Homo sapiens

0 known processes

HECW2

HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2

(Aliases: NEDL2,DKFZp686M17164)

HECW2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.126
cell developmentGO:00484683280.101
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781250.090
regulation of cellular component biogenesisGO:00440872810.089
mitotic cell cycle processGO:19030472860.086
enzyme linked receptor protein signaling pathwayGO:00071673030.080
post embryonic developmentGO:000979120.078
protein catabolic processGO:00301633250.075
cell cycle phase transitionGO:00447701730.074
mitotic cell cycle phase transitionGO:00447721620.074
regulation of cellular amine metabolic processGO:0033238110.072
cellular macromolecule catabolic processGO:00442653800.072
positive regulation of cellular component organizationGO:00511303760.070
determination of adult lifespanGO:000834020.070
multicellular organismal agingGO:001025930.068
modification dependent protein catabolic processGO:00199412090.068
chromatin organizationGO:00063253510.068
regulation of cellular ketone metabolic processGO:0010565500.067
purine ribonucleotide catabolic processGO:00091544040.066
organophosphate catabolic processGO:00464344300.065
nervous system developmentGO:00073992930.065
nucleoside triphosphate metabolic processGO:00091414220.064
purine ribonucleoside catabolic processGO:00461303980.063
regulation of locomotionGO:00400123290.063
purine nucleotide catabolic processGO:00061954050.063
nucleotide catabolic processGO:00091664080.061
mitotic cell cycleGO:00002783260.060
proteolysis involved in cellular protein catabolic processGO:00516032440.060
proteasomal protein catabolic processGO:00104981760.060
purine ribonucleoside triphosphate metabolic processGO:00092054110.060
cellular amine metabolic processGO:0044106410.059
purine nucleoside triphosphate metabolic processGO:00091444120.057
cell projection organizationGO:00300302520.056
amine metabolic processGO:0009308440.055
cellular protein catabolic processGO:00442572610.055
purine nucleoside catabolic processGO:00061523980.055
cellular ketone metabolic processGO:0042180800.054
cell morphogenesisGO:00009022960.054
regulation of nucleotide metabolic processGO:00061402690.054
nucleoside phosphate catabolic processGO:19012924120.054
ribonucleoside triphosphate catabolic processGO:00092033910.053
ras protein signal transductionGO:0007265730.053
nucleoside triphosphate catabolic processGO:00091433940.053
defense responseGO:00069523150.053
purine ribonucleoside metabolic processGO:00461284370.053
ribonucleotide catabolic processGO:00092614050.052
scf dependent proteasomal ubiquitin dependent protein catabolic processGO:0031146150.052
purine ribonucleoside triphosphate catabolic processGO:00092073910.052
small gtpase mediated signal transductionGO:0007264780.051
regulation of cellular amino acid metabolic processGO:000652160.051
negative regulation of apoptotic processGO:00430663160.051
ubiquitin dependent protein catabolic processGO:00065112060.050
purine containing compound catabolic processGO:00725234110.049
ribonucleoside triphosphate metabolic processGO:00091994120.049
oogenesisGO:004847720.049
nucleoside catabolic processGO:00091644080.048
cellular amino acid metabolic processGO:00065201160.047
positive regulation of cellular amino acid metabolic processGO:004576430.046
cellular component morphogenesisGO:00329893140.046
locomotory behaviorGO:000762610.046
female gamete generationGO:000729220.045
glycosyl compound catabolic processGO:19016584130.045
neuron differentiationGO:00301821380.045
purine nucleoside triphosphate catabolic processGO:00091463920.044
g2 m transition of mitotic cell cycleGO:0000086410.044
gtp catabolic processGO:00061842370.043
protein ubiquitinationGO:00165673140.043
protein modification by small protein conjugationGO:00324463420.043
generation of neuronsGO:00486991520.043
negative regulation of protein metabolic processGO:00512483910.042
ribonucleoside catabolic processGO:00424544060.042
neurogenesisGO:00220081690.041
modification dependent macromolecule catabolic processGO:00436322120.041
positive regulation of cellular amine metabolic processGO:003324070.041
negative regulation of multicellular organismal processGO:00512413170.040
positive regulation of catabolic processGO:00098963100.040
guanosine containing compound metabolic processGO:19010682440.040
negative regulation of cell deathGO:00605483450.040
cell adhesionGO:00071553250.040
inorganic ion transmembrane transportGO:00986602310.039
regulation of response to external stimulusGO:00321012220.039
cell cycle g2 m phase transitionGO:0044839430.038
regulation of cellular component movementGO:00512703340.038
mitochondrion organizationGO:00070051560.038
regulation of nucleoside metabolic processGO:00091182090.037
regulation of cell differentiationGO:00455953930.037
morphogenesis of embryonic epitheliumGO:001633140.037
regulation of purine nucleotide metabolic processGO:19005422640.036
single organism cellular localizationGO:19025803320.036
response to biotic stimulusGO:00096072760.036
regulation of anatomical structure morphogenesisGO:00226032860.035
guanosine containing compound catabolic processGO:19010692390.034
neuron projection developmentGO:00311751060.034
regulation of nucleotide catabolic processGO:00308112050.034
regulation of purine nucleotide catabolic processGO:00331212050.034
negative regulation of cellular protein metabolic processGO:00322693530.034
gtp metabolic processGO:00460392390.033
protein localization to organelleGO:00333652800.033
bmp signaling pathwayGO:0030509490.033
regulation of cell developmentGO:00602841610.033
cofactor metabolic processGO:0051186870.032
inorganic cation transmembrane transportGO:00986621940.032
transmembrane transportGO:00550853990.032
hindbrain developmentGO:003090230.032
regenerationGO:003109940.032
biological adhesionGO:00226103310.031
positive regulation of phosphorylationGO:00423273940.031
cellular response to dna damage stimulusGO:00069743790.031
regulation of cytoskeleton organizationGO:00514931770.031
response to external biotic stimulusGO:00432072610.031
regulation of establishment of protein localizationGO:00702012420.031
regulation of cellular component sizeGO:0032535820.030
regulation of cell migrationGO:00303342890.030
actin cytoskeleton organizationGO:00300362070.030
chemical homeostasisGO:00488783060.029
memoryGO:000761330.029
regulation of gtpase activityGO:00430871800.029
positive regulation of transportGO:00510503360.029
rna processingGO:00063962550.029
neuromuscular junction developmentGO:000752830.029
lipid biosynthetic processGO:00086101770.028
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092900.028
histone modificationGO:00165702510.027
regulation of cell motilityGO:20001452990.027
positive regulation of cell proliferationGO:00082843010.027
segmentationGO:003528240.027
regulation of cell morphogenesisGO:00226041530.027
rho protein signal transductionGO:0007266260.027
immune responseGO:00069553070.027
negative regulation of catalytic activityGO:00430863350.026
neuron developmentGO:00486661130.026
cell morphogenesis involved in differentiationGO:00009041440.026
positive regulation of hydrolase activityGO:00513453310.026
regulation of gtp catabolic processGO:00331241800.026
regulation of protein complex assemblyGO:00432541470.026
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.025
intracellular protein transportGO:00068862700.025
oocyte developmentGO:004859910.025
metal ion transportGO:00300012720.025
cell part morphogenesisGO:00329901370.025
system processGO:00030083490.025
regulation of sequence specific dna binding transcription factor activityGO:00510902110.025
cellular response to growth factor stimulusGO:00713631970.025
microtubule based processGO:00070172100.024
positive regulation of cell motilityGO:20001471770.024
central nervous system developmentGO:00074171230.024
positive regulation of cellular catabolic processGO:00313312840.024
response to other organismGO:00517072610.024
negative regulation of phosphorus metabolic processGO:00105632670.024
positive regulation of organelle organizationGO:00106381950.024
regulation of cell cycle processGO:00105642660.024
regulation of transferase activityGO:00513383550.024
limbic system developmentGO:002176130.023
negative regulation of phosphate metabolic processGO:00459362670.023
positive regulation of bmp signaling pathwayGO:003051390.023
negative regulation of cellular component organizationGO:00511292350.023
mapk cascadeGO:00001652880.023
regulation of mapk cascadeGO:00434082620.023
negative regulation of developmental processGO:00510932470.023
oocyte differentiationGO:000999420.023
response to abiotic stimulusGO:00096283360.022
compound eye developmentGO:004874910.022
vesicle mediated transportGO:00161923710.022
regulation of actin filament based processGO:00329701410.022
negative regulation of protein modification processGO:00314002000.022
regulation of cellular response to stressGO:00801352440.022
regulation of anatomical structure sizeGO:00900661010.022
reactive oxygen species metabolic processGO:0072593750.022
covalent chromatin modificationGO:00165692540.022
stem cell divisionGO:001714520.021
response to radiationGO:00093141510.021
single organism cell adhesionGO:00986021790.021
regulation of bmp signaling pathwayGO:0030510270.021
positive regulation of purine nucleotide metabolic processGO:19005442270.021
negative regulation of response to external stimulusGO:0032102830.021
maintenance of locationGO:00512351120.021
positive regulation of protein phosphorylationGO:00019343130.021
positive regulation of locomotionGO:00400171860.021
cellular response to abiotic stimulusGO:00712141170.021
negative regulation of hydrolase activityGO:00513461820.021
positive regulation of nucleotide metabolic processGO:00459812300.021
cell projection morphogenesisGO:00488581290.021
organic hydroxy compound metabolic processGO:19016151470.021
chromatin modificationGO:00165682980.021
peripheral nervous system developmentGO:000742220.021
primary neural tube formationGO:001402030.021
membrane organizationGO:00610242920.020
positive regulation of transferase activityGO:00513472270.020
neuroblast proliferationGO:000740540.020
interspecies interaction between organismsGO:00444191560.020
regulation of growthGO:00400081650.020
embryonic epithelial tube formationGO:000183840.020
regulation of cell adhesionGO:00301551660.020
positive regulation of programmed cell deathGO:00430682490.020
cellular lipid metabolic processGO:00442553030.020
response to disaccharideGO:003428510.019
neural tube formationGO:000184130.019
cell fate determinationGO:000170930.019
regulation of intracellular transportGO:00323861950.019
endosomal transportGO:00161971290.019
viral processGO:00160321460.019
secretionGO:00469032540.019
protein maturationGO:00516042330.019
metencephalon developmentGO:002203720.019
negative regulation of phosphorylationGO:00423261740.019
regulation of nervous system developmentGO:0051960880.019
negative regulation of programmed cell deathGO:00430693210.019
regulation of ion transportGO:00432691890.019
anterior posterior axis specificationGO:000994820.019
regulation of ion transmembrane transportGO:00347651320.019
signal transduction by phosphorylationGO:00230142970.018
muscle contractionGO:0006936730.018
single organism membrane organizationGO:00448022680.018
negative regulation of cellular amine metabolic processGO:003323930.018
taxisGO:00423301570.018
regulation of protein transportGO:00512232130.018
regulation of cytoplasmic transportGO:19036491490.018
ion transmembrane transportGO:00342203380.018
sodium ion transportGO:0006814610.018
response to bacteriumGO:00096171440.018
spermatid developmentGO:000728640.018
organonitrogen compound biosynthetic processGO:19015662000.018
regulation of neurogenesisGO:0050767820.018
cytoplasmic transportGO:00164823790.018
dephosphorylationGO:00163112090.018
spermatid differentiationGO:004851540.018
blastoderm segmentationGO:000735020.018
cell activationGO:00017752130.018
cerebellum developmentGO:002154920.018
symbiosis encompassing mutualism through parasitismGO:00444031560.017
endomembrane system organizationGO:00102561960.017
positive regulation of developmental processGO:00510943140.017
regulation of cell growthGO:00015581350.017
single organism carbohydrate metabolic processGO:00447231930.017
chromosome segregationGO:00070591140.017
positive regulation of proteolysisGO:00458621420.017
response to woundingGO:00096111680.017
regulation of transporter activityGO:0032409820.017
regulation of cell cycleGO:00517263930.017
response to axon injuryGO:004867810.017
positive regulation of nucleotide catabolic processGO:00308131850.017
autophagyGO:0006914880.017
positive regulation of axon extensionGO:004577340.017
actin filament based processGO:00300292240.017
regulation of mitotic cell cycleGO:00073461890.017
organophosphate biosynthetic processGO:00904071630.017
growthGO:00400072020.017
regulation of small gtpase mediated signal transductionGO:00510561560.017
nerve developmentGO:002167540.016
positive regulation of cell differentiationGO:00455972110.016
positive regulation of cell migrationGO:00303351720.016
negative regulation of intracellular signal transductionGO:19025321830.016
head developmentGO:00603221080.016
cell growthGO:00160491600.016
microtubule cytoskeleton organizationGO:00002261760.016
carbohydrate metabolic processGO:00059752070.016
multi organism cellular processGO:00447641560.016
positive regulation of purine nucleotide catabolic processGO:00331231850.016
innate immune responseGO:00450871780.016
vasodilationGO:004231140.016
regulation of synaptic plasticityGO:004816730.016
regulation of protein maturationGO:19033171500.016
endocytosisGO:00068971590.016
secretion by cellGO:00329402260.016
motor neuron axon guidanceGO:000804520.016
long term memoryGO:000761620.016
cell projection assemblyGO:00300311260.016
negative regulation of protein phosphorylationGO:00019331400.016
positive regulation of gtp catabolic processGO:00331261660.016
regulation of vesicle mediated transportGO:00606271300.016
cation transportGO:00068123310.016
purine nucleoside monophosphate metabolic processGO:00091261860.016
regulation of peptidase activityGO:00525471800.016
nitrogen compound transportGO:00717051910.016
negative regulation of cellular amino acid metabolic processGO:004576320.016
adult locomotory behaviorGO:000834410.016
embryo developmentGO:00097901230.016
tube morphogenesisGO:0035239950.016
apoptotic signaling pathwayGO:00971902680.016
meiotic chromosome segregationGO:004513240.016
regulation of kinase activityGO:00435493140.015
positive regulation of gtpase activityGO:00435471660.015
response to inorganic substanceGO:00100351270.015
oxidation reduction processGO:00551143960.015
ribonucleoside monophosphate metabolic processGO:00091611870.015
positive regulation of nucleoside metabolic processGO:00459791860.015
neural tube closureGO:000184330.015
nuclear transportGO:00511691790.015
neurotransmitter secretionGO:000726940.015
regulation of protein kinase activityGO:00458592890.015
cellular homeostasisGO:00197251960.015
positive regulation of cellular component movementGO:00512721810.015
positive regulation of cell cycleGO:00457871400.015
regulation of actin cytoskeleton organizationGO:00329561160.015
neuron projection regenerationGO:003110210.015
positive regulation of cell developmentGO:0010720920.015
regulation of neuron differentiationGO:0045664700.015
positive regulation of mapk cascadeGO:00434101900.015
axon regenerationGO:003110310.015
mrna metabolic processGO:00160711750.015
purine ribonucleoside monophosphate metabolic processGO:00091671860.015
epithelial cell differentiationGO:00308551410.015
negative regulation of platelet aggregationGO:009033130.015
posttranscriptional regulation of gene expressionGO:00106082130.015
regulation of protein catabolic processGO:00421761550.015
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090100410.015
protein processingGO:00164852260.015
dna repairGO:00062811980.015
protein oligomerizationGO:00512591730.015
neurological system processGO:00508771630.014
protein acylationGO:00435431380.014
regulation of secretionGO:00510461940.014
regulation of proteolysisGO:00301622930.014
brain developmentGO:0007420970.014
regulation of proteasomal protein catabolic processGO:0061136870.014
tube closureGO:006060630.014
regulation of protein serine threonine kinase activityGO:00719001790.014
nucleoside monophosphate metabolic processGO:00091231910.014
single organism reproductive processGO:0044702980.014
monovalent inorganic cation transportGO:00156721280.014
positive regulation of cellular component biogenesisGO:00440891580.014
ion homeostasisGO:00508012300.014
peptidyl lysine modificationGO:00182051440.014
nuclear divisionGO:00002801280.014
regulation of cell cycle phase transitionGO:19019871260.014
protein autophosphorylationGO:00467771230.014
negative regulation of proteolysisGO:00458611320.014
epithelial cell migrationGO:00106311190.014
atp catabolic processGO:00062001570.014
cellular response to cytokine stimulusGO:00713451810.014
chemotaxisGO:00069351570.014
cellular macromolecular complex assemblyGO:00346223240.014
regulation of ras protein signal transductionGO:00465781550.014
forebrain generation of neuronsGO:002187230.014
regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032434710.014
cell cycle checkpointGO:00000751170.014
regulation of protein localizationGO:00328802960.014
cell type specific apoptotic processGO:00972851250.014
regulation of membrane potentialGO:0042391950.014
carbohydrate derivative biosynthetic processGO:19011372070.014
fatty acid biosynthetic processGO:0006633460.014
response to organic cyclic compoundGO:00140702040.014
protein localization to membraneGO:00726571600.014
regulation of lipid metabolic processGO:0019216960.014
regulation of ras gtpase activityGO:00323181280.014
positive regulation of protein complex assemblyGO:0031334860.013
tube developmentGO:00352951250.013
ossificationGO:00015031210.013
second messenger mediated signalingGO:0019932780.013
muscle system processGO:0003012810.013
organelle localizationGO:0051640840.013
ribonucleoside monophosphate catabolic processGO:00091581580.013
blood circulationGO:00080151130.013
regulation of ossificationGO:0030278580.013
regulation of transmembrane transporter activityGO:0022898740.013
hippocampus developmentGO:002176610.013
negative regulation of protein processingGO:00109551420.013
associative learningGO:000830610.013
cranial nerve developmentGO:002154540.013
cellular response to oxygen containing compoundGO:19017012760.013
negative regulation of muscle contractionGO:004593230.013
response to extracellular stimulusGO:0009991850.013
defense response to other organismGO:00985421290.013
regulation of immune responseGO:00507762010.013
organelle assemblyGO:00709251760.013
negative regulation of organelle organizationGO:00106391260.013
cell substrate adhesionGO:00315891320.013
protein polyubiquitinationGO:00002091100.013
regulation of homeostatic processGO:00328441210.013
response to oxygen containing compoundGO:19017003690.013
monocarboxylic acid metabolic processGO:00327871850.013
immune system developmentGO:00025201950.013
embryonic camera type eye developmentGO:003107620.013
organelle fissionGO:00482851490.013
negative regulation of cell cycle processGO:00109481210.013
regulation of cell activationGO:00508651250.013
regulation of dephosphorylationGO:0035303960.013
nucleoside monophosphate catabolic processGO:00091251590.013
positive regulation of synaptic transmissionGO:005080640.013
single organismal cell cell adhesionGO:00163371480.013
cation transmembrane transportGO:00986552380.013
regulation of protein processingGO:00706131500.012
steroid metabolic processGO:0008202940.012
negative regulation of cell cycleGO:00457861930.012
regulation of endopeptidase activityGO:00525481700.012
positive regulation of ras gtpase activityGO:00323201170.012
retinal ganglion cell axon guidanceGO:003129020.012
regulation of neuron projection developmentGO:0010975570.012
tripartite regional subdivisionGO:000735120.012
negative regulation of growthGO:0045926970.012
cellular component disassemblyGO:0022411920.012
angiogenesisGO:00015251470.012
regulation of lipid biosynthetic processGO:0046890470.012
positive regulation of cytoskeleton organizationGO:0051495830.012
protein targetingGO:00066051870.012
sequestering of calcium ionGO:0051208170.012
positive regulation of sequence specific dna binding transcription factor activityGO:00510911310.012
atp metabolic processGO:00460341760.012
purine ribonucleoside monophosphate catabolic processGO:00091691580.012
sequestering of metal ionGO:0051238240.012
peptidyl lysine acetylationGO:00183941010.012
somatic stem cell divisionGO:004810310.012
embryonic eye morphogenesisGO:004804820.012
regulation of dna metabolic processGO:00510521530.012
regulation of response to woundingGO:19030341010.012
regulation of glial cell differentiationGO:004568530.012
glycoprotein metabolic processGO:00091001100.012
lipid metabolic processGO:00066293810.012
asymmetric stem cell divisionGO:009872210.012
negative regulation of protein maturationGO:19033181420.012
isoprenoid metabolic processGO:0006720390.012
cardiovascular system developmentGO:00723582620.012
matingGO:000761810.012
negative regulation of immune system processGO:00026831360.012
negative regulation of homotypic cell cell adhesionGO:003411130.012
internal protein amino acid acetylationGO:00064751010.012
regulation of platelet aggregationGO:009033040.012
positive regulation of intracellular transportGO:00323881040.012
positive regulation of cell deathGO:00109422630.012
regulation of metal ion transportGO:00109591200.012
negative regulation of kinase activityGO:00336731060.012
regulation of reactive oxygen species metabolic processGO:2000377410.012
positive regulation of secretionGO:00510471160.012
regulation of cytokine productionGO:00018172320.012
regulation of cell morphogenesis involved in differentiationGO:0010769830.012
cellular response to radiationGO:0071478650.012
plasma membrane organizationGO:00070091150.012
purine nucleoside monophosphate catabolic processGO:00091281580.012
establishment of protein localization to membraneGO:00901501210.012
visual behaviorGO:000763220.012
regulation of mitotic cell cycle phase transitionGO:19019901180.011
oxidative stress induced premature senescenceGO:009040330.011
neural crest cell developmentGO:001403230.011
syncytium formation by plasma membrane fusionGO:000076820.011
protein acetylationGO:00064731160.011
establishment or maintenance of bipolar cell polarityGO:006124520.011
rhythmic behaviorGO:000762220.011
photoreceptor cell differentiationGO:004653020.011
circadian behaviorGO:004851220.011
response to growth factorGO:00708482050.011
calcium ion transportGO:00068161470.011
response to cytokineGO:00340972320.011
spinal cord developmentGO:002151040.011
tissue regenerationGO:004224630.011
cellular protein complex assemblyGO:00436231880.011
divalent inorganic cation transportGO:00725111580.011
rna interferenceGO:001624640.011
circulatory system developmentGO:00723592620.011
cellular ion homeostasisGO:00068731680.011
reproductive processGO:00224141060.011
peptidyl serine modificationGO:00182091060.011
response to uvGO:0009411730.011
asymmetric neuroblast divisionGO:005505910.011
positive regulation of gliogenesisGO:001401540.011
reactive oxygen species biosynthetic processGO:190340940.011
regulation of immune effector processGO:0002697910.011
regulation of intracellular protein transportGO:00331571230.011
lung alveolus developmentGO:004828640.011
vasculature developmentGO:00019441810.011
protein polymerizationGO:0051258710.011
epithelium developmentGO:00604292270.011
cerebral cortex cell migrationGO:002179530.011
metal ion homeostasisGO:00550651690.011
mitotic nuclear divisionGO:00070671190.011
anterior posterior axis specification embryoGO:000859520.011
nuclear migrationGO:000709710.011
positive regulation of protein serine threonine kinase activityGO:00719021190.011
regulation of secretion by cellGO:19035301770.011
nucleocytoplasmic transportGO:00069131760.011
sulfur compound metabolic processGO:00067901010.011
lens development in camera type eyeGO:000208820.011
regulation of muscle system processGO:0090257530.011
glycerolipid metabolic processGO:00464861070.011
embryonic camera type eye formationGO:006090020.011
neuroblast divisionGO:005505710.011
cardiac muscle cell contractionGO:008600340.011
regulation of defense responseGO:00313471540.011
intrinsic apoptotic signaling pathwayGO:00971931270.011
potassium ion transportGO:0006813620.011
positive regulation of reactive oxygen species metabolic processGO:2000379240.011

HECW2 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
nervous system diseaseDOID:8634310.024
sensory system diseaseDOID:00501552030.024
disease of metabolismDOID:00146672950.022
cardiovascular system diseaseDOID:12871060.021
musculoskeletal system diseaseDOID:172230.018
eye diseaseDOID:56141490.018
eye and adnexa diseaseDOID:14921500.018
central nervous system diseaseDOID:3311860.017
disease of cellular proliferationDOID:145661740.017
organ system cancerDOID:00506861640.017
cancerDOID:1621670.017
inherited metabolic disorderDOID:6552420.016
retinal diseaseDOID:56791180.013