IMP: Integrative Multi-species Prediction

Homo sapiens

15 known processes

FANCG

Fanconi anemia, complementation group G

(Aliases: XRCC9,FAG)

HPRD: 04262
Entrez: 2189
Ensembl: ENSG00000221829
MIM: 602956
HGNC: 3588
UniProtKB: O15287
UniProtKB: Q53XM5

Process Predictions
Disease Predictions

FANCG biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
female gamete generation	GO:0007292	2	0.540
oocyte development	GO:0048599	1	0.486
dna dependent dna replication	GO:0006261	44	0.426
nucleotide excision repair	GO:0006289	31	0.410
cellular response to dna damage stimulus	GO:0006974	379	0.367
meiotic chromosome separation	GO:0051307	3	0.339
meiosis i	GO:0007127	4	0.320
resolution of meiotic recombination intermediates	GO:0000712	3	0.297
dna replication	GO:0006260	116	0.272
male meiosis	GO:0007140	1	0.233
reproductive process	GO:0022414	106	0.183
mitotic cell cycle process	GO:1903047	286	0.180
nuclear division	GO:0000280	128	0.178
oocyte maturation	GO:0001556	1	0.172
dna repair	GO:0006281	198	0.160
protein ubiquitination	GO:0016567	314	0.140
reciprocal dna recombination	GO:0035825	4	0.130
meiotic chromosome segregation	GO:0045132	4	0.127
microtubule based process	GO:0007017	210	0.124
microtubule cytoskeleton organization	GO:0000226	176	0.119
oocyte differentiation	GO:0009994	2	0.119
single organism reproductive process	GO:0044702	98	0.109
oogenesis	GO:0048477	2	0.109
organelle fission	GO:0048285	149	0.107
replication fork processing	GO:0031297	13	0.106
chromosome segregation	GO:0007059	114	0.098
cellular amino acid metabolic process	GO:0006520	116	0.097
regulation of microtubule cytoskeleton organization	GO:0070507	61	0.093
regulation of cellular amino acid metabolic process	GO:0006521	6	0.091
regulation of cellular ketone metabolic process	GO:0010565	50	0.084
determination of adult lifespan	GO:0008340	2	0.082
cell division	GO:0051301	168	0.074
negative regulation of cell cycle	GO:0045786	193	0.071
mitotic cell cycle	GO:0000278	326	0.068
mitotic cell cycle phase transition	GO:0044772	162	0.067
lagging strand elongation	GO:0006273	3	0.058
negative regulation of phosphate metabolic process	GO:0045936	267	0.057
microtubule organizing center organization	GO:0031023	62	0.057
dna conformation change	GO:0071103	113	0.057
purine nucleotide catabolic process	GO:0006195	405	0.054
response to radiation	GO:0009314	151	0.053
negative regulation of cellular protein metabolic process	GO:0032269	353	0.053
ribonucleotide catabolic process	GO:0009261	405	0.053
developmental process involved in reproduction	GO:0003006	66	0.052
multicellular organismal aging	GO:0010259	3	0.049
reciprocal meiotic recombination	GO:0007131	4	0.049
centrosome organization	GO:0051297	58	0.045
double strand break repair via homologous recombination	GO:0000724	50	0.045
regulation of microtubule based process	GO:0032886	74	0.045
regulation of cellular amine metabolic process	GO:0033238	11	0.044
cellular amine metabolic process	GO:0044106	41	0.043
endocytosis	GO:0006897	159	0.042
amine metabolic process	GO:0009308	44	0.040
regulation of dna metabolic process	GO:0051052	153	0.040
epithelium development	GO:0060429	227	0.040
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.039
nucleoside phosphate catabolic process	GO:1901292	412	0.038
base excision repair	GO:0006284	21	0.038
growth	GO:0040007	202	0.037
cell cycle checkpoint	GO:0000075	117	0.035
protein modification by small protein conjugation	GO:0032446	342	0.034
regulation of cell cycle process	GO:0010564	266	0.033
regulation of mitotic cell cycle	GO:0007346	189	0.033
ribonucleoside triphosphate catabolic process	GO:0009203	391	0.033
response to uv	GO:0009411	73	0.032
purine containing compound catabolic process	GO:0072523	411	0.031
sex differentiation	GO:0007548	45	0.029
post embryonic development	GO:0009791	2	0.029
regeneration	GO:0031099	4	0.028
mitotic cell cycle checkpoint	GO:0007093	68	0.028
reproduction	GO:0000003	63	0.028
reproductive system development	GO:0061458	56	0.027
chromatin remodeling	GO:0006338	55	0.027
regulation of cellular response to stress	GO:0080135	244	0.027
purine ribonucleoside monophosphate catabolic process	GO:0009169	158	0.026
chromatin modification	GO:0016568	298	0.026
nucleoside triphosphate catabolic process	GO:0009143	394	0.024
negative regulation of phosphorus metabolic process	GO:0010563	267	0.024
mitotic nuclear division	GO:0007067	119	0.024
regulation of cytoskeleton organization	GO:0051493	177	0.024
negative regulation of organelle organization	GO:0010639	126	0.024
negative regulation of hydrolase activity	GO:0051346	182	0.024
dna dependent dna replication maintenance of fidelity	GO:0045005	14	0.024
regulation of transferase activity	GO:0051338	355	0.023
positive regulation of cellular amine metabolic process	GO:0033240	7	0.023
dna strand elongation involved in dna replication	GO:0006271	3	0.023
ribonucleoside catabolic process	GO:0042454	406	0.023
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	125	0.022
negative regulation of apoptotic process	GO:0043066	316	0.022
genetic imprinting	GO:0071514	1	0.022
macromolecule methylation	GO:0043414	97	0.020
negative regulation of cell cycle process	GO:0010948	121	0.020
organelle assembly	GO:0070925	176	0.020
ribonucleoside monophosphate catabolic process	GO:0009158	158	0.020
negative regulation of phosphorylation	GO:0042326	174	0.019
response to ionizing radiation	GO:0010212	65	0.019
negative regulation of dna metabolic process	GO:0051053	57	0.019
chromatin organization	GO:0006325	351	0.019
g2 dna damage checkpoint	GO:0031572	26	0.019
regulation of nucleotide catabolic process	GO:0030811	205	0.019
peptidyl lysine acetylation	GO:0018394	101	0.019
positive regulation of cellular component organization	GO:0051130	376	0.018
blastocyst development	GO:0001824	3	0.018
negative regulation of programmed cell death	GO:0043069	321	0.018
neuromuscular junction development	GO:0007528	3	0.018
negative regulation of protein modification process	GO:0031400	200	0.017
gonad development	GO:0008406	34	0.017
positive regulation of hydrolase activity	GO:0051345	331	0.017
double strand break repair	GO:0006302	101	0.017
regulation of cellular component biogenesis	GO:0044087	281	0.017
compound eye development	GO:0048749	1	0.017
dephosphorylation	GO:0016311	209	0.017
dna duplex unwinding	GO:0032508	30	0.017
multi organism reproductive process	GO:0044703	54	0.017
response to abiotic stimulus	GO:0009628	336	0.017
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	116	0.017
multicellular organismal reproductive process	GO:0048609	40	0.017
positive regulation of organelle organization	GO:0010638	195	0.017
embryo development	GO:0009790	123	0.017
positive regulation of purine nucleotide metabolic process	GO:1900544	227	0.016
cellular response to abiotic stimulus	GO:0071214	117	0.016
negative regulation of developmental process	GO:0051093	247	0.016
neuron development	GO:0048666	113	0.015
protein processing	GO:0016485	226	0.015
nucleoside monophosphate catabolic process	GO:0009125	159	0.015
stress activated mapk cascade	GO:0051403	93	0.015
cell projection morphogenesis	GO:0048858	129	0.015
nervous system development	GO:0007399	293	0.015
cellular ketone metabolic process	GO:0042180	80	0.015
chemical homeostasis	GO:0048878	306	0.015
glycosyl compound catabolic process	GO:1901658	413	0.015
organonitrogen compound biosynthetic process	GO:1901566	200	0.015
purine nucleoside triphosphate metabolic process	GO:0009144	412	0.014
spermatid development	GO:0007286	4	0.014
purine ribonucleoside triphosphate catabolic process	GO:0009207	391	0.014
positive regulation of nucleoside metabolic process	GO:0045979	186	0.014
negative regulation of catalytic activity	GO:0043086	335	0.014
secretion by cell	GO:0032940	226	0.014
response to inorganic substance	GO:0010035	127	0.014
regulation of dna replication	GO:0006275	68	0.014
single organism membrane organization	GO:0044802	268	0.014
negative regulation of cell death	GO:0060548	345	0.014
nucleotide catabolic process	GO:0009166	408	0.014
regulation of chromosome organization	GO:0033044	103	0.014
sexual reproduction	GO:0019953	37	0.013
purine nucleoside triphosphate catabolic process	GO:0009146	392	0.013
positive regulation of protein modification by small protein conjugation or removal	GO:1903322	61	0.013
dna geometric change	GO:0032392	32	0.013
anatomical structure formation involved in morphogenesis	GO:0048646	284	0.013
regulation of immune effector process	GO:0002697	91	0.013
positive regulation of mitotic cell cycle	GO:0045931	60	0.013
hemopoiesis	GO:0030097	180	0.013
cell morphogenesis	GO:0000902	296	0.013
gland development	GO:0048732	48	0.013
covalent chromatin modification	GO:0016569	254	0.012
positive regulation of apoptotic process	GO:0043065	246	0.012
cell development	GO:0048468	328	0.012
membrane organization	GO:0061024	292	0.012
methylation	GO:0032259	106	0.012
vesicle mediated transport	GO:0016192	371	0.012
brain development	GO:0007420	97	0.012
atp catabolic process	GO:0006200	157	0.012
peptidyl lysine modification	GO:0018205	144	0.011
meiotic nuclear division	GO:0007126	10	0.011
multicellular organism reproduction	GO:0032504	42	0.011
actin filament based process	GO:0030029	224	0.011
protein acylation	GO:0043543	138	0.011
purine nucleoside catabolic process	GO:0006152	398	0.011
cellular amide metabolic process	GO:0043603	69	0.011
positive regulation of dna replication	GO:0045740	35	0.011
dna biosynthetic process	GO:0071897	40	0.011
reproductive structure development	GO:0048608	55	0.011
cilium organization	GO:0044782	68	0.011
signal transduction in response to dna damage	GO:0042770	57	0.011
negative regulation of protein phosphorylation	GO:0001933	140	0.011
cellular macromolecule catabolic process	GO:0044265	380	0.011
double strand break repair via nonhomologous end joining	GO:0006303	10	0.011
protein localization to nucleus	GO:0034504	136	0.011
regulation of proteolysis	GO:0030162	293	0.011
intracellular protein transport	GO:0006886	270	0.011
regulation of mitotic recombination	GO:0000019	1	0.011
nucleoside triphosphate metabolic process	GO:0009141	422	0.011
regulation of response to dna damage stimulus	GO:2001020	94	0.011
purine nucleoside monophosphate catabolic process	GO:0009128	158	0.011
positive regulation of gtp catabolic process	GO:0033126	166	0.011
neurogenesis	GO:0022008	169	0.011
nucleoside catabolic process	GO:0009164	408	0.010
male sex differentiation	GO:0046661	25	0.010
rna processing	GO:0006396	255	0.010
regulation of cell adhesion	GO:0030155	166	0.010
negative regulation of proteolysis	GO:0045861	132	0.010
regulation of protein localization	GO:0032880	296	0.010
respiratory gaseous exchange	GO:0007585	3	0.010
positive regulation of programmed cell death	GO:0043068	249	0.010

FANCG disease predictions

Disease	DO term ID	Size	Probability
anemia	DOID:2355	55	1.000
bone marrow disease	DOID:4961	31	1.000
hematopoietic system disease	DOID:74	100	1.000
aplastic anemia	DOID:12449	30	1.000
immune system disease	DOID:2914	155	1.000
congenital hypoplastic anemia	DOID:1342	26	1.000
fanconi s anemia	DOID:13636	16	1.000
disease of cellular proliferation	DOID:14566	174	0.328
cancer	DOID:162	167	0.328
central nervous system disease	DOID:331	186	0.174
nervous system disease	DOID:863	431	0.174
neonatal period electroclinical syndrome	DOID:0050702	19	0.174
brain disease	DOID:936	73	0.174
electroclinical syndrome	DOID:0050701	32	0.174
epilepsy syndrome	DOID:1826	41	0.174
organ system cancer	DOID:0050686	164	0.081
urinary system cancer	DOID:3996	15	0.017
kidney cancer	DOID:263	11	0.017
gastrointestinal system cancer	DOID:3119	52	0.012

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