Homo sapiens

9 known processes

SHMT2

serine hydroxymethyltransferase 2 (mitochondrial)

(Aliases: SHMT,GLYA)

SHMT2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular amino acid metabolic processGO:00065201160.930
Human
small molecule biosynthetic processGO:00442831570.773
coenzyme metabolic processGO:0006732650.716
Human
trna aminoacylation for protein translationGO:000641880.696
amino acid activationGO:0043038120.657
post embryonic developmentGO:000979120.560
multicellular organismal agingGO:001025930.502
trna aminoacylationGO:0043039120.476
cellular response to oxidative stressGO:0034599850.445
organonitrogen compound biosynthetic processGO:19015662000.424
Human
monocarboxylic acid metabolic processGO:00327871850.386
response to organonitrogen compoundGO:00102431560.383
cellular macromolecule catabolic processGO:00442653800.349
nucleotide biosynthetic processGO:00091651090.301
organophosphate biosynthetic processGO:00904071630.284
alpha amino acid metabolic processGO:1901605720.270
Human
purine containing compound biosynthetic processGO:0072522880.244
Human
chemical homeostasisGO:00488783060.216
regulation of translationGO:0006417890.216
glycine metabolic processGO:000654440.188
response to nitrogen compoundGO:19016981840.185
regulation of mitotic cell cycleGO:00073461890.165
oxidation reduction processGO:00551143960.159
female gamete generationGO:000729220.149
nucleoside phosphate biosynthetic processGO:19012931090.147
determination of adult lifespanGO:000834020.129
response to hormoneGO:00097251750.127
purine nucleoside triphosphate metabolic processGO:00091444120.122
serine family amino acid metabolic processGO:0009069120.121
Human
regulation of cell cycleGO:00517263930.116
response to oxygen containing compoundGO:19017003690.116
mitochondrion organizationGO:00070051560.112
organic acid biosynthetic processGO:0016053970.097
cofactor metabolic processGO:0051186870.096
Human
embryo developmentGO:00097901230.096
oogenesisGO:004847720.096
positive regulation of mitotic cell cycleGO:0045931600.095
purine ribonucleotide biosynthetic processGO:0009152790.093
regulation of dna metabolic processGO:00510521530.091
negative regulation of cellular component organizationGO:00511292350.090
cellular response to oxygen containing compoundGO:19017012760.089
cellular homeostasisGO:00197251960.088
negative regulation of developmental processGO:00510932470.087
dicarboxylic acid metabolic processGO:0043648290.084
Human
negative regulation of protein metabolic processGO:00512483910.081
cellular modified amino acid metabolic processGO:0006575640.076
Human
negative regulation of catalytic activityGO:00430863350.074
response to peptide hormoneGO:0043434610.073
purine ribonucleoside metabolic processGO:00461284370.072
response to abiotic stimulusGO:00096283360.071
sulfur compound metabolic processGO:00067901010.070
single organism carbohydrate metabolic processGO:00447231930.069
protein catabolic processGO:00301633250.062
ribose phosphate biosynthetic processGO:0046390820.060
protein oligomerizationGO:00512591730.060
Human
carboxylic acid biosynthetic processGO:0046394970.060
regulation of cell cycle processGO:00105642660.058
regulation of cellular ketone metabolic processGO:0010565500.058
translationGO:00064121320.057
negative regulation of apoptotic processGO:00430663160.056
cell cycle phase transitionGO:00447701730.056
positive regulation of cellular amino acid metabolic processGO:004576430.055
g1 s transition of mitotic cell cycleGO:0000082780.055
regulation of cellular amino acid metabolic processGO:000652160.055
epithelium developmentGO:00604292270.055
response to steroid hormoneGO:0048545800.055
negative regulation of organelle organizationGO:00106391260.054
purine nucleotide biosynthetic processGO:0006164840.052
purine ribonucleoside triphosphate metabolic processGO:00092054110.051
regulation of response to dna damage stimulusGO:2001020940.051
mitotic cell cycle phase transitionGO:00447721620.050
dna repairGO:00062811980.050
ribonucleoside monophosphate metabolic processGO:00091611870.048
cellular response to dna damage stimulusGO:00069743790.048
regulation of cell differentiationGO:00455953930.047
mitotic cell cycle processGO:19030472860.047
positive regulation of response to dna damage stimulusGO:2001022430.047
positive regulation of dna metabolic processGO:0051054730.046
secretionGO:00469032540.046
glutamine family amino acid metabolic processGO:0009064170.044
purine ribonucleoside monophosphate metabolic processGO:00091671860.043
ribonucleotide biosynthetic processGO:0009260810.043
posttranscriptional regulation of gene expressionGO:00106082130.043
trna metabolic processGO:0006399350.042
proline transportGO:001582440.042
negative regulation of phosphate metabolic processGO:00459362670.042
protein homooligomerizationGO:00512601000.041
cellular response to cytokine stimulusGO:00713451810.039
response to insulinGO:0032868450.039
cellular protein complex assemblyGO:00436231880.039
regulation of cellular amine metabolic processGO:0033238110.038
response to oxidative stressGO:00069791210.038
negative regulation of cellular protein metabolic processGO:00322693530.038
alanine transportGO:003232830.037
cellular amine metabolic processGO:0044106410.037
purine nucleoside monophosphate metabolic processGO:00091261860.037
cellular response to nitrogen compoundGO:19016991440.037
cellular response to endogenous stimulusGO:00714953360.037
nucleoside monophosphate metabolic processGO:00091231910.036
regulation of cellular response to stressGO:00801352440.036
cellular macromolecular complex assemblyGO:00346223240.036
carbohydrate metabolic processGO:00059752070.036
mitochondrial rna metabolic processGO:0000959150.036
nitrogen compound transportGO:00717051910.035
positive regulation of cellular amine metabolic processGO:003324070.035
transmembrane transportGO:00550853990.035
positive regulation of secretion by cellGO:19035321080.034
gamma aminobutyric acid metabolic processGO:000944810.033
cellular response to hormone stimulusGO:00328701250.033
ion transmembrane transportGO:00342203380.033
cell divisionGO:00513011680.033
ncrna metabolic processGO:00346601080.032
vesicle mediated transportGO:00161923710.032
cell developmentGO:00484683280.031
cellular chemical homeostasisGO:00550821800.031
growthGO:00400072020.031
rna processingGO:00063962550.031
negative regulation of protein modification processGO:00314002000.031
amine metabolic processGO:0009308440.031
ribonucleoside triphosphate metabolic processGO:00091994120.031
response to organic cyclic compoundGO:00140702040.030
regulation of transferase activityGO:00513383550.030
negative regulation of cell differentiationGO:00455961710.030
response to peptideGO:1901652650.030
peptide transportGO:0015833740.029
positive regulation of catabolic processGO:00098963100.029
regulation of growthGO:00400081650.028
regulation of hormone secretionGO:0046883570.028
positive regulation of cell cycleGO:00457871400.028
purine nucleoside triphosphate catabolic processGO:00091463920.028
system processGO:00030083490.027
regulation of cellular component biogenesisGO:00440872810.027
regulation of locomotionGO:00400123290.027
metencephalon developmentGO:002203720.025
organophosphate catabolic processGO:00464344300.025
embryo development ending in birth or egg hatchingGO:0009792340.025
atp metabolic processGO:00460341760.025
cytoplasmic transportGO:00164823790.025
cellular ketone metabolic processGO:0042180800.024
secretion by cellGO:00329402260.024
regulation of response to external stimulusGO:00321012220.024
cellular response to organonitrogen compoundGO:00714171240.023
carbohydrate derivative biosynthetic processGO:19011372070.023
negative regulation of phosphorus metabolic processGO:00105632670.023
response to endoplasmic reticulum stressGO:0034976490.023
ribonucleoside catabolic processGO:00424544060.022
guanosine containing compound metabolic processGO:19010682440.022
positive regulation of dna repairGO:0045739250.022
purine ribonucleoside catabolic processGO:00461303980.022
negative regulation of kinase activityGO:00336731060.022
hexose metabolic processGO:0019318550.021
regulation of nucleotide metabolic processGO:00061402690.021
regulation of dna repairGO:0006282470.021
hemopoiesisGO:00300971800.021
negative regulation of hydrolase activityGO:00513461820.021
multi organism cellular processGO:00447641560.021
purine ribonucleotide catabolic processGO:00091544040.020
l serine metabolic processGO:000656350.020
Human
response to acid chemicalGO:0001101660.020
nucleotide catabolic processGO:00091664080.020
negative regulation of transferase activityGO:00513481240.020
regulation of immune responseGO:00507762010.020
central nervous system developmentGO:00074171230.020
negative regulation of cell deathGO:00605483450.020
purine ribonucleoside triphosphate catabolic processGO:00092073910.020
positive regulation of cellular component organizationGO:00511303760.020
regulation of protein complex assemblyGO:00432541470.019
nucleoside triphosphate catabolic processGO:00091433940.019
response to amino acidGO:0043200140.019
leukocyte activationGO:00453211640.019
positive regulation of immune system processGO:00026842830.019
agingGO:0007568660.019
response to hypoxiaGO:0001666960.018
endocytosisGO:00068971590.018
respiratory tube developmentGO:0030323200.018
receptor mediated endocytosisGO:0006898840.018
modified amino acid transportGO:0072337110.018
nuclear transportGO:00511691790.018
response to lipidGO:00339932060.018
positive regulation of transportGO:00510503360.018
cytoplasmic translational initiationGO:000218360.018
anion transmembrane transportGO:0098656760.017
positive regulation of transferase activityGO:00513472270.017
negative regulation of programmed cell deathGO:00430693210.017
double strand break repairGO:00063021010.017
response to biotic stimulusGO:00096072760.017
cap independent translational initiationGO:000219040.017
immune system developmentGO:00025201950.017
positive regulation of developmental processGO:00510943140.017
negative regulation of immune system processGO:00026831360.017
cellular response to peptide hormone stimulusGO:0071375560.017
mitotic cell cycleGO:00002783260.016
protein processingGO:00164852260.016
single organism reproductive processGO:0044702980.016
enzyme linked receptor protein signaling pathwayGO:00071673030.016
hindbrain developmentGO:003090230.016
positive regulation of cellular catabolic processGO:00313312840.016
tube developmentGO:00352951250.016
regulation of kinase activityGO:00435493140.016
reproductive processGO:00224141060.016
dna conformation changeGO:00711031130.016
organic anion transportGO:00157111030.016
neurological system processGO:00508771630.016
negative regulation of multicellular organismal processGO:00512413170.015
defense responseGO:00069523150.015
regulation of nucleoside metabolic processGO:00091182090.015
alpha amino acid biosynthetic processGO:1901607230.015
cell activationGO:00017752130.015
positive regulation of secretionGO:00510471160.015
regulation of defense responseGO:00313471540.015
proteolysis involved in cellular protein catabolic processGO:00516032440.015
inorganic anion transportGO:0015698600.015
regulation of protein localizationGO:00328802960.015
regulation of cytoskeleton organizationGO:00514931770.015
chromatin organizationGO:00063253510.015
cellular glucose homeostasisGO:0001678110.015
negative regulation of cell proliferationGO:00082852280.014
response to external biotic stimulusGO:00432072610.014
cell cycle g1 s phase transitionGO:0044843800.014
small molecule catabolic processGO:0044282920.014
Human
regulation of secretionGO:00510461940.014
organelle assemblyGO:00709251760.014
glutamine metabolic processGO:000654120.014
purine nucleoside catabolic processGO:00061523980.014
modification dependent macromolecule catabolic processGO:00436322120.014
nucleoside triphosphate metabolic processGO:00091414220.014
ribonucleotide catabolic processGO:00092614050.014
positive regulation of organelle organizationGO:00106381950.014
regulation of cytokine productionGO:00018172320.014
negative regulation of phosphorylationGO:00423261740.014
ion homeostasisGO:00508012300.014
nucleoside catabolic processGO:00091644080.014
response to oxygen levelsGO:00704821000.014
cytokine productionGO:00018162470.013
regulation of multi organism processGO:00439001570.013
cellular protein catabolic processGO:00442572610.013
hematopoietic or lymphoid organ developmentGO:00485341860.013
defense response to other organismGO:00985421290.013
maintenance of locationGO:00512351120.013
regulation of innate immune responseGO:0045088970.013
regulation of protein kinase activityGO:00458592890.013
regulation of hormone levelsGO:00108171250.013
developmental process involved in reproductionGO:0003006660.013
glucose homeostasisGO:0042593310.013
regulation of translational initiationGO:0006446240.013
response to cytokineGO:00340972320.012
glycosyl compound biosynthetic processGO:1901659270.012
protein acetylationGO:00064731160.012
d aspartate transportGO:007077730.012
rna splicingGO:00083801310.012
protein acylationGO:00435431380.012
cation transmembrane transportGO:00986552380.012
metal ion transportGO:00300012720.012
sulfur amino acid transportGO:000010120.012
demethylationGO:0070988370.012
purine nucleotide catabolic processGO:00061954050.012
ires dependent translational initiationGO:000219240.012
regenerationGO:003109940.012
cellular response to insulin stimulusGO:0032869410.012
actin filament based processGO:00300292240.012
peptidyl tyrosine phosphorylationGO:00181081700.012
immune responseGO:00069553070.011
rna catabolic processGO:0006401710.011
pyruvate metabolic processGO:0006090260.011
regulation of lipid metabolic processGO:0019216960.011
glycosyl compound catabolic processGO:19016584130.011
viral processGO:00160321460.011
organic acid transportGO:0015849650.011
apoptotic signaling pathwayGO:00971902680.011
regulation of viral processGO:00507921030.011
mammary gland morphogenesisGO:006044320.011
reproductionGO:0000003630.011
cell adhesionGO:00071553250.011
nucleic acid phosphodiester bond hydrolysisGO:00903051020.011
negative regulation of cell cycle processGO:00109481210.011
regulation of cellular component movementGO:00512703340.011
regulation of anatomical structure morphogenesisGO:00226032860.011
cellular response to lipidGO:00713961270.011
lymphocyte activationGO:00466491330.011
positive regulation of growthGO:0045927580.011
negative regulation of protein phosphorylationGO:00019331400.011
cation transportGO:00068123310.011
symbiosis encompassing mutualism through parasitismGO:00444031560.011
protein tetramerizationGO:0051262470.011
Human
response to radiationGO:00093141510.011
purine ribonucleoside biosynthetic processGO:0046129230.010
ribonucleoprotein complex assemblyGO:0022618780.010
regulation of cell developmentGO:00602841610.010
regulation of protein modification by small protein conjugation or removalGO:19033201070.010
regulation of cell divisionGO:00513021160.010
multicellular organism reproductionGO:0032504420.010
protein maturationGO:00516042330.010
patterning of blood vesselsGO:000156920.010
regulation of cell adhesionGO:00301551660.010
protein foldingGO:0006457380.010
negative regulation of protein kinase activityGO:0006469980.010
purine nucleoside monophosphate catabolic processGO:00091281580.010
microtubule based processGO:00070172100.010
myeloid cell differentiationGO:00300991170.010

SHMT2 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
inherited metabolic disorderDOID:6552420.756
disease of metabolismDOID:00146672950.756
amino acid metabolic disorderDOID:9252500.756
neuropathyDOID:870520.267
nervous system diseaseDOID:8634310.267
immune system diseaseDOID:29141550.082
central nervous system diseaseDOID:3311860.057
neuromuscular diseaseDOID:440380.056
charcot marie tooth diseaseDOID:10595330.025