Homo sapiens

120 known processes

OTX2

orthodenticle homeobox 2

(Aliases: MCOPS5,MGC45000)

OTX2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
neuron fate commitmentGO:004866320.233
Mouse Worm Fly
forebrain regionalizationGO:002187130.226
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.184
Fly
extraocular skeletal muscle developmentGO:000207410.166
specification of organ identityGO:001009230.163
organ morphogenesisGO:00098871470.161
Mouse Fly
cell fate determinationGO:000170930.151
Mouse
nervous system developmentGO:00073992930.148
organ formationGO:004864530.143
regulation of cell differentiationGO:00455953930.128
Fly
tube morphogenesisGO:0035239950.124
Mouse
cell developmentGO:00484683280.123
generation of neuronsGO:00486991520.115
circulatory system developmentGO:00723592620.113
hindbrain developmentGO:003090230.112
Zebrafish Mouse
somitogenesisGO:000175620.104
Mouse
post embryonic developmentGO:000979120.097
segmentationGO:003528240.097
Mouse Fly
anterior posterior axis specificationGO:000994820.096
Mouse
epithelium developmentGO:00604292270.095
Zebrafish Mouse
positive regulation of developmental processGO:00510943140.094
Mouse Fly
tube developmentGO:00352951250.093
Zebrafish Mouse
anatomical structure formation involved in morphogenesisGO:00486462840.092
Mouse
cell morphogenesisGO:00009022960.084
digestive tract developmentGO:0048565750.077
Mouse
neurogenesisGO:00220081690.077
system processGO:00030083490.074
Worm
central nervous system developmentGO:00074171230.072
Zebrafish Mouse Fly
cell projection organizationGO:00300302520.071
neuron differentiationGO:00301821380.070
metencephalon developmentGO:002203720.070
Mouse
stem cell differentiationGO:0048863930.069
cardiovascular system developmentGO:00723582620.069
locomotory behaviorGO:000762610.067
detection of stimulusGO:0051606850.065
compound eye developmentGO:004874910.064
Fly
cellular component morphogenesisGO:00329893140.062
enzyme linked receptor protein signaling pathwayGO:00071673030.062
brain developmentGO:0007420970.060
Zebrafish Mouse Fly
amine metabolic processGO:0009308440.060
tissue morphogenesisGO:0048729960.059
forebrain developmentGO:0030900260.059
Mouse
embryonic morphogenesisGO:0048598850.059
Mouse
regulation of cell cycleGO:00517263930.058
limbic system developmentGO:002176130.058
canonical wnt signaling pathway involved in cardiac muscle cell fate commitmentGO:006131730.058
adult locomotory behaviorGO:000834410.057
menstrual cycle phaseGO:002260120.057
positive regulation of cell differentiationGO:00455972110.056
Fly
positive regulation of cellular amino acid metabolic processGO:004576430.056
forebrain generation of neuronsGO:002187230.055
positive regulation of cellular amine metabolic processGO:003324070.055
head developmentGO:00603221080.054
Zebrafish Mouse Fly
regulation of cellular amino acid metabolic processGO:000652160.054
somatic stem cell maintenanceGO:003501940.053
regulation of cellular ketone metabolic processGO:0010565500.052
negative regulation of catalytic activityGO:00430863350.052
formation of primary germ layerGO:0001704420.052
response to oxygen containing compoundGO:19017003690.052
Zebrafish
negative regulation of apoptotic processGO:00430663160.051
urogenital system developmentGO:0001655650.051
neurological system processGO:00508771630.049
Worm
chemical homeostasisGO:00488783060.049
regulation of proteolysisGO:00301622930.048
cellular amino acid metabolic processGO:00065201160.048
positive regulation of cell proliferationGO:00082843010.047
cardiac cell fate determinationGO:006091330.047
digestive system developmentGO:0055123750.047
Mouse
cell morphogenesis involved in differentiationGO:00009041440.047
spinal cord developmentGO:002151040.046
ectoderm developmentGO:000739830.046
negative regulation of cell proliferationGO:00082852280.046
response to lipidGO:00339932060.045
negative regulation of developmental processGO:00510932470.045
regulation of peptidase activityGO:00525471800.044
epithelial tube morphogenesisGO:0060562380.044
associative learningGO:000830610.043
heart formationGO:006091420.043
female gamete generationGO:000729220.043
pituitary gland developmentGO:002198320.042
renal system developmentGO:0072001630.042
negative regulation of multicellular organismal processGO:00512413170.042
regulation of cell developmentGO:00602841610.042
Fly
regulation of cellular amine metabolic processGO:0033238110.042
heart field specificationGO:000312820.042
kidney developmentGO:0001822530.041
muscle structure developmentGO:0061061980.041
negative regulation of cellular protein metabolic processGO:00322693530.039
epithelial tube branching involved in lung morphogenesisGO:006044140.039
stem cell developmentGO:0048864690.038
cellular amine metabolic processGO:0044106410.037
growthGO:00400072020.037
memoryGO:000761330.037
neuromuscular junction developmentGO:000752830.036
positive regulation of cell developmentGO:0010720920.036
Fly
negative regulation of cell differentiationGO:00455961710.036
regulation of cell cycle processGO:00105642660.036
regulation of nervous system developmentGO:0051960880.036
Fly
lipid metabolic processGO:00066293810.035
determination of adult lifespanGO:000834020.035
neuron projection developmentGO:00311751060.035
sensory organ developmentGO:0007423520.035
Zebrafish Mouse Fly
epithelial cell differentiationGO:00308551410.035
regulation of neuron differentiationGO:0045664700.035
Fly
cell projection morphogenesisGO:00488581290.035
cellular homeostasisGO:00197251960.035
cerebellum developmentGO:002154920.034
digestive tract morphogenesisGO:0048546560.034
Mouse
cellular ketone metabolic processGO:0042180800.034
secondary heart field specificationGO:000313920.034
regulation of transferase activityGO:00513383550.034
behaviorGO:00076101120.033
Worm
regulation of endopeptidase activityGO:00525481700.033
posttranscriptional regulation of gene expressionGO:00106082130.033
positive regulation of cell cycleGO:00457871400.033
negative regulation of cell deathGO:00605483450.033
morphogenesis of embryonic epitheliumGO:001633140.033
skeletal system developmentGO:0001501790.032
negative regulation of phosphorus metabolic processGO:00105632670.032
negative regulation of phosphate metabolic processGO:00459362670.032
mitotic cell cycleGO:00002783260.032
response to abiotic stimulusGO:00096283360.032
Worm
peptide transportGO:0015833740.032
regulation of growthGO:00400081650.031
positive regulation of sequence specific dna binding transcription factor activityGO:00510911310.031
negative regulation of protein metabolic processGO:00512483910.031
cellular macromolecule catabolic processGO:00442653800.031
heart developmentGO:0007507950.031
regulation of sequence specific dna binding transcription factor activityGO:00510902110.031
cytoplasmic transportGO:00164823790.031
cell part morphogenesisGO:00329901370.031
regulation of membrane potentialGO:0042391950.031
single organism cellular localizationGO:19025803320.031
positive regulation of proteolysisGO:00458621420.031
nephric duct developmentGO:007217640.031
positive regulation of cellular component organizationGO:00511303760.030
cellular response to dna damage stimulusGO:00069743790.030
ossificationGO:00015031210.030
endocrine system developmentGO:0035270260.030
oogenesisGO:004847720.030
forebrain dorsal ventral pattern formationGO:002179810.029
cellular response to oxygen containing compoundGO:19017012760.029
Zebrafish
cellular response to endogenous stimulusGO:00714953360.029
negative regulation of phosphorylationGO:00423261740.029
actin filament based processGO:00300292240.029
regulation of ossificationGO:0030278580.029
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781250.028
eye developmentGO:0001654420.028
Zebrafish Mouse Fly
blastoderm segmentationGO:000735020.028
neuron developmentGO:00486661130.028
inner ear morphogenesisGO:004247240.028
Mouse
endoderm developmentGO:0007492330.028
Mouse
negative regulation of programmed cell deathGO:00430693210.027
regulation of mitotic cell cycleGO:00073461890.027
secretionGO:00469032540.027
cell cell signalingGO:00072671550.027
secretion by cellGO:00329402260.027
mesodermal cell fate specificationGO:000750120.027
multicellular organismal agingGO:001025930.027
regulation of anatomical structure morphogenesisGO:00226032860.027
Mouse Fly
regulation of response to external stimulusGO:00321012220.027
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691810.027
regulation of cell growthGO:00015581350.026
positive regulation of neural precursor cell proliferationGO:200017920.026
negative regulation of cellular component organizationGO:00511292350.026
mesenchymal cell differentiationGO:0048762520.026
blood vessel morphogenesisGO:00485141620.026
kidney morphogenesisGO:0060993190.026
cell growthGO:00160491600.026
nucleocytoplasmic transportGO:00069131760.025
paramesonephric duct developmentGO:006120520.025
vasculature developmentGO:00019441810.025
soft palate developmentGO:006002330.025
negative regulation of cell cycleGO:00457861930.025
muscle cell fate commitmentGO:004269340.025
regulation of secretionGO:00510461940.025
regulation of neural precursor cell proliferationGO:200017740.025
photoreceptor cell differentiationGO:004653020.025
Mouse Fly
embryo developmentGO:00097901230.025
Zebrafish Mouse Worm Fly
morphogenesis of an epitheliumGO:0002009600.025
heart morphogenesisGO:0003007480.025
taxisGO:00423301570.025
biological adhesionGO:00226103310.024
protein localization to organelleGO:00333652800.024
response to nitrogen compoundGO:19016981840.024
action potentialGO:0001508340.024
nuclear transportGO:00511691790.024
regulation of ion transmembrane transportGO:00347651320.024
signal transduction by phosphorylationGO:00230142970.024
regenerationGO:003109940.024
mesonephric duct developmentGO:007217730.024
regulation of protein localizationGO:00328802960.024
embryonic epithelial tube formationGO:000183840.024
ion transmembrane transportGO:00342203380.023
hard palate developmentGO:006002210.023
regulation of secretion by cellGO:19035301770.023
neural tube patterningGO:002153220.023
Zebrafish
motor neuron axon guidanceGO:000804520.023
regulation of homeostatic processGO:00328441210.023
sensory organ morphogenesisGO:0090596210.023
Mouse Fly
muscle system processGO:0003012810.023
neuronal action potentialGO:001922890.022
cellular macromolecular complex assemblyGO:00346223240.022
regulation of cell migrationGO:00303342890.022
mesodermal cell fate commitmentGO:000171020.022
positive regulation of programmed cell deathGO:00430682490.022
regulation of neurogenesisGO:0050767820.022
Fly
membrane organizationGO:00610242920.022
embryonic viscerocranium morphogenesisGO:004870310.022
eye photoreceptor cell differentiationGO:000175420.022
Mouse Fly
primary neural tube formationGO:001402030.022
reproductive processGO:00224141060.022
positive regulation of nervous system developmentGO:0051962540.022
Fly
regulation of establishment of protein localizationGO:00702012420.022
regulation of cysteine type endopeptidase activityGO:20001161270.022
nitrogen compound transportGO:00717051910.022
positive regulation of cell deathGO:00109422630.022
embryonic camera type eye developmentGO:003107620.021
ion homeostasisGO:00508012300.021
long term memoryGO:000761620.021
regulation of branching involved in ureteric bud morphogenesisGO:009018930.021
metal ion transportGO:00300012720.021
cell proliferation in forebrainGO:002184610.021
mesenchyme developmentGO:0060485590.021
positive regulation of hydrolase activityGO:00513453310.021
midgut developmentGO:000749410.021
cell divisionGO:00513011680.021
small molecule biosynthetic processGO:00442831570.021
positive regulation of apoptotic processGO:00430652460.021
cation transmembrane transportGO:00986552380.021
cardiac muscle cell contractionGO:008600340.021
endodermal cell fate commitmentGO:000171140.021
muscle organ developmentGO:0007517560.021
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:00432811160.021
positive regulation of transportGO:00510503360.020
regulation of cell divisionGO:00513021160.020
cellular chemical homeostasisGO:00550821800.020
regulation of kinase activityGO:00435493140.020
angiogenesisGO:00015251470.020
negative regulation of transportGO:00510511760.020
glial cell migrationGO:000834740.020
protein catabolic processGO:00301633250.020
menstruationGO:004270310.020
response to organic cyclic compoundGO:00140702040.020
transmembrane transportGO:00550853990.020
ventral spinal cord developmentGO:002151710.020
positive regulation of endopeptidase activityGO:0010950840.020
neural tube formationGO:000184130.020
regulation of cardiac muscle cell proliferationGO:006004340.020
embryonic placenta developmentGO:000189210.020
cell differentiation in spinal cordGO:002151510.020
sensory perception of painGO:001923340.020
regulation of heart growthGO:006042040.020
forebrain neuron differentiationGO:002187930.020
chromatin modificationGO:00165682980.020
cellular response to organic cyclic compoundGO:00714071270.020
lipid biosynthetic processGO:00086101770.019
regulation of meiotic cell cycleGO:005144540.019
gastrulationGO:0007369510.019
Mouse
positive regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043280690.019
rhythmic behaviorGO:000762220.019
embryonic organ morphogenesisGO:0048562240.019
Mouse
syncytium formation by plasma membrane fusionGO:000076820.019
positive regulation of neurogenesisGO:0050769490.019
Fly
mapk cascadeGO:00001652880.019
sensory perception of smellGO:000760820.019
osteoblast differentiationGO:0001649920.019
spermatid differentiationGO:004851540.019
pharynx developmentGO:006046510.019
single organism reproductive processGO:0044702980.018
neuron projection morphogenesisGO:0048812500.018
circadian behaviorGO:004851220.018
chemotaxisGO:00069351570.018
regulation of actin filament based processGO:00329701410.018
inorganic cation transmembrane transportGO:00986621940.018
negative regulation of intracellular signal transductionGO:19025321830.018
single organism membrane organizationGO:00448022680.018
endodermal cell fate specificationGO:000171440.018
cellular response to hormone stimulusGO:00328701250.018
apoptotic signaling pathwayGO:00971902680.018
neuroendocrine cell differentiationGO:006110120.018
peripheral nervous system developmentGO:000742220.018
signal releaseGO:0023061700.018
dephosphorylationGO:00163112090.018
regulation of cardiac muscle tissue growthGO:005502140.018
cell fate commitmentGO:0045165270.018
Mouse Worm Fly
regulation of cell morphogenesisGO:00226041530.018
response to fungusGO:000962040.018
neural crest cell developmentGO:001403230.018
regulation of cellular response to stressGO:00801352440.018
monovalent inorganic cation transportGO:00156721280.017
sensory perceptionGO:00076001030.017
Worm
positive regulation of phosphorylationGO:00423273940.017
pericardium developmentGO:006003920.017
detection of chemical stimulusGO:0009593550.017
organonitrogen compound biosynthetic processGO:19015662000.017
sex determinationGO:000753030.017
regulation of meiosisGO:004002030.017
vesicle mediated transportGO:00161923710.017
negative regulation of cell developmentGO:0010721480.017
regulation of protein transportGO:00512232130.017
cation transportGO:00068123310.017
nerve developmentGO:002167540.017
salivary gland morphogenesisGO:000743540.017
thymus developmentGO:004853830.017
tripartite regional subdivisionGO:000735120.017
striated muscle contractionGO:0006941520.017
regulation of epithelial cell differentiation involved in kidney developmentGO:200069640.017
neuroblast proliferationGO:000740540.017
protein localization to nucleusGO:00345041360.017
cell cycle phase transitionGO:00447701730.017
regulation of transmembrane transportGO:00347621390.017
regulation of intracellular transportGO:00323861950.017
immune responseGO:00069553070.017
immune system developmentGO:00025201950.017
protein targetingGO:00066051870.017
negative regulation of transferase activityGO:00513481240.016
positive regulation of protein phosphorylationGO:00019343130.016
oocyte differentiationGO:000999420.016
interspecies interaction between organismsGO:00444191560.016
negative regulation of hydrolase activityGO:00513461820.016
cellular protein catabolic processGO:00442572610.016
regulation of intracellular protein transportGO:00331571230.016
myoblast fusionGO:000752010.016
gastrulation with mouth forming secondGO:000170210.016
Mouse
response to organonitrogen compoundGO:00102431560.016
viral life cycleGO:00190581320.016
neurotransmitter secretionGO:000726940.016
regulation of cellular component biogenesisGO:00440872810.016
positive regulation of synaptic transmissionGO:005080640.016
amide transportGO:0042886760.016
response to woundingGO:00096111680.016
cation homeostasisGO:00550801890.016
reproductive system developmentGO:0061458560.016
mesenchymal cell developmentGO:0014031500.016
response to external biotic stimulusGO:00432072610.016
multicellular organismal signalingGO:0035637340.016
protein oligomerizationGO:00512591730.016
cranial nerve developmentGO:002154540.016
negative regulation of cell growthGO:0030308830.016
hormone secretionGO:0046879650.016
hemopoiesisGO:00300971800.016
startle responseGO:000196430.016
lung alveolus developmentGO:004828640.016
cardiac muscle contractionGO:0060048340.016
oocyte developmentGO:004859910.016
blood vessel developmentGO:00015681720.015
negative regulation of kidney developmentGO:009018520.015
spermatid developmentGO:000728640.015
defense responseGO:00069523150.015
kidney epithelium developmentGO:0072073250.015
negative regulation of protein processingGO:00109551420.015
regulation of mapk cascadeGO:00434082620.015
negative regulation of protein modification processGO:00314002000.015
organelle assemblyGO:00709251760.015
negative regulation of growthGO:0045926970.015
response to cytokineGO:00340972320.015
inorganic ion transmembrane transportGO:00986602310.015
response to other organismGO:00517072610.015
oxidation reduction processGO:00551143960.015
carbohydrate metabolic processGO:00059752070.015
regulation of cellular component movementGO:00512703340.015
regulation of protein kinase activityGO:00458592890.015
rna processingGO:00063962550.015
negative regulation of mitotic cell cycleGO:00459301020.015
mitotic cell cycle processGO:19030472860.015
renal sodium ion absorptionGO:007029420.015
hippocampus developmentGO:002176610.015
regulation of stem cell differentiationGO:2000736560.015
regionalizationGO:0003002290.015
Zebrafish Mouse Fly
regulation of canonical wnt signaling pathwayGO:0060828880.015
positive regulation of mapk cascadeGO:00434101900.015
response to radiationGO:00093141510.015
protein ubiquitinationGO:00165673140.015
innate immune responseGO:00450871780.015
retinal ganglion cell axon guidanceGO:003129020.015
intracellular protein transportGO:00068862700.015
axis elongationGO:000340140.015
covalent chromatin modificationGO:00165692540.015
tube closureGO:006060630.015
canonical wnt signaling pathwayGO:00600701160.015
nephron epithelium developmentGO:0072009230.015
intracellular receptor signaling pathwayGO:00305221040.014
response to light stimulusGO:0009416870.014
organophosphate biosynthetic processGO:00904071630.014
nephron developmentGO:0072006300.014
wnt signaling pathwayGO:00160551560.014
regulation of wnt signaling pathwayGO:00301111230.014
response to axon injuryGO:004867810.014
regulation of osteoblast differentiationGO:0045667380.014
dna repairGO:00062811980.014
purine nucleoside catabolic processGO:00061523980.014
negative regulation of wnt signaling pathwayGO:0030178690.014
regulation of nucleocytoplasmic transportGO:0046822980.014
mitotic cell cycle phase transitionGO:00447721620.014
positive regulation of peptidase activityGO:0010952880.014
pattern specification processGO:0007389430.014
Zebrafish Mouse Fly
positive regulation of catabolic processGO:00098963100.014
protein modification by small protein conjugationGO:00324463420.014
developmental process involved in reproductionGO:0003006660.014
protein importGO:00170381300.014
hematopoietic or lymphoid organ developmentGO:00485341860.014
sodium ion transmembrane transportGO:0035725590.014
convergent extensionGO:006002610.014
post embryonic organ developmentGO:004856910.014
positive regulation of nucleocytoplasmic transportGO:0046824540.014
matingGO:000761810.014
muscle contractionGO:0006936730.014
negative regulation of proteolysisGO:00458611320.014
anterior posterior axis specification embryoGO:000859520.014
proteolysis involved in cellular protein catabolic processGO:00516032440.014
regulation of peptide transportGO:0090087620.014
transmission of nerve impulseGO:0019226110.014
translationGO:00064121320.013
actin mediated cell contractionGO:0070252120.013
regulation of multi organism processGO:00439001570.013
positive regulation of organelle organizationGO:00106381950.013
cell differentiation in hindbrainGO:002153310.013
visual behaviorGO:000763220.013
cellular response to lipidGO:00713961270.013
behavioral response to ethanolGO:004814920.013
endoderm formationGO:0001706330.013
intracellular steroid hormone receptor signaling pathwayGO:0030518610.013
establishment of protein localization to organelleGO:00725941720.013
regulation of lipid metabolic processGO:0019216960.013
protein import into nucleusGO:00066061040.013
reproductive structure developmentGO:0048608550.013
cell cycle arrestGO:0007050710.013
positive regulation of cysteine type endopeptidase activityGO:2001056790.013
protein localization to membraneGO:00726571600.013
positive regulation of canonical wnt signaling pathwayGO:0090263330.013
cell adhesionGO:00071553250.013
protein targeting to nucleusGO:00447441040.013
cellular response to organonitrogen compoundGO:00714171240.013
anion transportGO:00068201610.013
regulation of cell motilityGO:20001452990.013
nephron morphogenesisGO:0072028150.013
sleepGO:003043120.013
response to growth factorGO:00708482050.013
cellular component assembly involved in morphogenesisGO:0010927730.013
cellular component disassemblyGO:0022411920.013
positive regulation of neuron differentiationGO:0045666400.013
Fly
regulation of hormone secretionGO:0046883570.013
nucleic acid phosphodiester bond hydrolysisGO:00903051020.013
mitochondrion organizationGO:00070051560.013
cellular response to growth factor stimulusGO:00713631970.013
reactive oxygen species biosynthetic processGO:190340940.013
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092900.013
alcohol metabolic processGO:00060661140.013
regulation of excitatory postsynaptic membrane potentialGO:006007910.013
positive regulation of gliogenesisGO:001401540.013
neuron projection regenerationGO:003110210.013
regulation of cytoskeleton organizationGO:00514931770.012
neural tube closureGO:000184330.012
signal transduction involved in regulation of gene expressionGO:002301910.012
negative regulation of kinase activityGO:00336731060.012
distal tubule developmentGO:007201740.012
purine ribonucleoside metabolic processGO:00461284370.012
organophosphate catabolic processGO:00464344300.012
negative regulation of cellular amino acid metabolic processGO:004576320.012
regulation of response to woundingGO:19030341010.012
neural crest cell migrationGO:000175520.012
regulation of body fluid levelsGO:0050878990.012
tissue regenerationGO:004224630.012
multi organism cellular processGO:00447641560.012
regulation of postsynaptic membrane potentialGO:006007810.012
regulation of ion transportGO:00432691890.012
regulation of locomotionGO:00400123290.012
proteasomal protein catabolic processGO:00104981760.012
nephron epithelium morphogenesisGO:0072088150.012
lung cell differentiationGO:006047910.012
adenylate cyclase inhibiting g protein coupled glutamate receptor signaling pathwayGO:000719640.012
protein localization to plasma membraneGO:0072659930.012
regulation of synaptic plasticityGO:004816730.012
telencephalon developmentGO:0021537170.012
ribonucleotide catabolic processGO:00092614050.012
divalent inorganic cation homeostasisGO:00725071360.012
mesoderm developmentGO:0007498140.012

OTX2 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
eye diseaseDOID:56141490.081
sensory system diseaseDOID:00501552030.081
eye and adnexa diseaseDOID:14921500.081
nervous system diseaseDOID:8634310.081
retinal diseaseDOID:56791180.026
Human
disease of metabolismDOID:00146672950.023
central nervous system diseaseDOID:3311860.019
retinal degenerationDOID:8466890.016
Human
neurodegenerative diseaseDOID:12891020.014
organ system cancerDOID:00506861640.013
disease of cellular proliferationDOID:145661740.013
cancerDOID:1621670.013
muscular diseaseDOID:00800001140.013
musculoskeletal system diseaseDOID:172230.013
muscle tissue diseaseDOID:661130.013