Homo sapiens

28 known processes

MTHFD1L

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like

(Aliases: dJ292B18.2,DKFZp586G1517,FLJ21145,MTC1THFS,FTHFSDC1)

MTHFD1L biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
oogenesisGO:004847720.125
organonitrogen compound biosynthetic processGO:19015662000.109
Yeast
peripheral nervous system developmentGO:000742220.107
determination of adult lifespanGO:000834020.084
mitotic cell cycleGO:00002783260.083
multicellular organismal agingGO:001025930.083
female gamete generationGO:000729220.081
protein catabolic processGO:00301633250.079
post embryonic developmentGO:000979120.078
proteolysis involved in cellular protein catabolic processGO:00516032440.077
cellular protein catabolic processGO:00442572610.075
negative regulation of cell deathGO:00605483450.073
regulation of mitotic cell cycleGO:00073461890.070
cellular amino acid metabolic processGO:00065201160.068
positive regulation of cell cycleGO:00457871400.066
mitotic cell cycle processGO:19030472860.065
compound eye developmentGO:004874910.063
cellular macromolecule catabolic processGO:00442653800.062
regulation of cell cycleGO:00517263930.062
negative regulation of cell proliferationGO:00082852280.060
spermatid developmentGO:000728640.057
negative regulation of apoptotic processGO:00430663160.055
protein modification by small protein removalGO:0070646920.053
cellular response to dna damage stimulusGO:00069743790.052
developmental programmed cell deathGO:001062330.049
autophagic cell deathGO:004810230.047
negative regulation of programmed cell deathGO:00430693210.046
mitotic cell cycle phase transitionGO:00447721620.045
single organism membrane organizationGO:00448022680.045
amine metabolic processGO:0009308440.044
melanin metabolic processGO:000658210.044
cellular ketone metabolic processGO:0042180800.044
membrane organizationGO:00610242920.043
modification dependent protein catabolic processGO:00199412090.043
organic hydroxy compound metabolic processGO:19016151470.042
amide biosynthetic processGO:0043604150.042
regulation of cell cycle processGO:00105642660.042
spermatid differentiationGO:004851540.041
regulation of protein localizationGO:00328802960.040
modification dependent macromolecule catabolic processGO:00436322120.040
cell morphogenesisGO:00009022960.039
cell projection organizationGO:00300302520.039
regulation of cellular amino acid metabolic processGO:000652160.039
cellular amine metabolic processGO:0044106410.038
regulation of protein transportGO:00512232130.038
vesicle mediated transportGO:00161923710.038
positive regulation of interleukin 1 beta secretionGO:0050718110.038
cellular component morphogenesisGO:00329893140.037
regulation of cellular amine metabolic processGO:0033238110.037
protein autoprocessingGO:001654040.036
posttranscriptional regulation of gene expressionGO:00106082130.036
regulation of secretion by cellGO:19035301770.035
cellular response to external stimulusGO:00714961110.035
regulation of cellular ketone metabolic processGO:0010565500.035
regulation of immune responseGO:00507762010.034
regulation of cell differentiationGO:00455953930.034
cell cycle phase transitionGO:00447701730.034
negative regulation of intracellular signal transductionGO:19025321830.034
endomembrane system organizationGO:00102561960.034
neuron remodelingGO:001632220.034
nervous system developmentGO:00073992930.033
cation transportGO:00068123310.033
positive regulation of cellular amino acid metabolic processGO:004576430.033
response to abiotic stimulusGO:00096283360.033
canonical wnt signaling pathwayGO:00600701160.033
regulation of cellular response to stressGO:00801352440.033
cellular component disassemblyGO:0022411920.033
purine ribonucleoside metabolic processGO:00461284370.032
apoptotic signaling pathwayGO:00971902680.032
positive regulation of transportGO:00510503360.032
dna integrity checkpointGO:0031570710.030
regulation of establishment of protein localizationGO:00702012420.030
positive regulation of cell cycle processGO:00900681060.030
protein deubiquitinationGO:0016579790.030
positive regulation of i kappab kinase nf kappab signalingGO:00431231320.030
regulation of proteolysisGO:00301622930.030
positive regulation of hydrolase activityGO:00513453310.029
nucleoside triphosphate metabolic processGO:00091414220.029
regulation of cell cycle phase transitionGO:19019871260.029
purine nucleoside triphosphate metabolic processGO:00091444120.029
myeloid cell differentiationGO:00300991170.029
positive regulation of cellular amine metabolic processGO:003324070.028
regulation of canonical wnt signaling pathwayGO:0060828880.028
secretion by cellGO:00329402260.028
negative regulation of catalytic activityGO:00430863350.027
positive regulation of cytokine productionGO:00018191670.027
cellular homeostasisGO:00197251960.027
secretionGO:00469032540.027
positive regulation of secretion by cellGO:19035321080.027
regulation of homeostatic processGO:00328441210.027
positive regulation of developmental processGO:00510943140.027
ribonucleotide catabolic processGO:00092614050.027
cell developmentGO:00484683280.027
cell divisionGO:00513011680.027
regulation of secretionGO:00510461940.027
positive regulation of cell differentiationGO:00455972110.026
purine ribonucleotide catabolic processGO:00091544040.026
peptide metabolic processGO:0006518510.026
positive regulation of response to external stimulusGO:0032103880.026
regulation of response to external stimulusGO:00321012220.026
innate immune responseGO:00450871780.026
positive regulation of phosphorylationGO:00423273940.026
organophosphate catabolic processGO:00464344300.026
neuromuscular junction developmentGO:000752830.025
positive regulation of cell deathGO:00109422630.025
anatomical structure formation involved in morphogenesisGO:00486462840.025
cell cycle checkpointGO:00000751170.025
negative regulation of protein metabolic processGO:00512483910.025
i kappab kinase nf kappab signalingGO:00072491660.025
hemopoiesisGO:00300971800.025
negative regulation of cell cycleGO:00457861930.025
nucleoside phosphate catabolic processGO:19012924120.025
ribonucleoside catabolic processGO:00424544060.025
cellular macromolecular complex assemblyGO:00346223240.025
epithelium developmentGO:00604292270.025
response to radiationGO:00093141510.025
negative regulation of mitotic cell cycleGO:00459301020.025
glycosyl compound catabolic processGO:19016584130.025
purine ribonucleoside triphosphate catabolic processGO:00092073910.025
positive regulation of cytokine secretionGO:0050715420.024
immune responseGO:00069553070.024
ribonucleoside triphosphate catabolic processGO:00092033910.024
positive regulation of protein phosphorylationGO:00019343130.024
regulation of transferase activityGO:00513383550.024
purine ribonucleoside catabolic processGO:00461303980.024
positive regulation of immune system processGO:00026842830.024
ion transmembrane transportGO:00342203380.023
positive regulation of cellular component organizationGO:00511303760.023
carbohydrate derivative biosynthetic processGO:19011372070.023
regulation of multi organism processGO:00439001570.023
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.023
positive regulation of secretionGO:00510471160.023
regulation of apoptotic signaling pathwayGO:20012331750.023
cellular amide metabolic processGO:0043603690.023
regulation of mitotic cell cycle phase transitionGO:19019901180.023
positive regulation of protein transportGO:00512221350.023
protein maturationGO:00516042330.023
locomotory behaviorGO:000762610.023
cellular response to radiationGO:0071478650.022
purine containing compound catabolic processGO:00725234110.022
cell projection morphogenesisGO:00488581290.022
neurogenesisGO:00220081690.022
circadian behaviorGO:004851220.022
regulation of defense responseGO:00313471540.022
ras protein signal transductionGO:0007265730.022
positive regulation of apoptotic processGO:00430652460.022
negative regulation of cell cycle processGO:00109481210.022
regulation of i kappab kinase nf kappab signalingGO:00431221620.022
positive regulation of proteolysisGO:00458621420.022
positive regulation of humoral immune responseGO:000292230.022
regulation of dna metabolic processGO:00510521530.022
metal ion transportGO:00300012720.022
organophosphate biosynthetic processGO:00904071630.022
negative regulation of mitotic cell cycle phase transitionGO:1901991850.022
purine ribonucleoside triphosphate metabolic processGO:00092054110.021
immune effector processGO:00022521590.021
cytoplasmic transportGO:00164823790.021
regulation of cell cycle arrestGO:0071156360.021
negative regulation of cellular protein metabolic processGO:00322693530.021
regulation of endopeptidase activityGO:00525481700.021
response to light stimulusGO:0009416870.021
protein oligomerizationGO:00512591730.021
dna replicationGO:00062601160.021
endocytosisGO:00068971590.021
wnt signaling pathwayGO:00160551560.021
immune system developmentGO:00025201950.021
purine nucleotide catabolic processGO:00061954050.021
positive regulation of catabolic processGO:00098963100.020
ribonucleoside triphosphate metabolic processGO:00091994120.020
regulation of kinase activityGO:00435493140.020
small gtpase mediated signal transductionGO:0007264780.020
generation of neuronsGO:00486991520.020
vesicle organizationGO:0016050620.020
nucleoside catabolic processGO:00091644080.020
regulation of purine nucleotide metabolic processGO:19005422640.020
negative regulation of phosphate metabolic processGO:00459362670.020
protein processingGO:00164852260.020
central nervous system developmentGO:00074171230.020
positive regulation of immune responseGO:00507781590.020
segmentationGO:003528240.020
regulation of protein kinase activityGO:00458592890.019
cell part morphogenesisGO:00329901370.019
purine nucleoside triphosphate catabolic processGO:00091463920.019
cellular response to abiotic stimulusGO:00712141170.019
antibacterial humoral responseGO:0019731240.019
trail activated apoptotic signaling pathwayGO:003646240.019
epithelial cell differentiationGO:00308551410.019
cell type specific apoptotic processGO:00972851250.019
response to cytokineGO:00340972320.019
regulation of nucleotide metabolic processGO:00061402690.019
regulation of protein stabilityGO:0031647870.019
neuron differentiationGO:00301821380.019
dna damage checkpointGO:0000077680.019
anion transportGO:00068201610.019
neuron projection developmentGO:00311751060.019
regulation of response to dna damage stimulusGO:2001020940.019
covalent chromatin modificationGO:00165692540.019
regulation of immune effector processGO:0002697910.019
cell morphogenesis involved in differentiationGO:00009041440.019
negative regulation of phosphorus metabolic processGO:00105632670.019
intrinsic apoptotic signaling pathwayGO:00971931270.019
regulation of myeloid cell differentiationGO:0045637810.019
positive regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathwayGO:200126910.019
membrane buddingGO:0006900280.018
regulation of cellular component movementGO:00512703340.018
purine nucleoside catabolic processGO:00061523980.018
negative regulation of cellular component organizationGO:00511292350.018
regulation of cytokine secretionGO:0050707570.018
biological adhesionGO:00226103310.018
protein depolymerizationGO:0051261300.018
positive regulation of kinase activityGO:00336742040.018
regulation of locomotionGO:00400123290.018
positive regulation of cellular catabolic processGO:00313312840.018
negative regulation of cell cycle phase transitionGO:1901988890.018
regulation of leukocyte differentiationGO:1902105610.018
cell adhesionGO:00071553250.018
regulation of wnt signaling pathwayGO:00301111230.018
positive regulation of transferase activityGO:00513472270.018
regulation of peptidase activityGO:00525471800.018
chemical homeostasisGO:00488783060.018
protein complex disassemblyGO:0043241520.018
positive regulation of smoothened signaling pathwayGO:004588040.018
regulation of mapk cascadeGO:00434082620.018
signal transduction by phosphorylationGO:00230142970.017
cation transmembrane transportGO:00986552380.017
carbohydrate metabolic processGO:00059752070.017
actin filament based processGO:00300292240.017
nucleotide catabolic processGO:00091664080.017
regulation of protein secretionGO:0050708860.017
regulation of protein serine threonine kinase activityGO:00719001790.017
positive regulation of canonical wnt signaling pathwayGO:0090263330.017
positive regulation of wnt signaling pathwayGO:0030177540.017
defense responseGO:00069523150.017
nucleoside triphosphate catabolic processGO:00091433940.017
protein stabilizationGO:0050821640.017
lipid metabolic processGO:00066293810.017
rhythmic behaviorGO:000762220.017
rho protein signal transductionGO:0007266260.017
regulation of cell migrationGO:00303342890.017
maintenance of locationGO:00512351120.017
dephosphorylationGO:00163112090.017
cellular protein complex disassemblyGO:0043624360.016
regenerationGO:003109940.016
protein modification by small protein conjugationGO:00324463420.016
regulation of antimicrobial humoral responseGO:000275910.016
macromolecular complex disassemblyGO:0032984600.016
system processGO:00030083490.016
humoral immune responseGO:0006959490.016
response to oxygen containing compoundGO:19017003690.016
neurological system processGO:00508771630.016
single organism cellular localizationGO:19025803320.016
single organism carbohydrate metabolic processGO:00447231930.016
response to uvGO:0009411730.016
cell cycle arrestGO:0007050710.016
cell cycle g1 s phase transitionGO:0044843800.016
guanosine containing compound metabolic processGO:19010682440.016
nucleoside monophosphate metabolic processGO:00091231910.016
g1 s transition of mitotic cell cycleGO:0000082780.016
negative regulation of hydrolase activityGO:00513461820.016
regulation of anatomical structure morphogenesisGO:00226032860.016
regulation of g1 s transition of mitotic cell cycleGO:2000045400.016
blastoderm segmentationGO:000735020.016
mapk cascadeGO:00001652880.015
positive regulation of protein secretionGO:0050714600.015
inorganic ion transmembrane transportGO:00986602310.015
chromatin modificationGO:00165682980.015
chromatin organizationGO:00063253510.015
regulation of cellular component biogenesisGO:00440872810.015
extrinsic apoptotic signaling pathwayGO:00971911190.015
regulation of innate immune responseGO:0045088970.015
cell activationGO:00017752130.015
regulation of cytokine productionGO:00018172320.015
neuron developmentGO:00486661130.015
cytokinesisGO:0000910960.015
regulation of cytoskeleton organizationGO:00514931770.015
cellular lipid metabolic processGO:00442553030.015
microtubule based processGO:00070172100.015
regulation of protein catabolic processGO:00421761550.015
zymogen activationGO:0031638700.015
morphogenesis of embryonic epitheliumGO:001633140.015
regulation of nucleoside metabolic processGO:00091182090.015
positive regulation of mitotic cell cycleGO:0045931600.015
rna processingGO:00063962550.015
single organism reproductive processGO:0044702980.015
regulation of purine nucleotide catabolic processGO:00331212050.015
regulation of branching involved in ureteric bud morphogenesisGO:009018930.015
defense response to virusGO:0051607710.015
protein secretionGO:0009306980.014
response to other organismGO:00517072610.014
positive regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043280690.014
hematopoietic or lymphoid organ developmentGO:00485341860.014
small molecule biosynthetic processGO:00442831570.014
autophagyGO:0006914880.014
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:00432811160.014
gtp metabolic processGO:00460392390.014
positive regulation of defense responseGO:0031349870.014
negative regulation of developmental processGO:00510932470.014
positive regulation of purine nucleotide metabolic processGO:19005442270.014
positive regulation of peptidase activityGO:0010952880.014
protein k63 linked deubiquitinationGO:0070536210.014
positive regulation of innate immune responseGO:0045089790.014
inorganic cation transmembrane transportGO:00986621940.014
positive regulation of nucleotide catabolic processGO:00308131850.014
negative regulation of multicellular organismal processGO:00512413170.014
cytokine secretionGO:0050663640.014
regulation of nucleotide catabolic processGO:00308112050.014
negative regulation of cellular amino acid metabolic processGO:004576320.014
gtp catabolic processGO:00061842370.014
actin filament based movementGO:0030048170.014
adult locomotory behaviorGO:000834410.014
proteasomal protein catabolic processGO:00104981760.014
organelle assemblyGO:00709251760.014
transmembrane transportGO:00550853990.014
response to biotic stimulusGO:00096072760.014
negative regulation of cellular amine metabolic processGO:003323930.014
regulation of cysteine type endopeptidase activityGO:20001161270.014
response to external biotic stimulusGO:00432072610.014
negative regulation of protein modification processGO:00314002000.014
oocyte developmentGO:004859910.014
guanosine containing compound catabolic processGO:19010692390.013
reproductive processGO:00224141060.013
hindbrain developmentGO:003090230.013
syncytium formation by plasma membrane fusionGO:000076820.013
microtubule cytoskeleton organizationGO:00002261760.013
regulation of intracellular transportGO:00323861950.013
positive regulation of antimicrobial humoral responseGO:000276010.013
activation of cysteine type endopeptidase activity involved in apoptotic processGO:0006919490.013
anterior posterior axis specificationGO:000994820.013
cellular protein complex assemblyGO:00436231880.013
positive regulation of programmed cell deathGO:00430682490.013
cellular response to uvGO:0034644320.013
oxidation reduction processGO:00551143960.013
Yeast
mitotic cell cycle checkpointGO:0007093680.013
negative regulation of protein processingGO:00109551420.013
regulation of autophagyGO:0010506520.013
positive regulation of endopeptidase activityGO:0010950840.013
positive regulation of purine nucleotide catabolic processGO:00331231850.013
response to tumor necrosis factorGO:0034612760.013
regulation of protein maturationGO:19033171500.013
purine ribonucleoside monophosphate metabolic processGO:00091671860.013
regulation of cell motilityGO:20001452990.013
divalent inorganic cation transportGO:00725111580.013
positive regulation of nucleotide metabolic processGO:00459812300.013
purine nucleoside monophosphate metabolic processGO:00091261860.013
histone modificationGO:00165702510.013
enzyme linked receptor protein signaling pathwayGO:00071673030.013
positive regulation of protein kinase activityGO:00458601900.013
leukocyte activationGO:00453211640.013
positive regulation of multi organism processGO:0043902560.013
limbic system developmentGO:002176130.013
myeloid leukocyte differentiationGO:0002573600.013
regulation of dna replicationGO:0006275680.012
cell growthGO:00160491600.012
regulation of interleukin 1 secretionGO:0050704140.012
embryonic epithelial tube formationGO:000183840.012
positive regulation of gtp catabolic processGO:00331261660.012
cation homeostasisGO:00550801890.012
protein targetingGO:00066051870.012
positive regulation of nucleoside metabolic processGO:00459791860.012
myoblast fusionGO:000752010.012
protein localization to membraneGO:00726571600.012
ion homeostasisGO:00508012300.012
neuroblast proliferationGO:000740540.012
regulation of response to biotic stimulusGO:0002831550.012
establishment of protein localization to membraneGO:00901501210.012
regulation of neural precursor cell proliferationGO:200017740.012
oocyte differentiationGO:000999420.012
nucleotide biosynthetic processGO:00091651090.012
growthGO:00400072020.012
cellular response to endogenous stimulusGO:00714953360.012
cellular cation homeostasisGO:00300031630.012
dna repairGO:00062811980.012
regulation of defense response to bacteriumGO:190042420.012
lipid biosynthetic processGO:00086101770.012
response to organic cyclic compoundGO:00140702040.012
organic acid transportGO:0015849650.012
regulation of cell morphogenesisGO:00226041530.012
actin cytoskeleton organizationGO:00300362070.012
protein ubiquitinationGO:00165673140.012
positive regulation of cell cycle arrestGO:0071158230.012
actin mediated cell contractionGO:0070252120.012
cytokine productionGO:00018162470.012
negative regulation of organelle organizationGO:00106391260.012
carboxylic acid transportGO:0046942630.012
activation of cysteine type endopeptidase activityGO:0097202570.012
regulation of ion transportGO:00432691890.012
regulation of gtp catabolic processGO:00331241800.012
ubiquitin dependent protein catabolic processGO:00065112060.012
response to bacteriumGO:00096171440.011
organ morphogenesisGO:00098871470.011
execution phase of apoptosisGO:0097194320.011
mitotic nuclear divisionGO:00070671190.011
signal transduction by p53 class mediatorGO:0072331720.011
regulation of protein processingGO:00706131500.011
regulation of cell cycle g1 s phase transitionGO:1902806420.011
positive regulation of cell proliferationGO:00082843010.011
mitochondrion organizationGO:00070051560.011
intracellular protein transportGO:00068862700.011
defense response to bacteriumGO:0042742630.011
leukocyte differentiationGO:0002521980.011
sequestering of metal ionGO:0051238240.011
smoothened signaling pathwayGO:0007224140.011
positive regulation of defense response to bacteriumGO:190042610.011
negative regulation of proteolysisGO:00458611320.011
ribonucleoside monophosphate metabolic processGO:00091611870.011
cellular chemical homeostasisGO:00550821800.011
cell projection assemblyGO:00300311260.011
positive regulation of interleukin 1 productionGO:0032732140.011
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.011
regulation of cell divisionGO:00513021160.011
developmental process involved in reproductionGO:0003006660.011
production of molecular mediator of immune responseGO:0002440370.011
inner ear morphogenesisGO:004247240.011
positive regulation of cysteine type endopeptidase activityGO:2001056790.011
response to axon injuryGO:004867810.011
midgut developmentGO:000749410.011
positive regulation of cell migrationGO:00303351720.011
single organism cell adhesionGO:00986021790.011
organic acid biosynthetic processGO:0016053970.011
positive regulation of organelle organizationGO:00106381950.011
response to nitrogen compoundGO:19016981840.011
defense response to other organismGO:00985421290.011
alpha amino acid metabolic processGO:1901605720.011
sleepGO:003043120.011
cardiac muscle cell contractionGO:008600340.011
calcium ion transportGO:00068161470.011
cellular ion homeostasisGO:00068731680.011
protein localization to organelleGO:00333652800.011
positive regulation of synaptic transmissionGO:005080640.011
nucleoside phosphate biosynthetic processGO:19012931090.011
nucleocytoplasmic transportGO:00069131760.010
tripartite regional subdivisionGO:000735120.010
regulation of vesicle mediated transportGO:00606271300.010
monocarboxylic acid metabolic processGO:00327871850.010
regulation of growthGO:00400081650.010
interleukin 1 beta productionGO:0032611220.010
nitrogen compound transportGO:00717051910.010
purine ribonucleoside monophosphate catabolic processGO:00091691580.010
reactive oxygen species metabolic processGO:0072593750.010
negative regulation of protein phosphorylationGO:00019331400.010
regulation of gtpase activityGO:00430871800.010
tissue regenerationGO:004224630.010
organelle fissionGO:00482851490.010
positive regulation of protein serine threonine kinase activityGO:00719021190.010
sensory organ developmentGO:0007423520.010
metal ion homeostasisGO:00550651690.010
regulation of defense response to virusGO:0050688330.010
neural tube formationGO:000184130.010
positive regulation of mapk cascadeGO:00434101900.010
metencephalon developmentGO:002203720.010
glycoprotein metabolic processGO:00091001100.010
associative learningGO:000830610.010
response to mechanical stimulusGO:0009612510.010
regulation of cell projection organizationGO:00313441070.010
reactive oxygen species biosynthetic processGO:190340940.010

MTHFD1L disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:00146672950.023
inherited metabolic disorderDOID:6552420.023
cancerDOID:1621670.022
organ system cancerDOID:00506861640.022
disease of cellular proliferationDOID:145661740.022
musculoskeletal system diseaseDOID:172230.021
central nervous system diseaseDOID:3311860.019
nervous system diseaseDOID:8634310.019
sensory system diseaseDOID:00501552030.016
eye diseaseDOID:56141490.012
eye and adnexa diseaseDOID:14921500.012
connective tissue diseaseDOID:651090.012
immune system diseaseDOID:29141550.011
retinal diseaseDOID:56791180.011
bone diseaseDOID:0080001880.011