Homo sapiens

0 known processes

POLA2

polymerase (DNA directed), alpha 2 (70kD subunit)

(Aliases: FLJ37250,FLJ21662)

POLA2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
dna replicationGO:00062601160.867
Yeast Mouse
dna dependent dna replicationGO:0006261440.662
Yeast
determination of adult lifespanGO:000834020.607
dna replication initiationGO:000627060.567
Yeast
multicellular organismal agingGO:001025930.565
double strand break repairGO:00063021010.443
establishment of nucleus localizationGO:004002310.383
dna synthesis involved in dna repairGO:000073160.353
negative regulation of smooth muscle cell proliferationGO:0048662140.336
embryo developmentGO:00097901230.230
Worm
nuclear migrationGO:000709710.229
nuclear divisionGO:00002801280.225
nucleus localizationGO:005164710.216
tube developmentGO:00352951250.214
receptor mediated endocytosisGO:0006898840.204
lagging strand elongationGO:000627330.193
response to oxygen containing compoundGO:19017003690.173
cellular response to endogenous stimulusGO:00714953360.173
post embryonic developmentGO:000979120.170
Worm
purine ribonucleoside triphosphate catabolic processGO:00092073910.170
purine ribonucleoside metabolic processGO:00461284370.158
regulation of mapk cascadeGO:00434082620.156
negative regulation of cellular protein metabolic processGO:00322693530.154
cellular amino acid metabolic processGO:00065201160.151
purine containing compound catabolic processGO:00725234110.148
regulation of cellular ketone metabolic processGO:0010565500.144
regulation of smooth muscle cell migrationGO:0014910150.139
cellular response to oxygen containing compoundGO:19017012760.135
methylationGO:00322591060.133
organ morphogenesisGO:00098871470.127
regulation of kinase activityGO:00435493140.120
regulation of protein serine threonine kinase activityGO:00719001790.119
nucleoside monophosphate catabolic processGO:00091251590.117
vesicle mediated transportGO:00161923710.113
negative regulation of protein modification processGO:00314002000.110
response to organic cyclic compoundGO:00140702040.110
covalent chromatin modificationGO:00165692540.103
single organism carbohydrate metabolic processGO:00447231930.103
negative regulation of programmed cell deathGO:00430693210.101
histone methylationGO:0016571600.101
cellular response to molecule of bacterial originGO:0071219620.099
negative regulation of multi organism processGO:0043901920.097
meiosis iGO:000712740.092
atp catabolic processGO:00062001570.091
ribonucleoside monophosphate metabolic processGO:00091611870.090
endocytosisGO:00068971590.090
histone modificationGO:00165702510.088
mitotic nuclear divisionGO:00070671190.088
nucleoside triphosphate catabolic processGO:00091433940.084
response to other organismGO:00517072610.083
purine ribonucleoside catabolic processGO:00461303980.083
negative regulation of protein phosphorylationGO:00019331400.082
lung developmentGO:0030324200.082
macromolecule methylationGO:0043414970.080
muscle cell proliferationGO:0033002350.079
organophosphate catabolic processGO:00464344300.078
regulation of cellular amine metabolic processGO:0033238110.077
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.076
sensory organ developmentGO:0007423520.074
cell divisionGO:00513011680.074
Worm
chromatin organizationGO:00063253510.073
negative regulation of smooth muscle cell migrationGO:001491270.071
chromatin modificationGO:00165682980.070
oogenesisGO:004847720.070
response to drugGO:0042493810.069
dna repairGO:00062811980.069
regulation of sequence specific dna binding transcription factor activityGO:00510902110.068
protein targetingGO:00066051870.067
Mouse
negative regulation of phosphate metabolic processGO:00459362670.066
respiratory tube developmentGO:0030323200.065
organelle fissionGO:00482851490.065
protein targeting to nucleusGO:00447441040.064
Mouse
nucleoside phosphate catabolic processGO:19012924120.063
eye developmentGO:0001654420.063
engulfment of apoptotic cellGO:004365220.060
amine metabolic processGO:0009308440.059
negative regulation of protein metabolic processGO:00512483910.058
respiratory gaseous exchangeGO:000758530.058
negative regulation of cell migrationGO:00303361020.058
purine nucleoside monophosphate metabolic processGO:00091261860.057
cellular response to biotic stimulusGO:0071216710.055
nucleotide catabolic processGO:00091664080.052
regulation of multi organism processGO:00439001570.052
negative regulation of multicellular organismal processGO:00512413170.051
regulation of protein localizationGO:00328802960.050
regulation of histone modificationGO:0031056470.050
negative regulation of developmental processGO:00510932470.049
response to molecule of bacterial originGO:0002237820.049
sex differentiationGO:0007548450.049
purine nucleoside triphosphate catabolic processGO:00091463920.049
rna splicingGO:00083801310.048
single organism nuclear importGO:19025931040.048
Mouse
cellular response to organic cyclic compoundGO:00714071270.047
negative regulation of catalytic activityGO:00430863350.046
non recombinational repairGO:0000726140.046
positive regulation of nucleotide catabolic processGO:00308131850.046
regulation of cellular amino acid metabolic processGO:000652160.045
purine nucleotide catabolic processGO:00061954050.045
negative regulation of sequence specific dna binding transcription factor activityGO:0043433890.045
response to external biotic stimulusGO:00432072610.045
negative regulation of organelle organizationGO:00106391260.045
cellular response to organonitrogen compoundGO:00714171240.045
cellular response to growth factor stimulusGO:00713631970.044
protein import into nucleusGO:00066061040.044
Mouse
protein alkylationGO:0008213740.043
membrane organizationGO:00610242920.043
response to biotic stimulusGO:00096072760.043
dna strand elongation involved in dna replicationGO:000627130.043
cellular ketone metabolic processGO:0042180800.042
agingGO:0007568660.042
negative regulation of cell motilityGO:20001461040.042
positive regulation of cellular catabolic processGO:00313312840.042
apoptotic cell clearanceGO:0043277120.042
regulation of smooth muscle cell proliferationGO:0048660280.041
cellular amide metabolic processGO:0043603690.040
cellular macromolecular complex assemblyGO:00346223240.040
regulation of lipopolysaccharide mediated signaling pathwayGO:0031664130.039
nucleoside catabolic processGO:00091644080.039
reproductive processGO:00224141060.036
single fertilizationGO:0007338110.036
negative regulation of protein kinase activityGO:0006469980.036
positive regulation of cellular amine metabolic processGO:003324070.036
negative regulation of cell deathGO:00605483450.036
female gamete generationGO:000729220.036
mitotic cell cycleGO:00002783260.035
reproductive system developmentGO:0061458560.035
carbohydrate metabolic processGO:00059752070.035
regulation of cytokine biosynthetic processGO:0042035350.035
purine ribonucleoside monophosphate metabolic processGO:00091671860.035
regenerationGO:003109940.034
mapk cascadeGO:00001652880.034
regulation of growthGO:00400081650.034
negative regulation of apoptotic processGO:00430663160.034
response to hydrogen peroxideGO:0042542400.033
developmental process involved in reproductionGO:0003006660.033
signal transduction by phosphorylationGO:00230142970.033
response to reactive oxygen speciesGO:0000302610.033
ribonucleoside catabolic processGO:00424544060.033
lipid metabolic processGO:00066293810.033
histone lysine methylationGO:0034968500.032
protein localization to nucleusGO:00345041360.032
Mouse
response to lipidGO:00339932060.031
bradykinin catabolic processGO:001081540.031
alpha amino acid metabolic processGO:1901605720.031
respiratory system processGO:000301630.030
regulation of establishment of protein localizationGO:00702012420.030
purine ribonucleoside triphosphate metabolic processGO:00092054110.030
response to hormoneGO:00097251750.030
g1 s transition of mitotic cell cycleGO:0000082780.029
negative regulation of cell proliferationGO:00082852280.029
respiratory system developmentGO:0060541220.029
double strand break repair via homologous recombinationGO:0000724500.028
response to decreased oxygen levelsGO:0036293960.028
single organism reproductive processGO:0044702980.028
gtp metabolic processGO:00460392390.028
phagocytosis engulfmentGO:000691170.027
cellular response to lipidGO:00713961270.027
response to bacteriumGO:00096171440.027
glycosyl compound catabolic processGO:19016584130.027
negative regulation of phosphorylationGO:00423261740.027
negative regulation of phosphorus metabolic processGO:00105632670.026
lung alveolus developmentGO:004828640.026
guanosine containing compound catabolic processGO:19010692390.025
mrna metabolic processGO:00160711750.025
regulation of intracellular transportGO:00323861950.025
fertilizationGO:0009566120.025
protein importGO:00170381300.025
Mouse
ribonucleoside triphosphate catabolic processGO:00092033910.025
lipid biosynthetic processGO:00086101770.025
protein methylationGO:0006479740.025
response to abiotic stimulusGO:00096283360.024
response to organonitrogen compoundGO:00102431560.024
regulation of peptidase activityGO:00525471800.024
cellular amine metabolic processGO:0044106410.024
regulation of response to external stimulusGO:00321012220.024
response to fungusGO:000962040.024
apoptotic signaling pathwayGO:00971902680.024
rna dependent dna replicationGO:0006278160.024
stress activated mapk cascadeGO:0051403930.024
regulation of histone h3 k27 methylationGO:006108540.023
negative regulation of response to external stimulusGO:0032102830.023
gonad developmentGO:0008406340.022
purine ribonucleoside monophosphate catabolic processGO:00091691580.022
stress activated protein kinase signaling cascadeGO:0031098940.022
neurogenesisGO:00220081690.022
negative regulation of cell differentiationGO:00455961710.022
negative regulation of mitotic cell cycleGO:00459301020.021
peptide metabolic processGO:0006518510.021
regulation of stress activated protein kinase signaling cascadeGO:0070302850.021
negative regulation of cell cycleGO:00457861930.021
smooth muscle cell migrationGO:0014909180.021
cellular component morphogenesisGO:00329893140.021
histone h3 k4 methylationGO:0051568270.021
atp metabolic processGO:00460341760.021
positive regulation of phosphorylationGO:00423273940.021
regulation of cell differentiationGO:00455953930.020
regulation of mrna metabolic processGO:1903311530.020
response to cytokineGO:00340972320.020
cell cycle g1 s phase transitionGO:0044843800.020
positive regulation of hydrolase activityGO:00513453310.020
cytokine metabolic processGO:0042107380.020
cardiovascular system developmentGO:00723582620.020
mitotic cell cycle phase transitionGO:00447721620.019
regulation of protein kinase activityGO:00458592890.019
nucleoside monophosphate metabolic processGO:00091231910.019
dna biosynthetic processGO:0071897400.019
Yeast
dephosphorylationGO:00163112090.019
dna strand elongationGO:002261650.019
purine ribonucleotide catabolic processGO:00091544040.019
microtubule organizing center organizationGO:0031023620.019
ribonucleoside triphosphate metabolic processGO:00091994120.019
nucleus organizationGO:0006997280.018
growthGO:00400072020.018
cellular carbohydrate metabolic processGO:0044262840.018
metencephalon developmentGO:002203720.018
negative regulation of retinoic acid receptor signaling pathwayGO:004838740.018
regulation of locomotionGO:00400123290.018
leading strand elongationGO:000627210.018
regulation of nucleocytoplasmic transportGO:0046822980.018
positive regulation of neural precursor cell proliferationGO:200017920.018
intracellular protein transportGO:00068862700.018
Mouse
ras protein signal transductionGO:0007265730.018
response to inorganic substanceGO:00100351270.018
regulation of g1 s transition of mitotic cell cycleGO:2000045400.018
positive regulation of purine nucleotide catabolic processGO:00331231850.018
mrna processingGO:00063971330.018
gtp catabolic processGO:00061842370.018
positive regulation of purine nucleotide metabolic processGO:19005442270.018
regulation of protein targetingGO:1903533910.018
cellular response to nitrogen compoundGO:19016991440.018
negative regulation of cellular component organizationGO:00511292350.017
regulation of transferase activityGO:00513383550.017
generation of neuronsGO:00486991520.017
negative regulation of transferase activityGO:00513481240.017
cell fate determinationGO:000170930.017
autophagyGO:0006914880.017
cellular response to hormone stimulusGO:00328701250.017
hindbrain developmentGO:003090230.017
negative regulation of cellular component movementGO:00512711060.017
response to oxidative stressGO:00069791210.016
regulation of intracellular protein transportGO:00331571230.016
regulation of gtp catabolic processGO:00331241800.016
cation homeostasisGO:00550801890.016
negative regulation of locomotionGO:00400131180.016
positive regulation of cytoplasmic transportGO:1903651820.016
cellular response to external stimulusGO:00714961110.016
histone h3 k9 methylationGO:0051567100.016
cellular glucan metabolic processGO:0006073220.016
circulatory system developmentGO:00723592620.016
response to activityGO:001482300.016
locomotory behaviorGO:000762610.016
viral life cycleGO:00190581320.015
negative regulation of gene expression epigeneticGO:0045814190.015
negative regulation of cell cycle phase transitionGO:1901988890.015
purine nucleoside monophosphate catabolic processGO:00091281580.015
cell projection morphogenesisGO:00488581290.015
negative regulation of peptidase activityGO:0010466910.015
reproductionGO:0000003630.015
positive regulation of protein kinase activityGO:00458601900.015
negative regulation of cell developmentGO:0010721480.015
regulation of cell migrationGO:00303342890.015
response to alcoholGO:0097305640.014
protein autophosphorylationGO:00467771230.014
regulation of map kinase activityGO:00434051080.014
regulation of dna metabolic processGO:00510521530.014
embryo development ending in birth or egg hatchingGO:0009792340.014
Worm
segmentationGO:003528240.014
reactive oxygen species metabolic processGO:0072593750.014
sister chromatid cohesionGO:0007062240.014
positive regulation of histone modificationGO:0031058290.014
positive regulation of cell cycle processGO:00900681060.014
blastocyst developmentGO:000182430.014
negative regulation of cellular amino acid metabolic processGO:004576320.014
response to extracellular stimulusGO:0009991850.014
positive regulation of catabolic processGO:00098963100.014
protein complex localizationGO:0031503310.014
extrinsic apoptotic signaling pathwayGO:00971911190.014
maintenance of locationGO:00512351120.014
anatomical structure homeostasisGO:00602491000.013
Yeast
neuromuscular junction developmentGO:000752830.013
chordate embryonic developmentGO:0043009340.013
energy reserve metabolic processGO:0006112220.013
skeletal system developmentGO:0001501790.013
regulation of cell cycle processGO:00105642660.013
peptidyl lysine modificationGO:00182051440.013
regulation of cell motilityGO:20001452990.013
regulation of cell divisionGO:00513021160.013
cytoplasmic transportGO:00164823790.013
Mouse
response to nitrogen compoundGO:19016981840.013
negative regulation of proteolysisGO:00458611320.013
interleukin 10 biosynthetic processGO:004209120.013
ribonucleoside monophosphate catabolic processGO:00091581580.013
regulation of dna replicationGO:0006275680.013
regulation of chromatin organizationGO:1902275560.013
regulation of nucleotide catabolic processGO:00308112050.013
positive regulation of gtp catabolic processGO:00331261660.013
microtubule based processGO:00070172100.013
positive regulation of cell differentiationGO:00455972110.013
phagocytosisGO:0006909420.013
positive regulation of cell proliferationGO:00082843010.013
positive regulation of developmental processGO:00510943140.013
reactive oxygen species biosynthetic processGO:190340940.012
purine ribonucleoside biosynthetic processGO:0046129230.012
meiotic chromosome separationGO:005130730.012
double strand break repair via nonhomologous end joiningGO:0006303100.012
reactive nitrogen species metabolic processGO:200105730.012
peptide catabolic processGO:0043171100.012
regulation of nucleoside metabolic processGO:00091182090.012
purine nucleoside triphosphate metabolic processGO:00091444120.012
neuron differentiationGO:00301821380.012
protein dealkylationGO:0008214170.012
response to toxic substanceGO:0009636370.012
cellular response to dna damage stimulusGO:00069743790.012
cell cycle dna replicationGO:0044786110.012
nervous system developmentGO:00073992930.012
positive regulation of gtpase activityGO:00435471660.012
histone demethylationGO:0016577150.011
regulation of response to biotic stimulusGO:0002831550.011
negative regulation of epidermal cell differentiationGO:004560540.011
jnk cascadeGO:0007254800.011
cellular lipid catabolic processGO:0044242650.011
carbohydrate derivative biosynthetic processGO:19011372070.011
rna processingGO:00063962550.011
cell part morphogenesisGO:00329901370.011
negative regulation of cellular amine metabolic processGO:003323930.011
central nervous system developmentGO:00074171230.011
negative regulation of cell cycle processGO:00109481210.011
response to oxygen levelsGO:00704821000.011
mrna splicing via spliceosomeGO:0000398890.011
sexual reproductionGO:0019953370.011
positive regulation of histone h3 k4 methylationGO:005157180.011
positive regulation of meiotic cell cycleGO:005144620.011
viral processGO:00160321460.011
embryonic organ developmentGO:0048568360.011
cellular response to hypoxiaGO:0071456510.011
positive regulation of cell deathGO:00109422630.011
protein modification by small protein conjugationGO:00324463420.011
regulation of protein import into nucleusGO:0042306780.011
reciprocal meiotic recombinationGO:000713140.011
regulation of neural precursor cell proliferationGO:200017740.011
nucleoside triphosphate metabolic processGO:00091414220.011
cell developmentGO:00484683280.011
digestive system developmentGO:0055123750.011
chemical homeostasisGO:00488783060.011
sodium ion export from cellGO:003637660.011
positive regulation of mapk cascadeGO:00434101900.010
negative regulation of endopeptidase activityGO:0010951840.010
bmp signaling pathwayGO:0030509490.010
regulation of growth rateGO:004000910.010
t cell activationGO:0042110990.010
nucleic acid phosphodiester bond hydrolysisGO:00903051020.010
purine nucleoside catabolic processGO:00061523980.010
regulation of viral genome replicationGO:0045069480.010
leukocyte activationGO:00453211640.010

POLA2 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
brugada syndromeDOID:005045180.346
cardiovascular system diseaseDOID:12871060.346
heart conduction diseaseDOID:10273180.346
disease of metabolismDOID:00146672950.069
organ system cancerDOID:00506861640.044
cancerDOID:1621670.044
disease of cellular proliferationDOID:145661740.044
gastrointestinal system cancerDOID:3119520.042
nervous system diseaseDOID:8634310.012
sensory system diseaseDOID:00501552030.012
aicardi goutieres syndromeDOID:005062970.011
neuropathyDOID:870520.011