Homo sapiens

8 known processes

AP1S1

adaptor-related protein complex 1, sigma 1 subunit

(Aliases: CLAPS1,SIGMA1A,WUGSC:H_DJ0747G18.2,FLJ92436,AP19)

AP1S1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
transmembrane transportGO:00550853990.195
post embryonic developmentGO:000979120.182
Worm
membrane organizationGO:00610242920.142
cytoplasmic transportGO:00164823790.141
single organism membrane organizationGO:00448022680.122
single organism cellular localizationGO:19025803320.121
purine ribonucleoside metabolic processGO:00461284370.100
determination of adult lifespanGO:000834020.092
protein localization to organelleGO:00333652800.085
endomembrane system organizationGO:00102561960.084
nucleoside phosphate catabolic processGO:19012924120.081
regulation of cellular ketone metabolic processGO:0010565500.078
nucleotide catabolic processGO:00091664080.076
intracellular protein transportGO:00068862700.075
multicellular organismal agingGO:001025930.075
regulation of cellular amine metabolic processGO:0033238110.075
protein localization to membraneGO:00726571600.072
glycosyl compound catabolic processGO:19016584130.071
vesicle mediated transportGO:00161923710.070
purine containing compound catabolic processGO:00725234110.070
nucleoside catabolic processGO:00091644080.069
intracellular protein transmembrane transportGO:0065002240.068
limbic system developmentGO:002176130.067
purine ribonucleoside triphosphate metabolic processGO:00092054110.065
organophosphate catabolic processGO:00464344300.065
nucleoside triphosphate catabolic processGO:00091433940.064
cellular amino acid metabolic processGO:00065201160.063
guanosine containing compound catabolic processGO:19010692390.062
purine ribonucleoside catabolic processGO:00461303980.062
cellular amine metabolic processGO:0044106410.060
amine metabolic processGO:0009308440.059
purine ribonucleotide catabolic processGO:00091544040.059
single organism membrane fusionGO:0044801370.059
ribonucleoside triphosphate metabolic processGO:00091994120.059
synaptic vesicle recyclingGO:003646530.057
purine ribonucleoside triphosphate catabolic processGO:00092073910.057
cellular ketone metabolic processGO:0042180800.056
establishment of protein localization to organelleGO:00725941720.056
establishment of protein localization to membraneGO:00901501210.055
purine nucleotide catabolic processGO:00061954050.054
protein targetingGO:00066051870.053
regulation of cellular amino acid metabolic processGO:000652160.053
purine nucleoside catabolic processGO:00061523980.053
ribonucleoside triphosphate catabolic processGO:00092033910.053
ribonucleoside catabolic processGO:00424544060.052
cation transportGO:00068123310.051
gtp metabolic processGO:00460392390.051
response to oxygen containing compoundGO:19017003690.051
synaptic vesicle endocytosisGO:004848820.050
positive regulation of transportGO:00510503360.049
intracellular protein transmembrane importGO:0044743230.047
gtp catabolic processGO:00061842370.045
locomotory behaviorGO:000762610.045
regulation of protein localizationGO:00328802960.044
nervous system developmentGO:00073992930.044
Zebrafish Fly
oogenesisGO:004847720.043
regulation of cytoplasmic transportGO:19036491490.043
positive regulation of cellular component organizationGO:00511303760.042
cell growthGO:00160491600.042
female gamete generationGO:000729220.042
regulation of intracellular transportGO:00323861950.042
protein maturationGO:00516042330.042
negative regulation of protein metabolic processGO:00512483910.041
immune responseGO:00069553070.041
positive regulation of hydrolase activityGO:00513453310.041
negative regulation of cellular protein metabolic processGO:00322693530.041
response to nitrogen compoundGO:19016981840.040
response to biotic stimulusGO:00096072760.040
biological adhesionGO:00226103310.040
negative regulation of apoptotic processGO:00430663160.040
cellular lipid metabolic processGO:00442553030.040
secretionGO:00469032540.039
organelle fusionGO:0048284360.039
negative regulation of cellular amine metabolic processGO:003323930.039
defense responseGO:00069523150.039
protein modification by small protein conjugationGO:00324463420.038
purine nucleoside triphosphate metabolic processGO:00091444120.038
plasma membrane organizationGO:00070091150.038
membrane fusionGO:0061025430.037
cellular component morphogenesisGO:00329893140.037
Fly
ribonucleotide catabolic processGO:00092614050.037
golgi vesicle transportGO:0048193800.037
lipid metabolic processGO:00066293810.037
purine nucleoside triphosphate catabolic processGO:00091463920.037
oxidation reduction processGO:00551143960.036
positive regulation of secretion by cellGO:19035321080.036
mitochondrion organizationGO:00070051560.036
compound eye developmentGO:004874910.036
Fly
guanosine containing compound metabolic processGO:19010682440.036
negative regulation of cellular amino acid metabolic processGO:004576320.035
small molecule biosynthetic processGO:00442831570.035
nucleoside triphosphate metabolic processGO:00091414220.035
regulation of cell cycleGO:00517263930.034
regulation of secretionGO:00510461940.034
ion transmembrane transportGO:00342203380.034
cellular response to oxygen containing compoundGO:19017012760.034
cellular macromolecule catabolic processGO:00442653800.034
endosomal transportGO:00161971290.034
negative regulation of cell deathGO:00605483450.034
carbohydrate derivative biosynthetic processGO:19011372070.034
regulation of secretion by cellGO:19035301770.033
negative regulation of programmed cell deathGO:00430693210.033
regulation of cell growthGO:00015581350.033
actin filament based processGO:00300292240.033
response to salt stressGO:000965130.032
negative regulation of catalytic activityGO:00430863350.032
regulation of transferase activityGO:00513383550.032
lipid biosynthetic processGO:00086101770.032
positive regulation of secretionGO:00510471160.032
epithelium developmentGO:00604292270.032
cell projection organizationGO:00300302520.031
Fly
anatomical structure formation involved in morphogenesisGO:00486462840.031
establishment of protein localization to plasma membraneGO:0090002680.031
small gtpase mediated signal transductionGO:0007264780.031
hindbrain developmentGO:003090230.031
cellular response to dna damage stimulusGO:00069743790.031
regulation of anatomical structure morphogenesisGO:00226032860.031
chemical homeostasisGO:00488783060.031
endocytosisGO:00068971590.031
positive regulation of cellular amine metabolic processGO:003324070.030
protein localization to plasma membraneGO:0072659930.030
negative regulation of protein modification processGO:00314002000.030
regulation of cell differentiationGO:00455953930.030
metal ion homeostasisGO:00550651690.030
circulatory system developmentGO:00723592620.030
establishment of protein localization to endoplasmic reticulum membraneGO:009705130.030
adult locomotory behaviorGO:000834410.030
neurogenesisGO:00220081690.030
Fly
protein ubiquitinationGO:00165673140.030
regulation of synaptic plasticityGO:004816730.030
positive regulation of cellular amino acid metabolic processGO:004576430.029
cilium assemblyGO:0042384630.029
negative regulation of cell proliferationGO:00082852280.029
positive regulation of exocytosisGO:0045921350.029
positive regulation of cell deathGO:00109422630.029
regulation of establishment of protein localizationGO:00702012420.029
positive regulation of apoptotic processGO:00430652460.029
exocytosisGO:0006887710.029
blood vessel morphogenesisGO:00485141620.029
positive regulation of cellular catabolic processGO:00313312840.028
vesicle organizationGO:0016050620.028
response to external biotic stimulusGO:00432072610.028
motor neuron axon guidanceGO:000804520.028
positive regulation of programmed cell deathGO:00430682490.028
divalent inorganic cation homeostasisGO:00725071360.028
sequestering of metal ionGO:0051238240.027
cilium organizationGO:0044782680.027
negative regulation of phosphate metabolic processGO:00459362670.027
positive regulation of developmental processGO:00510943140.027
post embryonic organ developmentGO:004856910.027
response to axon injuryGO:004867810.027
metal ion transportGO:00300012720.027
growthGO:00400072020.027
positive regulation of catabolic processGO:00098963100.026
response to abiotic stimulusGO:00096283360.026
regulation of vesicle mediated transportGO:00606271300.026
cell divisionGO:00513011680.026
regulation of cellular component biogenesisGO:00440872810.026
spermatid differentiationGO:004851540.026
neurotransmitter secretionGO:000726940.026
regulation of proteolysisGO:00301622930.025
negative regulation of cellular component organizationGO:00511292350.025
cellular macromolecular complex assemblyGO:00346223240.025
ras protein signal transductionGO:0007265730.025
protein processingGO:00164852260.025
cellular response to endogenous stimulusGO:00714953360.025
regulation of protein transportGO:00512232130.025
immune system developmentGO:00025201950.024
cellular chemical homeostasisGO:00550821800.024
actin cytoskeleton organizationGO:00300362070.024
cation homeostasisGO:00550801890.024
establishment or maintenance of apical basal cell polarityGO:003508820.024
organic acid biosynthetic processGO:0016053970.024
sensory perception of painGO:001923340.024
anion transportGO:00068201610.024
negative regulation of phosphorus metabolic processGO:00105632670.024
posttranscriptional regulation of gene expressionGO:00106082130.024
neuromuscular junction developmentGO:000752830.023
response to cytokineGO:00340972320.023
membrane lipid metabolic processGO:0006643530.023
protein catabolic processGO:00301633250.023
cellular metal ion homeostasisGO:00068751460.023
mitotic cell cycleGO:00002783260.023
response to other organismGO:00517072610.023
positive regulation of immune system processGO:00026842830.023
negative regulation of phosphorylationGO:00423261740.023
cell developmentGO:00484683280.023
Fly
cellular cation homeostasisGO:00300031630.023
immune effector processGO:00022521590.023
protein targeting to membraneGO:0006612420.023
developmental programmed cell deathGO:001062330.023
modification dependent macromolecule catabolic processGO:00436322120.023
response to radiationGO:00093141510.022
receptor metabolic processGO:0043112810.022
hemopoiesisGO:00300971800.022
modification dependent protein catabolic processGO:00199412090.022
positive regulation of purine nucleotide metabolic processGO:19005442270.022
associative learningGO:000830610.022
regulation of kinase activityGO:00435493140.022
cardiovascular system developmentGO:00723582620.022
cell projection assemblyGO:00300311260.022
organic hydroxy compound metabolic processGO:19016151470.022
cell morphogenesisGO:00009022960.022
Fly
protein importGO:00170381300.022
apoptotic process involved in morphogenesisGO:006056130.022
regulation of immune responseGO:00507762010.022
response to lipidGO:00339932060.022
cellular homeostasisGO:00197251960.022
angiogenesisGO:00015251470.022
regulation of cytoskeleton organizationGO:00514931770.022
regulation of protein kinase activityGO:00458592890.022
patterning of blood vesselsGO:000156920.022
response to organonitrogen compoundGO:00102431560.022
peripheral nervous system developmentGO:000742220.022
organophosphate biosynthetic processGO:00904071630.022
sequestering of calcium ionGO:0051208170.021
regenerationGO:003109940.021
innate immune responseGO:00450871780.021
generation of neuronsGO:00486991520.021
Fly
response to cocaineGO:004222010.021
oocyte developmentGO:004859910.021
positive regulation of cell proliferationGO:00082843010.021
response to organic cyclic compoundGO:00140702040.021
negative regulation of multicellular organismal processGO:00512413170.021
negative regulation of cell cycleGO:00457861930.021
regulation of metal ion transportGO:00109591200.021
covalent chromatin modificationGO:00165692540.021
endoplasmic reticulum organizationGO:0007029200.021
regulation of growthGO:00400081650.021
carbohydrate metabolic processGO:00059752070.020
regulation of transmembrane transportGO:00347621390.020
cellular response to abiotic stimulusGO:00712141170.020
cerebellum developmentGO:002154920.020
negative regulation of developmental processGO:00510932470.020
head developmentGO:00603221080.020
cellular protein catabolic processGO:00442572610.020
regulation of purine nucleotide metabolic processGO:19005422640.020
maintenance of locationGO:00512351120.020
cell adhesionGO:00071553250.020
segmentationGO:003528240.020
hypothalamus developmentGO:002185410.020
positive regulation of ion transportGO:0043270870.020
positive regulation of cell differentiationGO:00455972110.020
cellular protein complex assemblyGO:00436231880.019
mitotic cell cycle processGO:19030472860.019
cell part morphogenesisGO:00329901370.019
Fly
regulation of cell developmentGO:00602841610.019
endoplasmic reticulum tubular network organizationGO:007178680.019
positive regulation of cellular component biogenesisGO:00440891580.019
neuron differentiationGO:00301821380.019
Fly
cell cell signalingGO:00072671550.019
regulation of neurotransmitter secretionGO:004692830.019
mitotic cell cycle phase transitionGO:00447721620.019
oocyte differentiationGO:000999420.019
regulation of bindingGO:00510981110.019
peptidyl serine phosphorylationGO:00181051010.019
positive regulation of proteolysisGO:00458621420.019
actin filament organizationGO:00070151280.019
regulation of cell cycle processGO:00105642660.019
cilium morphogenesisGO:0060271750.019
proteolysis involved in cellular protein catabolic processGO:00516032440.019
regulation of apoptotic process involved in morphogenesisGO:190233710.019
cranial nerve developmentGO:002154540.019
regulation of anatomical structure sizeGO:00900661010.019
negative regulation of axon extensionGO:003051720.019
establishment or maintenance of bipolar cell polarityGO:006124520.019
regulation of nucleotide metabolic processGO:00061402690.019
regulation of dna metabolic processGO:00510521530.018
liposaccharide metabolic processGO:1903509270.018
response to fungusGO:000962040.018
nerve developmentGO:002167540.018
calcium ion homeostasisGO:00550741220.018
response to woundingGO:00096111680.018
cellular ion homeostasisGO:00068731680.018
regulation of ion homeostasisGO:2000021730.018
establishment of planar polarityGO:000173630.018
positive regulation of nucleotide metabolic processGO:00459812300.018
protein targeting to peroxisomeGO:0006625150.018
positive regulation of organelle organizationGO:00106381950.018
cell cycle phase transitionGO:00447701730.018
apoptotic signaling pathwayGO:00971902680.018
blood vessel developmentGO:00015681720.017
positive regulation of kinase activityGO:00336742040.017
metencephalon developmentGO:002203720.017
organonitrogen compound biosynthetic processGO:19015662000.017
morphogenesis of a polarized epitheliumGO:000173830.017
positive regulation of phosphorylationGO:00423273940.017
regulation of cell motilityGO:20001452990.017
regulation of synaptic vesicle transportGO:190280330.017
brain developmentGO:0007420970.017
regulation of endopeptidase activityGO:00525481700.017
ubiquitin dependent protein catabolic processGO:00065112060.017
negative regulation of protein maturationGO:19033181420.017
positive regulation of protein phosphorylationGO:00019343130.017
multicellular organismal homeostasisGO:0048871670.017
histone modificationGO:00165702510.017
hematopoietic or lymphoid organ developmentGO:00485341860.017
positive regulation of cytoplasmic transportGO:1903651820.017
cell activationGO:00017752130.017
regulation of transmembrane transporter activityGO:0022898740.017
single organism carbohydrate metabolic processGO:00447231930.017
regulation of transporter activityGO:0032409820.017
ion homeostasisGO:00508012300.017
reactive oxygen species metabolic processGO:0072593750.017
symbiosis encompassing mutualism through parasitismGO:00444031560.017
positive regulation of immune responseGO:00507781590.017
regulation of gtp catabolic processGO:00331241800.017
synaptic vesicle exocytosisGO:001607930.017
positive regulation of nucleotide catabolic processGO:00308131850.017
establishment of tissue polarityGO:000716430.017
protein localization to endoplasmic reticulumGO:0070972190.017
regulation of cellular component sizeGO:0032535820.017
nucleoside monophosphate metabolic processGO:00091231910.017
interspecies interaction between organismsGO:00444191560.017
chromatin organizationGO:00063253510.017
regulation of nucleoside metabolic processGO:00091182090.017
post golgi vesicle mediated transportGO:0006892360.017
regulation of cell migrationGO:00303342890.017
tissue morphogenesisGO:0048729960.017
cellular response to nitrogen compoundGO:19016991440.017
peptidyl serine modificationGO:00182091060.017
visual behaviorGO:000763220.017
golgi vesicle fusion to target membraneGO:004821020.016
carboxylic acid biosynthetic processGO:0046394970.016
purine ribonucleoside monophosphate metabolic processGO:00091671860.016
system processGO:00030083490.016
central nervous system developmentGO:00074171230.016
dna repairGO:00062811980.016
cofactor metabolic processGO:0051186870.016
multi organism cellular processGO:00447641560.016
response to inorganic substanceGO:00100351270.016
leukocyte activationGO:00453211640.016
cytokinesisGO:0000910960.016
secretion by cellGO:00329402260.016
response to hormoneGO:00097251750.016
regulation of locomotionGO:00400123290.016
regulation of exocytosisGO:0017157460.016
dephosphorylationGO:00163112090.016
negative regulation of protein phosphorylationGO:00019331400.016
regulation of apoptotic signaling pathwayGO:20012331750.016
cytosolic calcium ion homeostasisGO:0051480890.016
mammary gland morphogenesisGO:006044320.016
regulation of homeostatic processGO:00328441210.016
hippocampus developmentGO:002176610.016
engulfment of apoptotic cellGO:004365220.016
cellular divalent inorganic cation homeostasisGO:00725031280.016
regulation of calcium ion transportGO:0051924790.016
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.016
monovalent inorganic cation homeostasisGO:0055067370.015
positive regulation of intracellular transportGO:00323881040.015
blastoderm segmentationGO:000735020.015
regulation of protein maturationGO:19033171500.015
chromatin modificationGO:00165682980.015
response to virusGO:00096151260.015
cell projection morphogenesisGO:00488581290.015
Fly
negative regulation of axonogenesisGO:005077140.015
regulation of cell projection organizationGO:00313441070.015
divalent inorganic cation transportGO:00725111580.015
single organism reproductive processGO:0044702980.015
negative regulation of organelle organizationGO:00106391260.015
regulation of small gtpase mediated signal transductionGO:00510561560.015
regulation of cellular component movementGO:00512703340.015
regulation of protein complex assemblyGO:00432541470.015
positive regulation of protein kinase activityGO:00458601900.015
generation of precursor metabolites and energyGO:0006091680.015
embryonic epithelial tube formationGO:000183840.015
organelle fissionGO:00482851490.015
positive regulation of purine nucleotide catabolic processGO:00331231850.015
nitrogen compound transportGO:00717051910.015
cytokine productionGO:00018162470.015
cerebral cortex radially oriented cell migrationGO:002179910.015
negative regulation of transportGO:00510511760.015
dna catabolic processGO:0006308490.015
glycolipid metabolic processGO:0006664270.014
positive regulation of leukocyte activationGO:0002696800.014
regulation of membrane potentialGO:0042391950.014
negative regulation of hydrolase activityGO:00513461820.014
visual learningGO:000854210.014
single organism cell adhesionGO:00986021790.014
memoryGO:000761330.014
positive regulation of nucleoside metabolic processGO:00459791860.014
purine nucleoside monophosphate metabolic processGO:00091261860.014
cell type specific apoptotic processGO:00972851250.014
notch receptor processingGO:000722020.014
regulation of mitotic cell cycleGO:00073461890.014
regulation of peptidase activityGO:00525471800.014
reactive oxygen species biosynthetic processGO:190340940.014
organelle localizationGO:0051640840.014
gastrulation with mouth forming secondGO:000170210.014
cerebral cortex cell migrationGO:002179530.014
regulation of response to external stimulusGO:00321012220.014
positive regulation of synaptic transmissionGO:005080640.014
organelle assemblyGO:00709251760.014
anterior posterior axis specificationGO:000994820.014
monocarboxylic acid metabolic processGO:00327871850.014
wnt signaling pathwayGO:00160551560.014
blood vessel remodelingGO:000197420.014
mitochondrion distributionGO:004831130.014
photoreceptor cell differentiationGO:004653020.014
Fly
regulation of ras protein signal transductionGO:00465781550.014
nucleic acid phosphodiester bond hydrolysisGO:00903051020.014
melanin metabolic processGO:000658210.014
interaction with hostGO:0051701420.014
regulation of calcium ion transport into cytosolGO:0010522330.014
tissue homeostasisGO:0001894630.014
positive regulation of cellular component movementGO:00512721810.014
spermatid developmentGO:000728640.013
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:00432811160.013
regulation of cell activationGO:00508651250.013
t cell homeostasisGO:004302930.013
positive regulation of protein transportGO:00512221350.013
vasculature developmentGO:00019441810.013
regulation of reactive oxygen species metabolic processGO:2000377410.013
rhythmic behaviorGO:000762220.013
cation transmembrane transportGO:00986552380.013
regulation of lymphocyte activationGO:00512491030.013
nucleocytoplasmic transportGO:00069131760.013
positive regulation of calcium ion transportGO:0051928510.013
response to metal ionGO:0010038840.013
nucleoside phosphate biosynthetic processGO:19012931090.013
sphingolipid metabolic processGO:0006665380.013
regulation of leukocyte activationGO:00026941150.013
mapk cascadeGO:00001652880.013
regulation of cytokine productionGO:00018172320.013
regulation of multi organism processGO:00439001570.013
regulation of mitotic cell cycle phase transitionGO:19019901180.013
positive regulation of gtp catabolic processGO:00331261660.013
viral processGO:00160321460.013
microtubule cytoskeleton organizationGO:00002261760.013
protein oligomerizationGO:00512591730.013
positive regulation of cell motilityGO:20001471770.013
translationGO:00064121320.013
regulation of protein modification by small protein conjugation or removalGO:19033201070.013
regulation of protein bindingGO:0043393660.013
anatomical structure homeostasisGO:00602491000.013
cranial nerve morphogenesisGO:002160210.013
regulation of nucleotide catabolic processGO:00308112050.013
signal transduction by phosphorylationGO:00230142970.013
positive regulation of cell developmentGO:0010720920.013
meiotic chromosome segregationGO:004513240.013
cellular component assembly involved in morphogenesisGO:0010927730.013
regulation of cellular response to stressGO:00801352440.013
sulfur compound metabolic processGO:00067901010.013
negative regulation of transferase activityGO:00513481240.013
positive regulation of transferase activityGO:00513472270.013
female genitalia developmentGO:003054020.013
protein autophosphorylationGO:00467771230.013
regulation of epithelial cell proliferationGO:00506781130.013
positive regulation of cell migrationGO:00303351720.013
negative regulation of proteolysisGO:00458611320.013
peroxisomal transportGO:0043574150.013
cellular response to growth factor stimulusGO:00713631970.012
anterior posterior axis specification embryoGO:000859520.012
enzyme linked receptor protein signaling pathwayGO:00071673030.012
ribonucleoside monophosphate metabolic processGO:00091611870.012
neuron developmentGO:00486661130.012
Fly
negative regulation of protein processingGO:00109551420.012
cellular response to external stimulusGO:00714961110.012
cell substrate adhesionGO:00315891320.012
regulation of protein localization to plasma membraneGO:1903076400.012
regulation of gtpase activityGO:00430871800.012
positive regulation of cell activationGO:0050867810.012
neuroblast proliferationGO:000740540.012
cellular component disassemblyGO:0022411920.012
rna processingGO:00063962550.012
establishment of protein localization to peroxisomeGO:0072663150.012
immune response activating signal transductionGO:0002757900.012
rho protein signal transductionGO:0007266260.012
regulation of protein processingGO:00706131500.012
morphogenesis of embryonic epitheliumGO:001633140.012
neurological system processGO:00508771630.012
regulation of cysteine type endopeptidase activityGO:20001161270.012
regulation of reactive oxygen species biosynthetic processGO:190342630.012
regulation of actin filament based processGO:00329701410.012
positive regulation of locomotionGO:00400171860.012
protein secretionGO:0009306980.012
reactive nitrogen species metabolic processGO:200105730.012

AP1S1 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:00146672950.034
disease of cellular proliferationDOID:145661740.029
inherited metabolic disorderDOID:6552420.029
cancerDOID:1621670.027
organ system cancerDOID:00506861640.027
nervous system diseaseDOID:8634310.019
central nervous system diseaseDOID:3311860.019
musculoskeletal system diseaseDOID:172230.016
gastrointestinal system cancerDOID:3119520.016
carbohydrate metabolic disorderDOID:2978550.015
eye and adnexa diseaseDOID:14921500.014
sensory system diseaseDOID:00501552030.014
connective tissue diseaseDOID:651090.013
eye diseaseDOID:56141490.012
immune system diseaseDOID:29141550.012
bone diseaseDOID:0080001880.012