Homo sapiens

68 known processes

EIF2AK3

eukaryotic translation initiation factor 2-alpha kinase 3

(Aliases: PERK,PEK,WRS,DKFZp781H1925)

EIF2AK3 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular macromolecule catabolic processGO:00442653800.193
modification dependent protein catabolic processGO:00199412090.152
modification dependent macromolecule catabolic processGO:00436322120.151
protein catabolic processGO:00301633250.145
cellular protein catabolic processGO:00442572610.132
proteolysis involved in cellular protein catabolic processGO:00516032440.124
ubiquitin dependent protein catabolic processGO:00065112060.119
endoplasmic reticulum unfolded protein responseGO:0030968160.114
negative regulation of cell deathGO:00605483450.113
Mouse
determination of adult lifespanGO:000834020.109
Worm
post embryonic developmentGO:000979120.092
Worm
negative regulation of programmed cell deathGO:00430693210.090
Mouse
response to abiotic stimulusGO:00096283360.089
cation transportGO:00068123310.087
negative regulation of apoptotic processGO:00430663160.081
Mouse
protein ubiquitinationGO:00165673140.077
multicellular organismal agingGO:001025930.077
Worm
vesicle mediated transportGO:00161923710.074
response to oxygen containing compoundGO:19017003690.073
reactive oxygen species metabolic processGO:0072593750.068
oogenesisGO:004847720.066
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.065
actin filament based processGO:00300292240.065
dephosphorylationGO:00163112090.065
maintenance of locationGO:00512351120.063
secretionGO:00469032540.059
Mouse
female gamete generationGO:000729220.058
cellular response to endogenous stimulusGO:00714953360.057
protein modification by small protein conjugationGO:00324463420.056
cellular response to oxygen containing compoundGO:19017012760.055
proteasomal protein catabolic processGO:00104981760.052
regulation of cellular amino acid metabolic processGO:000652160.051
segmentationGO:003528240.046
membrane organizationGO:00610242920.046
single organism cellular localizationGO:19025803320.046
regulation of cell differentiationGO:00455953930.045
ribonucleotide catabolic processGO:00092614050.044
oocyte differentiationGO:000999420.043
system processGO:00030083490.043
Mouse
transmembrane transportGO:00550853990.043
cellular response to organic cyclic compoundGO:00714071270.042
purine ribonucleoside catabolic processGO:00461303980.042
pharynx developmentGO:006046510.041
ribonucleoside triphosphate catabolic processGO:00092033910.041
nucleoside phosphate catabolic processGO:19012924120.040
ribonucleoside catabolic processGO:00424544060.040
regulation of reactive oxygen species metabolic processGO:2000377410.040
carbohydrate derivative biosynthetic processGO:19011372070.040
purine ribonucleotide catabolic processGO:00091544040.040
blastoderm segmentationGO:000735020.039
anterior posterior axis specification embryoGO:000859520.039
amine metabolic processGO:0009308440.039
regulation of cellular amine metabolic processGO:0033238110.039
response to decreased oxygen levelsGO:0036293960.038
actin cytoskeleton organizationGO:00300362070.038
organophosphate catabolic processGO:00464344300.037
regulation of apoptotic signaling pathwayGO:20012331750.037
Mouse
secretion by cellGO:00329402260.037
regulation of cellular response to stressGO:00801352440.036
Mouse
glycosyl compound catabolic processGO:19016584130.036
regulation of cell cycleGO:00517263930.036
Fly
oocyte developmentGO:004859910.036
purine containing compound catabolic processGO:00725234110.036
response to hypoxiaGO:0001666960.036
establishment or maintenance of cytoskeleton polarityGO:003095230.035
purine ribonucleoside metabolic processGO:00461284370.035
response to disaccharideGO:003428510.035
purine nucleotide catabolic processGO:00061954050.034
regulation of cellular component biogenesisGO:00440872810.034
cellular amine metabolic processGO:0044106410.034
positive regulation of hydrolase activityGO:00513453310.034
Mouse
response to organonitrogen compoundGO:00102431560.033
regulation of nucleotide metabolic processGO:00061402690.033
nervous system developmentGO:00073992930.033
Mouse
tripartite regional subdivisionGO:000735120.033
regulation of purine nucleotide catabolic processGO:00331212050.033
response to organic cyclic compoundGO:00140702040.033
negative regulation of intracellular signal transductionGO:19025321830.033
nucleoside triphosphate metabolic processGO:00091414220.033
nucleotide catabolic processGO:00091664080.032
regulation of cellular ketone metabolic processGO:0010565500.032
Mouse
hindbrain developmentGO:003090230.031
positive regulation of nucleotide metabolic processGO:00459812300.031
guanosine containing compound catabolic processGO:19010692390.031
response to woundingGO:00096111680.031
ribonucleoside triphosphate metabolic processGO:00091994120.031
establishment or maintenance of microtubule cytoskeleton polarityGO:003095120.031
cellular amino acid metabolic processGO:00065201160.030
response to unfolded proteinGO:0006986240.029
gtp metabolic processGO:00460392390.029
positive regulation of transferase activityGO:00513472270.029
purine nucleoside triphosphate catabolic processGO:00091463920.028
cell cycle phase transitionGO:00447701730.028
Fly
cellular ketone metabolic processGO:0042180800.028
Mouse
response to nitrogen compoundGO:19016981840.027
microtubule based processGO:00070172100.027
positive regulation of transportGO:00510503360.027
metal ion transportGO:00300012720.027
cell projection organizationGO:00300302520.027
response to oxygen levelsGO:00704821000.027
positive regulation of reactive oxygen species metabolic processGO:2000379240.027
regulation of blood coagulationGO:0030193420.027
positive regulation of cellular amine metabolic processGO:003324070.026
cellular component morphogenesisGO:00329893140.026
protein localization to organelleGO:00333652800.026
regulation of nucleoside metabolic processGO:00091182090.026
regenerationGO:003109940.026
mitotic cell cycle processGO:19030472860.026
Fly
cellular response to cytokine stimulusGO:00713451810.026
metencephalon developmentGO:002203720.026
regulation of dephosphorylationGO:0035303960.026
positive regulation of immune system processGO:00026842830.026
purine ribonucleoside triphosphate metabolic processGO:00092054110.026
anterior posterior axis specificationGO:000994820.025
regulation of transferase activityGO:00513383550.025
nucleoside catabolic processGO:00091644080.025
intracellular mrna localizationGO:000829810.025
purine nucleoside triphosphate metabolic processGO:00091444120.024
positive regulation of catabolic processGO:00098963100.024
Fly
er associated ubiquitin dependent protein catabolic processGO:0030433310.024
lipid metabolic processGO:00066293810.024
Mouse
positive regulation of cellular component organizationGO:00511303760.024
positive regulation of phosphorylationGO:00423273940.024
positive regulation of nucleoside metabolic processGO:00459791860.024
cellular response to organonitrogen compoundGO:00714171240.023
microtubule cytoskeleton organizationGO:00002261760.023
ion transmembrane transportGO:00342203380.023
negative regulation of phosphorus metabolic processGO:00105632670.023
positive regulation of gtp catabolic processGO:00331261660.023
positive regulation of purine nucleotide catabolic processGO:00331231850.023
ras protein signal transductionGO:0007265730.023
negative regulation of apoptotic signaling pathwayGO:2001234970.022
regulation of protein localizationGO:00328802960.022
positive regulation of cellular catabolic processGO:00313312840.022
Fly
regulation of cell activationGO:00508651250.022
rho protein signal transductionGO:0007266260.022
positive regulation of cellular amino acid metabolic processGO:004576430.022
cytoplasmic transportGO:00164823790.022
regulation of protein modification by small protein conjugation or removalGO:19033201070.022
positive regulation of developmental processGO:00510943140.022
cerebellum developmentGO:002154920.022
locomotory behaviorGO:000762610.022
response to fungusGO:000962040.022
lipid biosynthetic processGO:00086101770.021
rna interferenceGO:001624640.021
protein targetingGO:00066051870.021
regulation of cellular component movementGO:00512703340.021
immune responseGO:00069553070.021
regulation of gtpase activityGO:00430871800.021
cellular lipid metabolic processGO:00442553030.021
Mouse
regulation of protein kinase activityGO:00458592890.021
cellular response to dna damage stimulusGO:00069743790.021
intracellular protein transportGO:00068862700.021
purine nucleoside catabolic processGO:00061523980.021
wound healingGO:00420601150.021
regulation of proteolysisGO:00301622930.021
Mouse
response to endoplasmic reticulum stressGO:0034976490.021
regulation of cell motilityGO:20001452990.020
regulation of purine nucleotide metabolic processGO:19005422640.020
neurological system processGO:00508771630.020
Mouse
cell developmentGO:00484683280.020
Mouse
positive regulation of purine nucleotide metabolic processGO:19005442270.020
lipid localizationGO:00108761060.020
inorganic ion transmembrane transportGO:00986602310.020
regulation of phosphatase activityGO:0010921810.020
regulation of cytokine productionGO:00018172320.019
coagulationGO:0050817780.019
negative regulation of multicellular organismal processGO:00512413170.019
Mouse
regulation of kinase activityGO:00435493140.019
negative regulation of cellular protein metabolic processGO:00322693530.019
Mouse Rat
regulation of gtp catabolic processGO:00331241800.019
negative regulation of cellular amino acid metabolic processGO:004576320.019
defense responseGO:00069523150.019
gtp catabolic processGO:00061842370.019
cytokine productionGO:00018162470.019
cellular response to nitrogen compoundGO:19016991440.019
positive regulation of kinase activityGO:00336742040.019
mitotic cell cycle phase transitionGO:00447721620.019
Fly
positive regulation of nucleotide catabolic processGO:00308131850.019
regulation of locomotionGO:00400123290.019
ribonucleoside monophosphate metabolic processGO:00091611870.019
chemical homeostasisGO:00488783060.019
regulation of nucleotide catabolic processGO:00308112050.018
cellular response to biotic stimulusGO:0071216710.018
nucleoside triphosphate catabolic processGO:00091433940.018
regulation of hemostasisGO:1900046420.018
protein oligomerizationGO:00512591730.018
cellular macromolecular complex assemblyGO:00346223240.018
actin filament organizationGO:00070151280.018
cellular response to superoxideGO:007145160.018
memoryGO:000761330.018
cation transmembrane transportGO:00986552380.018
cellular response to oxidative stressGO:0034599850.018
negative regulation of protein modification processGO:00314002000.018
purine ribonucleoside triphosphate catabolic processGO:00092073910.018
establishment of protein localization to organelleGO:00725941720.017
positive regulation of blood coagulationGO:0030194110.017
apoptotic signaling pathwayGO:00971902680.017
Mouse
positive regulation of protein kinase activityGO:00458601900.017
glycerolipid metabolic processGO:00464861070.017
mitotic cell cycleGO:00002783260.017
Fly
response to other organismGO:00517072610.017
response to hormoneGO:00097251750.017
blood coagulationGO:0007596760.017
positive regulation of protein phosphorylationGO:00019343130.017
cellular response to hydrogen peroxideGO:0070301370.017
negative regulation of catalytic activityGO:00430863350.017
positive regulation of gtpase activityGO:00435471660.017
regulation of multi organism processGO:00439001570.017
regulation of growthGO:00400081650.017
Worm
regulation of establishment of protein localizationGO:00702012420.017
response to organophosphorusGO:0046683410.017
regulation of response to external stimulusGO:00321012220.017
regulation of immune responseGO:00507762010.016
cell morphogenesisGO:00009022960.016
monovalent inorganic cation transportGO:00156721280.016
endocytosisGO:00068971590.016
posttranscriptional regulation of gene expressionGO:00106082130.016
Mouse Rat
regulation of intrinsic apoptotic signaling pathwayGO:2001242720.016
Mouse
response to external biotic stimulusGO:00432072610.016
guanosine containing compound metabolic processGO:19010682440.016
regulation of coagulationGO:0050818440.016
regulation of wound healingGO:0061041560.016
negative regulation of protein metabolic processGO:00512483910.016
Mouse Rat
biological adhesionGO:00226103310.016
proteasomal ubiquitin independent protein catabolic processGO:001049930.016
regulation of protein catabolic processGO:00421761550.016
single organism membrane organizationGO:00448022680.016
cellular response to fluid shear stressGO:007149870.016
morphogenesis of embryonic epitheliumGO:001633140.015
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.015
regulation of cell migrationGO:00303342890.015
spermatid developmentGO:000728640.015
small molecule biosynthetic processGO:00442831570.015
regulation of cell maturationGO:190342930.015
regulation of neural precursor cell proliferationGO:200017740.015
regulation of cell cycle processGO:00105642660.015
Fly
hemostasisGO:0007599760.015
inorganic cation transmembrane transportGO:00986621940.015
small gtpase mediated signal transductionGO:0007264780.015
negative regulation of cellular amine metabolic processGO:003323930.015
mononuclear cell proliferationGO:0032943710.015
positive regulation of cellular component movementGO:00512721810.015
negative regulation of phosphate metabolic processGO:00459362670.015
purine nucleoside monophosphate catabolic processGO:00091281580.015
neurogenesisGO:00220081690.015
regulation of cell developmentGO:00602841610.015
positive regulation of cell migrationGO:00303351720.015
innate immune responseGO:00450871780.014
response to sucroseGO:000974410.014
regulation of leukocyte activationGO:00026941150.014
positive regulation of cell proliferationGO:00082843010.014
rna processingGO:00063962550.014
organonitrogen compound biosynthetic processGO:19015662000.014
protein localization to membraneGO:00726571600.014
cation homeostasisGO:00550801890.014
response to cytokineGO:00340972320.014
negative regulation of phosphorylationGO:00423261740.014
peripheral nervous system developmentGO:000742220.014
embryo developmentGO:00097901230.014
growthGO:00400072020.014
Worm
positive regulation of immune responseGO:00507781590.014
phospholipid metabolic processGO:0006644990.014
spermatid differentiationGO:004851540.014
adult locomotory behaviorGO:000834410.014
lymphocyte activationGO:00466491330.014
regulation of oocyte developmentGO:006028110.014
nitrogen compound transportGO:00717051910.014
cell projection morphogenesisGO:00488581290.014
negative regulation of cell proliferationGO:00082852280.014
cellular response to reactive oxygen speciesGO:0034614500.014
response to oxidative stressGO:00069791210.013
positive regulation of hemostasisGO:1900048110.013
oxidation reduction processGO:00551143960.013
cell adhesionGO:00071553250.013
cellular metal ion homeostasisGO:00068751460.013
leukocyte activationGO:00453211640.013
protein k33 linked ubiquitinationGO:199039010.013
negative regulation of developmental processGO:00510932470.013
Mouse
neuron differentiationGO:00301821380.013
neurotransmitter secretionGO:000726940.013
epithelial cell differentiationGO:00308551410.013
primary neural tube formationGO:001402030.013
neuromuscular junction developmentGO:000752830.013
regulation of transcription involved in g2 m transition of mitotic cell cycleGO:000011710.013
regulation of secretion by cellGO:19035301770.013
positive regulation of organelle organizationGO:00106381950.013
positive regulation of response to woundingGO:1903036280.013
hemopoiesisGO:00300971800.013
purine nucleoside monophosphate metabolic processGO:00091261860.013
signal transduction by phosphorylationGO:00230142970.013
maintenance of protein locationGO:0045185570.013
cellular response to tumor necrosis factorGO:0071356630.013
golgi vesicle transportGO:0048193800.013
toxin transportGO:190199840.013
negative regulation of immune system processGO:00026831360.013
negative regulation of intrinsic apoptotic signaling pathwayGO:2001243400.013
regulation of secretionGO:00510461940.012
generation of neuronsGO:00486991520.012
ion homeostasisGO:00508012300.012
inner ear morphogenesisGO:004247240.012
regulation of protein transportGO:00512232130.012
positive regulation of cytokine productionGO:00018191670.012
protein importGO:00170381300.012
tissue regenerationGO:004224630.012
associative learningGO:000830610.012
regulation of protein ubiquitinationGO:0031396950.012
regulation of intracellular transportGO:00323861950.012
activation of immune responseGO:00022531140.012
positive regulation of cellular component biogenesisGO:00440891580.012
sodium ion transportGO:0006814610.012
reactive oxygen species biosynthetic processGO:190340940.012
response to inorganic substanceGO:00100351270.012
neural tube closureGO:000184330.012
regulation of ion transportGO:00432691890.012
cellular protein complex assemblyGO:00436231880.012
vesicle targeting rough er to cis golgiGO:004820720.012
purine ribonucleoside monophosphate metabolic processGO:00091671860.012
response to tumor necrosis factorGO:0034612760.012
nucleoside monophosphate metabolic processGO:00091231910.012
circadian behaviorGO:004851220.011
negative regulation of oxidative stress induced cell deathGO:1903202170.011
response to purine containing compoundGO:0014074400.011
positive regulation of cell motilityGO:20001471770.011
response to transforming growth factor betaGO:0071559940.011
histone modificationGO:00165702510.011
peptidyl tyrosine phosphorylationGO:00181081700.011
head developmentGO:00603221080.011
embryonic epithelial tube formationGO:000183840.011
establishment of protein localization to membraneGO:00901501210.011
cellular homeostasisGO:00197251960.011
cell projection assemblyGO:00300311260.011
atp catabolic processGO:00062001570.011
protein localization to nucleusGO:00345041360.011
regulation of cellular response to growth factor stimulusGO:0090287760.011
cell type specific apoptotic processGO:00972851250.011
mapk cascadeGO:00001652880.011
negative regulation of protein phosphorylationGO:00019331400.011
g2 m transition of mitotic cell cycleGO:0000086410.011
Fly
covalent chromatin modificationGO:00165692540.011
single organism cell adhesionGO:00986021790.011
cardiac muscle cell contractionGO:008600340.011
positive regulation of wound healingGO:0090303200.011
matingGO:000761810.011
organophosphate biosynthetic processGO:00904071630.011
positive regulation of locomotionGO:00400171860.011
rhythmic behaviorGO:000762220.011
g1 s transition of mitotic cell cycleGO:0000082780.011
nucleoside monophosphate catabolic processGO:00091251590.011
nerve developmentGO:002167540.011
enzyme linked receptor protein signaling pathwayGO:00071673030.011
Mouse
monosaccharide metabolic processGO:0005996740.011
negative regulation of cellular component organizationGO:00511292350.011
chromatin modificationGO:00165682980.011
cellular ion homeostasisGO:00068731680.011
cell cycle g2 m phase transitionGO:0044839430.011
Fly
regulation of anatomical structure morphogenesisGO:00226032860.011
carbohydrate metabolic processGO:00059752070.011
regulation of mononuclear cell proliferationGO:0032944650.011
atp metabolic processGO:00460341760.011
purine ribonucleoside monophosphate catabolic processGO:00091691580.010
reproductive processGO:00224141060.010
peptidyl serine phosphorylationGO:00181051010.010
Worm
tube closureGO:006060630.010
regulation of cellular response to oxidative stressGO:1900407260.010
negative regulation of glycogen metabolic processGO:007087440.010
cell death in response to oxidative stressGO:0036473290.010
positive regulation of protein transportGO:00512221350.010
cellular response to transforming growth factor beta stimulusGO:0071560940.010
sex determinationGO:000753030.010
cellular response to lipidGO:00713961270.010
ossificationGO:00015031210.010
immune effector processGO:00022521590.010
organic acid biosynthetic processGO:0016053970.010
compound eye developmentGO:004874910.010
ribonucleoside monophosphate catabolic processGO:00091581580.010
regulation of dna metabolic processGO:00510521530.010
protein homooligomerizationGO:00512601000.010
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092900.010
cellular chemical homeostasisGO:00550821800.010
cellular response to oxygen levelsGO:0071453550.010
regulation of cell divisionGO:00513021160.010

EIF2AK3 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
nervous system diseaseDOID:8634310.033
central nervous system diseaseDOID:3311860.033
musculoskeletal system diseaseDOID:172230.020
sensory system diseaseDOID:00501552030.016
eye and adnexa diseaseDOID:14921500.016
eye diseaseDOID:56141490.016
disease of metabolismDOID:00146672950.014
cancerDOID:1621670.013
disease of cellular proliferationDOID:145661740.013
organ system cancerDOID:00506861640.013
connective tissue diseaseDOID:651090.012
retinal diseaseDOID:56791180.012
retinal degenerationDOID:8466890.010
bone diseaseDOID:0080001880.010
brain diseaseDOID:936730.010