IMP: Integrative Multi-species Prediction

Homo sapiens

6 known processes

CTSD

cathepsin D

(Aliases: CPSD,MGC2311,CLN10)

Entrez: 1509
Ensembl: ENSG00000117984
MIM: 116840
HPRD: 00291
HGNC: 2529
UniProtKB: V9HWI3
UniProtKB: P07339

Process Predictions
Disease Predictions

CTSD biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability	Func Analog Org
elastin catabolic process	GO:0060309	1	0.779
regulation of elastin catabolic process	GO:0060310	1	0.743
regulation of blood vessel remodeling	GO:0060312	2	0.703
vacuole organization	GO:0007033	44	0.484	Mouse
negative regulation of elastin catabolic process	GO:0060311	1	0.415
negative regulation of collagen catabolic process	GO:0010711	1	0.378
regulation of lipid metabolic process	GO:0019216	96	0.314
negative regulation of blood vessel remodeling	GO:0060313	1	0.275
ion homeostasis	GO:0050801	230	0.252
cellular amine metabolic process	GO:0044106	41	0.233
regulation of mapk cascade	GO:0043408	262	0.219	Human
lipid metabolic process	GO:0006629	381	0.211
oxidation reduction process	GO:0055114	396	0.205
epithelium development	GO:0060429	227	0.200	Zebrafish
ion transmembrane transport	GO:0034220	338	0.174
negative regulation of cell death	GO:0060548	345	0.169
response to abiotic stimulus	GO:0009628	336	0.166
locomotory behavior	GO:0007626	1	0.164
response to oxygen containing compound	GO:1901700	369	0.131
carbohydrate metabolic process	GO:0005975	207	0.131
regulation of oxidative stress induced cell death	GO:1903201	24	0.124
maintenance of location	GO:0051235	112	0.123
circadian behavior	GO:0048512	2	0.118
positive regulation of cellular amine metabolic process	GO:0033240	7	0.117
regulation of protein processing	GO:0070613	150	0.116
neuromuscular process	GO:0050905	15	0.114
response to oxidative stress	GO:0006979	121	0.106
cellular lipid metabolic process	GO:0044255	303	0.099
positive regulation of phosphorylation	GO:0042327	394	0.098
regulation of cellular ketone metabolic process	GO:0010565	50	0.093
neurological system process	GO:0050877	163	0.091
regulation of cellular response to stress	GO:0080135	244	0.090
cellular response to hydrogen peroxide	GO:0070301	37	0.086
regulation of peptidase activity	GO:0052547	180	0.085
negative regulation of response to oxidative stress	GO:1902883	18	0.084
peptidyl tyrosine phosphorylation	GO:0018108	170	0.081
vesicle mediated transport	GO:0016192	371	0.079
epithelial cell differentiation	GO:0030855	141	0.079
cellular response to reactive oxygen species	GO:0034614	50	0.078
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.076
chemical homeostasis	GO:0048878	306	0.075	Human
central nervous system development	GO:0007417	123	0.075
cellular response to oxidative stress	GO:0034599	85	0.075
regulation of transferase activity	GO:0051338	355	0.075
eye development	GO:0001654	42	0.075	Zebrafish
negative regulation of protein metabolic process	GO:0051248	391	0.075
signal transduction by phosphorylation	GO:0023014	297	0.073	Human
cellular amide metabolic process	GO:0043603	69	0.073	Human
regulation of cellular amino acid metabolic process	GO:0006521	6	0.072
organ morphogenesis	GO:0009887	147	0.072
collagen catabolic process	GO:0030574	10	0.071
amine metabolic process	GO:0009308	44	0.070
transmembrane transport	GO:0055085	399	0.070
negative regulation of collagen metabolic process	GO:0010713	3	0.069
regulation of cellular response to oxidative stress	GO:1900407	26	0.066
cell morphogenesis	GO:0000902	296	0.066
cellular amino acid metabolic process	GO:0006520	116	0.065
negative regulation of cellular protein metabolic process	GO:0032269	353	0.065
cation transport	GO:0006812	331	0.063
negative regulation of peptidase activity	GO:0010466	91	0.059
cation transmembrane transport	GO:0098655	238	0.059
response to hormone	GO:0009725	175	0.059
glycerophospholipid metabolic process	GO:0006650	84	0.058
cellular ketone metabolic process	GO:0042180	80	0.058
negative regulation of multicellular organismal metabolic process	GO:0044252	3	0.058
mapk cascade	GO:0000165	288	0.057	Human
response to hydrogen peroxide	GO:0042542	40	0.057
carbohydrate catabolic process	GO:0016052	36	0.056
sensory perception of bitter taste	GO:0050913	28	0.056
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger	GO:0007187	43	0.055
proteolysis involved in cellular protein catabolic process	GO:0051603	244	0.055	Yeast
cell development	GO:0048468	328	0.055
monovalent inorganic cation transport	GO:0015672	128	0.054
inorganic ion transmembrane transport	GO:0098660	231	0.054
positive regulation of cell proliferation	GO:0008284	301	0.054
positive regulation of protein kinase activity	GO:0045860	190	0.054
circulatory system development	GO:0072359	262	0.053
lipid localization	GO:0010876	106	0.053
post embryonic development	GO:0009791	2	0.052
single organism carbohydrate metabolic process	GO:0044723	193	0.052
anatomical structure homeostasis	GO:0060249	100	0.052	Human
protein processing	GO:0016485	226	0.051	Human
hematopoietic or lymphoid organ development	GO:0048534	186	0.051
negative regulation of cellular response to oxidative stress	GO:1900408	18	0.049
response to cytokine	GO:0034097	232	0.048
apoptotic signaling pathway	GO:0097190	268	0.048
cellular carbohydrate metabolic process	GO:0044262	84	0.047
nervous system development	GO:0007399	293	0.047
positive regulation of transport	GO:0051050	336	0.047
prostate gland development	GO:0030850	3	0.046
negative regulation of apoptotic process	GO:0043066	316	0.046
amino acid transport	GO:0006865	28	0.046
regulation of secretion	GO:0051046	194	0.046
negative regulation of cellular amine metabolic process	GO:0033239	3	0.046
immune response	GO:0006955	307	0.045
response to reactive oxygen species	GO:0000302	61	0.045
regulation of collagen catabolic process	GO:0010710	3	0.045
hexose catabolic process	GO:0019320	7	0.044
regulation of vesicle mediated transport	GO:0060627	130	0.044
regulation of protein maturation	GO:1903317	150	0.044
negative regulation of protein maturation	GO:1903318	142	0.043
cellular response to oxygen containing compound	GO:1901701	276	0.043
negative regulation of protein processing	GO:0010955	142	0.042
response to organic cyclic compound	GO:0014070	204	0.042
negative regulation of cellular component organization	GO:0051129	235	0.041
protein localization to organelle	GO:0033365	280	0.040
detection of chemical stimulus	GO:0009593	55	0.040
response to axon injury	GO:0048678	1	0.040
regulation of cellular amine metabolic process	GO:0033238	11	0.039
cell death in response to oxidative stress	GO:0036473	29	0.038
alcohol metabolic process	GO:0006066	114	0.037
gland development	GO:0048732	48	0.037
negative regulation of multicellular organismal process	GO:0051241	317	0.037
lipid catabolic process	GO:0016042	84	0.037
organic hydroxy compound metabolic process	GO:1901615	147	0.036
positive regulation of protein phosphorylation	GO:0001934	313	0.036
cellular homeostasis	GO:0019725	196	0.036
negative regulation of catalytic activity	GO:0043086	335	0.035
reproductive process	GO:0022414	106	0.035
muscle cell cellular homeostasis	GO:0046716	3	0.034
cellular macromolecule catabolic process	GO:0044265	380	0.033	Yeast
exocytosis	GO:0006887	71	0.033
negative regulation of proteolysis	GO:0045861	132	0.033
negative regulation of programmed cell death	GO:0043069	321	0.033
system process	GO:0003008	349	0.032	Human
monovalent inorganic cation homeostasis	GO:0055067	37	0.032
cation homeostasis	GO:0055080	189	0.032
positive regulation of mapk cascade	GO:0043410	190	0.032
negative regulation of hydrolase activity	GO:0051346	182	0.031
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	181	0.031
cell activation	GO:0001775	213	0.031
regulation of peptidyl tyrosine phosphorylation	GO:0050730	108	0.031
secretion by cell	GO:0032940	226	0.030
negative regulation of oxidative stress induced cell death	GO:1903202	17	0.030
regulation of anatomical structure morphogenesis	GO:0022603	286	0.030
lipid storage	GO:0019915	28	0.030
cytoplasmic transport	GO:0016482	379	0.030
negative regulation of intracellular signal transduction	GO:1902532	183	0.029
response to decreased oxygen levels	GO:0036293	96	0.029
myeloid cell differentiation	GO:0030099	117	0.029
response to oxygen levels	GO:0070482	100	0.028
negative regulation of cellular amino acid metabolic process	GO:0045763	2	0.028
determination of adult lifespan	GO:0008340	2	0.028	Worm
cellular component morphogenesis	GO:0032989	314	0.028
glycoprotein catabolic process	GO:0006516	7	0.028
positive regulation of cellular component organization	GO:0051130	376	0.027
membrane lipid metabolic process	GO:0006643	53	0.027
hair cell differentiation	GO:0035315	2	0.027
regulation of kinase activity	GO:0043549	314	0.026
rhythmic behavior	GO:0007622	2	0.026
positive regulation of protein serine threonine kinase activity	GO:0071902	119	0.026
regulation of glycoprotein metabolic process	GO:1903018	19	0.026
nuclear division	GO:0000280	128	0.026
sleep	GO:0030431	2	0.025
skin development	GO:0043588	76	0.025
peptide catabolic process	GO:0043171	10	0.025
positive regulation of transferase activity	GO:0051347	227	0.024
generation of precursor metabolites and energy	GO:0006091	68	0.024
amino sugar catabolic process	GO:0046348	3	0.024
negative regulation of glycoprotein metabolic process	GO:1903019	8	0.024
chordate embryonic development	GO:0043009	34	0.024
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	156	0.023
multicellular organismal macromolecule metabolic process	GO:0044259	29	0.023
response to inorganic substance	GO:0010035	127	0.023
carboxylic acid transport	GO:0046942	63	0.023
single organism reproductive process	GO:0044702	98	0.023
immune system development	GO:0002520	195	0.023
response to thyroid hormone	GO:0097066	9	0.023
proteasomal protein catabolic process	GO:0010498	176	0.023
protein modification by small protein conjugation	GO:0032446	342	0.023
posttranscriptional regulation of gene expression	GO:0010608	213	0.023
negative regulation of protein modification process	GO:0031400	200	0.022
response to alcohol	GO:0097305	64	0.022
regulation of intracellular transport	GO:0032386	195	0.022
regulation of cytokine production	GO:0001817	232	0.022
defense response	GO:0006952	315	0.022	Worm
cellular ion homeostasis	GO:0006873	168	0.022
peripheral nervous system development	GO:0007422	2	0.022
response to hypoxia	GO:0001666	96	0.022
positive regulation of epithelial cell proliferation	GO:0050679	65	0.021
positive regulation of kinase activity	GO:0033674	204	0.021
cytokine production	GO:0001816	247	0.021
regulation of erk1 and erk2 cascade	GO:0070372	99	0.021
positive regulation of leukocyte degranulation	GO:0043302	3	0.021
microtubule based process	GO:0007017	210	0.021
regulation of proteolysis	GO:0030162	293	0.021
regulation of cell adhesion	GO:0030155	166	0.021
regulation of endopeptidase activity	GO:0052548	170	0.020
regulation of response to oxidative stress	GO:1902882	26	0.020
negative regulation of endopeptidase activity	GO:0010951	84	0.020
response to organonitrogen compound	GO:0010243	156	0.020
regulation of cellular ph	GO:0030641	17	0.020
cellular protein catabolic process	GO:0044257	261	0.020	Yeast
cellular cation homeostasis	GO:0030003	163	0.020
reactive oxygen species biosynthetic process	GO:1903409	4	0.020
sensory perception	GO:0007600	103	0.020
wnt signaling pathway	GO:0016055	156	0.020
response to fungus	GO:0009620	4	0.020
circadian sleep wake cycle process	GO:0022410	2	0.019
epidermis development	GO:0008544	59	0.019
regulation of protein kinase activity	GO:0045859	289	0.019
sulfur compound metabolic process	GO:0006790	101	0.019
negative regulation of cellular catabolic process	GO:0031330	83	0.019
cerebellum development	GO:0021549	2	0.019
female gamete generation	GO:0007292	2	0.019
cellular protein complex assembly	GO:0043623	188	0.019
dna replication	GO:0006260	116	0.019
response to lipid	GO:0033993	206	0.018
reproductive system development	GO:0061458	56	0.018
blood vessel remodeling	GO:0001974	2	0.018
growth	GO:0040007	202	0.018
regulation of wnt signaling pathway	GO:0030111	123	0.018
small molecule biosynthetic process	GO:0044283	157	0.018
head development	GO:0060322	108	0.018
positive regulation of secretion by cell	GO:1903532	108	0.018
developmental process involved in reproduction	GO:0003006	66	0.017
carbohydrate derivative biosynthetic process	GO:1901137	207	0.017
reactive oxygen species metabolic process	GO:0072593	75	0.017
phospholipid metabolic process	GO:0006644	99	0.017
cellular chemical homeostasis	GO:0055082	180	0.017
positive regulation of immune system process	GO:0002684	283	0.017
single organism membrane organization	GO:0044802	268	0.017	Yeast
regulation of cellular component movement	GO:0051270	334	0.017
protein stabilization	GO:0050821	64	0.017
multicellular organismal metabolic process	GO:0044236	34	0.017
protein ubiquitination	GO:0016567	314	0.016
regeneration	GO:0031099	4	0.016
urogenital system development	GO:0001655	65	0.016	Human
protein maturation	GO:0051604	233	0.016	Human
thiamine transport	GO:0015888	3	0.016
regulation of cell motility	GO:2000145	299	0.016
reactive nitrogen species metabolic process	GO:2001057	3	0.016
multicellular organismal aging	GO:0010259	3	0.016	Worm
divalent metal ion transport	GO:0070838	152	0.016
regulation of establishment of protein localization	GO:0070201	242	0.016
developmental growth involved in morphogenesis	GO:0060560	23	0.016
neuromuscular process controlling balance	GO:0050885	7	0.016
embryo development	GO:0009790	123	0.016
neurogenesis	GO:0022008	169	0.016
positive regulation of necrotic cell death	GO:0010940	4	0.015
hemopoiesis	GO:0030097	180	0.015
sensory perception of taste	GO:0050909	36	0.015
lysosome organization	GO:0007040	24	0.015
response to nitrogen compound	GO:1901698	184	0.015
ubiquitin dependent protein catabolic process	GO:0006511	206	0.015
positive regulation of endocytosis	GO:0045807	42	0.015
reproductive structure development	GO:0048608	55	0.015
embryonic morphogenesis	GO:0048598	85	0.015
metal ion homeostasis	GO:0055065	169	0.015
leukocyte mediated immunity	GO:0002443	59	0.015
activation of protein kinase activity	GO:0032147	90	0.015
negative regulation of transferase activity	GO:0051348	124	0.015
positive regulation of secretion	GO:0051047	116	0.015
azole transport	GO:0045117	4	0.015
hydrogen transport	GO:0006818	23	0.015
hormone metabolic process	GO:0042445	61	0.015	Human
brain development	GO:0007420	97	0.015
leukocyte activation	GO:0045321	164	0.015
respiratory system process	GO:0003016	3	0.014
negative regulation of protein catabolic process	GO:0042177	59	0.014
cellular component disassembly	GO:0022411	92	0.014
cellular divalent inorganic cation homeostasis	GO:0072503	128	0.014
regulation of exocytosis	GO:0017157	46	0.014
cholesterol metabolic process	GO:0008203	28	0.014
tissue regeneration	GO:0042246	3	0.014
regulation of lymphocyte activation	GO:0051249	103	0.014
regulation of growth	GO:0040008	165	0.014
bone resorption	GO:0045453	6	0.014
regulation of homeostatic process	GO:0032844	121	0.014
hindbrain development	GO:0030902	3	0.014
internal peptidyl lysine acetylation	GO:0018393	97	0.014
neuromuscular junction development	GO:0007528	3	0.014
detection of chemical stimulus involved in sensory perception of taste	GO:0050912	31	0.014
neuromuscular process controlling posture	GO:0050884	2	0.014
cell type specific apoptotic process	GO:0097285	125	0.013
alcohol biosynthetic process	GO:0046165	52	0.013
negative regulation of protein phosphorylation	GO:0001933	140	0.013
generation of neurons	GO:0048699	152	0.013
steroid metabolic process	GO:0008202	94	0.013
response to external biotic stimulus	GO:0043207	261	0.013	Zebrafish
antigen processing and presentation	GO:0019882	33	0.013	Human
lipid biosynthetic process	GO:0008610	177	0.013
peptidyl lysine modification	GO:0018205	144	0.013
calcium ion homeostasis	GO:0055074	122	0.013
cellular metal ion homeostasis	GO:0006875	146	0.013
regulation of protein catabolic process	GO:0042176	155	0.013
regulation of cell cycle process	GO:0010564	266	0.013
regulation of bone remodeling	GO:0046850	6	0.013
negative regulation of phosphorylation	GO:0042326	174	0.013
regulation of multicellular organismal metabolic process	GO:0044246	17	0.012
protein localization to endoplasmic reticulum	GO:0070972	19	0.012
tissue morphogenesis	GO:0048729	96	0.012
cell growth	GO:0016049	160	0.012
blastocyst development	GO:0001824	3	0.012
organic hydroxy compound transport	GO:0015850	63	0.012
epithelial tube branching involved in lung morphogenesis	GO:0060441	4	0.012
protein autophosphorylation	GO:0046777	123	0.012
negative regulation of phosphate metabolic process	GO:0045936	267	0.012
cell projection organization	GO:0030030	252	0.012
segmentation	GO:0035282	4	0.012
cellular lipid catabolic process	GO:0044242	65	0.012
circadian sleep wake cycle sleep	GO:0050802	2	0.012
negative regulation of catabolic process	GO:0009895	104	0.012
monocarboxylic acid metabolic process	GO:0032787	185	0.012
heart morphogenesis	GO:0003007	48	0.012
regulation of cell cycle	GO:0051726	393	0.012
receptor metabolic process	GO:0043112	81	0.012
regulation of apoptotic signaling pathway	GO:2001233	175	0.012
negative regulation of hydrogen peroxide induced cell death	GO:1903206	9	0.012
organic acid transport	GO:0015849	65	0.012
hexose metabolic process	GO:0019318	55	0.012
regulation of cell activation	GO:0050865	125	0.012
cholesterol transport	GO:0030301	39	0.011
innate immune response	GO:0045087	178	0.011
negative regulation of platelet derived growth factor receptor signaling pathway	GO:0010642	4	0.011
cellular monovalent inorganic cation homeostasis	GO:0030004	26	0.011
divalent inorganic cation homeostasis	GO:0072507	136	0.011
regulation of cell division	GO:0051302	116	0.011
detection of stimulus	GO:0051606	85	0.011
extracellular matrix disassembly	GO:0022617	16	0.011
regulation of endocytosis	GO:0030100	72	0.011
sequestering of metal ion	GO:0051238	24	0.011
cell substrate adhesion	GO:0031589	132	0.011
divalent inorganic cation transport	GO:0072511	158	0.011
ph reduction	GO:0045851	11	0.011
cell part morphogenesis	GO:0032990	137	0.011
erbb signaling pathway	GO:0038127	44	0.011
regulation of secretion by cell	GO:1903530	177	0.011
response to estrogen	GO:0043627	47	0.011
cell adhesion	GO:0007155	325	0.011
decidualization	GO:0046697	4	0.011
positive regulation of cell death	GO:0010942	263	0.011
modification dependent macromolecule catabolic process	GO:0043632	212	0.011
actin filament based process	GO:0030029	224	0.011
negative regulation of cell cycle	GO:0045786	193	0.010
involuntary skeletal muscle contraction	GO:0003011	1	0.010
monosaccharide metabolic process	GO:0005996	74	0.010
negative regulation of synaptic transmission	GO:0050805	2	0.010
mitotic cell cycle	GO:0000278	326	0.010
negative regulation of organelle organization	GO:0010639	126	0.010
syncytium formation by plasma membrane fusion	GO:0000768	2	0.010
secretion	GO:0046903	254	0.010
endocrine process	GO:0050886	25	0.010	Human
cellular macromolecular complex assembly	GO:0034622	324	0.010
behavior	GO:0007610	112	0.010
erk1 and erk2 cascade	GO:0070371	104	0.010
metencephalon development	GO:0022037	2	0.010

CTSD disease predictions

Disease	DO term ID	Size	Probability
inherited metabolic disorder	DOID:655	242	0.986
disease of metabolism	DOID:0014667	295	0.986
lysosomal storage disease	DOID:3211	47	0.961
lipid storage disease	DOID:9455	28	0.961
nervous system disease	DOID:863	431	0.595
central nervous system disease	DOID:331	186	0.595
brain disease	DOID:936	73	0.299
cerebral degeneration	DOID:1443	16	0.299
leukodystrophy	DOID:10579	8	0.299
neuronal ceroid lipofuscinosis	DOID:14503	11	0.209
neurodegenerative disease	DOID:1289	102	0.101
eye and adnexa disease	DOID:1492	150	0.044
eye disease	DOID:5614	149	0.044
sensory system disease	DOID:0050155	203	0.044
acquired metabolic disease	DOID:0060158	58	0.042
carbohydrate metabolic disorder	DOID:2978	55	0.041
glycogen metabolism disorder	DOID:0050728	10	0.041
degeneration of macula and posterior pole	DOID:2007	17	0.030
retinal disease	DOID:5679	118	0.030
retinal degeneration	DOID:8466	89	0.030
macular degeneration	DOID:4448	20	0.030
cognitive disorder	DOID:1561	29	0.029
disease of mental health	DOID:150	70	0.029
sphingolipidosis	DOID:1927	14	0.028
glycogen storage disease	DOID:2747	10	0.024
immune system disease	DOID:2914	155	0.021
cancer	DOID:162	167	0.020
disease of cellular proliferation	DOID:14566	174	0.020
musculoskeletal system disease	DOID:17	223	0.012
disease by infectious agent	DOID:0050117	34	0.012
age related macular degeneration	DOID:10871	17	0.011
hematopoietic system disease	DOID:74	100	0.010
cardiovascular system disease	DOID:1287	106	0.010

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