Homo sapiens

0 known processes

TANK

TRAF family member-associated NFKB activator

(Aliases: TRAF2,I-TRAF)

TANK biological process predictions


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Biological processGO term IDProcess sizeProbabilityFunc Analog Org
regulation of interferon beta biosynthetic processGO:004535740.995
positive regulation of cytokine productionGO:00018191670.867
peptidyl serine autophosphorylationGO:003628920.805
regulation of i kappab kinase nf kappab signalingGO:00431221620.798
lymphocyte proliferationGO:0046651700.767
positive regulation of i kappab kinase nf kappab signalingGO:00431231320.750
response to tumor necrosis factorGO:0034612760.724
positive regulation of sequence specific dna binding transcription factor activityGO:00510911310.675
positive regulation of necroptotic processGO:006054520.639
regulation of interferon beta productionGO:0032648220.620
cellular amine metabolic processGO:0044106410.597
response to cytokineGO:00340972320.592
positive regulation of apoptotic processGO:00430652460.586
regulation of mononuclear cell proliferationGO:0032944650.577
positive regulation of programmed cell deathGO:00430682490.565
adaptive immune responseGO:0002250490.551
positive regulation of extrinsic apoptotic signaling pathwayGO:2001238260.543
extrinsic apoptotic signaling pathwayGO:00971911190.536
regulation of apoptotic signaling pathwayGO:20012331750.522
positive regulation of apoptotic signaling pathwayGO:2001235700.518
ripoptosome assemblyGO:009734310.505
cellular response to tumor necrosis factorGO:0071356630.484
programmed necrotic cell deathGO:0097300180.472
regulation of sequence specific dna binding transcription factor activityGO:00510902110.470
mononuclear cell proliferationGO:0032943710.460
regulation of cytokine productionGO:00018172320.445
regulation of cellular amine metabolic processGO:0033238110.439
peptidyl serine phosphorylationGO:00181051010.434
protein modification by small protein conjugationGO:00324463420.408
cell activationGO:00017752130.389
cellular amino acid metabolic processGO:00065201160.361
necrotic cell deathGO:0070265210.349
regulation of defense responseGO:00313471540.346
apoptotic signaling pathwayGO:00971902680.339
positive regulation of hydrolase activityGO:00513453310.338
regulation of cell cycleGO:00517263930.329
nucleoside triphosphate catabolic processGO:00091433940.327
positive regulation of cellular amino acid metabolic processGO:004576430.316
serine phosphorylation of stat proteinGO:004250140.303
purine ribonucleoside triphosphate catabolic processGO:00092073910.277
regulation of leukocyte proliferationGO:0070663670.276
regulation of adaptive immune responseGO:0002819330.272
positive regulation of immune responseGO:00507781590.272
response to nitrogen compoundGO:19016981840.271
positive regulation of protein phosphorylationGO:00019343130.264
leukocyte activationGO:00453211640.263
activation of immune responseGO:00022531140.256
positive regulation of cell deathGO:00109422630.255
positive regulation of cellular amine metabolic processGO:003324070.243
lymphocyte activationGO:00466491330.242
regulation of proteolysisGO:00301622930.240
regulation of extrinsic apoptotic signaling pathwayGO:2001236850.234
regulation of cellular amino acid metabolic processGO:000652160.229
regulation of lymphocyte activationGO:00512491030.228
hematopoietic or lymphoid organ developmentGO:00485341860.226
peptidyl threonine phosphorylationGO:0018107410.225
regulation of anion transportGO:0044070250.219
determination of adult lifespanGO:000834020.213
cellular ketone metabolic processGO:0042180800.212
positive regulation of peptidyl tyrosine phosphorylationGO:0050731850.212
interleukin 2 productionGO:0032623200.211
positive regulation of phosphorylationGO:00423273940.211
regulation of necrotic cell deathGO:001093990.205
positive regulation of defense responseGO:0031349870.199
regulation of kinase activityGO:00435493140.190
purine nucleoside triphosphate catabolic processGO:00091463920.177
response to oxidative stressGO:00069791210.177
positive regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043280690.176
endocytic recyclingGO:0032456120.167
positive regulation of developmental processGO:00510943140.164
ribonucleoside triphosphate metabolic processGO:00091994120.164
regulation of leukocyte differentiationGO:1902105610.161
regulation of lymphocyte proliferationGO:0050670640.160
positive regulation of transportGO:00510503360.159
purine ribonucleoside triphosphate metabolic processGO:00092054110.158
organophosphate catabolic processGO:00464344300.154
response to lipopolysaccharideGO:0032496700.153
ribonucleoside triphosphate catabolic processGO:00092033910.153
positive regulation of kinase activityGO:00336742040.142
regulation of protein kinase activityGO:00458592890.141
response to lipidGO:00339932060.141
immune responseGO:00069553070.141
amine metabolic processGO:0009308440.133
toll like receptor 2 signaling pathwayGO:003413440.132
positive regulation of necrotic cell deathGO:001094040.131
regulation of leukocyte activationGO:00026941150.130
cellular response to external stimulusGO:00714961110.128
cytokine productionGO:00018162470.127
positive regulation of protein kinase activityGO:00458601900.126
i kappab kinase nf kappab signalingGO:00072491660.123
Mouse
regulation of immune responseGO:00507762010.122
purine nucleoside triphosphate metabolic processGO:00091444120.119
mapk cascadeGO:00001652880.119
response to other organismGO:00517072610.119
nucleoside triphosphate metabolic processGO:00091414220.118
protein oligomerizationGO:00512591730.118
regulation of transferase activityGO:00513383550.116
positive regulation of nf kappab transcription factor activityGO:0051092810.116
response to biotic stimulusGO:00096072760.111
cellular response to nitrogen compoundGO:19016991440.109
immune response activating cell surface receptor signaling pathwayGO:0002429450.109
positive regulation of transferase activityGO:00513472270.109
regulation of immune effector processGO:0002697910.107
immune system developmentGO:00025201950.102
purine ribonucleoside metabolic processGO:00461284370.101
cell type specific apoptotic processGO:00972851250.100
regulation of peptidase activityGO:00525471800.099
small gtpase mediated signal transductionGO:0007264780.099
regulation of cell activationGO:00508651250.097
purine nucleotide catabolic processGO:00061954050.096
purine containing compound catabolic processGO:00725234110.096
negative regulation of apoptotic processGO:00430663160.096
cellular response to lipopolysaccharideGO:0071222570.094
actin filament based processGO:00300292240.093
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:00432811160.092
peptidyl serine modificationGO:00182091060.092
regulation of wnt signaling pathwayGO:00301111230.092
carbohydrate derivative transportGO:1901264200.089
response to molecule of bacterial originGO:0002237820.086
gtp metabolic processGO:00460392390.083
golgi ribbon formationGO:009016130.083
positive regulation of interferon alpha productionGO:0032727110.082
regulation of t cell proliferationGO:0042129420.081
response to abiotic stimulusGO:00096283360.080
peptidyl tyrosine phosphorylationGO:00181081700.080
intracellular protein transportGO:00068862700.079
regulation of nucleoside metabolic processGO:00091182090.077
leukocyte proliferationGO:0070661740.077
regulation of reactive oxygen species metabolic processGO:2000377410.077
regulation of innate immune responseGO:0045088970.077
positive regulation of gtpase activityGO:00435471660.077
multicellular organismal agingGO:001025930.075
leukocyte differentiationGO:0002521980.074
regulation of t cell activationGO:0050863770.074
positive regulation of interferon beta productionGO:0032728170.071
immune response activating signal transductionGO:0002757900.071
canonical wnt signaling pathwayGO:00600701160.070
cd4 positive alpha beta t cell differentiationGO:004336740.069
positive regulation of cd4 positive alpha beta t cell activationGO:200051630.068
type i interferon biosynthetic processGO:004535140.067
myeloid leukocyte differentiationGO:0002573600.067
vesicle mediated transportGO:00161923710.064
negative regulation of protein maturationGO:19033181420.064
cellular response to endogenous stimulusGO:00714953360.063
positive regulation of gtp catabolic processGO:00331261660.063
regulation of canonical wnt signaling pathwayGO:0060828880.063
purine nucleoside catabolic processGO:00061523980.062
endosomal transportGO:00161971290.062
cellular response to muramyl dipeptideGO:007122530.060
regulation of cysteine type endopeptidase activityGO:20001161270.060
cellular response to oxygen containing compoundGO:19017012760.058
response to external biotic stimulusGO:00432072610.057
regulation of cytokine production involved in immune responseGO:0002718220.057
signal transduction by phosphorylationGO:00230142970.057
positive regulation of cellular catabolic processGO:00313312840.057
glycosyl compound catabolic processGO:19016584130.057
nucleoside phosphate catabolic processGO:19012924120.057
innate immune responseGO:00450871780.055
cellular response to biotic stimulusGO:0071216710.055
vesicle organizationGO:0016050620.055
nervous system developmentGO:00073992930.054
protein ubiquitinationGO:00165673140.053
positive regulation of cellular component organizationGO:00511303760.053
negative regulation of extrinsic apoptotic signaling pathwayGO:2001237520.052
ribonucleotide catabolic processGO:00092614050.052
reactive oxygen species metabolic processGO:0072593750.052
epithelium developmentGO:00604292270.052
nitrogen compound transportGO:00717051910.052
lymphocyte mediated immunityGO:0002449480.051
heart developmentGO:0007507950.050
protein catabolic processGO:00301633250.050
cellular response to molecule of bacterial originGO:0071219620.050
positive regulation of endopeptidase activityGO:0010950840.049
regulation of cellular response to stressGO:00801352440.049
positive regulation of nucleotide catabolic processGO:00308131850.048
positive regulation of cell differentiationGO:00455972110.048
positive regulation of interleukin 8 productionGO:0032757360.048
nucleotide catabolic processGO:00091664080.047
regulation of nucleotide catabolic processGO:00308112050.047
regulation of phosphatase activityGO:0010921810.047
regulation of purine nucleotide catabolic processGO:00331212050.046
regulation of cell differentiationGO:00455953930.046
activation of protein kinase activityGO:0032147900.045
syncytium formation by plasma membrane fusionGO:000076820.045
anion transportGO:00068201610.045
guanosine containing compound catabolic processGO:19010692390.044
negative regulation of sequence specific dna binding transcription factor activityGO:0043433890.044
post embryonic developmentGO:000979120.044
defense responseGO:00069523150.042
proteolysis involved in cellular protein catabolic processGO:00516032440.042
response to mechanical stimulusGO:0009612510.042
mitotic cell cycleGO:00002783260.041
t cell receptor signaling pathwayGO:0050852210.041
response to bacteriumGO:00096171440.041
peptide transportGO:0015833740.041
positive regulation of proteolysisGO:00458621420.040
positive regulation of mononuclear cell proliferationGO:0032946470.040
positive regulation of nucleoside metabolic processGO:00459791860.040
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002460400.040
positive regulation of mapk cascadeGO:00434101900.040
microtubule bundle formationGO:0001578150.039
regulation of establishment of protein localizationGO:00702012420.037
positive regulation of adaptive immune responseGO:0002821210.037
positive regulation of myeloid cell differentiationGO:0045639390.037
cell activation involved in immune responseGO:0002263300.037
positive regulation of immune system processGO:00026842830.037
regulation of system processGO:00440571010.037
regulation of cellular ketone metabolic processGO:0010565500.036
regulation of nucleotide metabolic processGO:00061402690.036
interferon beta productionGO:0032608230.036
regulation of ras protein signal transductionGO:00465781550.036
dephosphorylationGO:00163112090.035
activation of innate immune responseGO:0002218550.035
jak stat cascadeGO:0007259460.034
immune response regulating signaling pathwayGO:0002764970.034
necroptotic processGO:0070266160.033
regulation of jnk cascadeGO:0046328730.033
positive regulation of innate immune responseGO:0045089790.033
response to hypoxiaGO:0001666960.032
positive regulation of lymphocyte activationGO:0051251730.032
positive regulation of myeloid leukocyte differentiationGO:0002763240.032
positive regulation of secretion by cellGO:19035321080.031
guanosine containing compound metabolic processGO:19010682440.031
purine ribonucleoside catabolic processGO:00461303980.031
cell developmentGO:00484683280.031
positive regulation of purine nucleotide catabolic processGO:00331231850.031
negative regulation of catalytic activityGO:00430863350.031
cellular response to cytokine stimulusGO:00713451810.031
response to fungusGO:000962040.030
regulation of mitotic cell cycleGO:00073461890.030
interferon alpha productionGO:0032607110.030
cellular component assembly involved in morphogenesisGO:0010927730.030
response to oxygen containing compoundGO:19017003690.030
positive regulation of cytokine biosynthetic processGO:0042108250.030
response to virusGO:00096151260.030
protein secretionGO:0009306980.029
positive regulation of t cell activationGO:0050870540.029
regulation of lymphocyte mediated immunityGO:0002706330.029
negative regulation of nf kappab transcription factor activityGO:0032088510.029
protein autoubiquitinationGO:0051865370.029
regulation of type i interferon productionGO:0032479260.029
cellular cation homeostasisGO:00300031630.028
regulation of protein serine threonine kinase activityGO:00719001790.028
nucleoside transportGO:001585880.028
amyloid fibril formationGO:199000030.028
protein localization to organelleGO:00333652800.028
positive regulation of cell activationGO:0050867810.027
regulation of protein modification by small protein conjugation or removalGO:19033201070.027
regulation of interferon alpha productionGO:0032647110.027
positive regulation of protein k63 linked ubiquitinationGO:190252310.027
cellular macromolecular complex assemblyGO:00346223240.027
positive regulation of protein serine threonine kinase activityGO:00719021190.026
stress activated mapk cascadeGO:0051403930.026
protein targetingGO:00066051870.026
regulation of bindingGO:00510981110.026
negative regulation of cell proliferationGO:00082852280.026
neurogenesisGO:00220081690.026
regulation of map kinase activityGO:00434051080.026
immune response regulating cell surface receptor signaling pathwayGO:0002768510.026
endomembrane system organizationGO:00102561960.026
positive regulation of ras gtpase activityGO:00323201170.025
regulation of protein linear polyubiquitinationGO:190252820.025
positive regulation of interleukin 2 productionGO:0032743110.025
cilium organizationGO:0044782680.025
regulation of cytokine biosynthetic processGO:0042035350.025
negative regulation of cysteine type endopeptidase activityGO:2000117480.025
nucleoside catabolic processGO:00091644080.025
lipopolysaccharide mediated signaling pathwayGO:0031663260.025
negative regulation of cellular protein metabolic processGO:00322693530.025
regulation of interleukin 8 productionGO:0032677490.025
cytokine mediated signaling pathwayGO:00192211090.025
positive regulation of nucleotide metabolic processGO:00459812300.024
ras protein signal transductionGO:0007265730.024
cellular response to lipidGO:00713961270.024
positive regulation of purine nucleotide metabolic processGO:19005442270.024
protein polyubiquitinationGO:00002091100.024
regulation of response to external stimulusGO:00321012220.024
t cell differentiationGO:0030217290.024
hemopoiesisGO:00300971800.023
cell cycle g1 s phase transitionGO:0044843800.023
regulation of ion transmembrane transportGO:00347651320.023
positive regulation of leukocyte proliferationGO:0070665480.023
positive regulation of t cell cytokine productionGO:000272640.023
regulation of endopeptidase activityGO:00525481700.023
gtp catabolic processGO:00061842370.023
regulation of t cell differentiationGO:0045580190.023
cellular response to organonitrogen compoundGO:00714171240.023
negative regulation of hydrolase activityGO:00513461820.022
positive regulation of cysteine type endopeptidase activityGO:2001056790.022
positive regulation of osteoclast differentiationGO:004567290.022
t cell activationGO:0042110990.022
receptor metabolic processGO:0043112810.022
regulation of gtpase activityGO:00430871800.021
apoptotic mitochondrial changesGO:0008637570.021
antigen receptor mediated signaling pathwayGO:0050851380.021
cardiovascular system developmentGO:00723582620.021
positive regulation of exocytosisGO:0045921350.021
positive regulation of protein modification by small protein conjugation or removalGO:1903322610.021
positive regulation of peptidyl threonine phosphorylationGO:001080090.021
regulation of cellular component biogenesisGO:00440872810.021
negative regulation of peptidase activityGO:0010466910.021
type i interferon productionGO:0032606270.020
response to growth factorGO:00708482050.020
regulation of endocytosisGO:0030100720.020
axoneme assemblyGO:003508230.020
regulation of cytoskeleton organizationGO:00514931770.020
osteoclast differentiationGO:0030316210.019
regulation of jak stat cascadeGO:0046425440.019
protein autophosphorylationGO:00467771230.019
regulation of mapk cascadeGO:00434082620.019
positive regulation of protein polyubiquitinationGO:190291630.019
b cell mediated immunityGO:0019724100.019
immune effector processGO:00022521590.019
regulation of protein monoubiquitinationGO:190252510.019
generation of neuronsGO:00486991520.019
mitochondrion organizationGO:00070051560.019
negative regulation of cell cycleGO:00457861930.019
cd4 positive alpha beta t cell differentiation involved in immune responseGO:000229440.019
mitotic cell cycle processGO:19030472860.019
muscle cell differentiationGO:0042692630.019
cytokine biosynthetic processGO:0042089370.019
negative regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043154460.018
wnt signaling pathwayGO:00160551560.018
negative regulation of phosphorus metabolic processGO:00105632670.018
positive regulation of endocytosisGO:0045807420.018
negative regulation of apoptotic signaling pathwayGO:2001234970.018
neuron remodelingGO:001632220.018
oocyte developmentGO:004859910.018
ubiquitin dependent protein catabolic processGO:00065112060.018
cellular protein catabolic processGO:00442572610.017
peptidyl tyrosine modificationGO:00182121700.017
negative regulation of endopeptidase activityGO:0010951840.017
nik nf kappab signalingGO:0038061120.017
establishment of protein localization to organelleGO:00725941720.017
positive regulation of dna bindingGO:0043388170.017
positive regulation of rho gtpase activityGO:0032321560.017
cellular macromolecule catabolic processGO:00442653800.017
neurotransmitter secretionGO:000726940.017
purine ribonucleotide catabolic processGO:00091544040.017
positive regulation of catabolic processGO:00098963100.017
regulation of purine nucleotide metabolic processGO:19005422640.017
leukocyte activation involved in immune responseGO:0002366300.017
modification dependent macromolecule catabolic processGO:00436322120.016
single organism membrane organizationGO:00448022680.016
blastoderm segmentationGO:000735020.016
regulation of secretionGO:00510461940.016
regulation of endothelial cell apoptotic processGO:2000351240.016
positive regulation of bindingGO:0051099450.015
negative regulation of proteolysisGO:00458611320.015
epithelial cell differentiationGO:00308551410.015
protein processingGO:00164852260.015
jnk cascadeGO:0007254800.015
anterior posterior axis specificationGO:000994820.015
negative regulation of protein metabolic processGO:00512483910.015
cell projection assemblyGO:00300311260.015
regulation of protein maturationGO:19033171500.015
positive regulation of secretionGO:00510471160.015
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002822290.015
regulation of protein processingGO:00706131500.015
positive regulation of t cell proliferationGO:0042102330.015
positive regulation of lymphocyte proliferationGO:0050671460.014
g1 s transition of mitotic cell cycleGO:0000082780.014
cellular response to abiotic stimulusGO:00712141170.014
cellular response to dna damage stimulusGO:00069743790.014
regulation of response to woundingGO:19030341010.014
regulation of protein localizationGO:00328802960.014
defense response to other organismGO:00985421290.014
positive regulation of protein ubiquitinationGO:0031398530.014
leukocyte mediated immunityGO:0002443590.014
regulation of ras gtpase activityGO:00323181280.014
rhythmic behaviorGO:000762220.013
interferon beta biosynthetic processGO:004535040.013
regulation of cell cycle processGO:00105642660.013
actin cytoskeleton organizationGO:00300362070.013
regulation of microtubule cytoskeleton organizationGO:0070507610.013
positive regulation of cell sizeGO:004579330.013
glycerolipid metabolic processGO:00464861070.013
circulatory system developmentGO:00723592620.013
somitogenesisGO:000175620.013
cytokine production involved in immune responseGO:0002367270.013
protein homooligomerizationGO:00512601000.013
metal ion transportGO:00300012720.013
production of molecular mediator of immune responseGO:0002440370.013
regulation of myeloid leukocyte differentiationGO:0002761390.013
ribonucleoside catabolic processGO:00424544060.013
negative regulation of complement activation classical pathwayGO:004595930.013
transmembrane transportGO:00550853990.013
microtubule based processGO:00070172100.013
regulation of protein stabilityGO:0031647870.013
membrane protein proteolysisGO:0033619380.013
regulation of dna metabolic processGO:00510521530.013
positive regulation of lymphocyte mediated immunityGO:0002708230.013
regulation of cell developmentGO:00602841610.013
regulation of t cell mediated immunityGO:0002709180.013
regulation of defense response to virusGO:0050688330.013
negative regulation of developmental processGO:00510932470.012
cell morphogenesisGO:00009022960.012
posttranscriptional regulation of gene expressionGO:00106082130.012
cilium assemblyGO:0042384630.012
purine ribonucleoside monophosphate metabolic processGO:00091671860.012
actin filament bundle organizationGO:0061572540.012
cytoplasmic transportGO:00164823790.012
cell adhesionGO:00071553250.012
positive regulation of protein bindingGO:0032092240.012
regulation of macrophage differentiationGO:004564990.012
proteasomal protein catabolic processGO:00104981760.012
membrane protein ectodomain proteolysisGO:0006509330.012
secretionGO:00469032540.012
regulation of cytoplasmic transportGO:19036491490.012
regulation of ion transportGO:00432691890.011
actin filament organizationGO:00070151280.011
regulation of lymphocyte differentiationGO:0045619220.011
neuron developmentGO:00486661130.011
tumor necrosis factor superfamily cytokine productionGO:0071706450.011
myeloid cell differentiationGO:00300991170.011
regulation of stress activated protein kinase signaling cascadeGO:0070302850.011
regulation of meiosisGO:004002030.011
neuron differentiationGO:00301821380.011
regulation of syncytium formation by plasma membrane fusionGO:006014220.011
t cell cytokine productionGO:0002369120.011
lymphocyte activation involved in immune responseGO:0002285200.011
agingGO:0007568660.011
chemical homeostasisGO:00488783060.011
intrinsic apoptotic signaling pathwayGO:00971931270.011
cell divisionGO:00513011680.011
negative regulation of blood circulationGO:190352340.011
single organism cellular localizationGO:19025803320.011
positive regulation of tumor necrosis factor superfamily cytokine productionGO:1903557220.011
positive regulation of stress activated protein kinase signaling cascadeGO:0070304610.011
stress activated protein kinase signaling cascadeGO:0031098940.011
tissue regenerationGO:004224630.011
negative regulation of cell cycle processGO:00109481210.010
action potentialGO:0001508340.010
regulation of peptidyl tyrosine phosphorylationGO:00507301080.010
erk1 and erk2 cascadeGO:00703711040.010
innate immune response activating signal transductionGO:0002758480.010
regulation of inflammatory responseGO:0050727460.010
natural killer cell apoptotic processGO:007024610.010
activation of nf kappab inducing kinase activityGO:000725090.010

TANK disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of cellular proliferationDOID:145661740.047
organ system cancerDOID:00506861640.047
cancerDOID:1621670.047
sensory system diseaseDOID:00501552030.031
nervous system diseaseDOID:8634310.031
eye and adnexa diseaseDOID:14921500.031
eye diseaseDOID:56141490.022
retinal diseaseDOID:56791180.022
retinal degenerationDOID:8466890.014
hematopoietic system diseaseDOID:741000.012
immune system diseaseDOID:29141550.012