| positive regulation of i kappab kinase nf kappab signaling | GO:0043123 | 132 | 1.000 | Human |
| peptidyl serine autophosphorylation | GO:0036289 | 2 | 1.000 | |
| regulation of i kappab kinase nf kappab signaling | GO:0043122 | 162 | 1.000 | Human |
| cellular response to muramyl dipeptide | GO:0071225 | 3 | 1.000 | |
| i kappab kinase nf kappab signaling | GO:0007249 | 166 | 1.000 | Human |
| activation of innate immune response | GO:0002218 | 55 | 1.000 | |
| programmed necrotic cell death | GO:0097300 | 18 | 1.000 | |
| response to muramyl dipeptide | GO:0032495 | 4 | 1.000 | |
| positive regulation of tumor necrosis factor superfamily cytokine production | GO:1903557 | 22 | 1.000 | |
| toll like receptor 2 signaling pathway | GO:0034134 | 4 | 1.000 | |
| positive regulation of interleukin 8 production | GO:0032757 | 36 | 1.000 | |
| positive regulation of defense response | GO:0031349 | 87 | 1.000 | |
| immune response activating signal transduction | GO:0002757 | 90 | 1.000 | |
| positive regulation of sequence specific dna binding transcription factor activity | GO:0051091 | 131 | 1.000 | |
| regulation of extrinsic apoptotic signaling pathway | GO:2001236 | 85 | 1.000 | |
| tumor necrosis factor production | GO:0032640 | 43 | 1.000 | |
| positive regulation of cytokine production | GO:0001819 | 167 | 1.000 | |
| positive regulation of phosphorylation | GO:0042327 | 394 | 1.000 | |
| regulation of tumor necrosis factor production | GO:0032680 | 43 | 0.999 | |
| positive regulation of immune response | GO:0050778 | 159 | 0.999 | |
| negative regulation of extrinsic apoptotic signaling pathway | GO:2001237 | 52 | 0.999 | |
| pattern recognition receptor signaling pathway | GO:0002221 | 48 | 0.999 | |
| positive regulation of extrinsic apoptotic signaling pathway | GO:2001238 | 26 | 0.999 | |
| activation of immune response | GO:0002253 | 114 | 0.999 | |
| positive regulation of apoptotic signaling pathway | GO:2001235 | 70 | 0.998 | |
| positive regulation of stress activated mapk cascade | GO:0032874 | 60 | 0.998 | |
| regulation of cytokine production | GO:0001817 | 232 | 0.998 | |
| apoptotic signaling pathway | GO:0097190 | 268 | 0.998 | |
| protein modification by small protein conjugation | GO:0032446 | 342 | 0.998 | |
| necroptotic process | GO:0070266 | 16 | 0.998 | |
| extrinsic apoptotic signaling pathway | GO:0097191 | 119 | 0.998 | |
| positive regulation of myeloid leukocyte differentiation | GO:0002763 | 24 | 0.998 | |
| negative regulation of apoptotic signaling pathway | GO:2001234 | 97 | 0.998 | |
| positive regulation of nf kappab transcription factor activity | GO:0051092 | 81 | 0.998 | |
| adaptive immune response | GO:0002250 | 49 | 0.998 | |
| positive regulation of immune system process | GO:0002684 | 283 | 0.997 | |
| regulation of cellular response to stress | GO:0080135 | 244 | 0.997 | |
| regulation of anion transport | GO:0044070 | 25 | 0.997 | |
| positive regulation of myeloid cell differentiation | GO:0045639 | 39 | 0.997 | |
| interleukin 2 production | GO:0032623 | 20 | 0.997 | |
| positive regulation of stress activated protein kinase signaling cascade | GO:0070304 | 61 | 0.997 | |
| regulation of reactive oxygen species metabolic process | GO:2000377 | 41 | 0.997 | Mouse |
| cytokine production | GO:0001816 | 247 | 0.996 | |
| regulation of apoptotic signaling pathway | GO:2001233 | 175 | 0.996 | |
| protein ubiquitination | GO:0016567 | 314 | 0.995 | |
| response to tumor necrosis factor | GO:0034612 | 76 | 0.995 | |
| innate immune response activating signal transduction | GO:0002758 | 48 | 0.995 | |
| regulation of transferase activity | GO:0051338 | 355 | 0.993 | |
| positive regulation of jnk cascade | GO:0046330 | 52 | 0.993 | |
| immune system development | GO:0002520 | 195 | 0.993 | |
| positive regulation of programmed cell death | GO:0043068 | 249 | 0.992 | |
| toll like receptor signaling pathway | GO:0002224 | 25 | 0.992 | |
| cellular response to biotic stimulus | GO:0071216 | 71 | 0.991 | |
| carbohydrate derivative transport | GO:1901264 | 20 | 0.991 | |
| positive regulation of interleukin 2 production | GO:0032743 | 11 | 0.990 | |
| regulation of macrophage differentiation | GO:0045649 | 9 | 0.990 | |
| regulation of ion transmembrane transport | GO:0034765 | 132 | 0.989 | |
| regulation of leukocyte differentiation | GO:1902105 | 61 | 0.988 | |
| response to oxygen containing compound | GO:1901700 | 369 | 0.988 | |
| cellular response to cytokine stimulus | GO:0071345 | 181 | 0.988 | |
| regulation of nucleoside transport | GO:0032242 | 1 | 0.987 | |
| positive regulation of cellular amino acid metabolic process | GO:0045764 | 3 | 0.987 | |
| positive regulation of production of molecular mediator of immune response | GO:0002702 | 11 | 0.987 | |
| protein polyubiquitination | GO:0000209 | 110 | 0.986 | Human |
| ripoptosome assembly | GO:0097343 | 1 | 0.986 | |
| cell type specific apoptotic process | GO:0097285 | 125 | 0.984 | Human |
| response to cytokine | GO:0034097 | 232 | 0.983 | |
| regulation of t cell proliferation | GO:0042129 | 42 | 0.982 | |
| response to molecule of bacterial origin | GO:0002237 | 82 | 0.981 | |
| hemopoiesis | GO:0030097 | 180 | 0.981 | |
| regulation of necroptotic process | GO:0060544 | 7 | 0.979 | |
| cytoplasmic pattern recognition receptor signaling pathway | GO:0002753 | 12 | 0.977 | |
| positive regulation of innate immune response | GO:0045089 | 79 | 0.976 | |
| cytokine mediated signaling pathway | GO:0019221 | 109 | 0.975 | |
| regulation of leukocyte proliferation | GO:0070663 | 67 | 0.973 | |
| anion transport | GO:0006820 | 161 | 0.973 | |
| positive regulation of apoptotic process | GO:0043065 | 246 | 0.971 | |
| cellular amino acid metabolic process | GO:0006520 | 116 | 0.971 | |
| immune response | GO:0006955 | 307 | 0.970 | |
| regulation of protein modification by small protein conjugation or removal | GO:1903320 | 107 | 0.970 | |
| regulation of cellular amine metabolic process | GO:0033238 | 11 | 0.970 | |
| response to nitrogen compound | GO:1901698 | 184 | 0.969 | |
| regulation of sequence specific dna binding transcription factor activity | GO:0051090 | 211 | 0.967 | |
| mononuclear cell proliferation | GO:0032943 | 71 | 0.966 | |
| defense response | GO:0006952 | 315 | 0.965 | |
| innate immune response | GO:0045087 | 178 | 0.965 | |
| response to biotic stimulus | GO:0009607 | 276 | 0.964 | |
| regulation of transmembrane transporter activity | GO:0022898 | 74 | 0.964 | |
| regulation of cytokine production involved in immune response | GO:0002718 | 22 | 0.963 | |
| cellular response to molecule of bacterial origin | GO:0071219 | 62 | 0.961 | |
| positive regulation of protein modification by small protein conjugation or removal | GO:1903322 | 61 | 0.956 | |
| regulation of innate immune response | GO:0045088 | 97 | 0.955 | |
| stress activated mapk cascade | GO:0051403 | 93 | 0.954 | |
| leukocyte differentiation | GO:0002521 | 98 | 0.953 | |
| positive regulation of mapk cascade | GO:0043410 | 190 | 0.950 | |
| interleukin 8 production | GO:0032637 | 51 | 0.950 | |
| nucleoside transport | GO:0015858 | 8 | 0.950 | |
| cellular macromolecule catabolic process | GO:0044265 | 380 | 0.950 | Human |
| peptidyl serine phosphorylation | GO:0018105 | 101 | 0.949 | |
| regulation of protein ubiquitination | GO:0031396 | 95 | 0.949 | |
| regulation of adaptive immune response | GO:0002819 | 33 | 0.947 | |
| positive regulation of tumor necrosis factor production | GO:0032760 | 21 | 0.946 | |
| regulation of jnk cascade | GO:0046328 | 73 | 0.945 | |
| regulation of leukocyte activation | GO:0002694 | 115 | 0.943 | |
| cellular ketone metabolic process | GO:0042180 | 80 | 0.942 | |
| protein k63 linked ubiquitination | GO:0070534 | 31 | 0.941 | Human |
| mapk cascade | GO:0000165 | 288 | 0.939 | |
| regulation of tumor necrosis factor superfamily cytokine production | GO:1903555 | 44 | 0.938 | |
| immune response regulating signaling pathway | GO:0002764 | 97 | 0.938 | |
| cellular amine metabolic process | GO:0044106 | 41 | 0.937 | |
| negative regulation of cell death | GO:0060548 | 345 | 0.937 | Human Mouse |
| positive regulation of cell death | GO:0010942 | 263 | 0.937 | |
| regulation of immune response | GO:0050776 | 201 | 0.935 | |
| regulation of mononuclear cell proliferation | GO:0032944 | 65 | 0.934 | |
| regulation of lymphocyte apoptotic process | GO:0070228 | 15 | 0.933 | Human |
| protein homooligomerization | GO:0051260 | 100 | 0.932 | |
| positive regulation of necroptotic process | GO:0060545 | 2 | 0.930 | |
| cellular response to tumor necrosis factor | GO:0071356 | 63 | 0.930 | |
| positive regulation of macrophage differentiation | GO:0045651 | 7 | 0.928 | |
| nucleotide binding domain leucine rich repeat containing receptor signaling pathway | GO:0035872 | 5 | 0.924 | |
| positive regulation of leukocyte differentiation | GO:1902107 | 37 | 0.920 | |
| response to peptidoglycan | GO:0032494 | 3 | 0.920 | |
| leukocyte apoptotic process | GO:0071887 | 31 | 0.919 | Human |
| stress activated protein kinase signaling cascade | GO:0031098 | 94 | 0.914 | |
| regulation of ion transmembrane transporter activity | GO:0032412 | 72 | 0.913 | |
| regulation of necrotic cell death | GO:0010939 | 9 | 0.912 | |
| regulation of myeloid cell differentiation | GO:0045637 | 81 | 0.908 | |
| lipopolysaccharide mediated signaling pathway | GO:0031663 | 26 | 0.904 | |
| regulation of lymphocyte activation | GO:0051249 | 103 | 0.903 | |
| negative regulation of apoptotic process | GO:0043066 | 316 | 0.903 | Human |
| positive regulation of necrotic cell death | GO:0010940 | 4 | 0.902 | |
| cellular response to oxygen containing compound | GO:1901701 | 276 | 0.902 | |
| regulation of myeloid leukocyte differentiation | GO:0002761 | 39 | 0.894 | |
| ion transmembrane transport | GO:0034220 | 338 | 0.888 | |
| t cell proliferation | GO:0042098 | 45 | 0.882 | |
| response to interleukin 1 | GO:0070555 | 47 | 0.880 | |
| positive regulation of kinase activity | GO:0033674 | 204 | 0.875 | |
| regulation of cell differentiation | GO:0045595 | 393 | 0.872 | |
| negative regulation of extrinsic apoptotic signaling pathway in absence of ligand | GO:2001240 | 16 | 0.872 | |
| cytokine biosynthetic process | GO:0042089 | 37 | 0.868 | |
| regulation of cd8 positive alpha beta t cell proliferation | GO:2000564 | 1 | 0.868 | |
| regulation of mapk cascade | GO:0043408 | 262 | 0.860 | |
| positive regulation of protein phosphorylation | GO:0001934 | 313 | 0.858 | |
| lymphocyte apoptotic process | GO:0070227 | 20 | 0.854 | Human |
| detection of muramyl dipeptide | GO:0032498 | 1 | 0.851 | |
| nucleotide binding oligomerization domain containing 2 signaling pathway | GO:0070431 | 4 | 0.848 | |
| protein oligomerization | GO:0051259 | 173 | 0.847 | Rat |
| regulation of leukocyte apoptotic process | GO:2000106 | 25 | 0.846 | Human |
| leukocyte mediated immunity | GO:0002443 | 59 | 0.844 | |
| cellular response to lipopolysaccharide | GO:0071222 | 57 | 0.844 | |
| cell activation | GO:0001775 | 213 | 0.840 | |
| positive regulation of cell activation | GO:0050867 | 81 | 0.838 | |
| macrophage differentiation | GO:0030225 | 11 | 0.835 | |
| regulation of defense response | GO:0031347 | 154 | 0.833 | |
| positive regulation of jun kinase activity | GO:0043507 | 23 | 0.830 | |
| regulation of t helper cell differentiation | GO:0045622 | 3 | 0.828 | |
| positive regulation of cell differentiation | GO:0045597 | 211 | 0.828 | |
| erk1 and erk2 cascade | GO:0070371 | 104 | 0.828 | |
| negative regulation of programmed cell death | GO:0043069 | 321 | 0.825 | Human Mouse |
| signal transduction by phosphorylation | GO:0023014 | 297 | 0.823 | |
| tumor necrosis factor superfamily cytokine production | GO:0071706 | 45 | 0.822 | |
| regulation of lymphocyte proliferation | GO:0050670 | 64 | 0.821 | |
| positive regulation of peptidyl serine phosphorylation | GO:0033138 | 42 | 0.820 | |
| positive regulation of developmental process | GO:0051094 | 314 | 0.816 | |
| immune response activating cell surface receptor signaling pathway | GO:0002429 | 45 | 0.815 | |
| myeloid leukocyte differentiation | GO:0002573 | 60 | 0.813 | |
| regulation of peptidyl tyrosine phosphorylation | GO:0050730 | 108 | 0.812 | |
| jnk cascade | GO:0007254 | 80 | 0.799 | |
| amyloid fibril formation | GO:1990000 | 3 | 0.799 | |
| positive regulation of t cell cytokine production | GO:0002726 | 4 | 0.796 | |
| amine metabolic process | GO:0009308 | 44 | 0.796 | |
| hematopoietic or lymphoid organ development | GO:0048534 | 186 | 0.790 | |
| lymphocyte activation | GO:0046649 | 133 | 0.789 | |
| cellular response to lipid | GO:0071396 | 127 | 0.789 | |
| activation of protein kinase activity | GO:0032147 | 90 | 0.786 | |
| alpha beta t cell proliferation | GO:0046633 | 5 | 0.783 | |
| regulation of transporter activity | GO:0032409 | 82 | 0.782 | |
| fibril organization | GO:0097435 | 10 | 0.778 | |
| cd4 positive alpha beta t cell differentiation | GO:0043367 | 4 | 0.774 | |
| positive regulation of cysteine type endopeptidase activity involved in apoptotic process | GO:0043280 | 69 | 0.770 | |
| regulation of immune effector process | GO:0002697 | 91 | 0.768 | |
| response to bacterium | GO:0009617 | 144 | 0.765 | |
| leukocyte proliferation | GO:0070661 | 74 | 0.758 | |
| immune effector process | GO:0002252 | 159 | 0.757 | |
| protein trimerization | GO:0070206 | 20 | 0.742 | |
| regulation of cysteine type endopeptidase activity involved in apoptotic process | GO:0043281 | 116 | 0.740 | Human |
| regulation of stress activated mapk cascade | GO:0032872 | 84 | 0.736 | |
| defense response to other organism | GO:0098542 | 129 | 0.728 | |
| interleukin 6 production | GO:0032635 | 37 | 0.728 | |
| negative regulation of i kappab kinase nf kappab signaling | GO:0043124 | 32 | 0.722 | |
| cd4 positive alpha beta t cell differentiation involved in immune response | GO:0002294 | 4 | 0.719 | |
| reactive oxygen species metabolic process | GO:0072593 | 75 | 0.700 | Mouse |
| positive regulation of peptidyl tyrosine phosphorylation | GO:0050731 | 85 | 0.698 | |
| positive regulation of t helper cell differentiation | GO:0045624 | 2 | 0.691 | |
| myeloid cell differentiation | GO:0030099 | 117 | 0.690 | |
| regulation of cell activation | GO:0050865 | 125 | 0.690 | |
| alpha beta t cell differentiation | GO:0046632 | 7 | 0.689 | |
| osteoclast differentiation | GO:0030316 | 21 | 0.676 | |
| regulation of interleukin 8 production | GO:0032677 | 49 | 0.671 | |
| t helper 1 cell differentiation | GO:0045063 | 1 | 0.663 | |
| positive regulation of adaptive immune response | GO:0002821 | 21 | 0.663 | |
| positive regulation of protein linear polyubiquitination | GO:1902530 | 2 | 0.663 | Human |
| response to lipoteichoic acid | GO:0070391 | 3 | 0.662 | |
| positive regulation of canonical wnt signaling pathway | GO:0090263 | 33 | 0.660 | Human |
| positive regulation of cytokine biosynthetic process | GO:0042108 | 25 | 0.659 | |
| cytokine metabolic process | GO:0042107 | 38 | 0.656 | |
| intrinsic apoptotic signaling pathway in response to dna damage | GO:0008630 | 50 | 0.655 | |
| nucleotide binding oligomerization domain containing signaling pathway | GO:0070423 | 4 | 0.650 | |
| regulation of ion transport | GO:0043269 | 189 | 0.647 | |
| positive regulation of protein ubiquitination | GO:0031398 | 53 | 0.641 | |
| regulation of peptidase activity | GO:0052547 | 180 | 0.638 | Human |
| extrinsic apoptotic signaling pathway via death domain receptors | GO:0008625 | 42 | 0.637 | |
| response to lipid | GO:0033993 | 206 | 0.637 | |
| positive regulation of protein kinase activity | GO:0045860 | 190 | 0.637 | |
| positive regulation of osteoclast differentiation | GO:0045672 | 9 | 0.633 | |
| nucleobase containing compound transport | GO:0015931 | 51 | 0.622 | |
| response to dsrna | GO:0043331 | 25 | 0.621 | |
| regulation of erk1 and erk2 cascade | GO:0070372 | 99 | 0.611 | |
| trail activated apoptotic signaling pathway | GO:0036462 | 4 | 0.608 | |
| antigen receptor mediated signaling pathway | GO:0050851 | 38 | 0.608 | |
| positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | GO:0002824 | 19 | 0.607 | |
| cellular response to external stimulus | GO:0071496 | 111 | 0.607 | |
| regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | GO:0002822 | 29 | 0.602 | |
| nitrogen compound transport | GO:0071705 | 191 | 0.600 | |
| regulation of interleukin 2 production | GO:0032663 | 19 | 0.598 | |
| positive regulation of cellular amine metabolic process | GO:0033240 | 7 | 0.593 | |
| activation of nf kappab inducing kinase activity | GO:0007250 | 9 | 0.585 | |
| necrotic cell death | GO:0070265 | 21 | 0.585 | |
| intrinsic apoptotic signaling pathway | GO:0097193 | 127 | 0.581 | |
| cellular response to nitrogen compound | GO:1901699 | 144 | 0.580 | |
| protein catabolic process | GO:0030163 | 325 | 0.576 | Human |
| protein k48 linked ubiquitination | GO:0070936 | 38 | 0.567 | Human |
| regulation of cellular amino acid metabolic process | GO:0006521 | 6 | 0.560 | |
| natural killer cell apoptotic process | GO:0070246 | 1 | 0.559 | Human |
| cellular response to organonitrogen compound | GO:0071417 | 124 | 0.548 | |
| t cell activation | GO:0042110 | 99 | 0.547 | |
| positive regulation of protein polyubiquitination | GO:1902916 | 3 | 0.546 | Human |
| regulation of kinase activity | GO:0043549 | 314 | 0.545 | |
| regulation of interleukin 1 production | GO:0032652 | 21 | 0.543 | |
| response to lipopolysaccharide | GO:0032496 | 70 | 0.542 | |
| cellular response to endogenous stimulus | GO:0071495 | 336 | 0.538 | |
| nik nf kappab signaling | GO:0038061 | 12 | 0.532 | |
| cellular protein catabolic process | GO:0044257 | 261 | 0.526 | Human |
| protein autoubiquitination | GO:0051865 | 37 | 0.526 | |
| negative regulation of multicellular organismal process | GO:0051241 | 317 | 0.523 | |
| positive regulation of mhc class i biosynthetic process | GO:0045345 | 4 | 0.516 | |
| positive regulation of endopeptidase activity | GO:0010950 | 84 | 0.515 | |
| response to virus | GO:0009615 | 126 | 0.510 | |
| canonical wnt signaling pathway | GO:0060070 | 116 | 0.509 | Human |
| lymphocyte proliferation | GO:0046651 | 70 | 0.496 | |
| regulation of atp adp antiporter activity | GO:0070926 | 1 | 0.487 | |
| regulation of protein kinase activity | GO:0045859 | 289 | 0.477 | |
| intracellular receptor signaling pathway | GO:0030522 | 104 | 0.473 | |
| positive regulation of cd4 positive alpha beta t cell differentiation | GO:0043372 | 2 | 0.472 | |
| t cell differentiation | GO:0030217 | 29 | 0.472 | |
| regulation of cytokine biosynthetic process | GO:0042035 | 35 | 0.471 | |
| response to external biotic stimulus | GO:0043207 | 261 | 0.470 | |
| cd8 positive alpha beta t cell proliferation | GO:0035740 | 1 | 0.468 | |
| cellular extravasation | GO:0045123 | 21 | 0.468 | |
| positive regulation of protein k48 linked ubiquitination | GO:1902524 | 1 | 0.466 | Human |
| regulation of protein monoubiquitination | GO:1902525 | 1 | 0.449 | Human |
| positive regulation of protein homodimerization activity | GO:0090073 | 5 | 0.447 | |
| regulation of protein localization | GO:0032880 | 296 | 0.446 | |
| positive regulation of cell proliferation | GO:0008284 | 301 | 0.442 | |
| regulation of protein linear polyubiquitination | GO:1902528 | 2 | 0.439 | Human |
| cytokine production involved in immune response | GO:0002367 | 27 | 0.438 | |
| immature t cell proliferation | GO:0033079 | 1 | 0.434 | |
| regulation of leukocyte migration | GO:0002685 | 63 | 0.429 | |
| peptidyl serine modification | GO:0018209 | 106 | 0.427 | |
| peptidyl threonine phosphorylation | GO:0018107 | 41 | 0.424 | |
| peptidyl tyrosine phosphorylation | GO:0018108 | 170 | 0.423 | |
| regulation of interferon gamma production | GO:0032649 | 36 | 0.418 | |
| regulation of peptidyl serine phosphorylation | GO:0033135 | 50 | 0.418 | |
| leukocyte activation | GO:0045321 | 164 | 0.416 | |
| regulation of intrinsic apoptotic signaling pathway | GO:2001242 | 72 | 0.414 | |
| protein secretion | GO:0009306 | 98 | 0.414 | |
| lymphocyte migration | GO:0072676 | 28 | 0.413 | |
| regulation of stress activated protein kinase signaling cascade | GO:0070302 | 85 | 0.408 | |
| regulation of t cell mediated immunity | GO:0002709 | 18 | 0.406 | |
| t cell cytokine production | GO:0002369 | 12 | 0.405 | |
| protein heterooligomerization | GO:0051291 | 16 | 0.403 | Rat |
| positive regulation of transferase activity | GO:0051347 | 227 | 0.400 | |
| positive regulation of jak stat cascade | GO:0046427 | 35 | 0.393 | |
| peptidyl tyrosine modification | GO:0018212 | 170 | 0.388 | |
| interferon gamma production | GO:0032609 | 39 | 0.383 | |
| transmission of nerve impulse | GO:0019226 | 11 | 0.381 | |
| t cell receptor signaling pathway | GO:0050852 | 21 | 0.378 | |
| positive regulation of transcription regulatory region dna binding | GO:2000679 | 8 | 0.377 | |
| regulation of proteolysis | GO:0030162 | 293 | 0.376 | Human |
| lymphocyte mediated immunity | GO:0002449 | 48 | 0.372 | |
| regulation of extrinsic apoptotic signaling pathway in absence of ligand | GO:2001239 | 20 | 0.370 | |
| negative regulation of cell proliferation | GO:0008285 | 228 | 0.362 | |
| necroptotic signaling pathway | GO:0097527 | 6 | 0.359 | |
| response to other organism | GO:0051707 | 261 | 0.358 | |
| positive regulation of protein k63 linked ubiquitination | GO:1902523 | 1 | 0.354 | Human |
| cellular response to lipoteichoic acid | GO:0071223 | 3 | 0.351 | |
| t cell mediated immunity | GO:0002456 | 25 | 0.341 | |
| regulation of cellular ketone metabolic process | GO:0010565 | 50 | 0.340 | |
| regulation of interleukin 6 production | GO:0032675 | 37 | 0.339 | |
| positive regulation of interleukin 6 production | GO:0032755 | 21 | 0.339 | |
| mature natural killer cell chemotaxis | GO:0035782 | 1 | 0.334 | |
| regulation of lymphocyte differentiation | GO:0045619 | 22 | 0.331 | |
| positive regulation of t cell proliferation | GO:0042102 | 33 | 0.327 | |
| negative regulation of sequence specific dna binding transcription factor activity | GO:0043433 | 89 | 0.323 | |
| negative regulation of t cell cytokine production | GO:0002725 | 4 | 0.322 | |
| regulation of natural killer cell apoptotic process | GO:0070247 | 1 | 0.321 | Human |
| transmembrane transport | GO:0055085 | 399 | 0.319 | |
| modification dependent macromolecule catabolic process | GO:0043632 | 212 | 0.319 | Human |
| positive regulation of wnt signaling pathway | GO:0030177 | 54 | 0.315 | Human |
| regulation of intracellular protein transport | GO:0033157 | 123 | 0.314 | |
| defense response to gram positive bacterium | GO:0050830 | 29 | 0.308 | |
| positive regulation of t helper 1 type immune response | GO:0002827 | 4 | 0.307 | |
| positive regulation of erk1 and erk2 cascade | GO:0070374 | 75 | 0.306 | |
| regulation of peptidyl threonine phosphorylation | GO:0010799 | 15 | 0.303 | |
| neurological system process | GO:0050877 | 163 | 0.303 | |
| positive regulation of intracellular protein transport | GO:0090316 | 76 | 0.303 | |
| proteolysis involved in cellular protein catabolic process | GO:0051603 | 244 | 0.299 | Human |
| response to organonitrogen compound | GO:0010243 | 156 | 0.297 | |
| regulation of t cell activation | GO:0050863 | 77 | 0.293 | |
| regulation of transcription factor import into nucleus | GO:0042990 | 39 | 0.290 | |
| adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | GO:0002460 | 40 | 0.290 | |
| positive regulation of interleukin 1 beta secretion | GO:0050718 | 11 | 0.288 | |
| positive regulation of protein binding | GO:0032092 | 24 | 0.283 | |
| peptidyl threonine modification | GO:0018210 | 45 | 0.283 | |
| modification dependent protein catabolic process | GO:0019941 | 209 | 0.279 | Human |
| positive regulation of map kinase activity | GO:0043406 | 80 | 0.278 | |
| positive regulation of cd8 positive alpha beta t cell proliferation | GO:2000566 | 1 | 0.275 | |
| establishment of protein localization to organelle | GO:0072594 | 172 | 0.273 | |
| purine ribonucleoside triphosphate metabolic process | GO:0009205 | 411 | 0.272 | |
| cellular response to dna damage stimulus | GO:0006974 | 379 | 0.271 | Human |
| immune response regulating cell surface receptor signaling pathway | GO:0002768 | 51 | 0.266 | |
| regulation of immunoglobulin production | GO:0002637 | 4 | 0.265 | |
| positive regulation of nik nf kappab signaling | GO:1901224 | 10 | 0.261 | |
| regulation of leukocyte mediated immunity | GO:0002703 | 38 | 0.261 | |
| response to peptide | GO:1901652 | 65 | 0.258 | |
| response to mechanical stimulus | GO:0009612 | 51 | 0.258 | |
| regulation of t cell cytokine production | GO:0002724 | 10 | 0.257 | |
| regulation of lymphocyte mediated immunity | GO:0002706 | 33 | 0.250 | |
| cellular response to interferon gamma | GO:0071346 | 24 | 0.247 | |
| tnfsf11 mediated signaling pathway | GO:0071847 | 2 | 0.246 | |
| interleukin 12 production | GO:0032615 | 15 | 0.244 | |
| alpha beta t cell activation | GO:0046631 | 15 | 0.238 | |
| regulation of cysteine type endopeptidase activity | GO:2000116 | 127 | 0.236 | Human |
| protein linear polyubiquitination | GO:0097039 | 5 | 0.234 | Human |
| regulation of interferon beta production | GO:0032648 | 22 | 0.233 | |
| regulation of phosphatase activity | GO:0010921 | 81 | 0.228 | |
| regulation of circadian sleep wake cycle | GO:0042749 | 2 | 0.221 | |
| regulation of transmembrane transport | GO:0034762 | 139 | 0.218 | |
| leukocyte activation involved in immune response | GO:0002366 | 30 | 0.217 | |
| negative regulation of lymphocyte activation | GO:0051250 | 24 | 0.216 | |
| response to interferon gamma | GO:0034341 | 39 | 0.216 | |
| regulation of canonical wnt signaling pathway | GO:0060828 | 88 | 0.214 | Human |
| regulation of chemokine production | GO:0032642 | 31 | 0.212 | |
| regulation of response to external stimulus | GO:0032101 | 222 | 0.211 | |
| negative regulation of intracellular signal transduction | GO:1902532 | 183 | 0.211 | |
| regulation of t helper 1 type immune response | GO:0002825 | 5 | 0.209 | |
| purine ribonucleoside metabolic process | GO:0046128 | 437 | 0.207 | |
| regulation of map kinase activity | GO:0043405 | 108 | 0.206 | |
| regulation of oxidoreductase activity | GO:0051341 | 43 | 0.202 | |
| lymphocyte differentiation | GO:0030098 | 35 | 0.201 | |
| negative regulation of secretion by cell | GO:1903531 | 52 | 0.200 | |
| defense response to bacterium | GO:0042742 | 63 | 0.198 | |
| regulation of mitotic cell cycle | GO:0007346 | 189 | 0.196 | |
| regulation of cytokine mediated signaling pathway | GO:0001959 | 41 | 0.192 | |
| positive regulation of cdc42 gtpase activity | GO:0043089 | 6 | 0.192 | |
| positive regulation of t cell activation | GO:0050870 | 54 | 0.192 | |
| positive regulation of proteolysis | GO:0045862 | 142 | 0.191 | |
| negative regulation of cysteine type endopeptidase activity involved in apoptotic process | GO:0043154 | 46 | 0.189 | Human |
| positive regulation of lymphocyte activation | GO:0051251 | 73 | 0.187 | |
| positive regulation of hydrolase activity | GO:0051345 | 331 | 0.183 | |
| positive regulation of protein monoubiquitination | GO:1902527 | 1 | 0.182 | Human |
| positive regulation of lymphocyte mediated immunity | GO:0002708 | 23 | 0.181 | |
| defense response to virus | GO:0051607 | 71 | 0.180 | |
| dephosphorylation | GO:0016311 | 209 | 0.177 | |
| detection of stimulus | GO:0051606 | 85 | 0.177 | |
| positive regulation of phosphatase activity | GO:0010922 | 14 | 0.176 | |
| negative regulation of catalytic activity | GO:0043086 | 335 | 0.176 | Human |
| positive regulation of nf kappab import into nucleus | GO:0042346 | 13 | 0.175 | |
| secretion | GO:0046903 | 254 | 0.171 | |
| negative regulation of cell cycle | GO:0045786 | 193 | 0.170 | |
| positive regulation of gtp catabolic process | GO:0033126 | 166 | 0.165 | |
| activation of cysteine type endopeptidase activity involved in apoptotic process | GO:0006919 | 49 | 0.164 | |
| regulation of interleukin 13 biosynthetic process | GO:0045366 | 1 | 0.163 | |
| cell activation involved in immune response | GO:0002263 | 30 | 0.162 | |
| negative regulation of protein processing | GO:0010955 | 142 | 0.156 | Human |
| response to exogenous dsrna | GO:0043330 | 10 | 0.156 | |
| negative regulation of phosphorus metabolic process | GO:0010563 | 267 | 0.154 | Mouse |
| negative regulation of toll like receptor 3 signaling pathway | GO:0034140 | 2 | 0.150 | |
| protein processing | GO:0016485 | 226 | 0.150 | Human |
| positive regulation of leukocyte activation | GO:0002696 | 80 | 0.149 | |
| response to organic cyclic compound | GO:0014070 | 204 | 0.149 | |
| negative regulation of systemic arterial blood pressure | GO:0003085 | 1 | 0.149 | |
| regulation of multi organism process | GO:0043900 | 157 | 0.148 | |
| negative regulation of nf kappab transcription factor activity | GO:0032088 | 51 | 0.147 | |
| regulation of cd4 positive alpha beta t cell differentiation | GO:0043370 | 3 | 0.147 | |
| regulation of protein secretion | GO:0050708 | 86 | 0.146 | |
| negative regulation of cd4 positive alpha beta t cell proliferation | GO:2000562 | 1 | 0.146 | |
| regulation of nik nf kappab signaling | GO:1901222 | 11 | 0.145 | |
| reactive nitrogen species metabolic process | GO:2001057 | 3 | 0.144 | |
| t cell differentiation in thymus | GO:0033077 | 4 | 0.144 | |
| wnt signaling pathway | GO:0016055 | 156 | 0.144 | Human |
| negative regulation of mitotic cell cycle | GO:0045930 | 102 | 0.141 | |
| positive regulation of lymphocyte proliferation | GO:0050671 | 46 | 0.140 | |
| regulation of protein serine threonine kinase activity | GO:0071900 | 179 | 0.139 | |
| ribonucleoside triphosphate metabolic process | GO:0009199 | 412 | 0.137 | |
| negative regulation of transcription from rna polymerase ii promoter | GO:0000122 | 281 | 0.137 | |
| negative regulation of immune system process | GO:0002683 | 136 | 0.137 | |
| positive regulation of alpha beta t cell proliferation | GO:0046641 | 5 | 0.135 | |
| tissue morphogenesis | GO:0048729 | 96 | 0.130 | |
| t helper 1 type immune response | GO:0042088 | 8 | 0.129 | |
| neuronal action potential | GO:0019228 | 9 | 0.129 | |
| regulation of reactive oxygen species biosynthetic process | GO:1903426 | 3 | 0.127 | |
| release of cytoplasmic sequestered nf kappab | GO:0008588 | 4 | 0.127 | |
| regulation of binding | GO:0051098 | 111 | 0.126 | |
| regulation of cell migration | GO:0030334 | 289 | 0.126 | |
| purine ribonucleoside triphosphate catabolic process | GO:0009207 | 391 | 0.125 | |
| positive regulation of alpha beta t cell activation | GO:0046635 | 10 | 0.125 | |
| eosinophil chemotaxis | GO:0048245 | 8 | 0.123 | |
| endothelial cell apoptotic process | GO:0072577 | 26 | 0.121 | |
| response to nitric oxide | GO:0071731 | 4 | 0.120 | |
| purine nucleoside triphosphate catabolic process | GO:0009146 | 392 | 0.119 | |
| nucleotide catabolic process | GO:0009166 | 408 | 0.119 | |
| alpha beta t cell activation involved in immune response | GO:0002287 | 5 | 0.117 | |
| positive regulation of cd4 positive alpha beta t cell activation | GO:2000516 | 3 | 0.116 | |
| gtp metabolic process | GO:0046039 | 239 | 0.115 | |
| cd8 positive alpha beta t cell activation | GO:0036037 | 3 | 0.115 | |
| positive regulation of cytokine mediated signaling pathway | GO:0001961 | 12 | 0.113 | |
| regulation of rho protein signal transduction | GO:0035023 | 79 | 0.112 | |
| positive regulation of leukocyte proliferation | GO:0070665 | 48 | 0.111 | |
| intrinsic apoptotic signaling pathway in response to oxidative stress | GO:0008631 | 21 | 0.110 | |
| purine nucleoside triphosphate metabolic process | GO:0009144 | 412 | 0.109 | |
| morphogenesis of an epithelium | GO:0002009 | 60 | 0.108 | |
| membrane protein proteolysis | GO:0033619 | 38 | 0.108 | |
| negative regulation of proteolysis | GO:0045861 | 132 | 0.107 | Human |
| regulation of type i interferon production | GO:0032479 | 26 | 0.107 | |
| regulation of nucleobase containing compound transport | GO:0032239 | 7 | 0.105 | |
| negative regulation of g1 s transition of mitotic cell cycle | GO:2000134 | 29 | 0.103 | |
| regulation of ras gtpase activity | GO:0032318 | 128 | 0.103 | |
| negative regulation of cell cycle process | GO:0010948 | 121 | 0.103 | |
| regulation of t cell differentiation | GO:0045580 | 19 | 0.100 | |
| nucleocytoplasmic transport | GO:0006913 | 176 | 0.099 | |
| regulation of endothelial cell apoptotic process | GO:2000351 | 24 | 0.099 | |
| posttranscriptional regulation of gene expression | GO:0010608 | 213 | 0.099 | |
| response to abiotic stimulus | GO:0009628 | 336 | 0.097 | |
| neurogenesis | GO:0022008 | 169 | 0.097 | |
| protein homotrimerization | GO:0070207 | 9 | 0.096 | |
| regulation of cell cycle | GO:0051726 | 393 | 0.095 | Human |
| regulation of protein binding | GO:0043393 | 66 | 0.093 | |
| positive regulation of immune effector process | GO:0002699 | 40 | 0.093 | |
| nucleoside triphosphate metabolic process | GO:0009141 | 422 | 0.088 | |
| regulation of protein localization to nucleus | GO:1900180 | 85 | 0.087 | |
| positive regulation of intrinsic apoptotic signaling pathway | GO:2001244 | 28 | 0.085 | |
| interleukin 1 beta secretion | GO:0050702 | 15 | 0.083 | |
| negative regulation of cellular protein metabolic process | GO:0032269 | 353 | 0.083 | Human |
| inflammatory response | GO:0006954 | 79 | 0.082 | |
| response to reactive oxygen species | GO:0000302 | 61 | 0.082 | |
| production of molecular mediator of immune response | GO:0002440 | 37 | 0.082 | |
| positive regulation of lymphocyte migration | GO:2000403 | 16 | 0.081 | |
| multi organism metabolic process | GO:0044033 | 41 | 0.081 | |
| cellular response to oxidative stress | GO:0034599 | 85 | 0.080 | |
| response to uv | GO:0009411 | 73 | 0.080 | |
| type i interferon production | GO:0032606 | 27 | 0.079 | |
| regulation of t cell apoptotic process | GO:0070232 | 8 | 0.078 | |
| regulation of wnt signaling pathway | GO:0030111 | 123 | 0.077 | Human |
| ubiquitin dependent protein catabolic process | GO:0006511 | 206 | 0.077 | Human |
| positive regulation of secretion by cell | GO:1903532 | 108 | 0.076 | |
| positive regulation of peptidyl threonine phosphorylation | GO:0010800 | 9 | 0.076 | |
| regulation of protein transport | GO:0051223 | 213 | 0.076 | |
| positive regulation of dephosphorylation | GO:0035306 | 26 | 0.075 | |
| guanosine containing compound metabolic process | GO:1901068 | 244 | 0.075 | |
| regulation of dephosphorylation | GO:0035303 | 96 | 0.073 | |
| system process | GO:0003008 | 349 | 0.073 | |
| myoblast fusion | GO:0007520 | 1 | 0.073 | |
| negative regulation of leukocyte activation | GO:0002695 | 26 | 0.072 | |
| positive regulation of interleukin 4 biosynthetic process | GO:0045404 | 1 | 0.072 | |
| amide transport | GO:0042886 | 76 | 0.071 | |
| response to oxidative stress | GO:0006979 | 121 | 0.071 | |
| positive regulation of transport | GO:0051050 | 336 | 0.071 | |
| negative regulation of interleukin 1 beta production | GO:0032691 | 6 | 0.070 | |
| vitamin d metabolic process | GO:0042359 | 10 | 0.070 | |
| positive regulation of t cell differentiation | GO:0045582 | 11 | 0.070 | |
| regulation of response to biotic stimulus | GO:0002831 | 55 | 0.070 | |
| positive regulation of lymphocyte differentiation | GO:0045621 | 13 | 0.069 | |
| negative regulation of alpha beta t cell proliferation | GO:0046642 | 1 | 0.068 | |
| regulation of inflammatory response | GO:0050727 | 46 | 0.067 | |
| positive regulation of locomotion | GO:0040017 | 186 | 0.067 | |
| regulation of cellular component movement | GO:0051270 | 334 | 0.067 | |
| mitotic cell cycle | GO:0000278 | 326 | 0.066 | |
| lymphocyte activation involved in immune response | GO:0002285 | 20 | 0.066 | |
| regulation of nucleoside metabolic process | GO:0009118 | 209 | 0.066 | |
| proteasome mediated ubiquitin dependent protein catabolic process | GO:0043161 | 156 | 0.065 | Human |
| negative regulation of endopeptidase activity | GO:0010951 | 84 | 0.065 | Human |
| positive regulation of protein transport | GO:0051222 | 135 | 0.064 | |
| syncytium formation by plasma membrane fusion | GO:0000768 | 2 | 0.064 | |
| regulation of cdc42 protein signal transduction | GO:0032489 | 14 | 0.063 | |
| positive regulation of cell migration | GO:0030335 | 172 | 0.063 | |
