Homo sapiens

175 known processes

BRCA2

breast cancer 2, early onset

(Aliases: FAD1,GLM3,PNCA2,BRCC2,FACD,FANCD,BROVCA2,FANCB,FAD,FANCD1)

BRCA2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
double strand break repair via homologous recombinationGO:0000724500.999
male meiosisGO:000714010.998
Mouse
cellular response to dna damage stimulusGO:00069743790.997
double strand break repairGO:00063021010.996
nuclear divisionGO:00002801280.996
Mouse
dna repairGO:00062811980.996
dna recombinationGO:0006310770.991
response to radiationGO:00093141510.989
Mouse
regulation of double strand break repair via homologous recombinationGO:0010569110.989
recombinational repairGO:0000725500.987
oocyte maturationGO:000155610.981
Mouse
response to caffeineGO:003100030.891
oocyte developmentGO:004859910.889
Mouse
regulation of cell cycleGO:00517263930.888
Mouse
oocyte differentiationGO:000999420.865
Mouse
regulation of cell cycle phase transitionGO:19019871260.858
reciprocal meiotic recombinationGO:000713140.850
spermatid developmentGO:000728640.849
reproductive processGO:00224141060.847
Mouse
female gamete generationGO:000729220.847
Mouse
nucleoside monophosphate catabolic processGO:00091251590.834
negative regulation of mitotic metaphase anaphase transitionGO:0045841170.811
oogenesisGO:004847720.804
Mouse
mitotic cell cycle checkpointGO:0007093680.798
purine nucleoside catabolic processGO:00061523980.790
meiotic chromosome segregationGO:004513240.780
response to ionizing radiationGO:0010212650.778
Mouse
double strand break repair via single strand annealingGO:004500240.771
g2 m transition of mitotic cell cycleGO:0000086410.756
cell cycle checkpointGO:00000751170.740
meiotic nuclear divisionGO:0007126100.715
Mouse
reciprocal dna recombinationGO:003582540.707
nucleoside phosphate catabolic processGO:19012924120.699
purine ribonucleoside catabolic processGO:00461303980.689
atp catabolic processGO:00062001570.659
sister chromatid cohesionGO:0007062240.635
regulation of mitotic cell cycleGO:00073461890.629
Mouse
regulation of meiotic cell cycleGO:005144540.602
mitotic recombinationGO:000631280.591
regulation of double strand break repairGO:2000779220.588
cell divisionGO:00513011680.564
cell developmentGO:00484683280.553
Mouse
purine ribonucleoside monophosphate catabolic processGO:00091691580.549
nucleoside triphosphate catabolic processGO:00091433940.535
purine nucleotide catabolic processGO:00061954050.530
ribonucleoside monophosphate catabolic processGO:00091581580.525
chromosome segregationGO:00070591140.457
dna integrity checkpointGO:0031570710.446
ribonucleotide catabolic processGO:00092614050.432
anterior posterior axis specificationGO:000994820.429
cellular response to abiotic stimulusGO:00712141170.428
dna conformation changeGO:00711031130.401
positive regulation of mitotic cell cycleGO:0045931600.398
Mouse
spermatid differentiationGO:004851540.379
dna dependent dna replicationGO:0006261440.377
Mouse
spindle checkpointGO:0031577260.363
non recombinational repairGO:0000726140.362
regulation of kinase activityGO:00435493140.360
mitotic cell cycle processGO:19030472860.355
regulation of protein modification by small protein conjugation or removalGO:19033201070.346
ubiquitin dependent protein catabolic processGO:00065112060.346
organelle fissionGO:00482851490.342
Mouse
mitotic cell cycle phase transitionGO:00447721620.329
glycosyl compound catabolic processGO:19016584130.319
regulation of dna metabolic processGO:00510521530.314
Mouse
negative regulation of dna metabolic processGO:0051053570.312
Mouse
strand invasionGO:004214820.307
cellular response to endogenous stimulusGO:00714953360.301
ribonucleoside catabolic processGO:00424544060.298
response to abiotic stimulusGO:00096283360.298
Mouse
cytokinesisGO:0000910960.294
single organism reproductive processGO:0044702980.289
Mouse
ribonucleoside monophosphate metabolic processGO:00091611870.280
meiotic cell cycleGO:0051321130.278
Mouse
purine nucleoside monophosphate catabolic processGO:00091281580.277
negative regulation of cell proliferationGO:00082852280.259
regulation of dna repairGO:0006282470.258
purine nucleoside triphosphate catabolic processGO:00091463920.258
dna geometric changeGO:0032392320.255
sister chromatid segregationGO:0000819540.255
dna replicationGO:00062601160.245
Mouse
nucleotide excision repairGO:0006289310.239
purine nucleoside monophosphate metabolic processGO:00091261860.226
regulation of transferase activityGO:00513383550.214
negative regulation of chromosome segregationGO:0051985180.210
centrosome organizationGO:0051297580.202
negative regulation of thymocyte apoptotic processGO:007024410.200
g2 dna damage checkpointGO:0031572260.200
negative regulation of cell cycleGO:00457861930.195
dna unwinding involved in dna replicationGO:000626820.193
multi organism reproductive processGO:0044703540.189
Mouse
negative regulation of mitotic cell cycleGO:00459301020.188
positive regulation of cell cycle processGO:00900681060.188
purine ribonucleotide catabolic processGO:00091544040.178
regulation of response to dna damage stimulusGO:2001020940.175
regulation of mitotic metaphase anaphase transitionGO:0030071260.170
nucleotide catabolic processGO:00091664080.169
regulation of protein serine threonine kinase activityGO:00719001790.169
mitotic sister chromatid segregationGO:0000070530.166
negative regulation of cell cycle processGO:00109481210.163
specification of axis polarityGO:006500110.162
regulation of protein kinase activityGO:00458592890.161
purine ribonucleoside metabolic processGO:00461284370.161
intracellular mrna localizationGO:000829810.154
dna duplex unwindingGO:0032508300.152
dna catabolic processGO:0006308490.151
dna double strand break processingGO:0000729100.150
nucleoside triphosphate metabolic processGO:00091414220.146
protein maturationGO:00516042330.142
chromosome separationGO:0051304230.139
proteasome mediated ubiquitin dependent protein catabolic processGO:00431611560.137
organophosphate catabolic processGO:00464344300.134
mitotic nuclear divisionGO:00070671190.130
developmental process involved in reproductionGO:0003006660.130
Mouse
cellular macromolecule catabolic processGO:00442653800.130
nucleoside monophosphate metabolic processGO:00091231910.123
dna damage checkpointGO:0000077680.123
dna ligationGO:0006266100.121
dna packagingGO:0006323770.119
positive regulation of cell cycleGO:00457871400.119
Mouse
negative regulation of proteolysis involved in cellular protein catabolic processGO:1903051350.119
regulation of dna replicationGO:0006275680.118
Mouse
negative regulation of cellular catabolic processGO:0031330830.118
regulation of protein maturationGO:19033171500.116
base excision repairGO:0006284210.114
regulation of mitotic sister chromatid separationGO:0010965270.114
spermatogenesisGO:0007283220.113
Mouse
double strand break repair via nonhomologous end joiningGO:0006303100.112
positive regulation of hydrolase activityGO:00513453310.110
regulation of cell divisionGO:00513021160.110
Mouse
ribonucleoside triphosphate metabolic processGO:00091994120.109
microtubule cytoskeleton organizationGO:00002261760.109
regulation of proteolysis involved in cellular protein catabolic processGO:1903050910.108
regulation of proteasomal protein catabolic processGO:0061136870.105
nucleoside catabolic processGO:00091644080.105
regulation of cyclin dependent protein serine threonine kinase activityGO:0000079360.104
positive regulation of protein phosphorylationGO:00019343130.104
negative regulation of cellular protein metabolic processGO:00322693530.103
purine nucleoside triphosphate metabolic processGO:00091444120.102
multicellular organism reproductionGO:0032504420.102
Mouse
negative regulation of chromosome organizationGO:2001251480.102
meiosis iGO:000712740.102
Mouse
cellular response to oxygen containing compoundGO:19017012760.101
negative regulation of mitotic sister chromatid separationGO:2000816170.100
regulation of cellular response to stressGO:00801352440.099
purine ribonucleoside triphosphate metabolic processGO:00092054110.098
negative regulation of protein metabolic processGO:00512483910.098
positive regulation of apoptotic processGO:00430652460.096
nervous system developmentGO:00073992930.094
Mouse
post embryonic developmentGO:000979120.093
determination of adult lifespanGO:000834020.093
negative regulation of sister chromatid segregationGO:0033046170.092
negative regulation of cell deathGO:00605483450.090
negative regulation of cellular protein catabolic processGO:1903363380.089
negative regulation of protein processingGO:00109551420.085
response to inorganic substanceGO:00100351270.084
multicellular organismal reproductive processGO:0048609400.083
Mouse
cellular response to alkaloidGO:0071312110.081
atp metabolic processGO:00460341760.081
negative regulation of organelle organizationGO:00106391260.079
intrinsic apoptotic signaling pathway in response to dna damageGO:0008630500.078
Mouse
rna localizationGO:0006403410.078
purine ribonucleoside triphosphate catabolic processGO:00092073910.077
dna damage induced protein phosphorylationGO:000697550.075
cellular response to ionizing radiationGO:0071479320.074
dna biosynthetic processGO:0071897400.073
positive regulation of cellular amine metabolic processGO:003324070.071
microtubule based processGO:00070172100.070
cellular process involved in reproduction in multicellular organismGO:0022412150.068
Mouse
negative regulation of multicellular organismal processGO:00512413170.068
positive regulation of cellular amino acid metabolic processGO:004576430.068
mitotic cell cycleGO:00002783260.068
Mouse
male gamete generationGO:0048232220.067
Mouse
negative regulation of developmental processGO:00510932470.067
developmental maturationGO:0021700280.065
Mouse
regulation of mitotic sister chromatid segregationGO:0033047270.065
response to uvGO:0009411730.063
Mouse
anatomical structure homeostasisGO:00602491000.063
negative regulation of mitosisGO:0045839240.061
positive regulation of meiotic cell cycleGO:005144620.060
regulation of sister chromatid segregationGO:0033045270.059
negative regulation of metaphase anaphase transition of cell cycleGO:1902100170.059
negative regulation of cell divisionGO:0051782310.058
response to light stimulusGO:0009416870.058
Mouse
mitotic dna damage checkpointGO:0044773280.057
metaphase anaphase transition of cell cycleGO:0044784210.057
signal transduction by phosphorylationGO:00230142970.056
reproductionGO:0000003630.055
Mouse
immune system developmentGO:00025201950.055
Mouse
cell cycle phase transitionGO:00447701730.054
regulation of mitotic cell cycle phase transitionGO:19019901180.054
nucleosome organizationGO:0034728660.054
dna catabolic process endonucleolyticGO:0000737370.054
regulation of centrosome cycleGO:0046605150.053
negative regulation of protein modification processGO:00314002000.051
positive regulation of cellular component organizationGO:00511303760.050
negative regulation of mitotic cell cycle phase transitionGO:1901991850.049
response to transition metal nanoparticleGO:1990267290.049
telomere maintenance via recombinationGO:000072240.049
intrinsic apoptotic signaling pathwayGO:00971931270.049
Mouse
protein modification by small protein conjugationGO:00324463420.047
positive regulation of phosphorylationGO:00423273940.046
mitotic spindle checkpointGO:0071174180.045
positive regulation of kinase activityGO:00336742040.044
sexual reproductionGO:0019953370.044
Mouse
regulation of protein ubiquitinationGO:0031396950.044
negative regulation of apoptotic processGO:00430663160.044
regulation of cellular amino acid metabolic processGO:000652160.044
negative regulation of protein phosphorylationGO:00019331400.043
regulation of metaphase anaphase transition of cell cycleGO:1902099260.043
regulation of cellular ketone metabolic processGO:0010565500.043
regulation of protein processingGO:00706131500.043
negative regulation of cellular component organizationGO:00511292350.042
chromatin remodelingGO:0006338550.042
purine ribonucleoside monophosphate metabolic processGO:00091671860.041
positive regulation of programmed cell deathGO:00430682490.041
hemopoiesisGO:00300971800.040
Mouse
regulation of cell cycle processGO:00105642660.040
Mouse
regulation of protein catabolic processGO:00421761550.040
negative regulation of catalytic activityGO:00430863350.040
regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032434710.040
regulation of endopeptidase activityGO:00525481700.039
cellular response to radiationGO:0071478650.039
negative regulation of phosphate metabolic processGO:00459362670.039
positive regulation of protein modification by small protein conjugation or removalGO:1903322610.038
telomere organizationGO:0032200330.037
positive regulation of catabolic processGO:00098963100.037
response to organic cyclic compoundGO:00140702040.037
negative regulation of cell sizeGO:004579230.036
cytokine productionGO:00018162470.036
purine containing compound catabolic processGO:00725234110.036
regulation of proteolysisGO:00301622930.035
gamete generationGO:0007276250.035
Mouse
regulation of protein localizationGO:00328802960.035
intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediatorGO:0042771230.034
Mouse
response to alkaloidGO:0043279200.034
regulation of vasculature developmentGO:1901342970.034
negative regulation of phosphorus metabolic processGO:00105632670.034
regulation of peptidase activityGO:00525471800.033
small gtpase mediated signal transductionGO:0007264780.033
response to organonitrogen compoundGO:00102431560.033
somatic diversification of immunoglobulins involved in immune responseGO:000220830.033
response to metal ionGO:0010038840.032
mitotic dna integrity checkpointGO:0044774300.032
protein oligomerizationGO:00512591730.031
negative regulation of phosphorylationGO:00423261740.031
negative regulation of protein maturationGO:19033181420.031
negative regulation of mitotic sister chromatid segregationGO:0033048170.031
cellular response to organic cyclic compoundGO:00714071270.031
regulation of cellular amine metabolic processGO:0033238110.031
regulation of dna dependent dna replicationGO:0090329190.031
Mouse
negative regulation of programmed cell deathGO:00430693210.030
regulation of growthGO:00400081650.030
negative regulation of cell cycle phase transitionGO:1901988890.030
regulation of nucleotide catabolic processGO:00308112050.030
negative regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032435300.030
regulation of sister chromatid cohesionGO:000706390.029
metaphase anaphase transition of mitotic cell cycleGO:0007091210.029
female gonad developmentGO:0008585100.029
Mouse
growthGO:00400072020.029
Mouse
positive regulation of developmental processGO:00510943140.029
mitotic sister chromatid separationGO:0051306180.029
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:00432811160.029
meiotic cell cycle processGO:190304680.029
Mouse
negative regulation of proteasomal protein catabolic processGO:1901799320.028
negative regulation of histone h3 k9 methylationGO:005157330.028
regulation of cell cycle checkpointGO:1901976210.028
mitotic sister chromatid cohesionGO:0007064120.027
development of primary female sexual characteristicsGO:0046545100.027
Mouse
protein ubiquitinationGO:00165673140.026
signal transduction in response to dna damageGO:0042770570.026
Mouse
regulation of centrosome duplicationGO:0010824140.025
positive regulation of proteolysisGO:00458621420.025
atp dependent chromatin remodelingGO:0043044250.025
cell cycle g1 s phase transitionGO:0044843800.025
ras protein signal transductionGO:0007265730.025
protein homooligomerizationGO:00512601000.025
positive regulation of intracellular transportGO:00323881040.025
telomere maintenanceGO:0000723320.024
germ cell developmentGO:000728180.024
Mouse
positive regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043280690.024
membrane organizationGO:00610242920.024
amine metabolic processGO:0009308440.024
positive regulation of cell deathGO:00109422630.023
epithelium developmentGO:00604292270.023
cohesin localization to chromatinGO:007192140.023
positive regulation of cysteine type endopeptidase activityGO:2001056790.023
apoptotic signaling pathwayGO:00971902680.023
Mouse
cellular response to external stimulusGO:00714961110.022
histone modificationGO:00165702510.022
cellular response to nitrogen compoundGO:19016991440.022
negative regulation of protein catabolic processGO:0042177590.022
generation of neuronsGO:00486991520.022
ribonucleoside triphosphate catabolic processGO:00092033910.022
negative regulation of kinase activityGO:00336731060.022
cellular response to organonitrogen compoundGO:00714171240.022
mapk cascadeGO:00001652880.022
metaphase plate congressionGO:0051310180.021
proteasomal protein catabolic processGO:00104981760.021
negative regulation of cell differentiationGO:00455961710.021
proteolysis involved in cellular protein catabolic processGO:00516032440.021
intra s dna damage checkpointGO:003157340.021
regulation of protein stabilityGO:0031647870.021
cellular protein catabolic processGO:00442572610.021
regenerationGO:003109940.021
regulation of cellular protein catabolic processGO:1903362960.021
negative regulation of proteolysisGO:00458611320.020
negative regulation of cellular amine metabolic processGO:003323930.020
positive regulation of cell divisionGO:0051781590.020
cellular ketone metabolic processGO:0042180800.020
negative regulation of hydrolase activityGO:00513461820.020
regulation of cytokine productionGO:00018172320.020
multi multicellular organism processGO:0044706180.020
regulation of microtubule cytoskeleton organizationGO:0070507610.019
response to oxygen containing compoundGO:19017003690.019
cell cycle arrestGO:0007050710.019
negative regulation of dna replicationGO:0008156290.019
Mouse
regulation of purine nucleotide catabolic processGO:00331212050.019
cell type specific apoptotic processGO:00972851250.019
regulation of bindingGO:00510981110.018
positive regulation of protein kinase activityGO:00458601900.018
regulation of chromosome segregationGO:0051983440.018
negative regulation of intracellular signal transductionGO:19025321830.018
negative regulation of catabolic processGO:00098951040.018
positive regulation of dna replicationGO:0045740350.018
positive regulation of cell differentiationGO:00455972110.018
hindbrain developmentGO:003090230.018
mitotic g1 dna damage checkpointGO:0031571170.018
rna catabolic processGO:0006401710.018
chemical homeostasisGO:00488783060.018
response to transforming growth factor betaGO:0071559940.017
pattern specification processGO:0007389430.017
cation homeostasisGO:00550801890.017
actin cytoskeleton organizationGO:00300362070.017
positive regulation of cell cycle phase transitionGO:1901989220.017
cellular amino acid metabolic processGO:00065201160.016
regulation of cell differentiationGO:00455953930.016
monocarboxylic acid biosynthetic processGO:0072330670.016
positive regulation of protein ubiquitinationGO:0031398530.016
protein localization to organelleGO:00333652800.016
leukocyte differentiationGO:0002521980.016
mrna metabolic processGO:00160711750.016
regulation of viral processGO:00507921030.016
regulation of nuclear divisionGO:0051783650.016
regulation of mitosisGO:0007088630.016
regulation of establishment of protein localizationGO:00702012420.016
negative regulation of protein kinase activityGO:0006469980.016
neuroblast proliferationGO:000740540.016
ovulation cycle processGO:002260290.015
segmentationGO:003528240.015
meiotic chromosome separationGO:005130730.015
g1 s transition of mitotic cell cycleGO:0000082780.015
regulation of gene expression epigeneticGO:0040029730.015
intrinsic apoptotic signaling pathway by p53 class mediatorGO:0072332370.015
Mouse
i kappab kinase nf kappab signalingGO:00072491660.015
protein deubiquitinationGO:0016579790.015
positive regulation of cellular catabolic processGO:00313312840.015
cellular response to hormone stimulusGO:00328701250.015
positive regulation of chromosome organizationGO:2001252410.015
response to gamma radiationGO:0010332140.014
Mouse
positive regulation of chromosome segregationGO:005198490.014
protein processingGO:00164852260.014
positive regulation of nucleotide metabolic processGO:00459812300.014
synaptic transmission cholinergicGO:000727120.014
negative regulation of reactive oxygen species metabolic processGO:2000378110.014
single organism cellular localizationGO:19025803320.014
rhythmic processGO:0048511310.014
gonad developmentGO:0008406340.014
Mouse
fatty acid biosynthetic processGO:0006633460.014
regulation of cysteine type endopeptidase activityGO:20001161270.014
cellular response to inorganic substanceGO:0071241450.013
regulation of purine nucleotide metabolic processGO:19005422640.013
lymphocyte proliferationGO:0046651700.013
cellular amine metabolic processGO:0044106410.013
regionalizationGO:0003002290.013
regulation of g2 m transition of mitotic cell cycleGO:0010389200.013
hematopoietic or lymphoid organ developmentGO:00485341860.013
Mouse
posttranscriptional regulation of gene expressionGO:00106082130.013
regulation of cell developmentGO:00602841610.013
lipid metabolic processGO:00066293810.013
regulation of neural precursor cell proliferationGO:200017740.013
rna interferenceGO:001624640.013
dna damage response signal transduction by p53 class mediatorGO:0030330440.013
Mouse
cell morphogenesisGO:00009022960.013
negative regulation of peptidyl lysine acetylationGO:200075780.013
female sex differentiationGO:0046660120.013
Mouse
regulation of gtpase activityGO:00430871800.013
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781250.012
response to nitrogen compoundGO:19016981840.012
regulation of chromosome organizationGO:00330441030.012
regulation of mapk cascadeGO:00434082620.012
mitotic spindle assembly checkpointGO:0007094140.012
positive regulation of gtp catabolic processGO:00331261660.012
chromosome condensationGO:0030261150.012
spindle assembly checkpointGO:0071173170.012
negative regulation of cyclin dependent protein serine threonine kinase activityGO:0045736150.012
receptor mediated endocytosisGO:0006898840.012
thymocyte apoptotic processGO:007024220.012
regulation of nucleotide metabolic processGO:00061402690.012
positive regulation of peptidase activityGO:0010952880.012
regulation of nervous system developmentGO:0051960880.012
regulation of cytoplasmic transportGO:19036491490.012
positive regulation of nuclear divisionGO:0051785270.012
endocytosisGO:00068971590.011
cell maturationGO:0048469110.011
Mouse
positive regulation of cytoplasmic transportGO:1903651820.011
positive regulation of mitotic cell cycle phase transitionGO:1901992190.011
regulation of non canonical wnt signaling pathwayGO:200005040.011
positive regulation of cellular protein catabolic processGO:1903364370.011
negative regulation of transcription from rna polymerase ii promoterGO:00001222810.011
protein catabolic processGO:00301633250.011
peptidyl lysine acetylationGO:00183941010.011
neural tube closureGO:000184330.011
positive regulation of endopeptidase activityGO:0010950840.011
cellular lipid metabolic processGO:00442553030.011
intestinal absorptionGO:005089240.011
response to drugGO:0042493810.010
histone exchangeGO:004348630.010
dna synthesis involved in dna repairGO:000073160.010
positive regulation of cell proliferationGO:00082843010.010
positive regulation of protein transportGO:00512221350.010
calcium ion homeostasisGO:00550741220.010
positive regulation of growthGO:0045927580.010
regulation of leukocyte activationGO:00026941150.010
organelle assemblyGO:00709251760.010
carboxylic acid biosynthetic processGO:0046394970.010
nuclear migrationGO:000709710.010
replication fork processingGO:0031297130.010

BRCA2 disease predictions

DiseaseDO term IDSizeProbabilityFunc Analog Org
immune system diseaseDOID:29141551.000
aplastic anemiaDOID:12449301.000
bone marrow diseaseDOID:4961311.000
anemiaDOID:2355551.000
hematopoietic system diseaseDOID:741001.000
fanconi s anemiaDOID:13636160.986
congenital hypoplastic anemiaDOID:1342260.986
organ system cancerDOID:00506861640.973
disease of cellular proliferationDOID:145661740.973
cancerDOID:1621670.973
thoracic cancerDOID:5093210.973
endocrine gland cancerDOID:170260.948
breast cancerDOID:1612210.920
pancreatic cancerDOID:179380.690
musculoskeletal system cancerDOID:0060100110.024
connective tissue cancerDOID:20170.024
reproductive organ cancerDOID:193230.007
nervous system cancerDOID:3093120.001
urinary system cancerDOID:3996150.001
central nervous system cancerDOID:362090.001
kidney cancerDOID:263110.001
brain cancerDOID:131940.000
infratentorial cancerDOID:470630.000
medulloblastomaDOID:005090230.000
nephroblastomaDOID:215430.000
prostate cancerDOID:10283130.000
male reproductive organ cancerDOID:3856160.000