592890.043
endomembrane system organizationGO:00102561960.042
microtubule cytoskeleton organizationGO:00002261760.042
glycosyl compound catabolic processGO:19016584130.042
cation transmembrane transportGO:00986552380.041
cellular amine metabolic processGO:0044106410.040
negative regulation of catalytic activityGO:00430863350.040
regulation of cellular amine metabolic processGO:0033238110.040
positive regulation of hydrolase activityGO:00513453310.040
ribonucleotide catabolic processGO:00092614050.040
protein targetingGO:00066051870.039
inorganic ion transmembrane transportGO:00986602310.039
neural tube formationGO:000184130.039
segmentationGO:003528240.039
negative regulation of phosphate metabolic processGO:00459362670.038
establishment or maintenance of cytoskeleton polarityGO:003095230.038
negative regulation of cellular protein metabolic processGO:00322693530.038
system processGO:00030083490.038
regulation of protein localizationGO:00328802960.037
positive regulation of nucleoside metabolic processGO:00459791860.037
neuromuscular junction developmentGO:000752830.037
Mouse
negative regulation of intracellular signal transductionGO:19025321830.037
negative regulation of protein metabolic processGO:00512483910.037
nervous system developmentGO:00073992930.036
purine nucleoside triphosphate catabolic processGO:00091463920.036
mitotic cell cycleGO:00002783260.035
cellular response to nitrogen compoundGO:19016991440.035
cellular ketone metabolic processGO:0042180800.035
locomotory behaviorGO:000762610.034
Mouse
protein localization to organelleGO:00333652800.034
signal transduction by phosphorylationGO:00230142970.034
regulation of kinase activityGO:00435493140.034
microtubule based processGO:00070172100.033
generation of neuronsGO:00486991520.033
cell morphogenesisGO:00009022960.033
anterior posterior axis specification embryoGO:000859520.033
mitotic cell cycle processGO:19030472860.033
regulation of mapk cascadeGO:00434082620.032
posttranscriptional regulation of gene expressionGO:00106082130.032
embryonic epithelial tube formationGO:000183840.032
blastoderm segmentationGO:000735020.032
cell projection morphogenesisGO:00488581290.031
regulation of meiotic cell cycleGO:005144540.030
ribonucleoside triphosphate catabolic processGO:00092033910.030
regulation of synaptic plasticityGO:004816730.030
positive regulation of cellular amino acid metabolic processGO:004576430.030
vesicle mediated transportGO:00161923710.030
nucleotide catabolic processGO:00091664080.030
cellular amino acid metabolic processGO:00065201160.029
cell projection organizationGO:00300302520.029
positive regulation of cellular amine metabolic processGO:003324070.029
regulation of cytoplasmic transportGO:19036491490.028
tripartite regional subdivisionGO:000735120.028
metal ion transportGO:00300012720.027
ribonucleoside catabolic processGO:00424544060.027
negative regulation of phosphorylationGO:00423261740.027
morphogenesis of embryonic epitheliumGO:001633140.027
protein processingGO:00164852260.027
maintenance of locationGO:00512351120.026
internal protein amino acid acetylationGO:00064751010.026
positive regulation of phosphorylationGO:00423273940.026
amine metabolic processGO:0009308440.026
cellular response to endogenous stimulusGO:00714953360.026
oocyte developmentGO:004859910.026
primary neural tube formationGO:001402030.026
regulation of rho protein signal transductionGO:0035023790.025
organelle assemblyGO:00709251760.025
negative regulation of hydrolase activityGO:00513461820.025
response to abiotic stimulusGO:00096283360.025
negative regulation of cell proliferationGO:00082852280.025
neurological system processGO:00508771630.025
negative regulation of protein modification processGO:00314002000.024
proteolysis involved in cellular protein catabolic processGO:00516032440.024
regulation of synaptic vesicle transportGO:190280330.024
cellular homeostasisGO:00197251960.024
internal peptidyl lysine acetylationGO:0018393970.023
negative regulation of cell deathGO:00605483450.023
regulation of protein serine threonine kinase activityGO:00719001790.023
meiotic chromosome segregationGO:004513240.023
histone modificationGO:00165702510.023
cilium assemblyGO:0042384630.023
positive regulation of cell proliferationGO:00082843010.023
sensory perception of smellGO:000760820.023
motor neuron axon guidanceGO:000804520.023
purine ribonucleoside catabolic processGO:00461303980.023
nucleoside triphosphate catabolic processGO:00091433940.023
oocyte differentiationGO:000999420.023
protein maturationGO:00516042330.023
regulation of cellular response to stressGO:00801352440.023
positive regulation of apoptotic processGO:00430652460.022
cilium morphogenesisGO:0060271750.022
negative regulation of cell cycleGO:00457861930.022
endocytosisGO:00068971590.022
regulation of cell differentiationGO:00455953930.022
nucleoside triphosphate metabolic processGO:00091414220.022
intracellular mrna localizationGO:000829810.022
monovalent inorganic cation transportGO:00156721280.022
regulation of protein transportGO:00512232130.022
regulation of anatomical structure sizeGO:00900661010.021
mapk cascadeGO:00001652880.021
lipid metabolic processGO:00066293810.021
inorganic cation transmembrane transportGO:00986621940.021
immune responseGO:00069553070.021
Fly
negative regulation of programmed cell deathGO:00430693210.021
axon cargo transportGO:000808820.021
cellular chemical homeostasisGO:00550821800.021
positive regulation of protein phosphorylationGO:00019343130.021
regulation of mitotic cell cycleGO:00073461890.021
protein modification by small protein conjugationGO:00324463420.021
regulation of cell morphogenesisGO:00226041530.021
regulation of membrane potentialGO:0042391950.020
positive regulation of synaptic transmissionGO:005080640.020
lipid localizationGO:00108761060.020
tor signalingGO:0031929390.020
anion transportGO:00068201610.020
translationGO:00064121320.020
regulation of cell projection organizationGO:00313441070.020
negative regulation of cellular amino acid metabolic processGO:004576320.020
positive regulation of protein kinase activityGO:00458601900.020
metal ion homeostasisGO:00550651690.019
cation homeostasisGO:00550801890.019
neurogenesisGO:00220081690.019
spermatid developmentGO:000728640.019
actin filament based processGO:00300292240.019
regulation of ras gtpase activityGO:00323181280.019
growthGO:00400072020.019
regulation of proteolysisGO:00301622930.019
protein acylationGO:00435431380.019
spermatid differentiationGO:004851540.018
tube closureGO:006060630.018
neuron differentiationGO:00301821380.018
negative regulation of cellular component organizationGO:00511292350.018
regulation of transferase activityGO:00513383550.018
cilium organizationGO:0044782680.018
establishment of protein localization to organelleGO:00725941720.018
cerebellum developmentGO:002154920.018
positive regulation of cellular component organizationGO:00511303760.018
regulation of endocytosisGO:0030100720.018
cellular macromolecule catabolic processGO:00442653800.018
neuron projection developmentGO:00311751060.018
defense responseGO:00069523150.018
Mouse Fly
neuroblast proliferationGO:000740540.018
cell part morphogenesisGO:00329901370.018
rhythmic behaviorGO:000762220.018
associative learningGO:000830610.018
cell projection assemblyGO:00300311260.018
response to oxygen containing compoundGO:19017003690.018
regulation of protein catabolic processGO:00421761550.018
positive regulation of developmental processGO:00510943140.017
positive regulation of transportGO:00510503360.017
positive regulation of transferase activityGO:00513472270.017
regulation of protein stabilityGO:0031647870.017
regulation of protein processingGO:00706131500.017
positive regulation of organelle organizationGO:00106381950.017
cytokinesisGO:0000910960.017
embryo developmentGO:00097901230.017
Rat
actin cytoskeleton organizationGO:00300362070.017
potassium ion transmembrane transportGO:0071805600.017
nucleocytoplasmic transportGO:00069131760.017
cellular protein catabolic processGO:00442572610.017
cell migration involved in gastrulationGO:004207410.017
cell cell signalingGO:00072671550.017
Mouse
regulation of protein maturationGO:19033171500.017
negative regulation of phosphatase activityGO:0010923610.017
negative regulation of cytosolic calcium ion concentrationGO:005148110.017
cellular divalent inorganic cation homeostasisGO:00725031280.017
negative regulation of protein maturationGO:19033181420.017
toxin transportGO:190199840.016
central nervous system developmentGO:00074171230.016
regulation of synaptic vesicle exocytosisGO:200030020.016
regulation of cellular component biogenesisGO:00440872810.016
compound eye developmentGO:004874910.016
regulation of growthGO:00400081650.016
protein acetylationGO:00064731160.016
reproductive processGO:00224141060.016
regulation of anatomical structure morphogenesisGO:00226032860.016
positive regulation of programmed cell deathGO:00430682490.016
peptidyl tyrosine dephosphorylationGO:0035335360.016
positive regulation of meiotic cell cycleGO:005144620.016
neural tube closureGO:000184330.016
cell morphogenesis involved in differentiationGO:00009041440.016
Rat
autophagyGO:0006914880.016
regenerationGO:003109940.016
wnt signaling pathwayGO:00160551560.016
regulation of endopeptidase activityGO:00525481700.016
cellular calcium ion homeostasisGO:00068741170.016
regulation of intracellular transportGO:00323861950.015
positive regulation of rho gtpase activityGO:0032321560.015
positive regulation of cell migrationGO:00303351720.015
post embryonic organ developmentGO:004856910.015
visual behaviorGO:000763220.015
regulation of translationGO:0006417890.015
peptidyl lysine modificationGO:00182051440.015
mitochondrion organizationGO:00070051560.015
neurotransmitter secretionGO:000726940.015
metencephalon developmentGO:002203720.015
negative regulation of apoptotic processGO:00430663160.015
nuclear transportGO:00511691790.015
cellular ion homeostasisGO:00068731680.015
chemotaxisGO:00069351570.015
histone acetylationGO:0016573930.015
anatomical structure formation involved in morphogenesisGO:00486462840.015
cellular cation homeostasisGO:00300031630.015
cellular response to nutrient levelsGO:0031669690.014
covalent chromatin modificationGO:00165692540.014
circadian behaviorGO:004851220.014
regulation of rab gtpase activityGO:0032313390.014
modification dependent macromolecule catabolic processGO:00436322120.014
negative regulation of proteolysisGO:00458611320.014
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:00432811160.014
sensory perceptionGO:00076001030.014
regulation of dephosphorylationGO:0035303960.014
regulation of cysteine type endopeptidase activityGO:20001161270.014
negative regulation of protein processingGO:00109551420.014
cellular metal ion homeostasisGO:00068751460.014
response to biotic stimulusGO:00096072760.014
histone h3 acetylationGO:0043966450.014
modification dependent protein catabolic processGO:00199412090.014
rna interferenceGO:001624640.014
negative regulation of transferase activityGO:00513481240.014
epithelium developmentGO:00604292270.014
regulation of establishment of protein localizationGO:00702012420.014
chromatin organizationGO:00063253510.014
cellular response to organonitrogen compoundGO:00714171240.014
negative regulation of peptidase activityGO:0010466910.014
mitotic nuclear divisionGO:00070671190.014
cardiac muscle cell contractionGO:008600340.013
cdc42 protein signal transductionGO:003248840.013
ribonucleoside monophosphate metabolic processGO:00091611870.013
regulation of intracellular protein transportGO:00331571230.013
ribonucleoprotein complex subunit organizationGO:0071826810.013
eye photoreceptor cell differentiationGO:000175420.013
regulation of cell activationGO:00508651250.013
cell cycle phase transitionGO:00447701730.013
cell fate determinationGO:000170930.013
regulation of response to external stimulusGO:00321012220.013
regulation of transmembrane transporter activityGO:0022898740.013
regulation of mitotic cell cycle phase transitionGO:19019901180.013
peptidyl serine modificationGO:00182091060.013
regulation of myeloid leukocyte mediated immunityGO:000288640.013
cellular response to abiotic stimulusGO:00712141170.013
regulation of cell cycle processGO:00105642660.013
regulation of ion transmembrane transportGO:00347651320.013
regulation of secretionGO:00510461940.013
cellular macromolecular complex assemblyGO:00346223240.013
calcium ion homeostasisGO:00550741220.013
negative regulation of protein phosphorylationGO:00019331400.013
cellular response to cytokine stimulusGO:00713451810.013
regulation of cell developmentGO:00602841610.013
nuclear divisionGO:00002801280.013
negative regulation of catabolic processGO:00098951040.013
nucleoside monophosphate metabolic processGO:00091231910.013
reactive oxygen species biosynthetic processGO:190340940.012
peptidyl lysine acetylationGO:00183941010.012
regulation of receptor mediated endocytosisGO:0048259320.012
single organism reproductive processGO:0044702980.012
response to radiationGO:00093141510.012
regulation of collagen catabolic processGO:001071030.012
cellular lipid metabolic processGO:00442553030.012
regulation of vesicle mediated transportGO:00606271300.012
purine nucleoside monophosphate metabolic processGO:00091261860.012
cellular response to oxygen containing compoundGO:19017012760.012
regulation of actin filament based processGO:00329701410.012
organ morphogenesisGO:00098871470.012
positive regulation of cell deathGO:00109422630.012
protein localization to plasma membraneGO:0072659930.012
cellular component assembly involved in morphogenesisGO:0010927730.012
peripheral nervous system developmentGO:000742220.012
circulatory system developmentGO:00723592620.012
inorganic anion transportGO:0015698600.012
g protein coupled receptor signaling pathwayGO:00071862070.012
mitotic cell cycle phase transitionGO:00447721620.012
regulation of feeding behaviorGO:006025930.012
rho protein signal transductionGO:0007266260.012
engulfment of apoptotic cellGO:004365220.012
stem cell divisionGO:001714520.012
innate immune responseGO:00450871780.012
Fly
memoryGO:000761330.012
response to other organismGO:00517072610.012
positive regulation of interleukin 5 productionGO:003275430.012
protein localization to nucleusGO:00345041360.012
cellular response to starvationGO:0009267580.011
sodium ion transmembrane transportGO:0035725590.011
chromosome segregationGO:00070591140.011
somitogenesisGO:000175620.011
response to organonitrogen compoundGO:00102431560.011
spinal cord developmentGO:002151040.011
divalent inorganic cation homeostasisGO:00725071360.011
single organism membrane fusionGO:0044801370.011
erythrocyte developmentGO:004882130.011
regulation of i kappab kinase nf kappab signalingGO:00431221620.011
anion transmembrane transportGO:0098656760.011
nerve developmentGO:002167540.011
meiosis iGO:000712740.011
regulation of map kinase activityGO:00434051080.011
ubiquitin dependent protein catabolic processGO:00065112060.011
positive regulation of peptidyl tyrosine phosphorylationGO:0050731850.011
cranial nerve developmentGO:002154540.011
cardiovascular system developmentGO:00723582620.011
apoptotic signaling pathwayGO:00971902680.011
establishment or maintenance of microtubule cytoskeleton polarityGO:003095120.011
regulation of protein kinase b signalingGO:0051896610.011
embryonic morphogenesisGO:0048598850.011
maintenance of cell polarityGO:003001120.011
maintenance of location in cellGO:0051651620.011
regulation of cell divisionGO:00513021160.011
regulation of actin cytoskeleton organizationGO:00329561160.011
atp metabolic processGO:00460341760.011
peptidyl tyrosine modificationGO:00182121700.011
inner ear morphogenesisGO:004247240.011
cell divisionGO:00513011680.011
matingGO:000761810.011
peptidyl serine phosphorylationGO:00181051010.011
positive regulation of immune system processGO:00026842830.011
regulation of secretion by cellGO:19035301770.011
protein dephosphorylationGO:0006470810.011
establishment or maintenance of bipolar cell polarityGO:006124520.011
negative regulation of protein kinase activityGO:0006469980.011
multi organism reproductive processGO:0044703540.011
cellular response to external stimulusGO:00714961110.011
neuron projection morphogenesisGO:0048812500.011
cell activationGO:00017752130.011
cellular response to dna damage stimulusGO:00069743790.011
regulation of phosphatase activityGO:0010921810.010
visual learningGO:000854210.010
oxidation reduction processGO:00551143960.010
response to external biotic stimulusGO:00432072610.010
positive regulation of kinase activityGO:00336742040.010
neuron developmentGO:00486661130.010
maintenance of protein location in cellGO:0032507560.010
negative regulation of cellular amine metabolic processGO:003323930.010
sodium ion transportGO:0006814610.010
negative regulation of dephosphorylationGO:0035305630.010
regulation of exocytosisGO:0017157460.010
response to bacteriumGO:00096171440.010
negative regulation of developmental processGO:00510932470.010
adult locomotory behaviorGO:000834410.010
establishment of protein localization to membraneGO:00901501210.010
organonitrogen compound biosynthetic processGO:19015662000.010
male meiosisGO:000714010.010
neuronal stem cell divisionGO:003644510.010
hair cell differentiationGO:003531520.010

ALS2 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:00146672950.024
central nervous system diseaseDOID:3311860.023
nervous system diseaseDOID:8634310.023
sensory system diseaseDOID:00501552030.022
eye diseaseDOID:56141490.020
eye and adnexa diseaseDOID:14921500.020
retinal diseaseDOID:56791180.017
musculoskeletal system diseaseDOID:172230.016
inherited metabolic disorderDOID:6552420.014
disease of cellular proliferationDOID:145661740.013
organ system cancerDOID:00506861640.012
cancerDOID:1621670.012
neurodegenerative diseaseDOID:12891020.012
retinal degenerationDOID:8466890.010
immune system diseaseDOID:29141550.010
motor neuron diseaseDOID:231270.003
amyotrophic lateral sclerosisDOID:332200.002