Homo sapiens

0 known processes

PPEF1

protein phosphatase, EF-hand calcium binding domain 1

(Aliases: PPP7C,PP7,PPEF,PPP7CA)

PPEF1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular amino acid metabolic processGO:00065201160.075
positive regulation of cellular amino acid metabolic processGO:004576430.065
amine metabolic processGO:0009308440.064
regulation of cellular amino acid metabolic processGO:000652160.063
ion transmembrane transportGO:00342203380.059
regulation of cellular amine metabolic processGO:0033238110.059
regulation of transmission of nerve impulseGO:005196920.059
post embryonic developmentGO:000979120.058
cellular ketone metabolic processGO:0042180800.052
positive regulation of cellular amine metabolic processGO:003324070.052
regulation of cellular ketone metabolic processGO:0010565500.050
cellular amine metabolic processGO:0044106410.049
positive regulation of transportGO:00510503360.046
transmembrane transportGO:00550853990.046
purine nucleotide catabolic processGO:00061954050.042
small gtpase mediated signal transductionGO:0007264780.041
ribonucleoside catabolic processGO:00424544060.041
purine ribonucleoside triphosphate catabolic processGO:00092073910.040
ras protein signal transductionGO:0007265730.040
purine ribonucleoside catabolic processGO:00461303980.040
vesicle mediated transportGO:00161923710.040
positive regulation of phosphorylationGO:00423273940.039
purine ribonucleoside triphosphate metabolic processGO:00092054110.039
multicellular organismal agingGO:001025930.037
regulation of cytokine productionGO:00018172320.037
regulation of secretion by cellGO:19035301770.037
purine containing compound catabolic processGO:00725234110.035
female gamete generationGO:000729220.035
guanosine containing compound metabolic processGO:19010682440.035
purine ribonucleotide catabolic processGO:00091544040.035
purine ribonucleoside metabolic processGO:00461284370.034
purine nucleoside triphosphate metabolic processGO:00091444120.034
nucleoside triphosphate metabolic processGO:00091414220.034
neuromuscular junction developmentGO:000752830.034
system processGO:00030083490.034
oogenesisGO:004847720.034
nucleotide catabolic processGO:00091664080.033
locomotory behaviorGO:000762610.033
positive regulation of acrosome reactionGO:200034440.033
regulation of protein localizationGO:00328802960.033
negative regulation of protein metabolic processGO:00512483910.033
Human
immune responseGO:00069553070.032
determination of adult lifespanGO:000834020.032
ribonucleotide catabolic processGO:00092614050.032
cell morphogenesisGO:00009022960.032
ribonucleoside triphosphate metabolic processGO:00091994120.032
glycosyl compound catabolic processGO:19016584130.031
ribonucleoside triphosphate catabolic processGO:00092033910.031
single organism membrane organizationGO:00448022680.031
nucleoside catabolic processGO:00091644080.031
secretion by cellGO:00329402260.031
regulation of secretionGO:00510461940.030
organophosphate catabolic processGO:00464344300.030
purine nucleoside catabolic processGO:00061523980.030
nervous system developmentGO:00073992930.030
nucleoside triphosphate catabolic processGO:00091433940.030
gtp catabolic processGO:00061842370.029
secretionGO:00469032540.029
positive regulation of cellular component organizationGO:00511303760.029
cell adhesionGO:00071553250.029
negative regulation of cellular protein metabolic processGO:00322693530.029
Human
negative regulation of transmission of nerve impulseGO:005197010.029
biological adhesionGO:00226103310.029
memoryGO:000761330.029
purine nucleoside triphosphate catabolic processGO:00091463920.028
nucleoside phosphate catabolic processGO:19012924120.028
gamma aminobutyric acid signaling pathwayGO:000721430.028
inorganic cation transmembrane transportGO:00986621940.027
regulation of nucleotide metabolic processGO:00061402690.027
regulation of kinase activityGO:00435493140.027
regulation of transferase activityGO:00513383550.027
cell developmentGO:00484683280.027
cell projection organizationGO:00300302520.027
positive regulation of nucleotide metabolic processGO:00459812300.026
membrane organizationGO:00610242920.026
gtp metabolic processGO:00460392390.026
positive regulation of protein phosphorylationGO:00019343130.026
regulation of proteolysisGO:00301622930.026
cellular response to histamineGO:007142030.026
positive regulation of hydrolase activityGO:00513453310.026
defense responseGO:00069523150.026
regulation of acrosome reactionGO:006004640.026
response to abiotic stimulusGO:00096283360.026
Fly
cellular response to endogenous stimulusGO:00714953360.026
single organism cellular localizationGO:19025803320.026
protein catabolic processGO:00301633250.025
rho protein signal transductionGO:0007266260.025
g protein coupled receptor signaling pathwayGO:00071862070.025
Fly
regenerationGO:003109940.025
positive regulation of catabolic processGO:00098963100.025
guanosine containing compound catabolic processGO:19010692390.025
response to organic cyclic compoundGO:00140702040.025
cellular macromolecule catabolic processGO:00442653800.025
cation transmembrane transportGO:00986552380.025
regulation of cell cycleGO:00517263930.025
enzyme linked receptor protein signaling pathwayGO:00071673030.024
negative regulation of catalytic activityGO:00430863350.024
protein localization to organelleGO:00333652800.024
cytoplasmic transportGO:00164823790.024
regulation of cellular component biogenesisGO:00440872810.024
response to external biotic stimulusGO:00432072610.024
cellular component morphogenesisGO:00329893140.024
positive regulation of cell proliferationGO:00082843010.023
protein processingGO:00164852260.023
cytokine productionGO:00018162470.023
negative regulation of phosphorus metabolic processGO:00105632670.023
Human
positive regulation of nucleoside metabolic processGO:00459791860.023
protein maturationGO:00516042330.023
negative regulation of cell deathGO:00605483450.023
regulation of cellular component movementGO:00512703340.023
anion transportGO:00068201610.023
regulation of cell migrationGO:00303342890.023
negative regulation of phosphate metabolic processGO:00459362670.023
Human
associative learningGO:000830610.023
cation transportGO:00068123310.023
startle responseGO:000196430.022
signal transduction by phosphorylationGO:00230142970.022
Human
regulation of establishment of protein localizationGO:00702012420.022
regulation of protein kinase activityGO:00458592890.022
regulation of nucleotide catabolic processGO:00308112050.022
regulation of nucleoside metabolic processGO:00091182090.022
negative regulation of multicellular organismal processGO:00512413170.022
negative regulation of programmed cell deathGO:00430693210.022
regulation of cell motilityGO:20001452990.022
positive regulation of cellular catabolic processGO:00313312840.022
innate immune responseGO:00450871780.021
negative regulation of cellular component organizationGO:00511292350.021
intracellular protein transportGO:00068862700.021
positive regulation of transferase activityGO:00513472270.021
photoreceptor cell differentiationGO:004653020.021
nitrogen compound transportGO:00717051910.021
neurogenesisGO:00220081690.021
positive regulation of cell differentiationGO:00455972110.021
response to biotic stimulusGO:00096072760.021
mitotic cell cycleGO:00002783260.021
inorganic ion transmembrane transportGO:00986602310.021
protein modification by small protein conjugationGO:00324463420.021
cellular protein catabolic processGO:00442572610.020
negative regulation of transportGO:00510511760.020
positive regulation of purine nucleotide metabolic processGO:19005442270.020
mapk cascadeGO:00001652880.020
Human
neurological system processGO:00508771630.020
regulation of gtp catabolic processGO:00331241800.020
positive regulation of kinase activityGO:00336742040.020
response to oxygen containing compoundGO:19017003690.020
regulation of locomotionGO:00400123290.020
regulation of anatomical structure morphogenesisGO:00226032860.020
regulation of ion transportGO:00432691890.020
regulation of cell differentiationGO:00455953930.020
single organism cell adhesionGO:00986021790.020
neurotransmitter secretionGO:000726940.020
regulation of purine nucleotide metabolic processGO:19005422640.020
adult locomotory behaviorGO:000834410.020
cellular macromolecular complex assemblyGO:00346223240.020
regulation of immune responseGO:00507762010.020
segmentationGO:003528240.019
cellular response to oxygen containing compoundGO:19017012760.019
lipid metabolic processGO:00066293810.019
anterior posterior axis specificationGO:000994820.019
cellular response to dna damage stimulusGO:00069743790.019
positive regulation of gtp catabolic processGO:00331261660.019
regulation of protein transportGO:00512232130.019
actin filament based processGO:00300292240.019
dephosphorylationGO:00163112090.019
Fly
positive regulation of organelle organizationGO:00106381950.019
response to other organismGO:00517072610.019
oocyte differentiationGO:000999420.019
regulation of response to external stimulusGO:00321012220.019
Fly
positive regulation of apoptotic processGO:00430652460.019
regulation of vesicle mediated transportGO:00606271300.019
protein ubiquitinationGO:00165673140.019
cellular lipid metabolic processGO:00442553030.018
generation of neuronsGO:00486991520.018
regulation of endopeptidase activityGO:00525481700.018
chromatin organizationGO:00063253510.018
oocyte developmentGO:004859910.018
positive regulation of synaptic transmissionGO:005080640.018
negative regulation of apoptotic processGO:00430663160.018
response to woundingGO:00096111680.018
positive regulation of cellular component movementGO:00512721810.018
regulation of synaptic plasticityGO:004816730.018
negative regulation of cell proliferationGO:00082852280.018
oxidation reduction processGO:00551143960.018
positive regulation of cellular component biogenesisGO:00440891580.018
mitotic cell cycle processGO:19030472860.018
positive regulation of secretion by cellGO:19035321080.018
spermatid differentiationGO:004851540.018
negative regulation of cellular amine metabolic processGO:003323930.018
positive regulation of purine nucleotide catabolic processGO:00331231850.017
regulation of purine nucleotide catabolic processGO:00331212050.017
positive regulation of immune system processGO:00026842830.017
regulation of ras protein signal transductionGO:00465781550.017
proteolysis involved in cellular protein catabolic processGO:00516032440.017
growthGO:00400072020.017
negative regulation of hydrolase activityGO:00513461820.017
regulation of cellular response to stressGO:00801352440.017
regulation of cytoskeleton organizationGO:00514931770.017
regulation of intracellular transportGO:00323861950.017
endomembrane system organizationGO:00102561960.017
cellular response to growth factor stimulusGO:00713631970.017
regulation of membrane potentialGO:0042391950.017
exocytosisGO:0006887710.017
protein targetingGO:00066051870.017
microtubule based processGO:00070172100.017
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.017
organonitrogen compound biosynthetic processGO:19015662000.017
regulation of multi organism processGO:00439001570.017
positive regulation of cell migrationGO:00303351720.017
anatomical structure formation involved in morphogenesisGO:00486462840.017
response to nitrogen compoundGO:19016981840.017
positive regulation of gtpase activityGO:00435471660.016
protein oligomerizationGO:00512591730.016
blastoderm segmentationGO:000735020.016
positive regulation of secretionGO:00510471160.016
cell growthGO:00160491600.016
carbohydrate derivative biosynthetic processGO:19011372070.016
regulation of protein catabolic processGO:00421761550.016
positive regulation of cell deathGO:00109422630.016
neuron developmentGO:00486661130.016
regulation of cell cycle processGO:00105642660.016
ion homeostasisGO:00508012300.016
apoptotic signaling pathwayGO:00971902680.016
positive regulation of developmental processGO:00510943140.016
nucleotide biosynthetic processGO:00091651090.016
response to fungusGO:000962040.016
establishment of protein localization to organelleGO:00725941720.016
negative regulation of cell cycleGO:00457861930.016
regulation of protein maturationGO:19033171500.016
spermatid developmentGO:000728640.016
reactive nitrogen species metabolic processGO:200105730.016
response to lipidGO:00339932060.016
hindbrain developmentGO:003090230.016
chromatin modificationGO:00165682980.016
chemical homeostasisGO:00488783060.016
tripartite regional subdivisionGO:000735120.016
negative regulation of cellular amino acid metabolic processGO:004576320.016
visual behaviorGO:000763220.015
response to growth factorGO:00708482050.015
posttranscriptional regulation of gene expressionGO:00106082130.015
response to radiationGO:00093141510.015
Fly
regulation of ras gtpase activityGO:00323181280.015
motor neuron axon guidanceGO:000804520.015
positive regulation of nucleotide catabolic processGO:00308131850.015
metal ion transportGO:00300012720.015
anterior posterior axis specification embryoGO:000859520.015
metencephalon developmentGO:002203720.015
peptidyl tyrosine phosphorylationGO:00181081700.015
negative regulation of protein maturationGO:19033181420.015
positive regulation of programmed cell deathGO:00430682490.015
forelimb morphogenesisGO:003513640.015
negative regulation of protein modification processGO:00314002000.015
Human
positive regulation of protein kinase activityGO:00458601900.015
visual learningGO:000854210.015
cellular chemical homeostasisGO:00550821800.015
transmission of nerve impulseGO:0019226110.015
organophosphate biosynthetic processGO:00904071630.015
regulation of hormone levelsGO:00108171250.015
postsynaptic membrane organizationGO:000194120.015
response to cytokineGO:00340972320.015
cellular protein complex assemblyGO:00436231880.015
organelle assemblyGO:00709251760.015
peptidyl tyrosine modificationGO:00182121700.015
regulation of protein processingGO:00706131500.015
neuropeptide signaling pathwayGO:0007218190.015
nuclear transportGO:00511691790.015
regulation of cell developmentGO:00602841610.015
neuroblast proliferationGO:000740540.015
regulation of cell adhesionGO:00301551660.015
lipid biosynthetic processGO:00086101770.015
muscle contractionGO:0006936730.015
neuron differentiationGO:00301821380.015
regulation of gtpase activityGO:00430871800.014
long term memoryGO:000761620.014
modification dependent macromolecule catabolic processGO:00436322120.014
glycoprotein metabolic processGO:00091001100.014
regulation of cytoplasmic transportGO:19036491490.014
reactive oxygen species biosynthetic processGO:190340940.014
cellular response to organic cyclic compoundGO:00714071270.014
actin cytoskeleton organizationGO:00300362070.014
cell part morphogenesisGO:00329901370.014
negative regulation of intracellular signal transductionGO:19025321830.014
Human
nerve developmentGO:002167540.014
protein localization to membraneGO:00726571600.014
i kappab kinase nf kappab signalingGO:00072491660.014
cellular response to ammonium ionGO:007124240.014
positive regulation of cell motilityGO:20001471770.014
negative regulation of proteolysisGO:00458611320.014
maintenance of locationGO:00512351120.014
reactive oxygen species metabolic processGO:0072593750.014
regulation of peptidase activityGO:00525471800.014
negative regulation of protein processingGO:00109551420.014
compound eye developmentGO:004874910.014
neuron projection regenerationGO:003110210.014
regulation of mapk cascadeGO:00434082620.014
Human
epidermal growth factor activated receptor transactivation by g protein coupled receptor signaling pathwayGO:003562540.014
response to axon injuryGO:004867810.014
taxisGO:00423301570.014
Fly
monovalent inorganic cation transportGO:00156721280.014
cell activationGO:00017752130.013
regulation of reactive oxygen species biosynthetic processGO:190342630.013
ameboidal type cell migrationGO:00016671350.013
synaptic transmission involved in micturitionGO:006008420.013
regulation of small gtpase mediated signal transductionGO:00510561560.013
circulatory system developmentGO:00723592620.013
negative regulation of cytokine productionGO:0001818820.013
histone modificationGO:00165702510.013
divalent metal ion transportGO:00708381520.013
modification dependent protein catabolic processGO:00199412090.013
protein localization to nucleusGO:00345041360.013
cellular response to nitrogen compoundGO:19016991440.013
ubiquitin dependent protein catabolic processGO:00065112060.013
mitochondrion organizationGO:00070051560.013
epithelial cell migrationGO:00106311190.013
negative regulation of phosphorylationGO:00423261740.013
Human
tissue regenerationGO:004224630.013
positive regulation of ras gtpase activityGO:00323201170.013
calcium ion transportGO:00068161470.013
cell substrate adhesionGO:00315891320.013
inner ear morphogenesisGO:004247240.013
synaptic transmission cholinergicGO:000727120.013
positive regulation of reactive oxygen species biosynthetic processGO:190342820.013
microtubule cytoskeleton organizationGO:00002261760.013
protein autophosphorylationGO:00467771230.013
regulation of meiotic cell cycleGO:005144540.013
metal ion homeostasisGO:00550651690.013
regulation of protein serine threonine kinase activityGO:00719001790.013
cell projection assemblyGO:00300311260.013
positive regulation of protein serine threonine kinase activityGO:00719021190.013
salivary gland morphogenesisGO:000743540.013
cell divisionGO:00513011680.013
morphogenesis of embryonic epitheliumGO:001633140.013
divalent inorganic cation transportGO:00725111580.013
regulation of growthGO:00400081650.013
regulation of cell growthGO:00015581350.013
positive regulation of locomotionGO:00400171860.013
ribonucleoside monophosphate metabolic processGO:00091611870.013
positive regulation of sequence specific dna binding transcription factor activityGO:00510911310.013
proteasomal protein catabolic processGO:00104981760.013
cerebellum developmentGO:002154920.013
cell cycle phase transitionGO:00447701730.013
sensory perception of painGO:001923340.012
response to organonitrogen compoundGO:00102431560.012
stem cell divisionGO:001714520.012
syncytium formation by plasma membrane fusionGO:000076820.012
limbic system developmentGO:002176130.012
regulation of mitotic cell cycleGO:00073461890.012
single organism carbohydrate metabolic processGO:00447231930.012
cellular response to organonitrogen compoundGO:00714171240.012
cell morphogenesis involved in differentiationGO:00009041440.012
response to hormoneGO:00097251750.012
dna repairGO:00062811980.012
serotonin transportGO:000683730.012
positive regulation of hormone biosynthetic processGO:004688640.012
defense response to fungusGO:005083240.012
regulation of cell morphogenesisGO:00226041530.012
cellular homeostasisGO:00197251960.012
regulation of transmembrane transportGO:00347621390.012
negative regulation of developmental processGO:00510932470.012
regulation of protein complex assemblyGO:00432541470.012
establishment of protein localization to membraneGO:00901501210.012
actin filament organizationGO:00070151280.012
peptidyl serine modificationGO:00182091060.012
rhythmic behaviorGO:000762220.012
regulation of peptidyl tyrosine phosphorylationGO:00507301080.012
cardiovascular system developmentGO:00723582620.012
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.012
mitotic cell cycle phase transitionGO:00447721620.012
peptidyl serine phosphorylationGO:00181051010.012
regulation of acetylcholine gated cation channel activityGO:190304810.012
purine nucleoside monophosphate metabolic processGO:00091261860.012
endocytosisGO:00068971590.012
negative regulation of synaptic transmissionGO:005080520.012
spinal cord developmentGO:002151040.012
positive regulation of immune responseGO:00507781590.012
carbohydrate metabolic processGO:00059752070.012
multicellular organismal signalingGO:0035637340.012
anion transmembrane transportGO:0098656760.012
negative regulation of neurological system processGO:003164520.012
immune effector processGO:00022521590.012
negative regulation of cellular catabolic processGO:0031330830.012
nucleocytoplasmic transportGO:00069131760.012
nucleoside phosphate biosynthetic processGO:19012931090.012
negative regulation of interleukin 5 secretionGO:200066310.012
regulation of cell activationGO:00508651250.012
cell cell signalingGO:00072671550.012
embryonic forelimb morphogenesisGO:003511540.012
behaviorGO:00076101120.012
positive regulation of mapk cascadeGO:00434101900.012
single organismal cell cell adhesionGO:00163371480.012
negative regulation of catabolic processGO:00098951040.011
meiotic chromosome segregationGO:004513240.011
positive regulation of proteolysisGO:00458621420.011
positive regulation of reactive oxygen species metabolic processGO:2000379240.011
regulation of cell projection organizationGO:00313441070.011
purine ribonucleotide biosynthetic processGO:0009152790.011
interspecies interaction between organismsGO:00444191560.011
purine ribonucleoside monophosphate metabolic processGO:00091671860.011
leukocyte activationGO:00453211640.011
matingGO:000761810.011
muscle system processGO:0003012810.011
positive regulation of cytokine productionGO:00018191670.011
regulation of apoptotic signaling pathwayGO:20012331750.011
endosomal transportGO:00161971290.011
sequestering of metal ionGO:0051238240.011
covalent chromatin modificationGO:00165692540.011
meiosis iGO:000712740.011
protein importGO:00170381300.011
regulation of sequence specific dna binding transcription factor activityGO:00510902110.011
ribonucleotide biosynthetic processGO:0009260810.011
peripheral nervous system developmentGO:000742220.011
nucleoside monophosphate metabolic processGO:00091231910.011
regulation of neurotransmitter secretionGO:004692830.011
regulation of cysteine type endopeptidase activityGO:20001161270.011
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781250.011
adenylate cyclase inhibiting serotonin receptor signaling pathwayGO:000719820.011
sensory perceptionGO:00076001030.011
multicellular organismal response to stressGO:003355510.011
regulation of meiosisGO:004002030.011
epithelium migrationGO:00901321190.011
osteoblast differentiationGO:0001649920.011
regulation of i kappab kinase nf kappab signalingGO:00431221620.011
positive regulation of peptidyl tyrosine phosphorylationGO:0050731850.011
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.011
negative regulation of acetylcholine gated cation channel activityGO:190304910.011
cardiac muscle cell contractionGO:008600340.011
sequestering of calcium ionGO:0051208170.011
positive regulation of protein transportGO:00512221350.011
regulation of exocytosisGO:0017157460.011
rna processingGO:00063962550.011
regulation of dna metabolic processGO:00510521530.011
cellular ion homeostasisGO:00068731680.011
regulation of transmembrane transporter activityGO:0022898740.011
regulation of ion transmembrane transporter activityGO:0032412720.011
response to inorganic substanceGO:00100351270.011
symbiosis encompassing mutualism through parasitismGO:00444031560.011
negative regulation of growthGO:0045926970.011
positive regulation of aldosterone metabolic processGO:003234620.011
behavioral response to ethanolGO:004814920.011
neuron projection developmentGO:00311751060.011
regulation of actin filament based processGO:00329701410.011
axon regenerationGO:003110310.011
cartilage condensationGO:000150210.011
regulation of transporter activityGO:0032409820.010
protein acylationGO:00435431380.010
ribose phosphate biosynthetic processGO:0046390820.010
atp metabolic processGO:00460341760.010
cell projection morphogenesisGO:00488581290.010
negative regulation of organelle organizationGO:00106391260.010
cellular cation homeostasisGO:00300031630.010
somitogenesisGO:000175620.010
tissue migrationGO:00901301190.010
nuclear importGO:00511701060.010
blood vessel developmentGO:00015681720.010
protein secretionGO:0009306980.010
regulation of actin cytoskeleton organizationGO:00329561160.010
regulation of bindingGO:00510981110.010
divalent inorganic cation homeostasisGO:00725071360.010
nucleus localizationGO:005164710.010
negative regulation of cell migrationGO:00303361020.010
hematopoietic or lymphoid organ developmentGO:00485341860.010
positive regulation of steroid hormone biosynthetic processGO:009003120.010
response to virusGO:00096151260.010
response to cocaineGO:004222010.010
cgmp catabolic processGO:004606930.010
receptor transactivationGO:003562440.010
immune system developmentGO:00025201950.010
cellular response to cytokine stimulusGO:00713451810.010
response to drugGO:0042493810.010

PPEF1 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
musculoskeletal system diseaseDOID:172230.041
central nervous system diseaseDOID:3311860.028
nervous system diseaseDOID:8634310.028
sensory system diseaseDOID:00501552030.027
eye and adnexa diseaseDOID:14921500.022
disease of metabolismDOID:00146672950.021
eye diseaseDOID:56141490.021
connective tissue diseaseDOID:651090.020
bone diseaseDOID:0080001880.020
retinal diseaseDOID:56791180.019
disease of cellular proliferationDOID:145661740.018
cancerDOID:1621670.018
organ system cancerDOID:00506861640.018
muscle tissue diseaseDOID:661130.016
muscular diseaseDOID:00800001140.016
neurodegenerative diseaseDOID:12891020.015
inherited metabolic disorderDOID:6552420.014
immune system diseaseDOID:29141550.014
brain diseaseDOID:936730.013
bone development diseaseDOID:0080006550.013
myopathyDOID:4231040.012
retinal degenerationDOID:8466890.012