Homo sapiens

96 known processes

TNFSF10

tumor necrosis factor (ligand) superfamily, member 10

(Aliases: CD253,APO2L,TL2,TRAIL,Apo-2L)

TNFSF10 biological process predictions


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Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular response to increased oxygen levelsGO:003629540.997
positive regulation of i kappab kinase nf kappab signalingGO:00431231320.981
trail activated apoptotic signaling pathwayGO:003646240.937
skeletal muscle satellite cell proliferationGO:001484110.931
cellular response to mechanical stimulusGO:0071260390.913
Human
defense responseGO:00069523150.908
Fly
response to biotic stimulusGO:00096072760.882
Fly
i kappab kinase nf kappab signalingGO:00072491660.882
programmed necrotic cell deathGO:0097300180.878
Human
cellular response to hyperoxiaGO:007145540.869
regulation of defense responseGO:00313471540.815
response to other organismGO:00517072610.797
Fly
inflammatory responseGO:0006954790.752
response to hyperoxiaGO:005509340.726
positive regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043280690.694
regulation of i kappab kinase nf kappab signalingGO:00431221620.680
apoptotic signaling pathwayGO:00971902680.651
response to cobalt ionGO:003202510.644
regulation of proteolysisGO:00301622930.642
regulation of skeletal muscle cell proliferationGO:001485710.611
response to external biotic stimulusGO:00432072610.609
Fly
positive regulation of cell deathGO:00109422630.591
defense response to other organismGO:00985421290.590
Fly
extrinsic apoptotic signaling pathway via death domain receptorsGO:0008625420.542
Human
cellular amine metabolic processGO:0044106410.503
regulation of cysteine type endopeptidase activityGO:20001161270.493
protein processingGO:00164852260.491
Human
negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:1902042150.475
regulation of response to external stimulusGO:00321012220.474
response to increased oxygen levelsGO:003629640.462
positive regulation of jak stat cascadeGO:0046427350.439
regulation of inflammatory responseGO:0050727460.433
response to woundingGO:00096111680.401
dna damage response signal transduction by p53 class mediator resulting in cell cycle arrestGO:000697790.395
negative regulation of response to woundingGO:1903035470.392
regulation of satellite cell proliferationGO:001484210.380
positive regulation of cellular amine metabolic processGO:003324070.367
jak stat cascadeGO:0007259460.357
negative regulation of defense responseGO:0031348470.355
response to mechanical stimulusGO:0009612510.344
Human
cellular amino acid metabolic processGO:00065201160.342
regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:1902041240.330
regulation of cellular ketone metabolic processGO:0010565500.329
negative regulation of proteolysisGO:00458611320.322
Human
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:00432811160.321
intrinsic apoptotic signaling pathwayGO:00971931270.317
extrinsic apoptotic signaling pathwayGO:00971911190.317
positive regulation of tyrosine phosphorylation of stat proteinGO:0042531280.315
symbiosis encompassing mutualism through parasitismGO:00444031560.315
regulation of peptidase activityGO:00525471800.311
necrotic cell deathGO:0070265210.310
Human
regulation of cellular amino acid metabolic processGO:000652160.301
immune responseGO:00069553070.301
Fly
positive regulation of cysteine type endopeptidase activityGO:2001056790.299
necroptotic processGO:0070266160.272
Human
viral life cycleGO:00190581320.269
negative regulation of inflammatory responseGO:0050728220.262
positive regulation of apoptotic processGO:00430652460.261
negative regulation of response to external stimulusGO:0032102830.258
regulation of response to woundingGO:19030341010.255
regulation of tyrosine phosphorylation of stat1 proteinGO:0042510110.240
response to oxygen containing compoundGO:19017003690.238
Rat
cellular response to abiotic stimulusGO:00712141170.222
Human
necroptotic signaling pathwayGO:009752760.222
Human
positive regulation of programmed cell deathGO:00430682490.220
negative regulation of muscle cell differentiationGO:0051148170.215
regulation of protein processingGO:00706131500.215
Human
interspecies interaction between organismsGO:00444191560.213
cellular ketone metabolic processGO:0042180800.211
defense response to virusGO:0051607710.209
positive regulation of apoptotic signaling pathwayGO:2001235700.207
amine metabolic processGO:0009308440.198
multi organism cellular processGO:00447641560.198
response to virusGO:00096151260.194
response to cytokineGO:00340972320.190
Human
positive regulation of phosphorylationGO:00423273940.188
Human
regulation of cellular amine metabolic processGO:0033238110.184
regulation of tyrosine phosphorylation of stat proteinGO:0042509300.183
positive regulation of innate immune responseGO:0045089790.182
regulation of endopeptidase activityGO:00525481700.181
immune system developmentGO:00025201950.178
Human
response to lipidGO:00339932060.177
positive regulation of cellular amino acid metabolic processGO:004576430.173
organonitrogen compound biosynthetic processGO:19015662000.170
anatomical structure formation involved in morphogenesisGO:00486462840.167
Human
positive regulation of tyrosine phosphorylation of stat1 proteinGO:004251180.167
response to endoplasmic reticulum stressGO:0034976490.165
negative regulation of protein maturationGO:19033181420.162
Human
regulation of extrinsic apoptotic signaling pathwayGO:2001236850.160
regulation of cytokine productionGO:00018172320.157
myoblast fusionGO:000752010.151
muscle system processGO:0003012810.151
response to abiotic stimulusGO:00096283360.149
Human
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressGO:0070059120.149
negative regulation of catalytic activityGO:00430863350.148
Human
positive regulation of immune responseGO:00507781590.147
immune response activating signal transductionGO:0002757900.142
innate immune responseGO:00450871780.142
Fly
positive regulation of hydrolase activityGO:00513453310.141
pattern recognition receptor signaling pathwayGO:0002221480.141
regulation of apoptotic signaling pathwayGO:20012331750.140
cytokine productionGO:00018162470.130
positive regulation of rig i signaling pathwayGO:190024640.129
negative regulation of multicellular organismal processGO:00512413170.126
Human
regulation of peptidyl tyrosine phosphorylationGO:00507301080.126
mitotic g1 dna damage checkpointGO:0031571170.125
positive regulation of peptidase activityGO:0010952880.113
intrinsic apoptotic signaling pathway in response to dna damageGO:0008630500.110
regulation of myoblast fusionGO:190173910.110
regulation of tumor necrosis factor productionGO:0032680430.110
tyrosine phosphorylation of stat proteinGO:0007260330.109
regulation of syncytium formation by plasma membrane fusionGO:006014220.108
cellular protein catabolic processGO:00442572610.104
negative regulation of immune system processGO:00026831360.102
cellular response to external stimulusGO:00714961110.101
Human
positive regulation of sequence specific dna binding transcription factor activityGO:00510911310.099
Human
regulation of sequence specific dna binding transcription factor activityGO:00510902110.095
Human
protein maturationGO:00516042330.094
Human
negative regulation of cell deathGO:00605483450.093
Human
cellular response to lipidGO:00713961270.089
negative regulation of intracellular signal transductionGO:19025321830.085
Human
response to oxygen levelsGO:00704821000.085
negative regulation of myotube differentiationGO:001083240.085
immune effector processGO:00022521590.084
activation of innate immune responseGO:0002218550.083
activation induced cell death of t cellsGO:000692420.078
positive regulation of peptidyl tyrosine phosphorylationGO:0050731850.078
cellular response to oxygen levelsGO:0071453550.077
positive regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:190204330.077
regulation of innate immune responseGO:0045088970.077
cardiovascular system developmentGO:00723582620.073
Human
negative regulation of hydrolase activityGO:00513461820.073
Human
execution phase of apoptosisGO:0097194320.071
positive regulation of immune system processGO:00026842830.067
Human
signal transduction involved in cell cycle checkpointGO:0072395160.067
negative regulation of cysteine type endopeptidase activityGO:2000117480.066
Human
thymocyte apoptotic processGO:007024220.066
cell cycle arrestGO:0007050710.065
regenerationGO:003109940.060
tissue regenerationGO:004224630.060
morphogenesis of embryonic epitheliumGO:001633140.060
peptidyl tyrosine modificationGO:00182121700.059
regulation of jak stat cascadeGO:0046425440.058
negative regulation of protein metabolic processGO:00512483910.058
Human
signal transduction in response to dna damageGO:0042770570.058
intracellular receptor signaling pathwayGO:00305221040.057
negative regulation of mitotic cell cycleGO:00459301020.056
activation of immune responseGO:00022531140.055
ion transmembrane transportGO:00342203380.054
vasculature developmentGO:00019441810.054
Human
carbohydrate derivative biosynthetic processGO:19011372070.052
glycosylationGO:0070085710.051
viral processGO:00160321460.051
organophosphate biosynthetic processGO:00904071630.050
regulation of symbiosis encompassing mutualism through parasitismGO:00439031090.050
response to radiationGO:00093141510.050
negative regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043154460.050
Human
defense response to bacteriumGO:0042742630.050
Fly
syncytium formation by plasma membrane fusionGO:000076820.050
purine nucleotide biosynthetic processGO:0006164840.049
positive regulation of multi organism processGO:0043902560.049
protein import into nucleusGO:00066061040.049
Human
negative regulation of protein processingGO:00109551420.048
Human
regulation of cell cycle g1 s phase transitionGO:1902806420.048
regulation of protein targetingGO:1903533910.048
Human
positive regulation of type i interferon productionGO:0032481200.048
positive regulation of endopeptidase activityGO:0010950840.047
response to interferon betaGO:0035456110.047
regulation of protein maturationGO:19033171500.047
Human
positive regulation of cytokine productionGO:00018191670.045
neural tube formationGO:000184130.044
regulation of protein secretionGO:0050708860.044
response to molecule of bacterial originGO:0002237820.043
regulation of lymphocyte activationGO:00512491030.043
Human
tumor necrosis factor productionGO:0032640430.043
protein oligomerizationGO:00512591730.042
proteolysis involved in cellular protein catabolic processGO:00516032440.042
innate immune response activating signal transductionGO:0002758480.042
negative regulation of peptidase activityGO:0010466910.041
Human
response to organic cyclic compoundGO:00140702040.041
epithelium developmentGO:00604292270.040
mitotic dna damage checkpointGO:0044773280.040
skeletal muscle cell proliferationGO:001485610.040
regulation of multi organism processGO:00439001570.040
regulation of interleukin 1 beta productionGO:0032651180.039
regulation of tumor necrosis factor superfamily cytokine productionGO:1903555440.039
cellular response to interferon alphaGO:003545740.039
lipoprotein metabolic processGO:0042157420.038
cellular response to oxygen containing compoundGO:19017012760.038
system processGO:00030083490.038
negative regulation of extrinsic apoptotic signaling pathwayGO:2001237520.036
response to lipopolysaccharideGO:0032496700.036
regulation of cytokine secretionGO:0050707570.035
negative regulation of phosphate metabolic processGO:00459362670.034
cell type specific apoptotic processGO:00972851250.034
Human
positive regulation of transportGO:00510503360.034
Human
circulatory system developmentGO:00723592620.033
Human
striated muscle cell differentiationGO:0051146430.033
regulation of intracellular transport of viral materialGO:190125220.033
positive regulation of protein phosphorylationGO:00019343130.033
Human
mitotic cell cycle checkpointGO:0007093680.032
signal transduction involved in mitotic g1 dna damage checkpointGO:0072431100.032
regulation of interleukin 1 productionGO:0032652210.032
macromolecule glycosylationGO:0043413630.032
regulation of viral processGO:00507921030.032
regulation of protein transportGO:00512232130.032
Human
blood vessel developmentGO:00015681720.031
Human
peptidyl tyrosine phosphorylationGO:00181081700.031
positive regulation of mapk cascadeGO:00434101900.031
Human
tyrosine phosphorylation of stat1 proteinGO:0042508110.030
regulation of mononuclear cell proliferationGO:0032944650.030
positive regulation of response to external stimulusGO:0032103880.030
negative regulation of cellular protein metabolic processGO:00322693530.029
Human
transmembrane transportGO:00550853990.029
response to drugGO:0042493810.029
cellular response to organic cyclic compoundGO:00714071270.029
cellular response to molecule of bacterial originGO:0071219620.029
response to bacteriumGO:00096171440.029
Fly
response to organonitrogen compoundGO:00102431560.028
Rat
negative regulation of protein deubiquitinationGO:009008630.028
muscle structure developmentGO:0061061980.028
determination of adult lifespanGO:000834020.028
positive regulation of immune effector processGO:0002699400.028
regulation of cell cycleGO:00517263930.028
response to waterGO:000941520.028
regulation of myeloid cell differentiationGO:0045637810.028
Human
striated muscle adaptationGO:001488840.027
posttranscriptional regulation of gene expressionGO:00106082130.027
regulation of establishment of protein localizationGO:00702012420.027
Human
positive regulation of cell motilityGO:20001471770.027
positive regulation of locomotionGO:00400171860.027
regulation of response to biotic stimulusGO:0002831550.027
response to interferon gammaGO:0034341390.026
negative regulation of viral genome replicationGO:0045071350.026
negative regulation of developmental processGO:00510932470.026
Human
negative regulation of apoptotic processGO:00430663160.026
Human
inflammatory cell apoptotic processGO:000692530.026
negative regulation of cell cycleGO:00457861930.026
negative regulation of multi organism processGO:0043901920.026
mitotic cell cycle processGO:19030472860.025
nucleoside phosphate biosynthetic processGO:19012931090.025
positive regulation of interferon beta productionGO:0032728170.025
protein targetingGO:00066051870.025
Human
purine containing compound biosynthetic processGO:0072522880.025
blood vessel morphogenesisGO:00485141620.025
Human
activated t cell proliferationGO:0050798130.025
regulation of g1 s transition of mitotic cell cycleGO:2000045400.025
response to hormoneGO:00097251750.024
Rat
activation of cysteine type endopeptidase activity involved in apoptotic processGO:0006919490.024
Human
cellular response to cytokine stimulusGO:00713451810.024
Human
regulation of viral genome replicationGO:0045069480.024
cytoplasmic transportGO:00164823790.024
Human
regulation of cell cycle processGO:00105642660.024
regulation of intracellular transportGO:00323861950.024
Human
protein homooligomerizationGO:00512601000.023
regulation of response to dna damage stimulusGO:2001020940.023
spleen developmentGO:004853610.023
negative regulation of endopeptidase activityGO:0010951840.023
Human
immune response regulating signaling pathwayGO:0002764970.023
negative regulation of viral processGO:0048525660.022
regulation of immune effector processGO:0002697910.022
interleukin 1 productionGO:0032612260.022
regulation of secretionGO:00510461940.022
extrinsic apoptotic signaling pathway in absence of ligandGO:0097192220.022
carbohydrate metabolic processGO:00059752070.022
cellular response to light stimulusGO:0071482340.022
mapk cascadeGO:00001652880.021
Human Fly
regulation of cytoskeleton organizationGO:00514931770.021
regulation of immune responseGO:00507762010.021
positive regulation of secretionGO:00510471160.021
signal transduction involved in dna integrity checkpointGO:0072401150.021
positive regulation of defense responseGO:0031349870.021
single organism carbohydrate metabolic processGO:00447231930.021
establishment of protein localization to organelleGO:00725941720.020
Human
multicellular organismal agingGO:001025930.020
protein catabolic processGO:00301633250.020
negative regulation of striated muscle cell differentiationGO:005115480.020
positive regulation of cell migrationGO:00303351720.020
positive regulation of release of cytochrome c from mitochondriaGO:0090200180.020
regulation of protein localizationGO:00328802960.019
Human
negative regulation of cell differentiationGO:00455961710.019
apoptotic mitochondrial changesGO:0008637570.019
negative regulation of apoptotic signaling pathwayGO:2001234970.019
cellular response to endogenous stimulusGO:00714953360.019
monosaccharide metabolic processGO:0005996740.019
spermatid developmentGO:000728640.019
positive regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathwayGO:200126910.019
positive regulation of interferon alpha productionGO:0032727110.019
regulation of proteolysis involved in cellular protein catabolic processGO:1903050910.019
regulation of ion transmembrane transportGO:00347651320.019
protein modification by small protein conjugationGO:00324463420.019
nuclear transportGO:00511691790.018
Human
cellular response to organonitrogen compoundGO:00714171240.018
cytokine mediated signaling pathwayGO:00192211090.018
Human
multi organism metabolic processGO:0044033410.018
cellular response to radiationGO:0071478650.018
release of cytochrome c from mitochondriaGO:0001836350.018
cellular response to tumor necrosis factorGO:0071356630.017
Human
actin filament based processGO:00300292240.017
circadian behaviorGO:004851220.017
protein glycosylationGO:0006486620.017
positive regulation of proteolysisGO:00458621420.017
protein targeting to nucleusGO:00447441040.017
Human
response to metal ionGO:0010038840.017
secretionGO:00469032540.017
fas signaling pathwayGO:003633730.017
glycoprotein biosynthetic processGO:0009101910.017
positive regulation of secretion by cellGO:19035321080.017
metal ion transportGO:00300012720.017
epithelial cell differentiationGO:00308551410.016
angiogenesisGO:00015251470.016
Human
regulation of protein complex assemblyGO:00432541470.016
regulation of dna metabolic processGO:00510521530.016
signal transduction by p53 class mediatorGO:0072331720.016
vesicle mediated transportGO:00161923710.016
Fly
intracellular protein transportGO:00068862700.016
Human
negative regulation of g1 s transition of mitotic cell cycleGO:2000134290.016
negative regulation of vasculature developmentGO:1901343430.016
Human
positive regulation of intracellular transportGO:00323881040.016
Human
actomyosin structure organizationGO:0031032590.016
positive regulation of protein transportGO:00512221350.016
Human
positive regulation of cell cycle processGO:00900681060.016
tube developmentGO:00352951250.016
response to extracellular stimulusGO:0009991850.015
cytokine metabolic processGO:0042107380.015
Human
regulation of protein import into nucleusGO:0042306780.015
Human
regulation of muscle cell differentiationGO:0051147310.015
negative regulation of cellular component organizationGO:00511292350.015
negative regulation of transferase activityGO:00513481240.015
nucleoside triphosphate metabolic processGO:00091414220.015
cellular response to estrogen stimulusGO:0071391160.015
rna interferenceGO:001624640.015
negative regulation of t cell apoptotic processGO:007023340.015
regulation of type i interferon productionGO:0032479260.015
cellular macromolecule catabolic processGO:00442653800.015
cellular response to dna damage stimulusGO:00069743790.015
protein secretionGO:0009306980.015
nervous system developmentGO:00073992930.015
positive regulation of t cell migrationGO:2000406130.015
ribonucleoside triphosphate catabolic processGO:00092033910.015
actin cytoskeleton organizationGO:00300362070.015
regulation of interleukin 2 secretionGO:190004020.015
regulation of viral induced cytoplasmic pattern recognition receptor signaling pathwayGO:003953170.014
adaptive immune responseGO:0002250490.014
spermatid differentiationGO:004851540.014
negative regulation of mitotic cell cycle phase transitionGO:1901991850.014
regulation of t cell activationGO:0050863770.014
Human
autophagic cell deathGO:004810230.014
regulation of defense response to virusGO:0050688330.014
regulation of viral transcriptionGO:0046782340.014
chromatin modificationGO:00165682980.014
ubiquitin dependent protein catabolic processGO:00065112060.014
dna damage response signal transduction by p53 class mediatorGO:0030330440.014
negative regulation of phosphorus metabolic processGO:00105632670.014
regulation of rig i signaling pathwayGO:003953560.014
release of cytoplasmic sequestered nf kappabGO:000858840.014
Human
cell developmentGO:00484683280.014
muscle cell proliferationGO:0033002350.014
compound eye developmentGO:004874910.014
regulation of protein catabolic processGO:00421761550.014
interleukin 2 secretionGO:007097030.014
defense response to gram positive bacteriumGO:0050830290.014
cellular response to growth factor stimulusGO:00713631970.014
regulation of purine nucleotide metabolic processGO:19005422640.013
nucleic acid phosphodiester bond hydrolysisGO:00903051020.013
response to light stimulusGO:0009416870.013
negative regulation of protein phosphorylationGO:00019331400.013
regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathwayGO:200126720.013
basement membrane organizationGO:007171130.013
response to cycloheximideGO:004689810.013
cytoplasmic pattern recognition receptor signaling pathway in response to virusGO:003952880.013
regulation of mapk cascadeGO:00434082620.013
Human
negative regulation of intracellular transportGO:0032387600.013
Human
skeletal muscle organ developmentGO:0060538260.013
response to dsrnaGO:0043331250.013
negative regulation of catabolic processGO:00098951040.013
cellular response to virusGO:009858690.013
purine ribonucleotide catabolic processGO:00091544040.013
dna damage checkpointGO:0000077680.013
positive regulation of viral entry into host cellGO:004659830.013
positive regulation of leukocyte activationGO:0002696800.013
Human
toxin transportGO:190199840.013
rhythmic behaviorGO:000762220.013
wound healingGO:00420601150.012
female gamete generationGO:000729220.012
t cell apoptotic processGO:0070231120.012
Human
regulation of macrophage differentiationGO:004564990.012
memoryGO:000761330.012
regulation of transferase activityGO:00513383550.012
Human
nucleotide biosynthetic processGO:00091651090.012
striated muscle cell developmentGO:0055002270.012
lymphocyte apoptotic processGO:0070227200.012
Human
response to uvGO:0009411730.012
peripheral nervous system developmentGO:000742220.012
positive regulation of response to biotic stimulusGO:0002833180.012
glycoprotein metabolic processGO:00091001100.012
response to nitrogen compoundGO:19016981840.012
Rat
regulation of interferon alpha productionGO:0032647110.012
regulation of cell cycle phase transitionGO:19019871260.012
response to toxic substanceGO:0009636370.012
cell activationGO:00017752130.012
Human
negative regulation of reactive oxygen species biosynthetic processGO:190342710.012
regulation of anatomical structure morphogenesisGO:00226032860.012
Human
cellular response to metal ionGO:0071248430.012
regulation of dna bindingGO:0051101370.012
oogenesisGO:004847720.011
regulation of neural precursor cell proliferationGO:200017740.011
toll like receptor 2 signaling pathwayGO:003413440.011
ribonucleoside catabolic processGO:00424544060.011
positive regulation of cellular component organizationGO:00511303760.011
response to alcoholGO:0097305640.011
response to nutrient levelsGO:0031667810.011
regulation of lymphocyte apoptotic processGO:0070228150.011
growthGO:00400072020.011
purine containing compound catabolic processGO:00725234110.011
modification dependent protein catabolic processGO:00199412090.011
regulation of protein stabilityGO:0031647870.011
viral genome replicationGO:0019079500.011
protein autoprocessingGO:001654040.010
neuron differentiationGO:00301821380.010
cellular response to glucocorticoid stimulusGO:007138540.010
immune response activating cell surface receptor signaling pathwayGO:0002429450.010
muscle adaptationGO:0043500120.010
neuron projection regenerationGO:003110210.010
regulation of cell differentiationGO:00455953930.010
Human
organophosphate catabolic processGO:00464344300.010
negative regulation of cytokine productionGO:0001818820.010
detection of stimulusGO:0051606850.010
t cell differentiationGO:0030217290.010
erythrocyte differentiationGO:0030218280.010
post embryonic developmentGO:000979120.010
positive regulation of interleukin 1 beta productionGO:0032731130.010
inorganic ion transmembrane transportGO:00986602310.010

TNFSF10 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of cellular proliferationDOID:145661740.572
Human
gastrointestinal system cancerDOID:3119520.046
organ system cancerDOID:00506861640.046
Human
cancerDOID:1621670.046
Human
immune system diseaseDOID:29141550.019
Human
hypersensitivity reaction diseaseDOID:0060056250.019
Human
stomach cancerDOID:10534120.014
disease of metabolismDOID:00146672950.013
sensory system diseaseDOID:00501552030.010
eye and adnexa diseaseDOID:14921500.010
nervous system diseaseDOID:8634310.010
eye diseaseDOID:56141490.010