Homo sapiens

32 known processes

KDM6B

lysine (K)-specific demethylase 6B

(Aliases: JMJD3,KIAA0346)

KDM6B biological process predictions


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Biological processGO term IDProcess sizeProbabilityFunc Analog Org
covalent chromatin modificationGO:00165692540.592
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.577
histone modificationGO:00165702510.488
small gtpase mediated signal transductionGO:0007264780.322
histone acetylationGO:0016573930.316
rho protein signal transductionGO:0007266260.278
purine nucleoside catabolic processGO:00061523980.273
chromatin modificationGO:00165682980.267
regulation of cellular amine metabolic processGO:0033238110.255
circadian behaviorGO:004851220.252
amine metabolic processGO:0009308440.227
internal protein amino acid acetylationGO:00064751010.218
cellular response to endogenous stimulusGO:00714953360.207
glycosyl compound catabolic processGO:19016584130.197
internal peptidyl lysine acetylationGO:0018393970.192
rhythmic behaviorGO:000762220.189
nucleotide catabolic processGO:00091664080.183
mitotic cell cycle processGO:19030472860.178
protein acetylationGO:00064731160.176
positive regulation of cellular amine metabolic processGO:003324070.172
ribonucleoside triphosphate catabolic processGO:00092033910.169
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781250.168
positive regulation of cellular amino acid metabolic processGO:004576430.161
regulation of kinase activityGO:00435493140.158
locomotory behaviorGO:000762610.158
response to radiationGO:00093141510.157
nervous system developmentGO:00073992930.157
neuron projection regenerationGO:003110210.153
regulation of cellular amino acid metabolic processGO:000652160.152
positive regulation of catabolic processGO:00098963100.151
regulation of nucleotide metabolic processGO:00061402690.151
cellular amine metabolic processGO:0044106410.151
peptidyl lysine acetylationGO:00183941010.150
positive regulation of phosphorylationGO:00423273940.149
protein acylationGO:00435431380.144
nucleoside catabolic processGO:00091644080.143
regulation of cellular ketone metabolic processGO:0010565500.142
guanosine containing compound metabolic processGO:19010682440.141
regulation of small gtpase mediated signal transductionGO:00510561560.138
positive regulation of gtpase activityGO:00435471660.135
histone h3 acetylationGO:0043966450.135
positive regulation of cellular catabolic processGO:00313312840.134
purine ribonucleoside metabolic processGO:00461284370.132
mapk cascadeGO:00001652880.130
regulation of gtpase activityGO:00430871800.130
regulation of protein kinase activityGO:00458592890.129
post embryonic developmentGO:000979120.129
regulation of transferase activityGO:00513383550.127
purine ribonucleoside catabolic processGO:00461303980.127
ribonucleoside catabolic processGO:00424544060.125
regulation of rho protein signal transductionGO:0035023790.125
regulation of gtp catabolic processGO:00331241800.124
purine nucleotide catabolic processGO:00061954050.124
regulation of sequence specific dna binding transcription factor activityGO:00510902110.121
ribonucleoside triphosphate metabolic processGO:00091994120.121
response to other organismGO:00517072610.117
vesicle mediated transportGO:00161923710.116
ribonucleotide catabolic processGO:00092614050.114
guanosine containing compound catabolic processGO:19010692390.114
cellular ketone metabolic processGO:0042180800.113
gtp catabolic processGO:00061842370.111
chromatin organizationGO:00063253510.110
cell cycle phase transitionGO:00447701730.110
generation of neuronsGO:00486991520.110
nucleoside triphosphate catabolic processGO:00091433940.109
regulation of rho gtpase activityGO:0032319660.109
purine nucleoside triphosphate metabolic processGO:00091444120.104
cellular response to growth factor stimulusGO:00713631970.103
positive regulation of hydrolase activityGO:00513453310.101
oogenesisGO:004847720.100
female gamete generationGO:000729220.099
cellular response to transforming growth factor beta stimulusGO:0071560940.097
nucleoside phosphate catabolic processGO:19012924120.096
cellular amino acid metabolic processGO:00065201160.094
negative regulation of cellular protein metabolic processGO:00322693530.090
purine nucleoside triphosphate catabolic processGO:00091463920.090
purine ribonucleoside triphosphate metabolic processGO:00092054110.090
anatomical structure formation involved in morphogenesisGO:00486462840.088
Mouse
regulation of response to external stimulusGO:00321012220.087
regulation of mapk cascadeGO:00434082620.085
response to growth factorGO:00708482050.085
ras protein signal transductionGO:0007265730.084
positive regulation of nucleotide metabolic processGO:00459812300.083
response to biotic stimulusGO:00096072760.083
cellular component morphogenesisGO:00329893140.081
smad protein signal transductionGO:0060395100.080
response to reactive oxygen speciesGO:0000302610.080
Mouse
organophosphate catabolic processGO:00464344300.079
cell developmentGO:00484683280.079
positive regulation of purine nucleotide metabolic processGO:19005442270.079
positive regulation of nucleoside metabolic processGO:00459791860.077
peptidyl lysine modificationGO:00182051440.076
neuromuscular junction developmentGO:000752830.074
signal transduction by phosphorylationGO:00230142970.074
positive regulation of purine nucleotide catabolic processGO:00331231850.074
gtp metabolic processGO:00460392390.074
multicellular organismal agingGO:001025930.072
regulation of cell cycleGO:00517263930.072
antimicrobial humoral responseGO:0019730260.070
purine ribonucleoside triphosphate catabolic processGO:00092073910.070
jnk cascadeGO:0007254800.069
cellular response to dna damage stimulusGO:00069743790.068
mitotic cell cycleGO:00002783260.068
neuron differentiationGO:00301821380.068
positive regulation of sequence specific dna binding transcription factor activityGO:00510911310.068
positive regulation of nucleotide catabolic processGO:00308131850.067
neurogenesisGO:00220081690.067
positive regulation of gtp catabolic processGO:00331261660.065
negative regulation of cellular component organizationGO:00511292350.063
regulation of ras gtpase activityGO:00323181280.063
immune responseGO:00069553070.062
positive regulation of rho gtpase activityGO:0032321560.061
negative regulation of cell deathGO:00605483450.060
nucleoside triphosphate metabolic processGO:00091414220.060
negative regulation of phosphate metabolic processGO:00459362670.058
regulation of nucleotide catabolic processGO:00308112050.057
regulation of defense responseGO:00313471540.056
regulation of purine nucleotide metabolic processGO:19005422640.056
transforming growth factor beta receptor signaling pathwayGO:0007179760.055
regulation of ras protein signal transductionGO:00465781550.055
positive regulation of cell proliferationGO:00082843010.053
response to oxygen containing compoundGO:19017003690.053
Mouse
regulation of cellular response to stressGO:00801352440.052
regulation of nucleoside metabolic processGO:00091182090.052
purine containing compound catabolic processGO:00725234110.052
viral life cycleGO:00190581320.051
cytokine productionGO:00018162470.050
cell morphogenesis involved in differentiationGO:00009041440.049
posttranscriptional regulation of gene expressionGO:00106082130.049
negative regulation of apoptotic processGO:00430663160.049
segmentationGO:003528240.047
negative regulation of phosphorus metabolic processGO:00105632670.047
multi organism cellular processGO:00447641560.046
response to transforming growth factor betaGO:0071559940.045
cellular response to oxygen containing compoundGO:19017012760.045
Mouse
cell part morphogenesisGO:00329901370.045
negative regulation of cell cycle processGO:00109481210.043
regulation of immune responseGO:00507762010.043
hindbrain developmentGO:003090230.042
developmental growth involved in morphogenesisGO:0060560230.042
regulation of purine nucleotide catabolic processGO:00331212050.042
endocytosisGO:00068971590.041
positive regulation of ras gtpase activityGO:00323201170.041
defense responseGO:00069523150.040
growthGO:00400072020.039
translationGO:00064121320.039
response to endoplasmic reticulum stressGO:0034976490.039
mitotic cell cycle phase transitionGO:00447721620.038
stress activated protein kinase signaling cascadeGO:0031098940.038
response to lipidGO:00339932060.037
negative regulation of chromosome organizationGO:2001251480.036
cell morphogenesisGO:00009022960.036
neuron projection developmentGO:00311751060.035
cell projection organizationGO:00300302520.035
somatic stem cell maintenanceGO:003501940.035
embryo developmentGO:00097901230.035
Mouse
protein ubiquitinationGO:00165673140.035
cell cell signalingGO:00072671550.035
cell projection morphogenesisGO:00488581290.035
interspecies interaction between organismsGO:00444191560.034
regulation of anatomical structure morphogenesisGO:00226032860.034
osteoblast differentiationGO:0001649920.034
determination of adult lifespanGO:000834020.034
viral processGO:00160321460.033
negative regulation of catalytic activityGO:00430863350.033
response to oxidative stressGO:00069791210.032
Mouse
positive regulation of protein phosphorylationGO:00019343130.032
regenerationGO:003109940.031
i kappab kinase nf kappab signalingGO:00072491660.031
positive regulation of mapk cascadeGO:00434101900.031
limbic system developmentGO:002176130.031
myeloid cell differentiationGO:00300991170.031
purine ribonucleotide catabolic processGO:00091544040.030
rna processingGO:00063962550.030
regulation of multi organism processGO:00439001570.030
negative regulation of cell cycleGO:00457861930.030
peptidyl serine phosphorylationGO:00181051010.030
regulation of cell projection organizationGO:00313441070.030
regulation of cell cycle processGO:00105642660.029
leukocyte differentiationGO:0002521980.029
hemopoiesisGO:00300971800.028
regulation of antimicrobial humoral responseGO:000275910.028
regulation of cyclin dependent protein serine threonine kinase activityGO:0000079360.028
response to abiotic stimulusGO:00096283360.028
regulation of protein localizationGO:00328802960.027
response to inorganic substanceGO:00100351270.027
Mouse
syncytium formation by plasma membrane fusionGO:000076820.027
regulation of cell morphogenesisGO:00226041530.026
stress activated mapk cascadeGO:0051403930.026
regulation of dna bindingGO:0051101370.026
mitochondrion organizationGO:00070051560.026
anterior posterior axis specificationGO:000994820.026
single organism cellular localizationGO:19025803320.026
carbohydrate metabolic processGO:00059752070.026
negative regulation of organelle organizationGO:00106391260.026
response to campGO:0051591250.026
negative regulation of intracellular signal transductionGO:19025321830.025
positive regulation of cellular component organizationGO:00511303760.025
single organism carbohydrate metabolic processGO:00447231930.025
regulation of i kappab kinase nf kappab signalingGO:00431221620.025
organonitrogen compound biosynthetic processGO:19015662000.025
response to woundingGO:00096111680.025
methylationGO:00322591060.025
regulation of cell cycle phase transitionGO:19019871260.025
positive regulation of cell migrationGO:00303351720.025
regulation of mitotic cell cycle phase transitionGO:19019901180.025
negative regulation of programmed cell deathGO:00430693210.025
regulation of growthGO:00400081650.025
regulation of cytokine productionGO:00018172320.024
extrinsic apoptotic signaling pathwayGO:00971911190.024
response to external biotic stimulusGO:00432072610.024
macromolecule methylationGO:0043414970.024
histone h4 acetylationGO:0043967470.024
erk1 and erk2 cascadeGO:00703711040.024
protein modification by small protein conjugationGO:00324463420.024
negative regulation of developmental processGO:00510932470.024
amide transportGO:0042886760.023
cell cycle checkpointGO:00000751170.023
enzyme linked receptor protein signaling pathwayGO:00071673030.023
positive regulation of developmental processGO:00510943140.023
single organism membrane organizationGO:00448022680.023
cell fate determinationGO:000170930.022
heart processGO:0003015620.022
intracellular protein transportGO:00068862700.022
actin cytoskeleton organizationGO:00300362070.022
regulation of protein serine threonine kinase activityGO:00719001790.022
negative regulation of multicellular organismal processGO:00512413170.022
regulation of cell developmentGO:00602841610.022
negative regulation of cellular amine metabolic processGO:003323930.022
embryonic placenta developmentGO:000189210.022
negative regulation of mitotic cell cycleGO:00459301020.021
apoptotic signaling pathwayGO:00971902680.021
membrane organizationGO:00610242920.021
protein alkylationGO:0008213740.021
positive regulation of cell cycleGO:00457871400.021
protein localization to organelleGO:00333652800.021
cytoplasmic transportGO:00164823790.021
regulation of mitotic cell cycleGO:00073461890.021
regulation of lipid metabolic processGO:0019216960.021
inflammatory responseGO:0006954790.021
positive regulation of cell deathGO:00109422630.021
negative regulation of protein metabolic processGO:00512483910.021
chemotaxisGO:00069351570.020
compound eye developmentGO:004874910.020
apoptotic mitochondrial changesGO:0008637570.020
peripheral nervous system developmentGO:000742220.020
negative regulation of protein maturationGO:19033181420.020
cd4 positive alpha beta t cell differentiationGO:004336740.020
cellular macromolecule catabolic processGO:00442653800.020
regulation of symbiosis encompassing mutualism through parasitismGO:00439031090.020
lipid localizationGO:00108761060.019
neuron developmentGO:00486661130.019
mitochondrial transportGO:0006839600.019
taxisGO:00423301570.019
cellular macromolecular complex assemblyGO:00346223240.019
negative regulation of sequence specific dna binding transcription factor activityGO:0043433890.019
nuclear transportGO:00511691790.019
negative regulation of response to external stimulusGO:0032102830.019
ossificationGO:00015031210.019
symbiosis encompassing mutualism through parasitismGO:00444031560.019
system processGO:00030083490.019
cellular response to abiotic stimulusGO:00712141170.019
regulation of establishment of protein localizationGO:00702012420.019
lung alveolus developmentGO:004828640.019
behaviorGO:00076101120.019
maintenance of locationGO:00512351120.018
blastocyst developmentGO:000182430.018
protein targetingGO:00066051870.018
regulation of wnt signaling pathwayGO:00301111230.018
oocyte differentiationGO:000999420.018
peptidyl serine modificationGO:00182091060.018
response to nitrogen compoundGO:19016981840.018
actin filament based processGO:00300292240.018
cellular response to hormone stimulusGO:00328701250.018
hippocampus developmentGO:002176610.017
organ morphogenesisGO:00098871470.017
regulation of transcription from rna polymerase ii promoter in response to stressGO:0043618170.017
sensory organ developmentGO:0007423520.017
negative regulation of mitotic cell cycle phase transitionGO:1901991850.017
lipid biosynthetic processGO:00086101770.017
protein catabolic processGO:00301633250.017
negative regulation of phosphorylationGO:00423261740.016
negative regulation of transferase activityGO:00513481240.016
regulation of jnk cascadeGO:0046328730.016
tumor necrosis factor superfamily cytokine productionGO:0071706450.016
myoblast fusionGO:000752010.016
protein importGO:00170381300.016
positive regulation of cell differentiationGO:00455972110.016
cell cycle g2 m phase transitionGO:0044839430.016
intracellular receptor signaling pathwayGO:00305221040.016
lipid metabolic processGO:00066293810.016
regulation of cellular component biogenesisGO:00440872810.016
microtubule based processGO:00070172100.016
carbohydrate biosynthetic processGO:0016051420.016
negative regulation of growthGO:0045926970.016
cellular response to calcium ionGO:0071277190.016
regulation of system processGO:00440571010.016
neurological system processGO:00508771630.016
cell growthGO:00160491600.016
histone lysine methylationGO:0034968500.016
epithelium developmentGO:00604292270.016
Mouse
immune system developmentGO:00025201950.015
monosaccharide metabolic processGO:0005996740.015
regulation of neurogenesisGO:0050767820.015
oocyte developmentGO:004859910.015
establishment of protein localization to organelleGO:00725941720.015
regulation of intracellular protein transportGO:00331571230.015
response to hormoneGO:00097251750.015
actin filament organizationGO:00070151280.015
response to calcium ionGO:0051592460.015
neuron projection morphogenesisGO:0048812500.015
protein methylationGO:0006479740.015
negative regulation of cell growthGO:0030308830.015
positive regulation of apoptotic processGO:00430652460.015
cell cycle g1 s phase transitionGO:0044843800.015
organelle assemblyGO:00709251760.015
myeloid leukocyte differentiationGO:0002573600.015
response to metal ionGO:0010038840.015
nitrogen compound transportGO:00717051910.015
hormone transportGO:0009914680.015
regulation of response to woundingGO:19030341010.015
regulation of cytoskeleton organizationGO:00514931770.015
hematopoietic or lymphoid organ developmentGO:00485341860.015
viral gene expressionGO:0019080350.015
negative regulation of hydrolase activityGO:00513461820.015
histone demethylationGO:0016577150.014
atp metabolic processGO:00460341760.014
regulation of gene expression epigeneticGO:0040029730.014
nucleoside monophosphate metabolic processGO:00091231910.014
cell activationGO:00017752130.014
regulation of chromatin modificationGO:1903308510.014
dna integrity checkpointGO:0031570710.014
negative regulation of protein modification processGO:00314002000.014
regulation of bindingGO:00510981110.014
regulation of nervous system developmentGO:0051960880.014
nucleocytoplasmic transportGO:00069131760.014
regulation of proteolysisGO:00301622930.014
axonogenesisGO:0007409310.014
g1 s transition of mitotic cell cycleGO:0000082780.014
immune effector processGO:00022521590.014
rhythmic processGO:0048511310.014
regulation of chromosome organizationGO:00330441030.014
demethylationGO:0070988370.014
response to purine containing compoundGO:0014074400.014
negative regulation of interleukin 8 biosynthetic processGO:004541530.014
protein autophosphorylationGO:00467771230.013
regulation of cell growthGO:00015581350.013
regulation of hormone levelsGO:00108171250.013
positive regulation of kinase activityGO:00336742040.013
head developmentGO:00603221080.013
humoral immune responseGO:0006959490.013
dna damage checkpointGO:0000077680.013
regulation of protein modification by small protein conjugation or removalGO:19033201070.013
trophectodermal cell differentiationGO:000182930.013
positive regulation of protein serine threonine kinase activityGO:00719021190.013
peptide transportGO:0015833740.013
cellular carbohydrate metabolic processGO:0044262840.013
regulation of inflammatory responseGO:0050727460.013
histone methylationGO:0016571600.013
g2 m transition of mitotic cell cycleGO:0000086410.013
response to bacteriumGO:00096171440.013
reproductive processGO:00224141060.013
protein deacetylationGO:0006476380.013
spermatid differentiationGO:004851540.013
negative regulation of cell cycle phase transitionGO:1901988890.013
dephosphorylationGO:00163112090.013
modification of morphology or physiology of other organismGO:0035821430.013
regulation of stress activated mapk cascadeGO:0032872840.013
tube closureGO:006060630.012
positive regulation of reactive oxygen species metabolic processGO:2000379240.012
single organism nuclear importGO:19025931040.012
regulation of epithelial cell proliferationGO:00506781130.012
negative regulation of cell differentiationGO:00455961710.012
regulation of intracellular transportGO:00323861950.012
regulation of neuron differentiationGO:0045664700.012
response to organic cyclic compoundGO:00140702040.012
positive regulation of multi organism processGO:0043902560.012
protein localization to nucleusGO:00345041360.012
positive regulation of transferase activityGO:00513472270.012
regulation of viral processGO:00507921030.012
blood vessel morphogenesisGO:00485141620.012
t cell differentiation in thymusGO:003307740.012
response to axon injuryGO:004867810.012
ion transmembrane transportGO:00342203380.012
protein kinase b signalingGO:0043491690.012
cuticle developmentGO:004233510.012
modification dependent protein catabolic processGO:00199412090.012
response to extracellular stimulusGO:0009991850.012
regulation of cell differentiationGO:00455953930.012
regulation of neural precursor cell proliferationGO:200017740.012
midgut developmentGO:000749410.012
protein targeting to nucleusGO:00447441040.012
response to light stimulusGO:0009416870.012
negative regulation of immune system processGO:00026831360.012
brain developmentGO:0007420970.012
nuclear importGO:00511701060.012
embryonic camera type eye developmentGO:003107620.011
regulation of axon guidanceGO:190266730.011
positive regulation of organelle organizationGO:00106381950.011
axon regenerationGO:003110310.011
rna interferenceGO:001624640.011
epithelial cell differentiationGO:00308551410.011
Mouse
rna splicingGO:00083801310.011
regulation of translationGO:0006417890.011
regulation of protein processingGO:00706131500.011
positive regulation of immune system processGO:00026842830.011
negative regulation of cell proliferationGO:00082852280.011
regulation of microtubule based processGO:0032886740.011
negative regulation of cellular amino acid metabolic processGO:004576320.011
skeletal system developmentGO:0001501790.011
rab protein signal transductionGO:003248240.011
regulation of protein maturationGO:19033171500.011
cd4 positive alpha beta t cell differentiation involved in immune responseGO:000229440.011
mrna metabolic processGO:00160711750.011
mitotic nuclear divisionGO:00070671190.011
response to virusGO:00096151260.011
cerebellum developmentGO:002154920.011
secretion by cellGO:00329402260.011
regulation of apoptotic signaling pathwayGO:20012331750.011
purine ribonucleoside monophosphate metabolic processGO:00091671860.011
purine nucleoside monophosphate metabolic processGO:00091261860.011
response to organonitrogen compoundGO:00102431560.011
ectoderm developmentGO:000739830.011
tumor necrosis factor productionGO:0032640430.011
polysaccharide metabolic processGO:0005976330.011
gene silencingGO:0016458490.011
microtubule cytoskeleton organizationGO:00002261760.011
regulation of secretionGO:00510461940.011
modulation by host of viral transcriptionGO:0043921200.011
cell morphogenesis involved in neuron differentiationGO:0048667440.011
carbohydrate derivative biosynthetic processGO:19011372070.011
respiratory gaseous exchangeGO:000758530.010
endochondral bone morphogenesisGO:006035030.010
dna repairGO:00062811980.010
response to fibroblast growth factorGO:0071774390.010
regulation of tumor necrosis factor productionGO:0032680430.010
cellular response to inorganic substanceGO:0071241450.010
negative regulation of phosphatase activityGO:0010923610.010
phagocytosisGO:0006909420.010
agingGO:0007568660.010
myosin filament assemblyGO:003103420.010
positive regulation of cell developmentGO:0010720920.010
positive regulation of chromosome organizationGO:2001252410.010
forebrain neuron developmentGO:002188420.010
regulation of mitochondrial membrane permeability involved in apoptotic processGO:1902108180.010
heart formationGO:006091420.010
secretionGO:00469032540.010
regulation of meiosisGO:004002030.010
endoplasmic reticulum unfolded protein responseGO:0030968160.010

KDM6B disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
immune system diseaseDOID:29141550.027
disease of metabolismDOID:00146672950.013
cancerDOID:1621670.011
organ system cancerDOID:00506861640.011
disease of cellular proliferationDOID:145661740.011
inherited metabolic disorderDOID:6552420.010