Homo sapiens

41 known processes

APOL1

apolipoprotein L, 1

(Aliases: FSGS4,APOL,APO-L,APOL-I)

APOL1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
defense responseGO:00069523150.474
inorganic anion transmembrane transportGO:0098661470.380
immune responseGO:00069553070.334
chloride transportGO:0006821410.330
anion transportGO:00068201610.285
anion transmembrane transportGO:0098656760.245
positive regulation of i kappab kinase nf kappab signalingGO:00431231320.177
Human
innate immune responseGO:00450871780.175
multi organism cellular processGO:00447641560.162
ion transmembrane transportGO:00342203380.161
interspecies interaction between organismsGO:00444191560.159
defense response to other organismGO:00985421290.137
response to other organismGO:00517072610.114
symbiosis encompassing mutualism through parasitismGO:00444031560.107
chloride transmembrane transportGO:1902476380.096
response to external biotic stimulusGO:00432072610.093
defense response to virusGO:0051607710.092
regulation of i kappab kinase nf kappab signalingGO:00431221620.088
Human
i kappab kinase nf kappab signalingGO:00072491660.085
Human
response to cytokineGO:00340972320.082
glycosylationGO:0070085710.078
response to biotic stimulusGO:00096072760.071
carbohydrate metabolic processGO:00059752070.070
cellular amine metabolic processGO:0044106410.068
viral genome replicationGO:0019079500.065
nucleoside phosphate biosynthetic processGO:19012931090.064
carbohydrate derivative biosynthetic processGO:19011372070.063
macromolecule glycosylationGO:0043413630.062
biological adhesionGO:00226103310.061
purine nucleotide catabolic processGO:00061954050.053
chemical homeostasisGO:00488783060.052
organophosphate catabolic processGO:00464344300.052
protein glycosylationGO:0006486620.052
cellular response to cytokine stimulusGO:00713451810.052
mhc class ii biosynthetic processGO:004534240.050
organonitrogen compound biosynthetic processGO:19015662000.050
cellular amino acid metabolic processGO:00065201160.050
regulation of dna metabolic processGO:00510521530.049
regulation of cellular ketone metabolic processGO:0010565500.049
protein modification by small protein conjugationGO:00324463420.049
regulation of establishment of protein localizationGO:00702012420.049
modification of morphology or physiology of other organismGO:0035821430.045
single organism carbohydrate metabolic processGO:00447231930.045
positive regulation of transportGO:00510503360.045
viral life cycleGO:00190581320.045
purine ribonucleotide catabolic processGO:00091544040.044
negative regulation of multicellular organismal processGO:00512413170.044
leukocyte differentiationGO:0002521980.044
regulation of protein transportGO:00512232130.043
regulation of symbiosis encompassing mutualism through parasitismGO:00439031090.042
regulation of cellular amino acid metabolic processGO:000652160.042
regulation of apoptotic signaling pathwayGO:20012331750.042
cytoplasmic transportGO:00164823790.042
cellular homeostasisGO:00197251960.041
glycoprotein biosynthetic processGO:0009101910.041
organophosphate biosynthetic processGO:00904071630.041
regulation of response to external stimulusGO:00321012220.041
nucleoside catabolic processGO:00091644080.041
negative regulation of protein metabolic processGO:00512483910.040
post embryonic developmentGO:000979120.040
response to interferon gammaGO:0034341390.040
negative regulation of cell proliferationGO:00082852280.039
negative regulation of apoptotic processGO:00430663160.039
cytokine productionGO:00018162470.039
protein maturationGO:00516042330.039
ras protein signal transductionGO:0007265730.038
purine nucleoside triphosphate catabolic processGO:00091463920.038
positive regulation of cellular amine metabolic processGO:003324070.037
inorganic ion transmembrane transportGO:00986602310.037
regulation of cellular amine metabolic processGO:0033238110.036
ribonucleoside triphosphate catabolic processGO:00092033910.036
t cell activationGO:0042110990.036
purine ribonucleoside triphosphate metabolic processGO:00092054110.036
transmembrane transportGO:00550853990.035
response to virusGO:00096151260.035
regulation of protein localizationGO:00328802960.034
nuclear transportGO:00511691790.034
determination of adult lifespanGO:000834020.034
apoptotic signaling pathwayGO:00971902680.033
leukocyte activationGO:00453211640.033
lipid metabolic processGO:00066293810.033
regulation of leukocyte activationGO:00026941150.033
viral processGO:00160321460.032
positive regulation of cellular amino acid metabolic processGO:004576430.032
protein oligomerizationGO:00512591730.032
immune effector processGO:00022521590.032
negative regulation of protein maturationGO:19033181420.031
proteolysis involved in cellular protein catabolic processGO:00516032440.031
positive regulation of hydrolase activityGO:00513453310.031
regulation of anatomical structure morphogenesisGO:00226032860.031
multicellular organismal agingGO:001025930.031
regulation of immune responseGO:00507762010.031
positive regulation of purine nucleotide metabolic processGO:19005442270.031
positive regulation of immune system processGO:00026842830.030
system processGO:00030083490.030
intracellular protein transportGO:00068862700.030
ion homeostasisGO:00508012300.030
vesicle mediated transportGO:00161923710.030
protein ubiquitinationGO:00165673140.029
glycoprotein metabolic processGO:00091001100.029
rho protein signal transductionGO:0007266260.029
oogenesisGO:004847720.029
myoblast fusionGO:000752010.028
negative regulation of hydrolase activityGO:00513461820.028
negative regulation of catalytic activityGO:00430863350.028
regulation of purine nucleotide metabolic processGO:19005422640.028
negative regulation of cellular protein metabolic processGO:00322693530.028
cellular ketone metabolic processGO:0042180800.028
cellular response to endogenous stimulusGO:00714953360.028
purine containing compound catabolic processGO:00725234110.027
cellular ion homeostasisGO:00068731680.027
ribonucleoside catabolic processGO:00424544060.027
regulation of cellular component movementGO:00512703340.027
cell adhesionGO:00071553250.027
purine nucleotide biosynthetic processGO:0006164840.027
regulation of cell adhesionGO:00301551660.027
positive regulation of transferase activityGO:00513472270.027
nucleoside triphosphate metabolic processGO:00091414220.026
small gtpase mediated signal transductionGO:0007264780.026
negative regulation of cell cycleGO:00457861930.026
cell fate determinationGO:000170930.026
glycosyl compound catabolic processGO:19016584130.026
cellular response to growth factor stimulusGO:00713631970.026
ribonucleoside triphosphate metabolic processGO:00091994120.026
negative regulation of viral genome replicationGO:0045071350.025
guanosine containing compound catabolic processGO:19010692390.025
purine containing compound biosynthetic processGO:0072522880.025
purine ribonucleoside triphosphate catabolic processGO:00092073910.025
cellular lipid metabolic processGO:00442553030.025
mitochondrion organizationGO:00070051560.025
regulation of mononuclear cell proliferationGO:0032944650.025
positive regulation of developmental processGO:00510943140.025
purine ribonucleoside metabolic processGO:00461284370.025
regulation of viral processGO:00507921030.025
cytolysisGO:001983580.025
regulation of mhc class ii biosynthetic processGO:004534640.025
positive regulation of locomotionGO:00400171860.025
regulation of nucleotide metabolic processGO:00061402690.025
regulation of viral genome replicationGO:0045069480.025
single organism cellular localizationGO:19025803320.024
protein catabolic processGO:00301633250.024
female gamete generationGO:000729220.024
protein import into nucleusGO:00066061040.024
regulation of transferase activityGO:00513383550.024
positive regulation of kinase activityGO:00336742040.023
cellular chemical homeostasisGO:00550821800.023
response to tumor necrosis factorGO:0034612760.023
response to nitrogen compoundGO:19016981840.023
regulation of intracellular transportGO:00323861950.023
cell activationGO:00017752130.023
positive regulation of intracellular transportGO:00323881040.023
purine ribonucleoside catabolic processGO:00461303980.023
positive regulation of programmed cell deathGO:00430682490.023
regulation of cell migrationGO:00303342890.022
extrinsic apoptotic signaling pathwayGO:00971911190.022
nucleoside triphosphate catabolic processGO:00091433940.022
nucleotide catabolic processGO:00091664080.022
regulation of cell differentiationGO:00455953930.022
negative regulation of programmed cell deathGO:00430693210.022
positive regulation of cellular catabolic processGO:00313312840.021
hematopoietic or lymphoid organ developmentGO:00485341860.021
syncytium formation by plasma membrane fusionGO:000076820.021
positive regulation of nucleoside metabolic processGO:00459791860.021
protein processingGO:00164852260.021
regulation of proteolysisGO:00301622930.021
compound eye developmentGO:004874910.021
lipoprotein metabolic processGO:0042157420.021
positive regulation of protein phosphorylationGO:00019343130.021
nervous system developmentGO:00073992930.021
regulation of cytoplasmic transportGO:19036491490.021
regulation of cytokine productionGO:00018172320.021
ribonucleotide catabolic processGO:00092614050.020
protein targetingGO:00066051870.020
hemopoiesisGO:00300971800.020
regulation of cellular component biogenesisGO:00440872810.020
purine nucleoside catabolic processGO:00061523980.020
sequestering of metal ionGO:0051238240.020
positive regulation of lymphocyte activationGO:0051251730.020
maintenance of locationGO:00512351120.020
regulation of gtpase activityGO:00430871800.020
cellular protein catabolic processGO:00442572610.020
monosaccharide metabolic processGO:0005996740.020
negative regulation of vasculature developmentGO:1901343430.020
regulation of protein maturationGO:19033171500.020
nucleotide biosynthetic processGO:00091651090.020
amine metabolic processGO:0009308440.020
protein acylationGO:00435431380.020
secretionGO:00469032540.019
mapk cascadeGO:00001652880.019
positive regulation of cell proliferationGO:00082843010.019
membrane organizationGO:00610242920.019
protein secretionGO:0009306980.019
negative regulation of intracellular signal transductionGO:19025321830.019
positive regulation of nucleotide metabolic processGO:00459812300.019
spermatid developmentGO:000728640.019
positive regulation of immune responseGO:00507781590.019
signal transduction by phosphorylationGO:00230142970.019
negative regulation of immune system processGO:00026831360.019
negative regulation of cell deathGO:00605483450.019
positive regulation of apoptotic processGO:00430652460.019
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.019
organic hydroxy compound metabolic processGO:19016151470.019
response to abiotic stimulusGO:00096283360.019
memoryGO:000761330.018
regulation of secretionGO:00510461940.018
response to growth factorGO:00708482050.018
regulation of extrinsic apoptotic signaling pathwayGO:2001236850.018
jnk cascadeGO:0007254800.018
negative regulation of developmental processGO:00510932470.018
cell cycle arrestGO:0007050710.018
mitotic cell cycle processGO:19030472860.018
positive regulation of phosphorylationGO:00423273940.018
negative regulation of multi organism processGO:0043901920.018
divalent inorganic cation homeostasisGO:00725071360.018
anatomical structure formation involved in morphogenesisGO:00486462840.018
metal ion transportGO:00300012720.018
protein localization to organelleGO:00333652800.018
positive regulation of cell differentiationGO:00455972110.018
positive regulation of nucleotide catabolic processGO:00308131850.018
nucleoside phosphate catabolic processGO:19012924120.018
positive regulation of cell deathGO:00109422630.018
single organism membrane organizationGO:00448022680.018
regulation of nuclease activityGO:0032069110.018
negative regulation of cytolysisGO:004591830.018
regulation of interleukin 10 secretionGO:200117940.018
positive regulation of catabolic processGO:00098963100.018
cation transportGO:00068123310.018
cation homeostasisGO:00550801890.017
regulation of peptidase activityGO:00525471800.017
lipoprotein biosynthetic processGO:0042158330.017
regulation of endopeptidase activityGO:00525481700.017
regulation of cell motilityGO:20001452990.017
inorganic anion transportGO:0015698600.017
spermatid differentiationGO:004851540.017
regulation of lymphocyte activationGO:00512491030.017
establishment of protein localization to organelleGO:00725941720.017
regulation of immune effector processGO:0002697910.017
cell cycle phase transitionGO:00447701730.017
double strand break repairGO:00063021010.017
regulation of cell activationGO:00508651250.016
regulation of membrane potentialGO:0042391950.016
rna interferenceGO:001624640.016
mitotic cell cycleGO:00002783260.016
regulation of cysteine type endopeptidase activityGO:20001161270.016
t cell mediated immunityGO:0002456250.016
negative regulation of endopeptidase activityGO:0010951840.016
purine nucleoside triphosphate metabolic processGO:00091444120.016
positive regulation of protein kinase activityGO:00458601900.016
positive regulation of cellular component biogenesisGO:00440891580.016
regulation of nucleoside metabolic processGO:00091182090.016
regulation of cellular response to stressGO:00801352440.016
cellular cation homeostasisGO:00300031630.016
cellular component morphogenesisGO:00329893140.016
ribonucleoside monophosphate metabolic processGO:00091611870.016
cellular macromolecule catabolic processGO:00442653800.016
positive regulation of leukocyte activationGO:0002696800.016
regulation of homeostatic processGO:00328441210.015
regulation of cell cycleGO:00517263930.015
cellular response to dna damage stimulusGO:00069743790.015
toxin transportGO:190199840.015
negative regulation of protein processingGO:00109551420.015
regulation of protein kinase activityGO:00458592890.015
response to oxygen containing compoundGO:19017003690.015
regulation of protein processingGO:00706131500.015
positive regulation of cellular component organizationGO:00511303760.015
divalent metal ion transportGO:00708381520.015
regulation of protein localization to nucleusGO:1900180850.015
positive regulation of organelle organizationGO:00106381950.015
response to woundingGO:00096111680.014
secretion by cellGO:00329402260.014
gtp catabolic processGO:00061842370.014
circadian behaviorGO:004851220.014
positive regulation of cell motilityGO:20001471770.014
myeloid leukocyte differentiationGO:0002573600.014
defense response to bacteriumGO:0042742630.014
negative regulation of protein modification processGO:00314002000.014
neuromuscular junction developmentGO:000752830.014
negative regulation of phosphorus metabolic processGO:00105632670.014
cell developmentGO:00484683280.014
regulation of kinase activityGO:00435493140.014
cellular divalent inorganic cation homeostasisGO:00725031280.014
cellular response to external stimulusGO:00714961110.014
regulation of intracellular protein transportGO:00331571230.014
negative regulation of cellular component organizationGO:00511292350.014
positive regulation of ras gtpase activityGO:00323201170.014
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:00432811160.014
calcium ion homeostasisGO:00550741220.013
regulation of secretion by cellGO:19035301770.013
regulation of myeloid cell differentiationGO:0045637810.013
cell killingGO:0001906340.013
nucleocytoplasmic transportGO:00069131760.013
peripheral nervous system developmentGO:000742220.013
mononuclear cell proliferationGO:0032943710.013
purine nucleoside monophosphate metabolic processGO:00091261860.013
nucleoside monophosphate metabolic processGO:00091231910.013
regulation of protein catabolic processGO:00421761550.013
small molecule catabolic processGO:0044282920.013
chromatin organizationGO:00063253510.013
stress activated mapk cascadeGO:0051403930.013
negative regulation of apoptotic signaling pathwayGO:2001234970.013
locomotory behaviorGO:000762610.013
positive regulation of t cell activationGO:0050870540.013
cellular calcium ion homeostasisGO:00068741170.013
regulation of multi organism processGO:00439001570.013
enzyme linked receptor protein signaling pathwayGO:00071673030.013
immune system developmentGO:00025201950.013
positive regulation of protein transportGO:00512221350.013
extrinsic apoptotic signaling pathway in absence of ligandGO:0097192220.013
cd8 positive alpha beta t cell activationGO:003603730.013
negative regulation of proteolysisGO:00458611320.013
cytokine mediated signaling pathwayGO:00192211090.013
apoptotic mitochondrial changesGO:0008637570.013
regulation of ion homeostasisGO:2000021730.013
sequestering of calcium ionGO:0051208170.013
regulation of purine nucleotide catabolic processGO:00331212050.013
establishment of protein localization to membraneGO:00901501210.013
neurological system processGO:00508771630.013
regulation of erk1 and erk2 cascadeGO:0070372990.013
regulation of cytoskeleton organizationGO:00514931770.013
negative regulation of cell motilityGO:20001461040.012
regulation of ras gtpase activityGO:00323181280.012
regulation of small gtpase mediated signal transductionGO:00510561560.012
positive regulation of secretionGO:00510471160.012
leukocyte mediated immunityGO:0002443590.012
negative regulation of transportGO:00510511760.012
phospholipid metabolic processGO:0006644990.012
regulation of innate immune responseGO:0045088970.012
atp metabolic processGO:00460341760.012
regulation of angiogenesisGO:0045765920.012
regulation of ras protein signal transductionGO:00465781550.012
negative regulation of peptidase activityGO:0010466910.012
ubiquitin dependent protein catabolic processGO:00065112060.012
regulation of mapk cascadeGO:00434082620.012
nitrogen compound transportGO:00717051910.012
cellular response to tumor necrosis factorGO:0071356630.012
protein localization to membraneGO:00726571600.012
positive regulation of endopeptidase activityGO:0010950840.012
positive regulation of erk1 and erk2 cascadeGO:0070374750.012
t cell proliferationGO:0042098450.012
regulation of nucleotide catabolic processGO:00308112050.012
response to auditory stimulusGO:001099640.012
regulation of defense response to virusGO:0050688330.012
cell growthGO:00160491600.012
negative regulation of cell growthGO:0030308830.012
cell morphogenesisGO:00009022960.012
regulation of cyclic nucleotide metabolic processGO:0030799630.012
divalent inorganic cation transportGO:00725111580.012
cardiovascular system developmentGO:00723582620.012
guanosine containing compound metabolic processGO:19010682440.012
regulation of protein targetingGO:1903533910.012
cdc42 protein signal transductionGO:003248840.012
negative regulation of extrinsic apoptotic signaling pathwayGO:2001237520.012
single organismal cell cell adhesionGO:00163371480.012
cellular metal ion homeostasisGO:00068751460.012
regulation of protein serine threonine kinase activityGO:00719001790.012
nuclear importGO:00511701060.012
negative regulation of mhc class ii biosynthetic processGO:004534710.011
lymphocyte activationGO:00466491330.011
positive regulation of purine nucleotide catabolic processGO:00331231850.011
regulation of cell cell adhesionGO:0022407570.011
regulation of myeloid leukocyte differentiationGO:0002761390.011
positive regulation of macrophage chemotaxisGO:001075930.011
positive regulation of mapk cascadeGO:00434101900.011
carbohydrate homeostasisGO:0033500310.011
regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:2001239200.011
negative regulation of cell differentiationGO:00455961710.011
cellular response to oxygen containing compoundGO:19017012760.011
hexose metabolic processGO:0019318550.011
oocyte developmentGO:004859910.011
protein localization to nucleusGO:00345041360.011
sensory perception of painGO:001923340.011
response to radiationGO:00093141510.011
activation of cysteine type endopeptidase activityGO:0097202570.011
response to organic cyclic compoundGO:00140702040.011
regulation of vasculature developmentGO:1901342970.011
negative regulation of cysteine type endopeptidase activityGO:2000117480.011
regulation of synaptic plasticityGO:004816730.011
regulation of syncytium formation by plasma membrane fusionGO:006014220.011
single organism nuclear importGO:19025931040.011
positive regulation of cytosolic calcium ion concentrationGO:0007204820.011
regulation of protein import into nucleusGO:0042306780.011
regulation of nucleocytoplasmic transportGO:0046822980.011
negative regulation of blood vessel morphogenesisGO:2000181410.011
actin filament based processGO:00300292240.011
positive regulation of ion transportGO:0043270870.011
melanin metabolic processGO:000658210.011
protein targeting to nucleusGO:00447441040.011
cell cell signalingGO:00072671550.011
regulation of cell cycle phase transitionGO:19019871260.011
response to lipidGO:00339932060.011
angiogenesisGO:00015251470.011
regulation of metal ion transportGO:00109591200.011
regenerationGO:003109940.011
negative regulation of mitotic cell cycleGO:00459301020.011
regulation of mitotic cell cycleGO:00073461890.011
dna repairGO:00062811980.011
response to hormoneGO:00097251750.011
regulation of transmembrane transportGO:00347621390.011
regulation of circadian sleep wake cycleGO:004274920.011
cellular response to lipidGO:00713961270.011
gtp metabolic processGO:00460392390.011
positive regulation of cellular component movementGO:00512721810.011
negative regulation of synaptic transmissionGO:005080520.011
metal ion homeostasisGO:00550651690.010
regulation of growthGO:00400081650.010
circulatory system developmentGO:00723592620.010
cellular response to interferon gammaGO:0071346240.010
positive regulation of protein serine threonine kinase activityGO:00719021190.010
positive regulation of cell migrationGO:00303351720.010
positive regulation of peptidase activityGO:0010952880.010
cell cycle checkpointGO:00000751170.010
negative regulation of cellular amino acid metabolic processGO:004576320.010
leukocyte migrationGO:00509001070.010
blood vessel morphogenesisGO:00485141620.010
reactive oxygen species metabolic processGO:0072593750.010
positive regulation of proteolysisGO:00458621420.010
positive regulation of lymphocyte migrationGO:2000403160.010
mitotic cell cycle phase transitionGO:00447721620.010
regulation of locomotionGO:00400123290.010

APOL1 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of cellular proliferationDOID:145661740.022
disease of metabolismDOID:00146672950.021
cancerDOID:1621670.018
organ system cancerDOID:00506861640.018
musculoskeletal system diseaseDOID:172230.017
nervous system diseaseDOID:8634310.014
sensory system diseaseDOID:00501552030.014
immune system diseaseDOID:29141550.011
cardiovascular system diseaseDOID:12871060.010
eye and adnexa diseaseDOID:14921500.010
urinary system diseaseDOID:18400.002
kidney diseaseDOID:557360.002
nephritisDOID:1095260.001
glomerulonephritisDOID:292160.001
focal segmental glomerulosclerosisDOID:131260.001
glomerulosclerosisDOID:005085160.001