IMP: Integrative Multi-species Prediction

Homo sapiens

39 known processes

CHAF1B

chromatin assembly factor 1, subunit B (p60)

(Aliases: CAF1A,CAF-IP60,MPP7,MPHOSPH7,CAF1,CAF-1,CAF1P60)

HGNC: 1911
HPRD: 03147
MIM: 601245
Ensembl: ENSG00000159259
Entrez: 8208
UniProtKB: Q13112

Process Predictions
Disease Predictions

CHAF1B biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability	Func Analog Org
dna replication dependent nucleosome assembly	GO:0006335	32	0.970
dna replication dependent nucleosome organization	GO:0034723	32	0.920
chromatin assembly or disassembly	GO:0006333	78	0.898
chromatin assembly	GO:0031497	61	0.864
protein dna complex assembly	GO:0065004	64	0.835
dna replication independent nucleosome assembly	GO:0006336	27	0.812
dna conformation change	GO:0071103	113	0.812
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	281	0.746
nucleosome assembly	GO:0006334	50	0.715
histone acetylation	GO:0016573	93	0.693
chromatin organization	GO:0006325	351	0.604
nucleosome organization	GO:0034728	66	0.570
dna replication	GO:0006260	116	0.504
mitotic sister chromatid segregation	GO:0000070	53	0.488
dna dependent dna replication	GO:0006261	44	0.485
oogenesis	GO:0048477	2	0.472
mitotic cell cycle phase transition	GO:0044772	162	0.391
cellular ketone metabolic process	GO:0042180	80	0.387
dna packaging	GO:0006323	77	0.372
female gamete generation	GO:0007292	2	0.369
regulation of cellular amine metabolic process	GO:0033238	11	0.313
dna repair	GO:0006281	198	0.307
protein modification by small protein conjugation	GO:0032446	342	0.267
cellular amine metabolic process	GO:0044106	41	0.257
covalent chromatin modification	GO:0016569	254	0.249
histone exchange	GO:0043486	3	0.247
cell development	GO:0048468	328	0.245
regulation of cellular ketone metabolic process	GO:0010565	50	0.236
protein dna complex subunit organization	GO:0071824	80	0.217
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.215
chromatin modification	GO:0016568	298	0.211
internal protein amino acid acetylation	GO:0006475	101	0.194
sister chromatid segregation	GO:0000819	54	0.194
dna replication independent nucleosome organization	GO:0034724	27	0.186
cellular amino acid metabolic process	GO:0006520	116	0.181
histone modification	GO:0016570	251	0.180
double strand break repair	GO:0006302	101	0.174
heterochromatin organization	GO:0070828	6	0.169
cellular macromolecular complex assembly	GO:0034622	324	0.158
regulation of chromosome segregation	GO:0051983	44	0.155
protein catabolic process	GO:0030163	325	0.151
positive regulation of cellular amine metabolic process	GO:0033240	7	0.150
post embryonic development	GO:0009791	2	0.146
mitotic cell cycle process	GO:1903047	286	0.133
internal peptidyl lysine acetylation	GO:0018393	97	0.128
protein acetylation	GO:0006473	116	0.125
single organism reproductive process	GO:0044702	98	0.118
regulation of chromatin organization	GO:1902275	56	0.114
nucleosome disassembly	GO:0006337	12	0.112
nuclear division	GO:0000280	128	0.107
regulation of chromatin modification	GO:1903308	51	0.106
positive regulation of organelle organization	GO:0010638	195	0.106
reproductive process	GO:0022414	106	0.101
regulation of cellular amino acid metabolic process	GO:0006521	6	0.100
modification dependent protein catabolic process	GO:0019941	209	0.100
cellular protein catabolic process	GO:0044257	261	0.100
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	156	0.097
recombinational repair	GO:0000725	50	0.096
nucleoside triphosphate catabolic process	GO:0009143	394	0.094
double strand break repair via homologous recombination	GO:0000724	50	0.094
amine metabolic process	GO:0009308	44	0.093
negative regulation of mitotic cell cycle	GO:0045930	102	0.091
cell projection organization	GO:0030030	252	0.089
histone ubiquitination	GO:0016574	31	0.086
determination of adult lifespan	GO:0008340	2	0.079
positive regulation of histone modification	GO:0031058	29	0.077
behavior	GO:0007610	112	0.076
cellular response to dna damage stimulus	GO:0006974	379	0.075
purine nucleoside triphosphate catabolic process	GO:0009146	392	0.075
nucleoside monophosphate metabolic process	GO:0009123	191	0.073
protein ubiquitination	GO:0016567	314	0.069
ubiquitin dependent protein catabolic process	GO:0006511	206	0.067
purine ribonucleotide catabolic process	GO:0009154	404	0.066
regulation of mitotic metaphase anaphase transition	GO:0030071	26	0.065
mitotic cell cycle	GO:0000278	326	0.062	Zebrafish
ras protein signal transduction	GO:0007265	73	0.062
chromatin remodeling	GO:0006338	55	0.062
organophosphate catabolic process	GO:0046434	430	0.060
embryo development	GO:0009790	123	0.060	Zebrafish
regulation of cell cycle	GO:0051726	393	0.060
regulation of gene silencing	GO:0060968	24	0.058
mitotic cell cycle checkpoint	GO:0007093	68	0.057
negative regulation of cell cycle process	GO:0010948	121	0.057
lagging strand elongation	GO:0006273	3	0.057
neuron differentiation	GO:0030182	138	0.057
purine ribonucleoside metabolic process	GO:0046128	437	0.057
regulation of mitotic cell cycle	GO:0007346	189	0.054
nervous system development	GO:0007399	293	0.053
base excision repair	GO:0006284	21	0.052
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	71	0.051
cell cycle phase transition	GO:0044770	173	0.050
negative regulation of cell cycle phase transition	GO:1901988	89	0.050
dna biosynthetic process	GO:0071897	40	0.050
purine ribonucleoside triphosphate catabolic process	GO:0009207	391	0.050
atp metabolic process	GO:0046034	176	0.049
cellular component morphogenesis	GO:0032989	314	0.049
ribonucleoside monophosphate metabolic process	GO:0009161	187	0.048
ribonucleotide catabolic process	GO:0009261	405	0.048
developmental process involved in reproduction	GO:0003006	66	0.047
chromatin silencing	GO:0006342	12	0.047
positive regulation of histone h3 k9 methylation	GO:0051574	3	0.047
mrna processing	GO:0006397	133	0.044
positive regulation of chromatin modification	GO:1903310	30	0.044
mitotic nuclear division	GO:0007067	119	0.044
protein maturation	GO:0051604	233	0.044
gene silencing	GO:0016458	49	0.044
regulation of chromosome organization	GO:0033044	103	0.044
mitotic sister chromatid separation	GO:0051306	18	0.043
reproductive structure development	GO:0048608	55	0.042
negative regulation of gene expression epigenetic	GO:0045814	19	0.042
nucleoside phosphate catabolic process	GO:1901292	412	0.041
chromosome segregation	GO:0007059	114	0.041
histone h2b ubiquitination	GO:0033523	8	0.041
mitotic sister chromatid cohesion	GO:0007064	12	0.040
regulation of proteasomal protein catabolic process	GO:0061136	87	0.040
neurogenesis	GO:0022008	169	0.039
organophosphate biosynthetic process	GO:0090407	163	0.039
rna processing	GO:0006396	255	0.039
neuron projection development	GO:0031175	106	0.039
proteasomal protein catabolic process	GO:0010498	176	0.038
centrosome organization	GO:0051297	58	0.038
regulation of mitosis	GO:0007088	63	0.038
protein alkylation	GO:0008213	74	0.037
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	91	0.037
purine containing compound catabolic process	GO:0072523	411	0.037
macromolecular complex disassembly	GO:0032984	60	0.037
purine nucleoside catabolic process	GO:0006152	398	0.037
cell morphogenesis	GO:0000902	296	0.036
protein processing	GO:0016485	226	0.036
nucleoside monophosphate catabolic process	GO:0009125	159	0.036
peptidyl lysine dimethylation	GO:0018027	3	0.036
transcription elongation from rna polymerase ii promoter	GO:0006368	18	0.035
purine nucleotide catabolic process	GO:0006195	405	0.035
modification dependent macromolecule catabolic process	GO:0043632	212	0.035
multicellular organismal aging	GO:0010259	3	0.035
regulation of cell cycle phase transition	GO:1901987	126	0.035
atp dependent chromatin remodeling	GO:0043044	25	0.035
dna synthesis involved in dna repair	GO:0000731	6	0.034
male meiosis	GO:0007140	1	0.034
regulation of protein maturation	GO:1903317	150	0.034
positive regulation of cellular component organization	GO:0051130	376	0.034
intracellular protein transport	GO:0006886	270	0.034
reproduction	GO:0000003	63	0.033
cell cycle g1 s phase transition	GO:0044843	80	0.033
rna splicing via transesterification reactions with bulged adenosine as nucleophile	GO:0000377	89	0.033
protein acylation	GO:0043543	138	0.033
regulation of transcription from rna polymerase ii promoter in response to stress	GO:0043618	17	0.033
regulation of dna templated transcription elongation	GO:0032784	23	0.033
g1 s transition of mitotic cell cycle	GO:0000082	78	0.032
dna recombination	GO:0006310	77	0.032
positive regulation of dna templated transcription elongation	GO:0032786	18	0.031
atp catabolic process	GO:0006200	157	0.031
response to external biotic stimulus	GO:0043207	261	0.030
multi organism reproductive process	GO:0044703	54	0.030
protein complex disassembly	GO:0043241	52	0.030
regulation of growth	GO:0040008	165	0.030
dna templated transcription elongation	GO:0006354	25	0.029
deoxyribonucleotide metabolic process	GO:0009262	6	0.029
cell projection morphogenesis	GO:0048858	129	0.029
cell growth	GO:0016049	160	0.029
positive regulation of cell proliferation	GO:0008284	301	0.029
purine ribonucleoside monophosphate catabolic process	GO:0009169	158	0.029
cell part morphogenesis	GO:0032990	137	0.029
ribonucleoside triphosphate catabolic process	GO:0009203	391	0.029
gene conversion	GO:0035822	1	0.028
positive regulation of dna metabolic process	GO:0051054	73	0.028
response to abiotic stimulus	GO:0009628	336	0.028
ribonucleoside catabolic process	GO:0042454	406	0.027
sister chromatid cohesion	GO:0007062	24	0.026
regulation of cell growth	GO:0001558	135	0.026
telomere maintenance	GO:0000723	32	0.026
positive regulation of hydrolase activity	GO:0051345	331	0.025
glycosyl compound catabolic process	GO:1901658	413	0.025
cellular component disassembly	GO:0022411	92	0.025
purine ribonucleoside monophosphate metabolic process	GO:0009167	186	0.025
negative regulation of mitotic metaphase anaphase transition	GO:0045841	17	0.025
muscle organ development	GO:0007517	56	0.025
peptidyl lysine acetylation	GO:0018394	101	0.025
regulation of transcription by chromatin organization	GO:0034401	1	0.024
regulation of histone modification	GO:0031056	47	0.024
negative regulation of mitotic cell cycle phase transition	GO:1901991	85	0.024
regulation of protein processing	GO:0070613	150	0.024
positive regulation of nuclease activity	GO:0032075	5	0.024
regulation of mitotic sister chromatid segregation	GO:0033047	27	0.024
peptidyl lysine modification	GO:0018205	144	0.023
regulation of histone acetylation	GO:0035065	19	0.023
mitotic dna integrity checkpoint	GO:0044774	30	0.023
immune response	GO:0006955	307	0.023
negative regulation of apoptotic process	GO:0043066	316	0.023
positive regulation of chromosome organization	GO:2001252	41	0.023
regeneration	GO:0031099	4	0.022
negative regulation of phosphate metabolic process	GO:0045936	267	0.022
rna splicing via transesterification reactions	GO:0000375	90	0.022
nucleoside catabolic process	GO:0009164	408	0.022
single organism cellular localization	GO:1902580	332	0.021
regulation of mrna metabolic process	GO:1903311	53	0.021
regulation of mitotic cell cycle phase transition	GO:1901990	118	0.021
purine ribonucleoside catabolic process	GO:0046130	398	0.021
neuron development	GO:0048666	113	0.021
carbohydrate derivative biosynthetic process	GO:1901137	207	0.021
regulation of cell cycle process	GO:0010564	266	0.021
protein oligomerization	GO:0051259	173	0.020
metaphase anaphase transition of mitotic cell cycle	GO:0007091	21	0.020
mrna splicing via spliceosome	GO:0000398	89	0.020
cellular macromolecule catabolic process	GO:0044265	380	0.020
macromolecule methylation	GO:0043414	97	0.020
sex determination	GO:0007530	3	0.019
anatomical structure formation involved in morphogenesis	GO:0048646	284	0.019
negative regulation of proteolysis	GO:0045861	132	0.019
cell cycle g2 m phase transition	GO:0044839	43	0.019
negative regulation of protein maturation	GO:1903318	142	0.019
cell morphogenesis involved in differentiation	GO:0000904	144	0.019
regulation of dna replication	GO:0006275	68	0.018
regulation of cellular component biogenesis	GO:0044087	281	0.018
dna replication initiation	GO:0006270	6	0.018
metaphase anaphase transition of cell cycle	GO:0044784	21	0.018
purine ribonucleoside triphosphate metabolic process	GO:0009205	411	0.018
growth	GO:0040007	202	0.017
regulation of dna templated transcription in response to stress	GO:0043620	18	0.017
negative regulation of cell death	GO:0060548	345	0.017
negative regulation of programmed cell death	GO:0043069	321	0.017
negative regulation of intracellular signal transduction	GO:1902532	183	0.017
nucleoside triphosphate metabolic process	GO:0009141	422	0.017
negative regulation of organelle organization	GO:0010639	126	0.017
regulation of protein catabolic process	GO:0042176	155	0.017
regulation of intracellular transport	GO:0032386	195	0.017
nucleoside phosphate biosynthetic process	GO:1901293	109	0.016
regulation of dna metabolic process	GO:0051052	153	0.016
blastocyst development	GO:0001824	3	0.016
response to ionizing radiation	GO:0010212	65	0.016
mrna metabolic process	GO:0016071	175	0.016
regulation of mitotic sister chromatid separation	GO:0010965	27	0.016
regulation of proteolysis	GO:0030162	293	0.016
circulatory system development	GO:0072359	262	0.016
dephosphorylation	GO:0016311	209	0.016
endomembrane system organization	GO:0010256	196	0.015
negative regulation of catabolic process	GO:0009895	104	0.015
vesicle mediated transport	GO:0016192	371	0.015
nucleotide biosynthetic process	GO:0009165	109	0.015
negative regulation of sister chromatid segregation	GO:0033046	17	0.015
response to fungus	GO:0009620	4	0.015
negative regulation of mitotic sister chromatid separation	GO:2000816	17	0.015
regulation of establishment of protein localization	GO:0070201	242	0.015
regulation of transcription elongation from rna polymerase ii promoter	GO:0034243	13	0.015
myosin filament assembly	GO:0031034	2	0.015
positive regulation of heterochromatin assembly	GO:0031453	1	0.015
g2 m transition of mitotic cell cycle	GO:0000086	41	0.015
ribonucleoside triphosphate metabolic process	GO:0009199	412	0.015
cytokinesis	GO:0000910	96	0.014
cellular response to endogenous stimulus	GO:0071495	336	0.014
small gtpase mediated signal transduction	GO:0007264	78	0.014
negative regulation of notch signaling pathway	GO:0045746	10	0.014
chromosome separation	GO:0051304	23	0.014
regulation of protein acetylation	GO:1901983	25	0.014
heterochromatin assembly	GO:0031507	6	0.014
positive regulation of mitotic cell cycle	GO:0045931	60	0.014
regulation of gene expression epigenetic	GO:0040029	73	0.014
embryo development ending in birth or egg hatching	GO:0009792	34	0.014
protein targeting	GO:0006605	187	0.014
spermatid development	GO:0007286	4	0.014
biological adhesion	GO:0022610	331	0.013
sex differentiation	GO:0007548	45	0.013
2 deoxyribonucleotide metabolic process	GO:0009394	6	0.013
generation of neurons	GO:0048699	152	0.013
multicellular organism reproduction	GO:0032504	42	0.013
purine nucleoside monophosphate catabolic process	GO:0009128	158	0.013
response to oxygen containing compound	GO:1901700	369	0.013
regulation of cell cycle g1 s phase transition	GO:1902806	42	0.013
protein localization to organelle	GO:0033365	280	0.013
regulation of cytoplasmic transport	GO:1903649	149	0.013
response to biotic stimulus	GO:0009607	276	0.013
purine nucleoside triphosphate metabolic process	GO:0009144	412	0.013
negative regulation of cell division	GO:0051782	31	0.013
positive regulation of cellular component biogenesis	GO:0044089	158	0.012
cell projection assembly	GO:0030031	126	0.012
negative regulation of cell cycle	GO:0045786	193	0.012
notch signaling pathway	GO:0007219	31	0.012	Fly
anatomical structure homeostasis	GO:0060249	100	0.012
negative regulation of cellular protein metabolic process	GO:0032269	353	0.012
response to uv	GO:0009411	73	0.012
negative regulation of proteolysis involved in cellular protein catabolic process	GO:1903051	35	0.012
purine nucleoside monophosphate metabolic process	GO:0009126	186	0.012
protein dna complex disassembly	GO:0032986	12	0.012
endocytosis	GO:0006897	159	0.012
meiosis i	GO:0007127	4	0.012
regulation of small gtpase mediated signal transduction	GO:0051056	156	0.012
dna dependent dna replication maintenance of fidelity	GO:0045005	14	0.012
cell division	GO:0051301	168	0.012
positive regulation of cell cycle	GO:0045787	140	0.012
regulation of kinase activity	GO:0043549	314	0.012
positive regulation of developmental process	GO:0051094	314	0.012
cell cell signaling	GO:0007267	155	0.012
organonitrogen compound biosynthetic process	GO:1901566	200	0.012
dna hypermethylation	GO:0044026	1	0.012
organelle fission	GO:0048285	149	0.012
neuron projection morphogenesis	GO:0048812	50	0.012
methylation	GO:0032259	106	0.012
gonad development	GO:0008406	34	0.012
dendrite development	GO:0016358	24	0.012
negative regulation of protein processing	GO:0010955	142	0.012
actin filament based process	GO:0030029	224	0.012
rna splicing	GO:0008380	131	0.011
negative regulation of dna metabolic process	GO:0051053	57	0.011
response to radiation	GO:0009314	151	0.011
ribonucleoside monophosphate catabolic process	GO:0009158	158	0.011
cell activation	GO:0001775	213	0.011
humoral immune response	GO:0006959	49	0.011
negative regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032435	30	0.011
microtubule based process	GO:0007017	210	0.011
regulation of ras protein signal transduction	GO:0046578	155	0.011
histone lysine methylation	GO:0034968	50	0.011
apoptotic signaling pathway	GO:0097190	268	0.011
regulation of chromatin silencing	GO:0031935	8	0.011
multicellular organismal reproductive process	GO:0048609	40	0.011
muscle structure development	GO:0061061	98	0.011
positive regulation of protein kinase activity	GO:0045860	190	0.011
positive regulation of mitotic cell cycle phase transition	GO:1901992	19	0.011
positive regulation of cytoplasmic transport	GO:1903651	82	0.011
regulation of g1 s transition of mitotic cell cycle	GO:2000045	40	0.011
negative regulation of catalytic activity	GO:0043086	335	0.011
cytoplasmic transport	GO:0016482	379	0.010
response to other organism	GO:0051707	261	0.010
cell fate determination	GO:0001709	3	0.010
establishment of protein localization to organelle	GO:0072594	172	0.010
cell type specific apoptotic process	GO:0097285	125	0.010
regulation of peptidyl lysine acetylation	GO:2000756	22	0.010
dna catabolic process	GO:0006308	49	0.010
cellular lipid metabolic process	GO:0044255	303	0.010
dna integrity checkpoint	GO:0031570	71	0.010
negative regulation of cellular catabolic process	GO:0031330	83	0.010
cofactor metabolic process	GO:0051186	87	0.010
regulation of rna splicing	GO:0043484	62	0.010
response to growth factor	GO:0070848	205	0.010
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process	GO:0031145	25	0.010

CHAF1B disease predictions

Disease	DO term ID	Size	Probability
hematopoietic system disease	DOID:74	100	0.217
immune system disease	DOID:2914	155	0.217
disease of cellular proliferation	DOID:14566	174	0.019
cancer	DOID:162	167	0.018
organ system cancer	DOID:0050686	164	0.018
bone disease	DOID:0080001	88	0.011
bone development disease	DOID:0080006	55	0.011
connective tissue disease	DOID:65	109	0.011
musculoskeletal system disease	DOID:17	223	0.011
disease of metabolism	DOID:0014667	295	0.010

Loading network...

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network