IMP: Integrative Multi-species Prediction

Homo sapiens

9 known processes

FANCA

Fanconi anemia, complementation group A

(Aliases: FACA,FA1,FA-H,FA,FAH,MGC75158,FAA,FANCH)

Entrez: 2175
MIM: 607139
HPRD: 06186
Ensembl: ENSG00000187741
HGNC: 3582
UniProtKB: Q86U55
UniProtKB: O15360

Process Predictions
Disease Predictions

FANCA biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
dna repair	GO:0006281	198	1.000
cellular response to dna damage stimulus	GO:0006974	379	0.990
recombinational repair	GO:0000725	50	0.983
dna dependent dna replication maintenance of fidelity	GO:0045005	14	0.965
double strand break repair via homologous recombination	GO:0000724	50	0.868
dna dependent dna replication	GO:0006261	44	0.656
regeneration	GO:0031099	4	0.606
g2 dna damage checkpoint	GO:0031572	26	0.445
mitochondrion organization	GO:0007005	156	0.412
chromatin modification	GO:0016568	298	0.397
oocyte development	GO:0048599	1	0.378
post embryonic development	GO:0009791	2	0.370
meiotic chromosome separation	GO:0051307	3	0.366
double strand break repair	GO:0006302	101	0.354
oogenesis	GO:0048477	2	0.324
negative regulation of mitotic cell cycle	GO:0045930	102	0.292
dna damage checkpoint	GO:0000077	68	0.271
meiosis i	GO:0007127	4	0.268
replication fork processing	GO:0031297	13	0.253
chromatin organization	GO:0006325	351	0.241
dna replication	GO:0006260	116	0.235
oocyte differentiation	GO:0009994	2	0.234
tissue regeneration	GO:0042246	3	0.208
telomere maintenance	GO:0000723	32	0.198
dna conformation change	GO:0071103	113	0.190
chromatin assembly or disassembly	GO:0006333	78	0.188
microtubule based process	GO:0007017	210	0.182
mitotic dna damage checkpoint	GO:0044773	28	0.172
chemical homeostasis	GO:0048878	306	0.151
chromatin remodeling	GO:0006338	55	0.147
atp metabolic process	GO:0046034	176	0.141
neuronal ion channel clustering	GO:0045161	2	0.103
oocyte maturation	GO:0001556	1	0.099
negative regulation of cell cycle	GO:0045786	193	0.096
organelle fission	GO:0048285	149	0.096	Mouse
dna recombination	GO:0006310	77	0.093
cell cycle checkpoint	GO:0000075	117	0.093
receptor mediated endocytosis	GO:0006898	84	0.088
protein complex disassembly	GO:0043241	52	0.085
positive regulation of developmental process	GO:0051094	314	0.084
vesicle mediated transport	GO:0016192	371	0.080
response to oxygen containing compound	GO:1901700	369	0.078
atp catabolic process	GO:0006200	157	0.077
covalent chromatin modification	GO:0016569	254	0.075
dna double strand break processing	GO:0000729	10	0.074
mitotic cell cycle process	GO:1903047	286	0.066
double strand break repair via single strand annealing	GO:0045002	4	0.064
t cell activation	GO:0042110	99	0.064
purine containing compound catabolic process	GO:0072523	411	0.063
endocytosis	GO:0006897	159	0.063
growth	GO:0040007	202	0.063
purine ribonucleoside catabolic process	GO:0046130	398	0.063
cellular macromolecule catabolic process	GO:0044265	380	0.062
anterior posterior axis specification	GO:0009948	2	0.062
cell cycle phase transition	GO:0044770	173	0.061
purine nucleoside catabolic process	GO:0006152	398	0.060
neuronal stem cell division	GO:0036445	1	0.059
determination of adult lifespan	GO:0008340	2	0.058
dna integrity checkpoint	GO:0031570	71	0.058
meiotic chromosome segregation	GO:0045132	4	0.056
cellular amino acid metabolic process	GO:0006520	116	0.055
nuclear division	GO:0000280	128	0.054	Mouse
purine ribonucleoside monophosphate catabolic process	GO:0009169	158	0.054
regulation of mitotic cell cycle phase transition	GO:1901990	118	0.053
response to organic cyclic compound	GO:0014070	204	0.052
ribonucleotide catabolic process	GO:0009261	405	0.052
male meiosis	GO:0007140	1	0.052	Mouse
ion homeostasis	GO:0050801	230	0.051
mitotic cell cycle phase transition	GO:0044772	162	0.050
negative regulation of cell cycle process	GO:0010948	121	0.050
purine nucleoside triphosphate metabolic process	GO:0009144	412	0.050
negative regulation of phosphate metabolic process	GO:0045936	267	0.048
cell projection morphogenesis	GO:0048858	129	0.048
regulation of cell cycle	GO:0051726	393	0.048
ribonucleoside triphosphate catabolic process	GO:0009203	391	0.048
chromosome separation	GO:0051304	23	0.047
nucleoside phosphate catabolic process	GO:1901292	412	0.047
female gamete generation	GO:0007292	2	0.047
tissue homeostasis	GO:0001894	63	0.046
cellular component disassembly	GO:0022411	92	0.046
neuron development	GO:0048666	113	0.043
regulation of cell cycle phase transition	GO:1901987	126	0.043
chromatin disassembly	GO:0031498	13	0.042
response to reactive oxygen species	GO:0000302	61	0.042
negative regulation of programmed cell death	GO:0043069	321	0.041
nucleotide catabolic process	GO:0009166	408	0.040
cell division	GO:0051301	168	0.040
multicellular organismal aging	GO:0010259	3	0.040
response to drug	GO:0042493	81	0.040
reproductive process	GO:0022414	106	0.039	Mouse
anatomical structure homeostasis	GO:0060249	100	0.039
cellular response to endogenous stimulus	GO:0071495	336	0.038
cellular ketone metabolic process	GO:0042180	80	0.038
neuron projection development	GO:0031175	106	0.038
response to inorganic substance	GO:0010035	127	0.037
chromosome segregation	GO:0007059	114	0.037
ribonucleoside triphosphate metabolic process	GO:0009199	412	0.037
epithelium development	GO:0060429	227	0.036
actin filament based process	GO:0030029	224	0.036
ribonucleoside catabolic process	GO:0042454	406	0.036
positive regulation of cellular amine metabolic process	GO:0033240	7	0.036
reciprocal meiotic recombination	GO:0007131	4	0.036
mitotic sister chromatid segregation	GO:0000070	53	0.035
leukocyte activation	GO:0045321	164	0.034
chromatin mediated maintenance of transcription	GO:0048096	2	0.033
nucleoside monophosphate metabolic process	GO:0009123	191	0.033
macromolecular complex disassembly	GO:0032984	60	0.031
positive regulation of organelle organization	GO:0010638	195	0.031
regulation of cellular response to stress	GO:0080135	244	0.031
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.031
negative regulation of cell cycle phase transition	GO:1901988	89	0.031
regulation of cellular ketone metabolic process	GO:0010565	50	0.031
purine nucleoside monophosphate catabolic process	GO:0009128	158	0.030
response to nitrogen compound	GO:1901698	184	0.029
protein dna complex subunit organization	GO:0071824	80	0.029
regulation of gene expression epigenetic	GO:0040029	73	0.029
dna geometric change	GO:0032392	32	0.029
organophosphate catabolic process	GO:0046434	430	0.029
nucleoside catabolic process	GO:0009164	408	0.028
ras protein signal transduction	GO:0007265	73	0.028
positive regulation of triglyceride metabolic process	GO:0090208	9	0.028
response to organonitrogen compound	GO:0010243	156	0.027
purine ribonucleoside triphosphate metabolic process	GO:0009205	411	0.027
positive regulation of leukocyte activation	GO:0002696	80	0.027
mitotic cell cycle	GO:0000278	326	0.027
protein modification by small protein conjugation	GO:0032446	342	0.026
embryo development	GO:0009790	123	0.026
immune response	GO:0006955	307	0.026
single organism reproductive process	GO:0044702	98	0.025	Mouse
cellular response to nitrogen compound	GO:1901699	144	0.025
regulation of protein kinase activity	GO:0045859	289	0.025
t cell differentiation	GO:0030217	29	0.024
mitotic nuclear division	GO:0007067	119	0.024
protein ubiquitination	GO:0016567	314	0.024
protein oligomerization	GO:0051259	173	0.024
nucleotide excision repair	GO:0006289	31	0.023
dephosphorylation	GO:0016311	209	0.023
mitotic dna integrity checkpoint	GO:0044774	30	0.023
regulation of transferase activity	GO:0051338	355	0.023
organ morphogenesis	GO:0009887	147	0.023
mitotic dna replication checkpoint	GO:0033314	2	0.023
neuroendocrine cell differentiation	GO:0061101	2	0.022
cell development	GO:0048468	328	0.022
protein maturation	GO:0051604	233	0.022
hemopoiesis	GO:0030097	180	0.022
signal transduction by phosphorylation	GO:0023014	297	0.022
purine nucleotide catabolic process	GO:0006195	405	0.022
regulation of cellular amino acid metabolic process	GO:0006521	6	0.021
regulation of growth	GO:0040008	165	0.021
regulation of meiotic cell cycle	GO:0051445	4	0.021
protein catabolic process	GO:0030163	325	0.021
blastocyst development	GO:0001824	3	0.021
nucleosome organization	GO:0034728	66	0.021
mitotic g2 m transition checkpoint	GO:0044818	9	0.021
cellular chemical homeostasis	GO:0055082	180	0.021
ribonucleoside monophosphate catabolic process	GO:0009158	158	0.020
neuromuscular junction development	GO:0007528	3	0.020
reproduction	GO:0000003	63	0.020	Mouse
cell activation	GO:0001775	213	0.020
anatomical structure formation involved in morphogenesis	GO:0048646	284	0.019
positive regulation of programmed cell death	GO:0043068	249	0.019
cellular protein catabolic process	GO:0044257	261	0.018
amine metabolic process	GO:0009308	44	0.018
positive regulation of protein kinase activity	GO:0045860	190	0.017
intracellular protein transport	GO:0006886	270	0.017
rna processing	GO:0006396	255	0.017
negative regulation of organelle organization	GO:0010639	126	0.017
regulation of mitotic cell cycle	GO:0007346	189	0.017
reproductive system development	GO:0061458	56	0.017	Mouse
circulatory system development	GO:0072359	262	0.017
positive regulation of sequence specific dna binding transcription factor activity	GO:0051091	131	0.017
positive regulation of lymphocyte activation	GO:0051251	73	0.017
protein dna complex disassembly	GO:0032986	12	0.017
regulation of multi organism process	GO:0043900	157	0.017
membrane organization	GO:0061024	292	0.017
regulation of cell cycle process	GO:0010564	266	0.017
positive regulation of cell proliferation	GO:0008284	301	0.016
mitotic cell cycle checkpoint	GO:0007093	68	0.016
muscle tissue development	GO:0060537	62	0.016
regulation of nucleotide catabolic process	GO:0030811	205	0.016
response to wounding	GO:0009611	168	0.016
response to hydrogen peroxide	GO:0042542	40	0.016
nucleoside monophosphate catabolic process	GO:0009125	159	0.016
positive regulation of immune system process	GO:0002684	283	0.016
gland development	GO:0048732	48	0.016
striated muscle cell differentiation	GO:0051146	43	0.016
cell type specific apoptotic process	GO:0097285	125	0.016
maintenance of location	GO:0051235	112	0.016
nervous system development	GO:0007399	293	0.016
carbohydrate metabolic process	GO:0005975	207	0.016
regulation of proteolysis	GO:0030162	293	0.015
proteasomal protein catabolic process	GO:0010498	176	0.015
somatic diversification of immunoglobulins involved in immune response	GO:0002208	3	0.015
regulation of establishment of protein localization	GO:0070201	242	0.015
double strand break repair via nonhomologous end joining	GO:0006303	10	0.015
proteolysis involved in cellular protein catabolic process	GO:0051603	244	0.015
long chain fatty acid biosynthetic process	GO:0042759	4	0.015
response to fungus	GO:0009620	4	0.015
peptidyl threonine phosphorylation	GO:0018107	41	0.015
positive regulation of cell activation	GO:0050867	81	0.015
positive regulation of immune response	GO:0050778	159	0.015
regulation of protein maturation	GO:1903317	150	0.015
regulation of hormone secretion	GO:0046883	57	0.015
organelle assembly	GO:0070925	176	0.015
cellular carbohydrate metabolic process	GO:0044262	84	0.015
microtubule cytoskeleton organization	GO:0000226	176	0.015
positive regulation of apoptotic process	GO:0043065	246	0.015
nuclear import	GO:0051170	106	0.015
regulation of lymphocyte activation	GO:0051249	103	0.015
establishment of protein localization to organelle	GO:0072594	172	0.014
cytoplasmic transport	GO:0016482	379	0.014
lymphocyte activation	GO:0046649	133	0.014
intrinsic apoptotic signaling pathway	GO:0097193	127	0.014
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	156	0.014
nucleoside triphosphate metabolic process	GO:0009141	422	0.014
single organism membrane organization	GO:0044802	268	0.014
negative regulation of cell death	GO:0060548	345	0.014
muscle cell differentiation	GO:0042692	63	0.014
calcium ion homeostasis	GO:0055074	122	0.014
t cell differentiation in thymus	GO:0033077	4	0.014
regulation of cell activation	GO:0050865	125	0.014
purine nucleoside monophosphate metabolic process	GO:0009126	186	0.014
ribonucleoside monophosphate metabolic process	GO:0009161	187	0.014
negative regulation of catalytic activity	GO:0043086	335	0.014
response to hypoxia	GO:0001666	96	0.013
resolution of meiotic recombination intermediates	GO:0000712	3	0.013
purine ribonucleoside triphosphate catabolic process	GO:0009207	391	0.013
multicellular organismal homeostasis	GO:0048871	67	0.013
regulation of protein catabolic process	GO:0042176	155	0.013
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	71	0.013
negative regulation of protein processing	GO:0010955	142	0.013
response to abiotic stimulus	GO:0009628	336	0.013
segmentation	GO:0035282	4	0.013
regulation of dna replication	GO:0006275	68	0.013
single organism cellular localization	GO:1902580	332	0.013
hindbrain development	GO:0030902	3	0.013
posttranscriptional regulation of gene expression	GO:0010608	213	0.013
glycosyl compound catabolic process	GO:1901658	413	0.013
protein targeting	GO:0006605	187	0.013
regulation of dna repair	GO:0006282	47	0.013
cell cycle g1 s phase transition	GO:0044843	80	0.012
mitotic sister chromatid separation	GO:0051306	18	0.012
cation homeostasis	GO:0055080	189	0.012
spermatid differentiation	GO:0048515	4	0.012
activation of protein kinase activity	GO:0032147	90	0.012
response to metal ion	GO:0010038	84	0.012
gene conversion	GO:0035822	1	0.012
neural tube closure	GO:0001843	3	0.012
regulation of protein localization	GO:0032880	296	0.012
myosin filament organization	GO:0031033	2	0.012
viral genome replication	GO:0019079	50	0.012
regulation of protein stability	GO:0031647	87	0.012
positive regulation of kinase activity	GO:0033674	204	0.012
regulation of cell development	GO:0060284	161	0.012
nucleoside triphosphate catabolic process	GO:0009143	394	0.011
signal release	GO:0023061	70	0.011
dna biosynthetic process	GO:0071897	40	0.011
regulation of cellular component biogenesis	GO:0044087	281	0.011
regulation of dna dependent dna replication	GO:0090329	19	0.011
actin cytoskeleton organization	GO:0030036	207	0.011
dna duplex unwinding	GO:0032508	30	0.011
cellular response to organonitrogen compound	GO:0071417	124	0.011
negative regulation of transferase activity	GO:0051348	124	0.011
cellular divalent inorganic cation homeostasis	GO:0072503	128	0.011
positive regulation of purine nucleotide metabolic process	GO:1900544	227	0.011
digestive system development	GO:0055123	75	0.011
striated muscle myosin thick filament assembly	GO:0071688	2	0.011
negative regulation of transport	GO:0051051	176	0.011
chromatin remodeling at centromere	GO:0031055	2	0.011
positive regulation of t cell activation	GO:0050870	54	0.011
glycogen catabolic process	GO:0005980	4	0.011
purine nucleoside triphosphate catabolic process	GO:0009146	392	0.011
regulation of centrosome cycle	GO:0046605	15	0.011
regulation of mitotic sister chromatid segregation	GO:0033047	27	0.011
negative regulation of mitotic cell cycle phase transition	GO:1901991	85	0.011
regulation of phosphatase activity	GO:0010921	81	0.011
negative regulation of cellular protein metabolic process	GO:0032269	353	0.011
regulation of t cell activation	GO:0050863	77	0.011
regulation of cell morphogenesis	GO:0022604	153	0.011
cell cycle g2 m phase transition	GO:0044839	43	0.011
maintenance of dna repeat elements	GO:0043570	4	0.011
peptidyl lysine modification	GO:0018205	144	0.011
cellular cation homeostasis	GO:0030003	163	0.010
translesion synthesis	GO:0019985	8	0.010
carbohydrate catabolic process	GO:0016052	36	0.010
cell morphogenesis	GO:0000902	296	0.010
regulation of viral process	GO:0050792	103	0.010
positive regulation of dna metabolic process	GO:0051054	73	0.010
response to ionizing radiation	GO:0010212	65	0.010
reciprocal dna recombination	GO:0035825	4	0.010
regulation of protein processing	GO:0070613	150	0.010
secretion	GO:0046903	254	0.010
muscle structure development	GO:0061061	98	0.010
metencephalon development	GO:0022037	2	0.010

FANCA disease predictions

Disease	DO term ID	Size	Probability
bone marrow disease	DOID:4961	31	1.000
hematopoietic system disease	DOID:74	100	1.000
immune system disease	DOID:2914	155	1.000
anemia	DOID:2355	55	1.000
aplastic anemia	DOID:12449	30	1.000
congenital hypoplastic anemia	DOID:1342	26	1.000
fanconi s anemia	DOID:13636	16	1.000
disease of cellular proliferation	DOID:14566	174	0.815
cancer	DOID:162	167	0.815
organ system cancer	DOID:0050686	164	0.370
breast cancer	DOID:1612	21	0.183
thoracic cancer	DOID:5093	21	0.183
nervous system disease	DOID:863	431	0.042
electroclinical syndrome	DOID:0050701	32	0.042
neonatal period electroclinical syndrome	DOID:0050702	19	0.042
brain disease	DOID:936	73	0.042
epilepsy syndrome	DOID:1826	41	0.042
central nervous system disease	DOID:331	186	0.042
idiopathic generalized epilepsy	DOID:1827	21	0.041
musculoskeletal system disease	DOID:17	223	0.035
connective tissue disease	DOID:65	109	0.035
ohtahara syndrome	DOID:0050709	17	0.019
gastrointestinal system cancer	DOID:3119	52	0.013
reproductive organ cancer	DOID:193	23	0.012
bone disease	DOID:0080001	88	0.012

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