Homo sapiens

13 known processes

SCUBE3

signal peptide, CUB domain, EGF-like 3

(Aliases: DKFZp686B1223,CEGF3,DKFZp686B09105,DKFZp686D20108,FLJ34743)

SCUBE3 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
system processGO:00030083490.107
cellular ketone metabolic processGO:0042180800.090
cell adhesionGO:00071553250.090
biological adhesionGO:00226103310.088
anatomical structure formation involved in morphogenesisGO:00486462840.086
regulation of cell differentiationGO:00455953930.085
negative regulation of developmental processGO:00510932470.085
regulation of locomotionGO:00400123290.083
post embryonic developmentGO:000979120.081
regulation of cellular amino acid metabolic processGO:000652160.080
regulation of cell migrationGO:00303342890.079
ion transmembrane transportGO:00342203380.078
regulation of cellular component movementGO:00512703340.077
organ morphogenesisGO:00098871470.076
regulation of cellular amine metabolic processGO:0033238110.076
cellular response to endogenous stimulusGO:00714953360.074
regulation of cellular ketone metabolic processGO:0010565500.074
circulatory system developmentGO:00723592620.074
cellular amine metabolic processGO:0044106410.070
enzyme linked receptor protein signaling pathwayGO:00071673030.068
cellular amino acid metabolic processGO:00065201160.067
purine ribonucleotide catabolic processGO:00091544040.067
positive regulation of cellular amine metabolic processGO:003324070.067
positive regulation of cellular amino acid metabolic processGO:004576430.066
negative regulation of cell differentiationGO:00455961710.064
regulation of anatomical structure morphogenesisGO:00226032860.062
cell developmentGO:00484683280.060
small gtpase mediated signal transductionGO:0007264780.060
positive regulation of phosphorylationGO:00423273940.059
purine nucleoside catabolic processGO:00061523980.058
cardiovascular system developmentGO:00723582620.057
positive regulation of protein phosphorylationGO:00019343130.057
locomotory behaviorGO:000762610.057
purine ribonucleoside triphosphate catabolic processGO:00092073910.056
nervous system developmentGO:00073992930.056
purine nucleotide catabolic processGO:00061954050.055
regulation of cell motilityGO:20001452990.055
purine containing compound catabolic processGO:00725234110.055
organ formationGO:004864530.054
amine metabolic processGO:0009308440.054
transmembrane transportGO:00550853990.054
lipid metabolic processGO:00066293810.053
positive regulation of cellular component organizationGO:00511303760.053
cellular response to growth factor stimulusGO:00713631970.052
ras protein signal transductionGO:0007265730.052
cell morphogenesisGO:00009022960.051
purine nucleoside triphosphate catabolic processGO:00091463920.051
nucleoside triphosphate metabolic processGO:00091414220.051
organophosphate catabolic processGO:00464344300.051
cellular component morphogenesisGO:00329893140.051
cation transmembrane transportGO:00986552380.051
nucleoside phosphate catabolic processGO:19012924120.050
cation transportGO:00068123310.050
ribonucleoside triphosphate metabolic processGO:00091994120.049
female gamete generationGO:000729220.049
inorganic ion transmembrane transportGO:00986602310.049
ribonucleotide catabolic processGO:00092614050.049
actin filament based processGO:00300292240.048
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.048
mapk cascadeGO:00001652880.048
purine nucleoside triphosphate metabolic processGO:00091444120.048
single organism cell adhesionGO:00986021790.048
nucleoside triphosphate catabolic processGO:00091433940.047
positive regulation of hydrolase activityGO:00513453310.047
negative regulation of multicellular organismal processGO:00512413170.046
purine ribonucleoside triphosphate metabolic processGO:00092054110.046
ribonucleoside triphosphate catabolic processGO:00092033910.046
signal transduction by phosphorylationGO:00230142970.046
membrane organizationGO:00610242920.046
purine ribonucleoside metabolic processGO:00461284370.045
positive regulation of cell proliferationGO:00082843010.045
chemical homeostasisGO:00488783060.044
inner ear morphogenesisGO:004247240.044
ribonucleoside catabolic processGO:00424544060.044
nucleotide catabolic processGO:00091664080.042
regulation of transferase activityGO:00513383550.042
vasculature developmentGO:00019441810.042
neurological system processGO:00508771630.042
negative regulation of cell proliferationGO:00082852280.041
positive regulation of aldosterone metabolic processGO:003234620.041
negative regulation of cell migrationGO:00303361020.041
positive regulation of protein kinase activityGO:00458601900.040
regulation of mapk cascadeGO:00434082620.040
positive regulation of aldosterone biosynthetic processGO:003234920.040
single organismal cell cell adhesionGO:00163371480.040
regulation of kinase activityGO:00435493140.040
metal ion transportGO:00300012720.039
mitotic cell cycleGO:00002783260.039
regulation of cell adhesionGO:00301551660.039
nucleoside catabolic processGO:00091644080.039
glycosyl compound catabolic processGO:19016584130.039
purine ribonucleoside catabolic processGO:00461303980.038
multicellular organismal agingGO:001025930.038
generation of neuronsGO:00486991520.038
single organism cellular localizationGO:19025803320.038
forelimb morphogenesisGO:003513640.038
negative regulation of locomotionGO:00400131180.038
blood vessel morphogenesisGO:00485141620.037
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.037
segmentationGO:003528240.037
cation homeostasisGO:00550801890.037
response to abiotic stimulusGO:00096283360.037
cytoplasmic transportGO:00164823790.037
negative regulation of cell deathGO:00605483450.037
gtp catabolic processGO:00061842370.037
regulation of protein kinase activityGO:00458592890.036
positive regulation of mapk cascadeGO:00434101900.036
cellular macromolecule catabolic processGO:00442653800.036
epithelium developmentGO:00604292270.036
ion homeostasisGO:00508012300.036
regulation of nucleotide metabolic processGO:00061402690.035
oogenesisGO:004847720.035
regulation of neurotransmitter secretionGO:004692830.035
cellular ion homeostasisGO:00068731680.035
cranial nerve developmentGO:002154540.035
single organism membrane organizationGO:00448022680.035
regulation of establishment of protein localizationGO:00702012420.035
determination of adult lifespanGO:000834020.035
morphogenesis of embryonic epitheliumGO:001633140.034
positive regulation of transferase activityGO:00513472270.034
immune responseGO:00069553070.034
cellular homeostasisGO:00197251960.034
positive regulation of developmental processGO:00510943140.034
protein localization to organelleGO:00333652800.034
gtp metabolic processGO:00460392390.033
regulation of cellular component biogenesisGO:00440872810.033
nerve developmentGO:002167540.033
muscle structure developmentGO:0061061980.033
metal ion homeostasisGO:00550651690.033
hindbrain developmentGO:003090230.033
cell projection organizationGO:00300302520.033
muscle contractionGO:0006936730.033
blastoderm segmentationGO:000735020.032
regulation of cell developmentGO:00602841610.032
negative regulation of cellular component organizationGO:00511292350.031
blood vessel developmentGO:00015681720.031
neuromuscular junction developmentGO:000752830.031
epithelial cell differentiationGO:00308551410.031
positive regulation of cell migrationGO:00303351720.031
neurogenesisGO:00220081690.031
guanosine containing compound metabolic processGO:19010682440.031
regulation of purine nucleotide catabolic processGO:00331212050.030
cellular chemical homeostasisGO:00550821800.030
positive regulation of cellular catabolic processGO:00313312840.030
cellular cation homeostasisGO:00300031630.030
rho protein signal transductionGO:0007266260.030
guanosine containing compound catabolic processGO:19010692390.030
inorganic cation transmembrane transportGO:00986621940.030
negative regulation of cellular component movementGO:00512711060.030
striated muscle contractionGO:0006941520.030
regulation of cell cycleGO:00517263930.029
positive regulation of kinase activityGO:00336742040.029
cell morphogenesis involved in differentiationGO:00009041440.029
tube developmentGO:00352951250.029
positive regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiationGO:000325730.029
cell substrate adhesionGO:00315891320.029
head developmentGO:00603221080.029
positive regulation of catabolic processGO:00098963100.028
embryonic forelimb morphogenesisGO:003511540.028
vesicle mediated transportGO:00161923710.028
behaviorGO:00076101120.028
regulation of protein localizationGO:00328802960.028
protein catabolic processGO:00301633250.028
negative regulation of apoptotic processGO:00430663160.028
endomembrane system organizationGO:00102561960.028
negative regulation of phosphorus metabolic processGO:00105632670.028
negative regulation of programmed cell deathGO:00430693210.028
regulation of gtp catabolic processGO:00331241800.027
sensory perceptionGO:00076001030.027
regulation of protein serine threonine kinase activityGO:00719001790.027
response to growth factorGO:00708482050.027
growthGO:00400072020.027
neurotransmitter secretionGO:000726940.027
brain developmentGO:0007420970.027
muscle system processGO:0003012810.026
stem cell differentiationGO:0048863930.026
blood circulationGO:00080151130.026
positive regulation of hormone biosynthetic processGO:004688640.026
regulation of purine nucleotide metabolic processGO:19005422640.026
negative regulation of phosphate metabolic processGO:00459362670.026
cellular metal ion homeostasisGO:00068751460.026
response to organic cyclic compoundGO:00140702040.026
anterior posterior axis specificationGO:000994820.026
embryonic morphogenesisGO:0048598850.026
regulation of mitotic cell cycleGO:00073461890.026
positive regulation of gtpase activityGO:00435471660.025
skeletal system developmentGO:0001501790.025
regulation of hormone levelsGO:00108171250.025
mitotic cell cycle processGO:19030472860.025
positive regulation of purine nucleotide catabolic processGO:00331231850.025
regulation of system processGO:00440571010.025
regulation of nucleotide catabolic processGO:00308112050.025
central nervous system developmentGO:00074171230.025
negative regulation of kidney developmentGO:009018520.025
intracellular protein transportGO:00068862700.025
specification of organ identityGO:001009230.025
angiogenesisGO:00015251470.025
thymus developmentGO:004853830.024
secretion by cellGO:00329402260.024
positive regulation of transportGO:00510503360.024
negative regulation of cell cycleGO:00457861930.024
divalent inorganic cation homeostasisGO:00725071360.024
regulation of nucleoside metabolic processGO:00091182090.024
chemotaxisGO:00069351570.024
actin cytoskeleton organizationGO:00300362070.024
oocyte developmentGO:004859910.024
response to woundingGO:00096111680.024
cardiac muscle cell contractionGO:008600340.024
nitrogen compound transportGO:00717051910.024
regulation of ras protein signal transductionGO:00465781550.024
anterior posterior axis specification embryoGO:000859520.024
adult locomotory behaviorGO:000834410.023
positive regulation of nucleotide metabolic processGO:00459812300.023
positive regulation of cell deathGO:00109422630.023
positive regulation of nucleoside metabolic processGO:00459791860.023
negative regulation of cell motilityGO:20001461040.023
actin filament based movementGO:0030048170.023
circulatory system processGO:00030131130.023
negative regulation of transportGO:00510511760.023
regulation of sequence specific dna binding transcription factor activityGO:00510902110.023
cardiac muscle contractionGO:0060048340.023
positive regulation of apoptotic processGO:00430652460.023
negative regulation of catalytic activityGO:00430863350.023
positive regulation of cell differentiationGO:00455972110.023
regulation of intracellular transportGO:00323861950.023
negative regulation of cellular protein metabolic processGO:00322693530.023
wnt signaling pathwayGO:00160551560.023
positive regulation of programmed cell deathGO:00430682490.023
cellular response to dna damage stimulusGO:00069743790.023
regulation of cell cycle processGO:00105642660.023
positive regulation of purine nucleotide metabolic processGO:19005442270.023
secretionGO:00469032540.023
cellular macromolecular complex assemblyGO:00346223240.023
regulation of gtpase activityGO:00430871800.023
glycoprotein metabolic processGO:00091001100.023
organic hydroxy compound metabolic processGO:19016151470.023
positive regulation of steroid hormone biosynthetic processGO:009003120.023
oocyte differentiationGO:000999420.023
tissue morphogenesisGO:0048729960.022
cellular divalent inorganic cation homeostasisGO:00725031280.022
regulation of angiogenesisGO:0045765920.022
regulation of response to external stimulusGO:00321012220.022
regulation of wnt signaling pathwayGO:00301111230.022
positive regulation of cellular component movementGO:00512721810.022
lung alveolus developmentGO:004828640.022
regulation of proteolysisGO:00301622930.022
plasma membrane organizationGO:00070091150.022
regulation of secretion by cellGO:19035301770.022
regulation of cellular response to stressGO:00801352440.022
cellular protein catabolic processGO:00442572610.022
regulation of ion transportGO:00432691890.022
positive regulation of cell motilityGO:20001471770.021
lipid biosynthetic processGO:00086101770.021
circadian behaviorGO:004851220.021
dephosphorylationGO:00163112090.021
tripartite regional subdivisionGO:000735120.021
positive regulation of nucleotide catabolic processGO:00308131850.021
motor neuron axon guidanceGO:000804520.021
positive regulation of map kinase activityGO:0043406800.021
regulation of cell growthGO:00015581350.021
response to oxygen containing compoundGO:19017003690.021
muscle tissue developmentGO:0060537620.021
monovalent inorganic cation transportGO:00156721280.021
cytokine productionGO:00018162470.021
hair follicle morphogenesisGO:003106920.021
regulation of growthGO:00400081650.021
positive regulation of cellular component biogenesisGO:00440891580.020
protein localization to membraneGO:00726571600.020
positive regulation of gtp catabolic processGO:00331261660.020
neuron differentiationGO:00301821380.020
positive regulation of proteolysisGO:00458621420.020
regulation of protein transportGO:00512232130.020
memoryGO:000761330.020
cell projection morphogenesisGO:00488581290.020
establishment of protein localization to organelleGO:00725941720.020
cartilage condensationGO:000150210.020
positive regulation of synaptic transmissionGO:005080640.020
negative regulation of intracellular signal transductionGO:19025321830.020
tube morphogenesisGO:0035239950.020
peripheral nervous system developmentGO:000742220.020
defense responseGO:00069523150.020
carbohydrate derivative biosynthetic processGO:19011372070.020
nucleocytoplasmic transportGO:00069131760.020
ameboidal type cell migrationGO:00016671350.020
taxisGO:00423301570.020
heart developmentGO:0007507950.020
negative regulation of protein metabolic processGO:00512483910.020
response to external biotic stimulusGO:00432072610.020
histone modificationGO:00165702510.019
protein ubiquitinationGO:00165673140.019
regulation of cell morphogenesisGO:00226041530.019
regulation of ion transmembrane transportGO:00347651320.019
proteolysis involved in cellular protein catabolic processGO:00516032440.019
cellular protein complex assemblyGO:00436231880.019
regulation of secretionGO:00510461940.019
cellular lipid metabolic processGO:00442553030.019
negative regulation of cellular amino acid metabolic processGO:004576320.019
regulation of cytoskeleton organizationGO:00514931770.019
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781250.019
regulation of actin filament based processGO:00329701410.019
reactive oxygen species biosynthetic processGO:190340940.019
regulation of muscle contractionGO:0006937450.019
salivary gland morphogenesisGO:000743540.019
cell growthGO:00160491600.019
regulation of feeding behaviorGO:006025930.019
reactive oxygen species metabolic processGO:0072593750.019
nuclear transportGO:00511691790.019
embryonic epithelial tube formationGO:000183840.019
morphogenesis of a polarized epitheliumGO:000173830.019
protein modification by small protein conjugationGO:00324463420.019
protein targetingGO:00066051870.019
retinal ganglion cell axon guidanceGO:003129020.019
cell cell signalingGO:00072671550.019
regulation of cytoplasmic transportGO:19036491490.018
forebrain regionalizationGO:002187130.018
protein oligomerizationGO:00512591730.018
apoptotic signaling pathwayGO:00971902680.018
response to nitrogen compoundGO:19016981840.018
calcium ion homeostasisGO:00550741220.018
protein localization to nucleusGO:00345041360.018
regulation of stem cell differentiationGO:2000736560.018
spinal cord developmentGO:002151040.018
canonical wnt signaling pathwayGO:00600701160.018
regulation of cytokine productionGO:00018172320.018
osteoblast differentiationGO:0001649920.018
negative regulation of cellular amine metabolic processGO:003323930.018
regenerationGO:003109940.018
cytosolic calcium ion homeostasisGO:0051480890.018
spermatid differentiationGO:004851540.018
signal releaseGO:0023061700.018
regulation of small gtpase mediated signal transductionGO:00510561560.018
positive regulation of locomotionGO:00400171860.018
positive regulation of organelle organizationGO:00106381950.018
rhythmic behaviorGO:000762220.018
patterning of blood vesselsGO:000156920.018
sensory perception of painGO:001923340.018
ossificationGO:00015031210.018
positive regulation of ras gtpase activityGO:00323201170.018
response to cytokineGO:00340972320.017
regulation of transmembrane transportGO:00347621390.017
detection of stimulusGO:0051606850.017
regulation of metal ion transportGO:00109591200.017
energy homeostasisGO:009700930.017
response to lipidGO:00339932060.017
regulation of homeostatic processGO:00328441210.017
axis elongationGO:000340140.017
wound healingGO:00420601150.017
spermatid developmentGO:000728640.017
modification dependent macromolecule catabolic processGO:00436322120.017
regulation of vesicle mediated transportGO:00606271300.017
protein importGO:00170381300.017
cellular response to transforming growth factor beta stimulusGO:0071560940.017
anion transportGO:00068201610.017
positive regulation of odontogenesisGO:004248230.017
organelle assemblyGO:00709251760.017
chromatin organizationGO:00063253510.017
cellular response to organic cyclic compoundGO:00714071270.017
neuron developmentGO:00486661130.017
regulation of cell substrate adhesionGO:0010810680.017
actin mediated cell contractionGO:0070252120.017
kidney developmentGO:0001822530.017
negative regulation of protein modification processGO:00314002000.017
cd8 positive alpha beta t cell differentiation involved in immune responseGO:000230210.017
heart contractionGO:0060047620.017
neuron projection developmentGO:00311751060.017
cell matrix adhesionGO:0007160850.017
regulation of vasculature developmentGO:1901342970.017
ubiquitin dependent protein catabolic processGO:00065112060.016
establishment of protein localization to membraneGO:00901501210.016
canonical wnt signaling pathway involved in mesenchymal stem cell differentiationGO:004433820.016
negative regulation of cell adhesionGO:0007162640.016
metencephalon developmentGO:002203720.016
limbic system developmentGO:002176130.016
regulation of ras gtpase activityGO:00323181280.016
positive regulation of epithelial cell proliferationGO:0050679650.016
regulation of canonical wnt signaling pathwayGO:0060828880.016
embryo developmentGO:00097901230.016
cell part morphogenesisGO:00329901370.016
purine ribonucleoside monophosphate metabolic processGO:00091671860.016
digestive system developmentGO:0055123750.016
positive regulation of protein serine threonine kinase activityGO:00719021190.016
negative regulation of synaptic transmissionGO:005080520.016
covalent chromatin modificationGO:00165692540.016
positive regulation of insulin like growth factor receptor signaling pathwayGO:004356840.016
cellular response to hormone stimulusGO:00328701250.016
epithelial cell migrationGO:00106311190.016
regulation of intracellular protein transportGO:00331571230.016
regulation of transmembrane transporter activityGO:0022898740.016
innate immune responseGO:00450871780.016
atp metabolic processGO:00460341760.016
morphogenesis of an epitheliumGO:0002009600.016
cell cycle phase transitionGO:00447701730.016
small molecule biosynthetic processGO:00442831570.016
positive regulation of epithelial cell proliferation involved in wound healingGO:006005430.016
cell divisionGO:00513011680.016
regulation of protein catabolic processGO:00421761550.016
multi organism cellular processGO:00447641560.016
chromatin modificationGO:00165682980.016
carbohydrate metabolic processGO:00059752070.016
sequestering of metal ionGO:0051238240.016
canonical wnt signaling pathway involved in osteoblast differentiationGO:004433920.016
embryonic camera type eye developmentGO:003107620.016
modification dependent protein catabolic processGO:00199412090.016
negative regulation of growthGO:0045926970.016
positive regulation of cell developmentGO:0010720920.016
single organism reproductive processGO:0044702980.016
neuroblast proliferationGO:000740540.016
response to virusGO:00096151260.016
cell aggregationGO:009874310.016
divalent metal ion transportGO:00708381520.016
hindlimb morphogenesisGO:003513720.016
calcium ion transportGO:00068161470.016
maintenance of locationGO:00512351120.016
reproductive processGO:00224141060.016
regulation of map kinase activityGO:00434051080.016
renal system developmentGO:0072001630.015
epithelium migrationGO:00901321190.015
regulation of endopeptidase activityGO:00525481700.015
protein localization to plasma membraneGO:0072659930.015
mesenchyme developmentGO:0060485590.015
cell fate determinationGO:000170930.015
posttranscriptional regulation of gene expressionGO:00106082130.015
microtubule based processGO:00070172100.015
single organism nuclear importGO:19025931040.015
multicellular organismal homeostasisGO:0048871670.015
reactive nitrogen species metabolic processGO:200105730.015
regulation of reactive oxygen species biosynthetic processGO:190342630.015
divalent inorganic cation transportGO:00725111580.015
positive regulation of immune system processGO:00026842830.015
hormone secretionGO:0046879650.015
cerebellum developmentGO:002154920.015
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092900.015
regulation of membrane potentialGO:0042391950.015
compound eye developmentGO:004874910.015
tissue migrationGO:00901301190.015
interspecies interaction between organismsGO:00444191560.015
wnt signaling pathway involved in wound healing spreading of epidermal cellsGO:003565910.015
regulation of muscle system processGO:0090257530.015
purine nucleoside monophosphate metabolic processGO:00091261860.015
regulation of blood circulationGO:1903522590.015
embryonic viscerocranium morphogenesisGO:004870310.015
somitogenesisGO:000175620.015
proteasomal protein catabolic processGO:00104981760.015
response to biotic stimulusGO:00096072760.015
non canonical wnt signaling pathway via mapk cascadeGO:003803040.015
pattern specification processGO:0007389430.015
peptidyl tyrosine modificationGO:00182121700.015
soft palate developmentGO:006002330.015
response to radiationGO:00093141510.015
mitotic cell cycle phase transitionGO:00447721620.015
response to transforming growth factor betaGO:0071559940.015
striated muscle tissue developmentGO:0014706590.015
regulation of meiotic cell cycleGO:005144540.015
cellular calcium ion homeostasisGO:00068741170.015
epithelial tube branching involved in lung morphogenesisGO:006044140.014
erk1 and erk2 cascadeGO:00703711040.014
tongue developmentGO:004358610.014
cell activationGO:00017752130.014
regulation of axon guidanceGO:190266730.014
regulation of nervous system developmentGO:0051960880.014
glial cell migrationGO:000834740.014
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.014
limb bud formationGO:006017410.014
muscle cell fate commitmentGO:004269340.014
nucleoside monophosphate metabolic processGO:00091231910.014
regulation of odontogenesisGO:004248140.014
symbiosis encompassing mutualism through parasitismGO:00444031560.014
forebrain neuron differentiationGO:002187930.014
protein maturationGO:00516042330.014
potassium ion transmembrane transportGO:0071805600.014
single organism carbohydrate metabolic processGO:00447231930.014
androgen biosynthetic processGO:000670230.014
response to hypoxiaGO:0001666960.014
regulation of behaviorGO:0050795820.014
neuron fate commitmentGO:004866320.014
epithelial cell proliferationGO:00506731280.014
negative regulation of cell cycle processGO:00109481210.014
regulation of cell morphogenesis involved in differentiationGO:0010769830.014
negative regulation of mitotic cell cycleGO:00459301020.014
regulation of epithelial cell proliferationGO:00506781130.014

SCUBE3 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
musculoskeletal system diseaseDOID:172230.033
nervous system diseaseDOID:8634310.029
sensory system diseaseDOID:00501552030.029
cancerDOID:1621670.026
disease of cellular proliferationDOID:145661740.026
cardiovascular system diseaseDOID:12871060.024
eye and adnexa diseaseDOID:14921500.023
organ system cancerDOID:00506861640.022
eye diseaseDOID:56141490.022
central nervous system diseaseDOID:3311860.021
disease of metabolismDOID:00146672950.020
retinal diseaseDOID:56791180.018
heart diseaseDOID:114680.014