Homo sapiens

70 known processes

PPIA

peptidylprolyl isomerase A (cyclophilin A)

(Aliases: MGC23397,CYPH,CYPA,MGC12404,MGC117158)

PPIA biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
glomerular mesangial cell developmentGO:007214410.889
multicellular organismal agingGO:001025930.598
cellular response to oxidative stressGO:0034599850.550
positive regulation of developmental processGO:00510943140.546
renal interstitial fibroblast developmentGO:007214110.375
cellular response to dna damage stimulusGO:00069743790.350
organelle assemblyGO:00709251760.278
regulation of nucleotide metabolic processGO:00061402690.261
nucleoside catabolic processGO:00091644080.249
cytoplasmic transportGO:00164823790.243
dna repairGO:00062811980.236
ribonucleotide catabolic processGO:00092614050.234
purine ribonucleoside triphosphate metabolic processGO:00092054110.214
protein acylationGO:00435431380.200
response to other organismGO:00517072610.191
cellular response to cytokine stimulusGO:00713451810.181
vesicle mediated transportGO:00161923710.180
negative regulation of cell deathGO:00605483450.165
response to external biotic stimulusGO:00432072610.162
regulation of sequence specific dna binding transcription factor activityGO:00510902110.159
nucleocytoplasmic transportGO:00069131760.152
organelle inheritanceGO:004830820.145
adult locomotory behaviorGO:000834410.129
response to cytokineGO:00340972320.128
post embryonic developmentGO:000979120.127
blood circulationGO:00080151130.127
cellular homeostasisGO:00197251960.125
positive regulation of transportGO:00510503360.122
ribonucleoprotein complex assemblyGO:0022618780.122
immune effector processGO:00022521590.122
anion transportGO:00068201610.120
immune responseGO:00069553070.114
determination of adult lifespanGO:000834020.112
negative regulation of apoptotic processGO:00430663160.107
positive regulation of bindingGO:0051099450.107
regulation of intracellular transportGO:00323861950.104
intrinsic apoptotic signaling pathwayGO:00971931270.103
immune system developmentGO:00025201950.098
response to acid chemicalGO:0001101660.096
anatomical structure homeostasisGO:00602491000.089
somatic muscle developmentGO:000752510.085
ribonucleoprotein complex biogenesisGO:00226131160.081
atp metabolic processGO:00460341760.080
heart processGO:0003015620.079
positive regulation of cell proliferationGO:00082843010.076
purine nucleotide catabolic processGO:00061954050.076
response to virusGO:00096151260.076
ribonucleoside triphosphate metabolic processGO:00091994120.074
apoptotic signaling pathwayGO:00971902680.073
endocytosisGO:00068971590.073
nucleoside triphosphate metabolic processGO:00091414220.073
nucleoside phosphate catabolic processGO:19012924120.070
positive regulation of cellular amine metabolic processGO:003324070.070
ribonucleoside catabolic processGO:00424544060.069
internal protein amino acid acetylationGO:00064751010.069
purine ribonucleotide catabolic processGO:00091544040.067
organophosphate catabolic processGO:00464344300.065
response to oxidative stressGO:00069791210.065
organonitrogen compound biosynthetic processGO:19015662000.064
kidney interstitial fibroblast differentiationGO:007207120.062
microvillus assemblyGO:003003320.062
cellular chemical homeostasisGO:00550821800.062
positive regulation of growthGO:0045927580.061
positive regulation of cellular catabolic processGO:00313312840.060
rna transportGO:0050658390.056
innate immune responseGO:00450871780.056
protein targetingGO:00066051870.055
positive regulation of cellular amino acid metabolic processGO:004576430.054
purine nucleoside triphosphate metabolic processGO:00091444120.054
nucleic acid phosphodiester bond hydrolysisGO:00903051020.053
negative regulation of cellular protein metabolic processGO:00322693530.052
regulation of establishment of protein localizationGO:00702012420.052
alcohol metabolic processGO:00060661140.051
ribonucleoprotein complex subunit organizationGO:0071826810.050
posttranscriptional regulation of gene expressionGO:00106082130.050
nucleotide catabolic processGO:00091664080.050
secretionGO:00469032540.050
positive regulation of nucleotide biosynthetic processGO:0030810380.049
hematopoietic or lymphoid organ developmentGO:00485341860.049
organelle fissionGO:00482851490.049
negative regulation of programmed cell deathGO:00430693210.048
cellular cation homeostasisGO:00300031630.048
cellular response to acid chemicalGO:0071229440.048
tissue homeostasisGO:0001894630.047
regulation of bindingGO:00510981110.047
meiotic chromosome segregationGO:004513240.047
nitrogen compound transportGO:00717051910.046
positive regulation of nucleotide metabolic processGO:00459812300.046
intracellular protein transportGO:00068862700.044
covalent chromatin modificationGO:00165692540.044
response to interleukin 4GO:007067070.042
positive regulation of cell deathGO:00109422630.042
ion homeostasisGO:00508012300.041
regulation of cyclic nucleotide biosynthetic processGO:0030802490.041
regulation of growthGO:00400081650.040
internal peptidyl lysine acetylationGO:0018393970.039
anatomical structure formation involved in morphogenesisGO:00486462840.038
positive regulation of catabolic processGO:00098963100.038
positive regulation of apoptotic processGO:00430652460.038
cellular macromolecular complex assemblyGO:00346223240.037
carboxylic acid biosynthetic processGO:0046394970.037
purine nucleoside catabolic processGO:00061523980.037
microtubule organizing center organizationGO:0031023620.036
cellular macromolecule catabolic processGO:00442653800.036
response to lipidGO:00339932060.035
regulation of nucleotide biosynthetic processGO:0030808500.035
regulation of apoptotic signaling pathwayGO:20012331750.035
cell agingGO:0007569520.034
neuron differentiationGO:00301821380.033
Mouse
single organism carbohydrate metabolic processGO:00447231930.033
regulation of intracellular protein transportGO:00331571230.033
rna interferenceGO:001624640.033
positive regulation of immune system processGO:00026842830.032
defense responseGO:00069523150.031
nuclear transportGO:00511691790.031
ribonucleoside triphosphate catabolic processGO:00092033910.031
heart contractionGO:0060047620.031
negative regulation of immune system processGO:00026831360.031
response to oxygen containing compoundGO:19017003690.031
cellular response to oxygen containing compoundGO:19017012760.030
muscle cell cellular homeostasisGO:004671630.030
negative regulation of intracellular transportGO:0032387600.030
cation homeostasisGO:00550801890.030
regulation of purine nucleotide biosynthetic processGO:1900371500.030
agingGO:0007568660.030
positive regulation of hydrolase activityGO:00513453310.029
purine ribonucleoside triphosphate catabolic processGO:00092073910.029
myoblast fusionGO:000752010.029
cellular amide metabolic processGO:0043603690.029
purine nucleoside triphosphate catabolic processGO:00091463920.029
response to inorganic substanceGO:00100351270.029
locomotory behaviorGO:000762610.029
microtubule based processGO:00070172100.028
chemical homeostasisGO:00488783060.028
regulation of cellular amino acid metabolic processGO:000652160.028
reactive oxygen species metabolic processGO:0072593750.028
translesion synthesisGO:001998580.028
positive regulation of purine nucleotide metabolic processGO:19005442270.028
mrna metabolic processGO:00160711750.028
regulation of purine nucleotide metabolic processGO:19005422640.028
neuromuscular junction developmentGO:000752830.027
single organism reproductive processGO:0044702980.027
positive regulation of purine nucleotide biosynthetic processGO:1900373380.027
gtp metabolic processGO:00460392390.027
cellular divalent inorganic cation homeostasisGO:00725031280.027
signal transduction in response to dna damageGO:0042770570.027
lipid biosynthetic processGO:00086101770.026
actomyosin structure organizationGO:0031032590.026
positive regulation of programmed cell deathGO:00430682490.026
oogenesisGO:004847720.026
female gamete generationGO:000729220.026
myeloid cell differentiationGO:00300991170.026
monocarboxylic acid metabolic processGO:00327871850.026
response to bacteriumGO:00096171440.026
negative regulation of phosphate metabolic processGO:00459362670.026
Rat
regulation of nucleocytoplasmic transportGO:0046822980.026
carbohydrate metabolic processGO:00059752070.026
oxidation reduction processGO:00551143960.026
positive regulation of camp biosynthetic processGO:0030819350.025
nucleoside triphosphate catabolic processGO:00091433940.025
positive regulation of gtpase activityGO:00435471660.025
nucleoside diphosphate metabolic processGO:0009132160.025
circulatory system processGO:00030131130.024
platelet activationGO:0030168440.024
microtubule cytoskeleton organizationGO:00002261760.024
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.024
actin myosin filament slidingGO:003327560.024
secretion by cellGO:00329402260.023
response to woundingGO:00096111680.023
regulation of cellular response to stressGO:00801352440.023
regulation of peptidase activityGO:00525471800.023
cell growthGO:00160491600.023
cellular response to endogenous stimulusGO:00714953360.023
regulation of protein targetingGO:1903533910.023
atp transportGO:001586740.023
negative regulation of transcription initiation from rna polymerase ii promoterGO:006063330.023
maintenance of locationGO:00512351120.022
regulation of membrane potentialGO:0042391950.022
regulation of cytoplasmic transportGO:19036491490.022
double strand break repairGO:00063021010.022
organic anion transportGO:00157111030.022
negative regulation of apoptotic signaling pathwayGO:2001234970.022
glycosyl compound catabolic processGO:19016584130.021
negative regulation of cell growthGO:0030308830.021
response to biotic stimulusGO:00096072760.021
protein targeting to nucleusGO:00447441040.021
regulation of cyclic nucleotide metabolic processGO:0030799630.021
establishment or maintenance of cell polarityGO:0007163310.021
regulation of gene expression epigeneticGO:0040029730.021
muscle structure developmentGO:0061061980.021
protein localization to nucleusGO:00345041360.021
actin filament based processGO:00300292240.021
system processGO:00030083490.020
cellular ion homeostasisGO:00068731680.020
positive regulation of mitochondrial membrane permeabilityGO:0035794170.020
multicellular organismal homeostasisGO:0048871670.020
cellular amine metabolic processGO:0044106410.020
epithelial cell differentiationGO:00308551410.020
replicative cell agingGO:000130230.020
negative regulation of neuron apoptotic processGO:0043524230.019
response to abiotic stimulusGO:00096283360.019
hemopoiesisGO:00300971800.019
organelle localizationGO:0051640840.019
regulation of protein localizationGO:00328802960.019
regulation of innate immune responseGO:0045088970.019
receptor mediated endocytosisGO:0006898840.019
regulation of protein processingGO:00706131500.019
protein acetylationGO:00064731160.019
morphogenesis of a polarized epitheliumGO:000173830.019
purine ribonucleoside monophosphate metabolic processGO:00091671860.019
histone acetylationGO:0016573930.018
nervous system developmentGO:00073992930.018
Mouse
establishment of protein localization to organelleGO:00725941720.018
single organism membrane organizationGO:00448022680.018
membrane organizationGO:00610242920.018
oocyte developmentGO:004859910.018
purine ribonucleoside catabolic processGO:00461303980.018
cellular metal ion homeostasisGO:00068751460.018
retina homeostasisGO:0001895420.018
regulation of proteolysisGO:00301622930.018
signal transduction by p53 class mediatorGO:0072331720.018
regulation of response to dna damage stimulusGO:2001020940.018
positive regulation of nf kappab transcription factor activityGO:0051092810.018
response to metal ionGO:0010038840.018
regulation of cellular ketone metabolic processGO:0010565500.017
regulation of developmental growthGO:0048638300.017
cellular ketone metabolic processGO:0042180800.017
divalent inorganic cation homeostasisGO:00725071360.017
cellular component morphogenesisGO:00329893140.017
neuron cellular homeostasisGO:007005030.017
oocyte differentiationGO:000999420.017
negative regulation of cellular response to oxidative stressGO:1900408180.017
positive regulation of developmental growthGO:0048639160.017
carbohydrate derivative biosynthetic processGO:19011372070.017
positive regulation of reactive oxygen species metabolic processGO:2000379240.017
camp biosynthetic processGO:0006171470.017
calcium ion homeostasisGO:00550741220.017
dna catabolic process endonucleolyticGO:0000737370.017
growthGO:00400072020.016
signal transduction by phosphorylationGO:00230142970.016
cell cycle checkpointGO:00000751170.016
mapk cascadeGO:00001652880.016
single organism cell adhesionGO:00986021790.016
spermatid developmentGO:000728640.016
negative regulation of sequence specific dna binding transcription factor activityGO:0043433890.016
protein localization to organelleGO:00333652800.016
epidermis developmentGO:0008544590.016
regulation of cytokine productionGO:00018172320.016
single organism nuclear importGO:19025931040.016
nuclear exportGO:0051168690.016
base excision repairGO:0006284210.016
negative regulation of catalytic activityGO:00430863350.016
Rat
protein homooligomerizationGO:00512601000.016
negative regulation of response to woundingGO:1903035470.016
pyrimidine nucleoside triphosphate biosynthetic processGO:000914810.016
regulation of actin filament depolymerizationGO:0030834100.015
regulation of rna splicingGO:0043484620.015
protein import into nucleusGO:00066061040.015
apoptotic mitochondrial changesGO:0008637570.015
cytosolic calcium ion homeostasisGO:0051480890.015
negative regulation of organelle organizationGO:00106391260.015
mitochondrial calcium ion homeostasisGO:0051560110.015
ribonucleotide biosynthetic processGO:0009260810.015
negative regulation of kinase activityGO:00336731060.015
rna processingGO:00063962550.015
positive regulation of synaptic transmissionGO:005080640.015
negative regulation of protein processingGO:00109551420.015
gtp catabolic processGO:00061842370.015
neural crest cell developmentGO:001403230.015
organic acid biosynthetic processGO:0016053970.015
translationGO:00064121320.015
tissue regenerationGO:004224630.015
single organism cellular localizationGO:19025803320.015
generation of precursor metabolites and energyGO:0006091680.015
nuclear importGO:00511701060.014
cyclic nucleotide metabolic processGO:0009187820.014
leukocyte mediated immunityGO:0002443590.014
circulatory system developmentGO:00723592620.014
regulation of reactive oxygen species metabolic processGO:2000377410.014
regulation of protein localization to nucleusGO:1900180850.014
cellular protein complex assemblyGO:00436231880.014
development of primary sexual characteristicsGO:0045137350.014
glomerulus vasculature developmentGO:007201260.014
peptidyl tyrosine phosphorylationGO:00181081700.014
striated muscle myosin thick filament assemblyGO:007168820.014
chromatin modificationGO:00165682980.014
detection of chemical stimulusGO:0009593550.014
mesenchymal cell developmentGO:0014031500.014
taxisGO:00423301570.014
positive regulation of sequence specific dna binding transcription factor activityGO:00510911310.014
regulation of protein maturationGO:19033171500.014
developmental process involved in reproductionGO:0003006660.014
regulation of myeloid cell differentiationGO:0045637810.014
response to hyperoxiaGO:005509340.014
guanosine containing compound metabolic processGO:19010682440.014
amine metabolic processGO:0009308440.014
negative regulation of protein metabolic processGO:00512483910.014
anterior posterior axis specificationGO:000994820.014
epithelium developmentGO:00604292270.014
negative regulation of cell differentiationGO:00455961710.014
cellular protein complex disassemblyGO:0043624360.013
pyrimidine ribonucleoside biosynthetic processGO:004613220.013
dna replicationGO:00062601160.013
phospholipid metabolic processGO:0006644990.013
sex differentiationGO:0007548450.013
interleukin 8 productionGO:0032637510.013
regulation of multicellular organism growthGO:004001480.013
purine containing compound catabolic processGO:00725234110.013
purine ribonucleoside metabolic processGO:00461284370.013
regulation of immune responseGO:00507762010.012
negative regulation of proteolysisGO:00458611320.012
cell developmentGO:00484683280.012
response to fatty acidGO:0070542130.012
regulation of peptide transportGO:0090087620.012
developmental growthGO:0048589480.012
reproductive processGO:00224141060.012
positive regulation of cell differentiationGO:00455972110.012
protein complex disassemblyGO:0043241520.012
cation transmembrane transportGO:00986552380.012
positive regulation of secretionGO:00510471160.012
regulation of camp metabolic processGO:0030814520.012
regulation of protein transportGO:00512232130.012
regulation of anatomical structure morphogenesisGO:00226032860.012
regulation of necroptotic processGO:006054470.012
blastoderm segmentationGO:000735020.012
cellular response to reactive oxygen speciesGO:0034614500.012
regulation of defense responseGO:00313471540.012
cofactor metabolic processGO:0051186870.012
positive regulation of cytokine productionGO:00018191670.012
striated muscle cell differentiationGO:0051146430.011
establishment of rna localizationGO:0051236390.011
negative regulation of oxidative stress induced cell deathGO:1903202170.011
purine nucleotide transportGO:001586560.011
positive regulation of cellular component movementGO:00512721810.011
cellular component disassemblyGO:0022411920.011
positive regulation of cyclic nucleotide metabolic processGO:0030801490.011
segmentationGO:003528240.011
response to interferon gammaGO:0034341390.011
lipid metabolic processGO:00066293810.011
regulation of transporter activityGO:0032409820.011
neural nucleus developmentGO:0048857470.011
extrinsic apoptotic signaling pathwayGO:00971911190.011
establishment of protein localization to membraneGO:00901501210.011
positive regulation of immune responseGO:00507781590.011
reproductive system developmentGO:0061458560.011
negative regulation of translationGO:0017148370.011
reproductive structure developmentGO:0048608550.011
negative regulation of hydrolase activityGO:00513461820.011
Rat
epithelial cell proliferationGO:00506731280.011
ribosomal subunit export from nucleusGO:000005440.011
regulation of cellular component movementGO:00512703340.011
regulation of response to external stimulusGO:00321012220.010
cell type specific apoptotic processGO:00972851250.010
regulation of secretionGO:00510461940.010
peptide transportGO:0015833740.010
dna damage response signal transduction by p53 class mediatorGO:0030330440.010
actin filament based movementGO:0030048170.010
regulation of mitochondrial membrane permeability involved in apoptotic processGO:1902108180.010
negative regulation of protein complex assemblyGO:0031333430.010
rna splicingGO:00083801310.010
regulation of cell differentiationGO:00455953930.010
pattern specification processGO:0007389430.010
ribonucleoside biosynthetic processGO:0042455250.010
regulation of mitochondrion organizationGO:0010821540.010
regulation of transcription factor import into nucleusGO:0042990390.010
negative regulation of protein maturationGO:19033181420.010
negative regulation of cytoplasmic transportGO:1903650460.010
stem cell developmentGO:0048864690.010
dna biosynthetic processGO:0071897400.010
response to hormoneGO:00097251750.010

PPIA disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
nervous system diseaseDOID:8634310.048
central nervous system diseaseDOID:3311860.048
auditory system diseaseDOID:2742530.045
autosomal dominant nonsyndromic deafnessDOID:0050564230.045
nonsyndromic deafnessDOID:0050563500.045
sensory system diseaseDOID:00501552030.045
neurodegenerative diseaseDOID:12891020.034
cancerDOID:1621670.028
disease of cellular proliferationDOID:145661740.028
organ system cancerDOID:00506861640.028
disease of metabolismDOID:00146672950.012