Homo sapiens

66 known processes

OTX1

orthodenticle homeobox 1

(Aliases: FLJ38361,MGC15736)

OTX1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
neuron fate commitmentGO:004866320.263
Worm Fly
post embryonic developmentGO:000979120.097
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.080
Fly
organ formationGO:004864530.072
nervous system developmentGO:00073992930.066
Human Zebrafish Mouse Worm Fly
segmentationGO:003528240.066
Fly
cell fate determinationGO:000170930.064
organ morphogenesisGO:00098871470.064
Mouse Fly
inner ear morphogenesisGO:004247240.062
Mouse
cellular component morphogenesisGO:00329893140.062
Human Fly
extraocular skeletal muscle developmentGO:000207410.059
specification of organ identityGO:001009230.048
circulatory system developmentGO:00723592620.047
cardiovascular system developmentGO:00723582620.043
cell morphogenesisGO:00009022960.042
Human Fly
neurogenesisGO:00220081690.041
Human Worm Fly
mitotic cell cycleGO:00002783260.041
determination of adult lifespanGO:000834020.040
regulation of cellular ketone metabolic processGO:0010565500.040
spinal cord developmentGO:002151040.040
cellular amino acid metabolic processGO:00065201160.038
multicellular organismal agingGO:001025930.038
regulation of cellular amine metabolic processGO:0033238110.037
regulation of cell cycleGO:00517263930.037
regulation of cellular amino acid metabolic processGO:000652160.037
purine ribonucleoside metabolic processGO:00461284370.037
anatomical structure formation involved in morphogenesisGO:00486462840.037
negative regulation of cellular protein metabolic processGO:00322693530.037
behaviorGO:00076101120.036
Worm
central nervous system developmentGO:00074171230.035
Zebrafish Mouse Fly
cranial nerve developmentGO:002154540.035
forebrain regionalizationGO:002187130.035
cell projection organizationGO:00300302520.034
Human Fly
blastoderm segmentationGO:000735020.034
response to abiotic stimulusGO:00096283360.034
Worm
enzyme linked receptor protein signaling pathwayGO:00071673030.034
female gamete generationGO:000729220.034
epithelium developmentGO:00604292270.033
Zebrafish
neuron differentiationGO:00301821380.032
Human Worm Fly
hindbrain developmentGO:003090230.032
Zebrafish Mouse
forelimb morphogenesisGO:003513640.032
ras protein signal transductionGO:0007265730.032
regulation of dermatome developmentGO:006118330.031
positive regulation of hydrolase activityGO:00513453310.031
anterior posterior axis specificationGO:000994820.031
locomotory behaviorGO:000762610.031
cell developmentGO:00484683280.030
Human Fly
regionalizationGO:0003002290.029
Zebrafish Mouse Fly
negative regulation of cell differentiationGO:00455961710.029
cytoplasmic transportGO:00164823790.029
regulation of cell migrationGO:00303342890.029
heart formationGO:006091420.029
vasculature developmentGO:00019441810.029
regulation of cell differentiationGO:00455953930.028
Fly
associative learningGO:000830610.028
regulation of anatomical structure morphogenesisGO:00226032860.028
Fly
negative regulation of multicellular organismal processGO:00512413170.028
purine ribonucleoside triphosphate catabolic processGO:00092073910.028
regulation of mitotic cell cycleGO:00073461890.027
tube developmentGO:00352951250.027
Zebrafish
positive regulation of cellular amino acid metabolic processGO:004576430.027
oogenesisGO:004847720.027
generation of neuronsGO:00486991520.027
Human Worm Fly
cellular amine metabolic processGO:0044106410.027
regulation of cell cycle processGO:00105642660.026
lipid metabolic processGO:00066293810.026
rho protein signal transductionGO:0007266260.026
positive regulation of cellular catabolic processGO:00313312840.026
wnt signaling pathwayGO:00160551560.025
skeletal system developmentGO:0001501790.025
negative regulation of cell proliferationGO:00082852280.025
head developmentGO:00603221080.025
Zebrafish Mouse Fly
cellular response to dna damage stimulusGO:00069743790.025
cellular response to endogenous stimulusGO:00714953360.025
negative regulation of programmed cell deathGO:00430693210.025
metencephalon developmentGO:002203720.025
Mouse
amine metabolic processGO:0009308440.025
cellular ketone metabolic processGO:0042180800.025
positive regulation of catabolic processGO:00098963100.024
negative regulation of developmental processGO:00510932470.024
response to hormoneGO:00097251750.024
response to oxygen containing compoundGO:19017003690.024
negative regulation of protein metabolic processGO:00512483910.024
regulation of kinase activityGO:00435493140.024
mitotic cell cycle processGO:19030472860.024
positive regulation of cellular amine metabolic processGO:003324070.024
regulation of pathway restricted smad protein phosphorylationGO:0060393340.024
regenerationGO:003109940.024
positive regulation of cell proliferationGO:00082843010.024
system processGO:00030083490.024
Worm
forebrain generation of neuronsGO:002187230.023
small gtpase mediated signal transductionGO:0007264780.023
pituitary gland developmentGO:002198320.023
reactive oxygen species metabolic processGO:0072593750.023
nucleoside catabolic processGO:00091644080.023
negative regulation of cell deathGO:00605483450.023
somitogenesisGO:000175620.023
muscle structure developmentGO:0061061980.023
actin filament based processGO:00300292240.023
protein localization to organelleGO:00333652800.022
negative regulation of phosphorus metabolic processGO:00105632670.022
canonical wnt signaling pathway involved in cardiac muscle cell fate commitmentGO:006131730.022
post embryonic organ developmentGO:004856910.022
cell part morphogenesisGO:00329901370.022
Human Fly
blood vessel developmentGO:00015681720.022
embryonic forelimb morphogenesisGO:003511540.022
spermatid differentiationGO:004851540.022
heart developmentGO:0007507950.022
cell morphogenesis involved in differentiationGO:00009041440.022
Human Fly
heart field specificationGO:000312820.021
ribonucleoside triphosphate metabolic processGO:00091994120.021
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781250.021
matingGO:000761810.021
positive regulation of cellular component organizationGO:00511303760.021
cellular lipid metabolic processGO:00442553030.021
limbic system developmentGO:002176130.021
purine nucleoside triphosphate catabolic processGO:00091463920.020
neuromuscular junction developmentGO:000752830.020
purine nucleoside triphosphate metabolic processGO:00091444120.020
compound eye developmentGO:004874910.020
Fly
somatic muscle developmentGO:000752510.020
ribonucleotide catabolic processGO:00092614050.020
negative regulation of catalytic activityGO:00430863350.020
cell cell signalingGO:00072671550.020
regulation of protein localizationGO:00328802960.020
oocyte differentiationGO:000999420.020
regulation of purine nucleotide metabolic processGO:19005422640.020
peripheral nervous system developmentGO:000742220.020
brain morphogenesisGO:004885410.020
Mouse
purine nucleoside catabolic processGO:00061523980.020
ribonucleoside catabolic processGO:00424544060.020
regulation of proteolysisGO:00301622930.020
glycosyl compound catabolic processGO:19016584130.019
positive regulation of cell developmentGO:0010720920.019
Fly
negative regulation of cell cycleGO:00457861930.019
biological adhesionGO:00226103310.019
positive regulation of apoptotic processGO:00430652460.019
regulation of cellular component biogenesisGO:00440872810.019
sex determinationGO:000753030.019
motor neuron axon guidanceGO:000804520.019
regulation of transferase activityGO:00513383550.019
dermatome developmentGO:006105430.019
immune responseGO:00069553070.019
lipid biosynthetic processGO:00086101770.019
immune system developmentGO:00025201950.019
response to organic cyclic compoundGO:00140702040.019
secretionGO:00469032540.019
positive regulation of developmental processGO:00510943140.019
Fly
regulation of cellular component movementGO:00512703340.019
memoryGO:000761330.019
taxisGO:00423301570.018
Human
photoreceptor cell differentiationGO:004653020.018
Fly
positive regulation of cell deathGO:00109422630.018
purine nucleotide catabolic processGO:00061954050.018
oocyte developmentGO:004859910.018
visual behaviorGO:000763220.018
cell projection morphogenesisGO:00488581290.018
Human Fly
regulation of cell motilityGO:20001452990.018
pattern specification processGO:0007389430.018
Zebrafish Mouse Fly
response to radiationGO:00093141510.018
dephosphorylationGO:00163112090.018
muscle tissue developmentGO:0060537620.018
negative regulation of cellular component organizationGO:00511292350.018
spermatid developmentGO:000728640.018
organophosphate catabolic processGO:00464344300.018
hematopoietic or lymphoid organ developmentGO:00485341860.018
regulation of meiotic cell cycleGO:005144540.017
regulation of endopeptidase activityGO:00525481700.017
brain developmentGO:0007420970.017
Zebrafish Mouse Fly
nucleoside phosphate catabolic processGO:19012924120.017
embryonic epithelial tube formationGO:000183840.017
chemotaxisGO:00069351570.017
Human
positive regulation of programmed cell deathGO:00430682490.017
positive regulation of nucleotide catabolic processGO:00308131850.017
negative regulation of apoptotic processGO:00430663160.017
negative regulation of protein modification processGO:00314002000.017
reactive oxygen species biosynthetic processGO:190340940.017
cellular response to oxygen containing compoundGO:19017012760.017
guanosine containing compound catabolic processGO:19010692390.017
ribonucleoside triphosphate catabolic processGO:00092033910.017
adult locomotory behaviorGO:000834410.017
blood vessel morphogenesisGO:00485141620.017
protein maturationGO:00516042330.017
regulation of sequence specific dna binding transcription factor activityGO:00510902110.017
neuroblast proliferationGO:000740540.017
nucleoside triphosphate catabolic processGO:00091433940.017
regulation of intracellular transportGO:00323861950.017
chromatin modificationGO:00165682980.017
regulation of cell morphogenesisGO:00226041530.017
negative regulation of phosphate metabolic processGO:00459362670.017
nucleoside triphosphate metabolic processGO:00091414220.016
regulation of cell developmentGO:00602841610.016
Fly
regulation of nucleoside metabolic processGO:00091182090.016
positive regulation of protein phosphorylationGO:00019343130.016
morphogenesis of embryonic epitheliumGO:001633140.016
regulation of nucleotide metabolic processGO:00061402690.016
purine containing compound catabolic processGO:00725234110.016
negative regulation of cellular amino acid metabolic processGO:004576320.016
thymus developmentGO:004853830.016
nuclear transportGO:00511691790.016
regulation of reactive oxygen species metabolic processGO:2000377410.016
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:00432811160.016
transmembrane transportGO:00550853990.016
purine ribonucleoside catabolic processGO:00461303980.016
regulation of reactive oxygen species biosynthetic processGO:190342630.016
forebrain developmentGO:0030900260.016
Mouse
single organism membrane organizationGO:00448022680.016
anterior posterior axis specification embryoGO:000859520.016
positive regulation of nucleotide metabolic processGO:00459812300.016
cellular macromolecular complex assemblyGO:00346223240.016
response to woundingGO:00096111680.016
long term memoryGO:000761620.016
syncytium formation by plasma membrane fusionGO:000076820.015
positive regulation of cytokine productionGO:00018191670.015
rna processingGO:00063962550.015
regulation of peptidase activityGO:00525471800.015
canonical wnt signaling pathwayGO:00600701160.015
muscle organ developmentGO:0007517560.015
cerebellum developmentGO:002154920.015
regulation of cellular response to stressGO:00801352440.015
organelle fissionGO:00482851490.015
histone modificationGO:00165702510.015
gtp catabolic processGO:00061842370.015
protein processingGO:00164852260.015
positive regulation of proteolysisGO:00458621420.015
positive regulation of transferase activityGO:00513472270.015
purine ribonucleoside triphosphate metabolic processGO:00092054110.015
regulation of purine nucleotide catabolic processGO:00331212050.015
pathway restricted smad protein phosphorylationGO:0060389380.015
nerve developmentGO:002167540.015
regulation of protein kinase activityGO:00458592890.015
soft palate developmentGO:006002330.015
cation transmembrane transportGO:00986552380.015
regulation of neural precursor cell proliferationGO:200017740.015
positive regulation of purine nucleotide catabolic processGO:00331231850.015
positive regulation of purine nucleotide metabolic processGO:19005442270.015
response to lipidGO:00339932060.015
ventral spinal cord developmentGO:002151710.015
mitotic sister chromatid segregationGO:0000070530.015
protein localization to nucleusGO:00345041360.015
intracellular protein transportGO:00068862700.015
positive regulation of cell migrationGO:00303351720.015
response to mercury ionGO:004668940.015
negative regulation of cellular component movementGO:00512711060.015
positive regulation of transportGO:00510503360.015
eye photoreceptor cell differentiationGO:000175420.015
Fly
embryo developmentGO:00097901230.015
Zebrafish Mouse Worm Fly
neural tube patterningGO:002153220.015
Zebrafish
positive regulation of ras gtpase activityGO:00323201170.014
response to growth factorGO:00708482050.014
regulation of nervous system developmentGO:0051960880.014
Fly
positive regulation of organelle organizationGO:00106381950.014
cell substrate adhesionGO:00315891320.014
neuron developmentGO:00486661130.014
Human Fly
endocrine system developmentGO:0035270260.014
negative regulation of phosphorylationGO:00423261740.014
forebrain neuron differentiationGO:002187930.014
gland developmentGO:0048732480.014
regulation of dna metabolic processGO:00510521530.014
negative regulation of cellular amine metabolic processGO:003323930.014
sensory organ morphogenesisGO:0090596210.014
Mouse Fly
positive regulation of phosphorylationGO:00423273940.014
rhythmic behaviorGO:000762220.014
regulation of establishment of protein localizationGO:00702012420.014
reactive nitrogen species metabolic processGO:200105730.014
cell divisionGO:00513011680.014
cellular response to lipidGO:00713961270.014
neuroendocrine cell differentiationGO:006110120.014
cellular macromolecule catabolic processGO:00442653800.014
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092900.014
positive regulation of reactive oxygen species biosynthetic processGO:190342820.014
canonical wnt signaling pathway involved in osteoblast differentiationGO:004433920.014
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.014
pharynx developmentGO:006046510.014
protein import into nucleusGO:00066061040.014
positive regulation of gtpase activityGO:00435471660.014
nucleocytoplasmic transportGO:00069131760.014
spinal cord dorsal ventral patterningGO:002151320.014
chromatin organizationGO:00063253510.014
axis elongationGO:000340140.014
protein targetingGO:00066051870.014
positive regulation of digestive system processGO:006045620.014
innate immune responseGO:00450871780.014
embryonic morphogenesisGO:0048598850.014
Mouse
negative regulation of cell fate specificationGO:000999630.014
negative regulation of hydrolase activityGO:00513461820.013
positive regulation of tooth mineralizationGO:007017220.013
protein oligomerizationGO:00512591730.013
single organism cellular localizationGO:19025803320.013
regulation of ras gtpase activityGO:00323181280.013
defense responseGO:00069523150.013
nitrogen compound transportGO:00717051910.013
response to axon injuryGO:004867810.013
regulation of cell substrate adhesionGO:0010810680.013
positive regulation of odontogenesisGO:004248230.013
regulation of glial cell differentiationGO:004568530.013
secretion by cellGO:00329402260.013
regulation of mitotic cell cycle phase transitionGO:19019901180.013
ion homeostasisGO:00508012300.013
cell proliferation in forebrainGO:002184610.013
stem cell divisionGO:001714520.013
establishment of protein localization to organelleGO:00725941720.013
cell adhesionGO:00071553250.013
endomembrane system organizationGO:00102561960.013
regulation of endothelial cell migrationGO:0010594670.013
protein importGO:00170381300.013
positive regulation of reactive oxygen species metabolic processGO:2000379240.013
cellular response to cytokine stimulusGO:00713451810.013
nucleotide catabolic processGO:00091664080.013
regulation of cell adhesionGO:00301551660.013
embryonic placenta developmentGO:000189210.013
protein catabolic processGO:00301633250.013
mitotic cell cycle phase transitionGO:00447721620.013
regulation of bindingGO:00510981110.013
tissue morphogenesisGO:0048729960.013
regulation of protein maturationGO:19033171500.013
tripartite regional subdivisionGO:000735120.013
positive regulation of nucleoside metabolic processGO:00459791860.013
myoblast fusionGO:000752010.013
positive regulation of neural precursor cell proliferationGO:200017920.013
negative regulation of gliogenesisGO:001401430.013
positive regulation of protein transportGO:00512221350.013
neurological system processGO:00508771630.013
Worm
regulation of meiosisGO:004002030.013
regulation of protein transportGO:00512232130.013
microtubule based processGO:00070172100.013
positive regulation of dermatome developmentGO:006118430.013
regulation of cysteine type endopeptidase activityGO:20001161270.013
response to fungusGO:000962040.013
chromosome segregationGO:00070591140.012
single organism cell adhesionGO:00986021790.012
regulation of growthGO:00400081650.012
positive regulation of gtp catabolic processGO:00331261660.012
regulation of gtpase activityGO:00430871800.012
carbohydrate derivative biosynthetic processGO:19011372070.012
inorganic cation transmembrane transportGO:00986621940.012
protein ubiquitinationGO:00165673140.012
regulation of cytokine productionGO:00018172320.012
regulation of cardioblast differentiationGO:005189040.012
dna conformation changeGO:00711031130.012
regulation of cytoskeleton organizationGO:00514931770.012
meiotic chromosome segregationGO:004513240.012
regulation of response to external stimulusGO:00321012220.012
positive regulation of cell cycleGO:00457871400.012
single organism carbohydrate metabolic processGO:00447231930.012
organonitrogen compound biosynthetic processGO:19015662000.012
mitotic nuclear divisionGO:00070671190.012
regulation of protein catabolic processGO:00421761550.012
hemopoiesisGO:00300971800.012
vesicle mediated transportGO:00161923710.012
negative regulation of protein processingGO:00109551420.012
hindlimb morphogenesisGO:003513720.012
cell chemotaxisGO:00603261120.012
wound healingGO:00420601150.012
maintenance of locationGO:00512351120.012
cellular protein complex assemblyGO:00436231880.012
positive regulation of immune system processGO:00026842830.012
cellular response to abiotic stimulusGO:00712141170.012
regulation of cell cycle phase transitionGO:19019871260.012
proteolysis involved in cellular protein catabolic processGO:00516032440.012
response to light stimulusGO:0009416870.012
t cell differentiation in thymusGO:003307740.012
negative regulation of transferase activityGO:00513481240.012
tissue regenerationGO:004224630.012
negative regulation of intracellular signal transductionGO:19025321830.012
regulation of small gtpase mediated signal transductionGO:00510561560.012
cell activationGO:00017752130.012
protein modification by small protein conjugationGO:00324463420.012
salivary gland morphogenesisGO:000743540.012
response to organonitrogen compoundGO:00102431560.012
actin cytoskeleton organizationGO:00300362070.012
negative regulation of locomotionGO:00400131180.012
muscle cell fate commitmentGO:004269340.012
positive regulation of cellular component biogenesisGO:00440891580.012
negative regulation of mitotic cell cycleGO:00459301020.012
cell aggregationGO:009874310.012
methylationGO:00322591060.012
positive regulation of cellular component movementGO:00512721810.012
dna repairGO:00062811980.011
developmental programmed cell deathGO:001062330.011
covalent chromatin modificationGO:00165692540.011
canonical wnt signaling pathway involved in mesenchymal stem cell differentiationGO:004433820.011
circadian behaviorGO:004851220.011
carboxylic acid biosynthetic processGO:0046394970.011
posttranscriptional regulation of gene expressionGO:00106082130.011
modification dependent protein catabolic processGO:00199412090.011
organ inductionGO:000175940.011
negative regulation of proteolysisGO:00458611320.011
positive regulation of kinase activityGO:00336742040.011
modification dependent macromolecule catabolic processGO:00436322120.011
tongue developmentGO:004358610.011
cardiac muscle cell contractionGO:008600340.011
cellular response to hormone stimulusGO:00328701250.011
regulation of cell projection organizationGO:00313441070.011
reproductive processGO:00224141060.011
cellular component disassemblyGO:0022411920.011
cell differentiation in spinal cordGO:002151510.011
cellular protein catabolic processGO:00442572610.011
regulation of wnt signaling pathwayGO:00301111230.011
regulation of secretion by cellGO:19035301770.011
negative regulation of cell fate commitmentGO:001045430.011
actin mediated cell contractionGO:0070252120.011
defense response to fungusGO:005083240.011
negative regulation of protein phosphorylationGO:00019331400.011
regulation of secretionGO:00510461940.011
epidermis morphogenesisGO:004873030.011
regulation of protein targetingGO:1903533910.011
monocarboxylic acid metabolic processGO:00327871850.011
cell cycle phase transitionGO:00447701730.011
cardiac cell fate determinationGO:006091330.011
regulation of ras protein signal transductionGO:00465781550.011
interspecies interaction between organismsGO:00444191560.011
epithelial cell differentiationGO:00308551410.011
startle responseGO:000196430.011
nuclear divisionGO:00002801280.011
epithelial cell migrationGO:00106311190.011
negative regulation of cell cycle processGO:00109481210.011
negative regulation of androgen biosynthetic processGO:200018010.011
positive regulation of endopeptidase activityGO:0010950840.011
positive regulation of cell motilityGO:20001471770.011
regulation of protein serine threonine kinase activityGO:00719001790.011
cell fate commitmentGO:0045165270.011
Worm Fly
copulationGO:000762010.011
positive regulation of cell differentiationGO:00455972110.011
Fly
positive regulation of response to external stimulusGO:0032103880.011
cochlea developmentGO:009010210.011
membrane organizationGO:00610242920.011
regulation of response to dna damage stimulusGO:2001020940.011
positive regulation of secretionGO:00510471160.011
visual learningGO:000854210.011
androgen biosynthetic processGO:000670230.011
primary neural tube formationGO:001402030.011
monovalent inorganic cation transportGO:00156721280.011
regulation of epithelial cell proliferationGO:00506781130.010
microtubule cytoskeleton organizationGO:00002261760.010
epithelial tube branching involved in lung morphogenesisGO:006044140.010
regulation of protein processingGO:00706131500.010
atrioventricular valve developmentGO:000317130.010
retinal ganglion cell axon guidanceGO:003129020.010
negative regulation of sequence specific dna binding transcription factor activityGO:0043433890.010
regulation of heart growthGO:006042040.010
embryonic organ developmentGO:0048568360.010
Mouse
ectodermal placode developmentGO:007169610.010
hippocampus developmentGO:002176610.010
signal transduction by phosphorylationGO:00230142970.010
gas transportGO:001566930.010
positive regulation of sequence specific dna binding transcription factor activityGO:00510911310.010
metal ion transportGO:00300012720.010
hard palate developmentGO:006002210.010
regulation of cytoplasmic transportGO:19036491490.010
organelle assemblyGO:00709251760.010
regulation of odontogenesisGO:004248140.010
proteasomal protein catabolic processGO:00104981760.010
mesodermal cell fate commitmentGO:000171020.010
regulation of mapk cascadeGO:00434082620.010
carbohydrate metabolic processGO:00059752070.010
dna packagingGO:0006323770.010
kidney epithelium developmentGO:0072073250.010
positive regulation of protein kinase activityGO:00458601900.010
response to nitrogen compoundGO:19016981840.010
tissue migrationGO:00901301190.010
negative regulation of protein maturationGO:19033181420.010
positive regulation of nervous system developmentGO:0051962540.010
Fly
negative regulation of kinase activityGO:00336731060.010

OTX1 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
musculoskeletal system diseaseDOID:172230.026
connective tissue diseaseDOID:651090.026
bone diseaseDOID:0080001880.018
disease of cellular proliferationDOID:145661740.017
cancerDOID:1621670.017
organ system cancerDOID:00506861640.017
sensory system diseaseDOID:00501552030.017
Human
nervous system diseaseDOID:8634310.017
Human
central nervous system diseaseDOID:3311860.015
eye diseaseDOID:56141490.014
Human
eye and adnexa diseaseDOID:14921500.014
Human
immune system diseaseDOID:29141550.014
retinal degenerationDOID:8466890.012
Human
retinal diseaseDOID:56791180.012
Human
disease of metabolismDOID:00146672950.011
cardiovascular system diseaseDOID:12871060.011