IMP: Integrative Multi-species Prediction

Homo sapiens

362 known processes

GNB2L1

guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1

(Aliases: H12.3,Gnb2-rs1,HLC-7,PIG21,RACK1)

HGNC: 4399
Ensembl: ENSG00000204628
HPRD: 01503
Entrez: 10399
MIM: 176981
UniProtKB: P63244
UniProtKB: E9KL35

Process Predictions
Disease Predictions

GNB2L1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
translation	GO:0006412	132	0.988	Yeast Rat
post embryonic development	GO:0009791	2	0.986	Worm
multicellular organismal aging	GO:0010259	3	0.690
mitotic spindle elongation	GO:0000022	4	0.661
determination of adult lifespan	GO:0008340	2	0.627
rna processing	GO:0006396	255	0.614
ribonucleoprotein complex biogenesis	GO:0022613	116	0.494
positive regulation of apoptotic process	GO:0043065	246	0.439
positive regulation of programmed cell death	GO:0043068	249	0.384
embryo development	GO:0009790	123	0.337	Zebrafish Worm
posttranscriptional regulation of gene expression	GO:0010608	213	0.310	Yeast Rat
vesicle mediated transport	GO:0016192	371	0.308
oogenesis	GO:0048477	2	0.292	Fly
embryo development ending in birth or egg hatching	GO:0009792	34	0.264	Worm
positive regulation of cell death	GO:0010942	263	0.237
negative regulation of cell death	GO:0060548	345	0.199
positive regulation of translation	GO:0045727	35	0.194
regulation of translation	GO:0006417	89	0.191	Yeast Rat
aging	GO:0007568	66	0.178
nitrogen compound transport	GO:0071705	191	0.170
negative regulation of programmed cell death	GO:0043069	321	0.166
nuclear division	GO:0000280	128	0.161	Worm
nucleoside catabolic process	GO:0009164	408	0.140
negative regulation of apoptotic process	GO:0043066	316	0.121
microtubule anchoring at microtubule organizing center	GO:0072393	1	0.120
ribonucleoprotein complex assembly	GO:0022618	78	0.120
immune system development	GO:0002520	195	0.119
tube development	GO:0035295	125	0.117	Zebrafish
female gamete generation	GO:0007292	2	0.110	Fly
mitotic cell cycle	GO:0000278	326	0.110	Worm
apoptotic signaling pathway	GO:0097190	268	0.108
regulation of apoptotic signaling pathway	GO:2001233	175	0.108
ribosome biogenesis	GO:0042254	48	0.106
tube morphogenesis	GO:0035239	95	0.103	Zebrafish
organophosphate catabolic process	GO:0046434	430	0.100
ribonucleotide catabolic process	GO:0009261	405	0.093
cellular response to cytokine stimulus	GO:0071345	181	0.093
heme metabolic process	GO:0042168	8	0.093
regulation of cell division	GO:0051302	116	0.092	Zebrafish
reproduction	GO:0000003	63	0.089	Worm Fly
nucleoside triphosphate catabolic process	GO:0009143	394	0.088
membrane organization	GO:0061024	292	0.079	Rat
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.078
regulation of purine nucleotide metabolic process	GO:1900542	264	0.078
ribonucleoside triphosphate metabolic process	GO:0009199	412	0.077
purine ribonucleoside triphosphate metabolic process	GO:0009205	411	0.075
response to cytokine	GO:0034097	232	0.074
organelle assembly	GO:0070925	176	0.072
actin filament based process	GO:0030029	224	0.068
reproductive structure development	GO:0048608	55	0.066	Worm
purine ribonucleoside triphosphate catabolic process	GO:0009207	391	0.065
nucleic acid phosphodiester bond hydrolysis	GO:0090305	102	0.063
guanosine containing compound metabolic process	GO:1901068	244	0.059
rna splicing	GO:0008380	131	0.059
positive regulation of cell proliferation	GO:0008284	301	0.056
mitotic nuclear division	GO:0007067	119	0.055
gtp catabolic process	GO:0006184	237	0.055
digestive system development	GO:0055123	75	0.055	Zebrafish
purine ribonucleoside catabolic process	GO:0046130	398	0.053
regulation of cell cycle process	GO:0010564	266	0.051
spindle elongation	GO:0051231	4	0.048
regulation of translational elongation	GO:0006448	2	0.048
regulation of cellular component biogenesis	GO:0044087	281	0.047
negative regulation of intracellular transport	GO:0032387	60	0.043
purine nucleoside triphosphate metabolic process	GO:0009144	412	0.040
receptor mediated endocytosis	GO:0006898	84	0.040
neuromuscular junction development	GO:0007528	3	0.039
translational initiation	GO:0006413	48	0.039
purine containing compound catabolic process	GO:0072523	411	0.038
guanosine containing compound catabolic process	GO:1901069	239	0.038
organelle localization	GO:0051640	84	0.037
microtubule cytoskeleton organization	GO:0000226	176	0.036
regulation of transferase activity	GO:0051338	355	0.036
mitotic cell cycle process	GO:1903047	286	0.035	Worm
maintenance of location	GO:0051235	112	0.035
negative regulation of transport	GO:0051051	176	0.034
sex differentiation	GO:0007548	45	0.034	Worm
oxidation reduction process	GO:0055114	396	0.034	Fly
reproductive process	GO:0022414	106	0.033	Worm Fly
cell morphogenesis	GO:0000902	296	0.033	Worm
regulation of nucleotide metabolic process	GO:0006140	269	0.032
nucleoside phosphate catabolic process	GO:1901292	412	0.032
nucleoside triphosphate metabolic process	GO:0009141	422	0.031
organelle fission	GO:0048285	149	0.031	Worm
hematopoietic or lymphoid organ development	GO:0048534	186	0.031
gtp metabolic process	GO:0046039	239	0.030
endocytosis	GO:0006897	159	0.030
neuron apoptotic process	GO:0051402	39	0.030
generation of neurons	GO:0048699	152	0.029	Worm
gonad development	GO:0008406	34	0.029	Worm
vasculature development	GO:0001944	181	0.029	Zebrafish
thymocyte apoptotic process	GO:0070242	2	0.028
regulation of oxidative stress induced neuron death	GO:1903203	9	0.028
iron coordination entity transport	GO:1901678	4	0.028
cell projection organization	GO:0030030	252	0.028	Worm
cellular amino acid metabolic process	GO:0006520	116	0.027
regulation of neuron apoptotic process	GO:0043523	35	0.027
cofactor transport	GO:0051181	11	0.027
developmental process involved in reproduction	GO:0003006	66	0.026	Worm Fly
cellular homeostasis	GO:0019725	196	0.025	Yeast Fly
cell development	GO:0048468	328	0.025	Worm Fly
regulation of nucleoside metabolic process	GO:0009118	209	0.025
nervous system development	GO:0007399	293	0.025	Worm
negative regulation of phosphorylation	GO:0042326	174	0.025
cellular response to dna damage stimulus	GO:0006974	379	0.025
anion transport	GO:0006820	161	0.025
multicellular organism reproduction	GO:0032504	42	0.025	Worm Fly
chemical homeostasis	GO:0048878	306	0.023
organonitrogen compound biosynthetic process	GO:1901566	200	0.023
defense response	GO:0006952	315	0.023
regulation of protein serine threonine kinase activity	GO:0071900	179	0.023
ribonucleoprotein complex subunit organization	GO:0071826	81	0.022
negative regulation of phosphorus metabolic process	GO:0010563	267	0.022
actin filament organization	GO:0007015	128	0.022
microtubule based process	GO:0007017	210	0.022
negative regulation of neuron apoptotic process	GO:0043524	23	0.022
regulation of mapk cascade	GO:0043408	262	0.022
t cell apoptotic process	GO:0070231	12	0.021
atp transport	GO:0015867	4	0.021
leukocyte activation	GO:0045321	164	0.021
regulation of cell cycle	GO:0051726	393	0.021
gastrulation	GO:0007369	51	0.021	Zebrafish
regulation of intracellular transport	GO:0032386	195	0.021
central nervous system development	GO:0007417	123	0.021
heme transport	GO:0015886	4	0.020
immune effector process	GO:0002252	159	0.020
rna splicing via transesterification reactions with bulged adenosine as nucleophile	GO:0000377	89	0.020
purine nucleoside catabolic process	GO:0006152	398	0.020
gamete generation	GO:0007276	25	0.020	Fly
regulation of cellular response to stress	GO:0080135	244	0.020
mrna metabolic process	GO:0016071	175	0.020
positive regulation of cellular component organization	GO:0051130	376	0.019
cell type specific apoptotic process	GO:0097285	125	0.019
negative regulation of apoptotic signaling pathway	GO:2001234	97	0.019
regulation of growth	GO:0040008	165	0.019
morphogenesis of an epithelium	GO:0002009	60	0.019	Zebrafish
hemopoiesis	GO:0030097	180	0.019
signal transduction by phosphorylation	GO:0023014	297	0.018
transmembrane transport	GO:0055085	399	0.018	Mouse
neuron death	GO:0070997	65	0.018
multicellular organismal reproductive process	GO:0048609	40	0.018	Worm Fly
negative regulation of cellular component organization	GO:0051129	235	0.017
regulation of purine nucleotide catabolic process	GO:0033121	205	0.017
neurogenesis	GO:0022008	169	0.017	Worm
regulation of kinase activity	GO:0043549	314	0.017
cytoplasmic translation	GO:0002181	8	0.017
nuclear transcribed mrna catabolic process	GO:0000956	48	0.017
spindle organization	GO:0007051	53	0.017
anatomical structure formation involved in morphogenesis	GO:0048646	284	0.017	Zebrafish
positive regulation of cellular amine metabolic process	GO:0033240	7	0.017
lymphocyte activation	GO:0046649	133	0.017
head development	GO:0060322	108	0.017
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	GO:1901029	4	0.017
lymphocyte proliferation	GO:0046651	70	0.016
negative regulation of intracellular signal transduction	GO:1902532	183	0.016
neuron development	GO:0048666	113	0.016	Worm
ncrna metabolic process	GO:0034660	108	0.016
purine nucleoside triphosphate catabolic process	GO:0009146	392	0.015
mrna splicing via spliceosome	GO:0000398	89	0.015
t cell homeostasis	GO:0043029	3	0.015
cofactor metabolic process	GO:0051186	87	0.015
reproductive system development	GO:0061458	56	0.015	Worm
glycosyl compound catabolic process	GO:1901658	413	0.015
behavior	GO:0007610	112	0.015	Worm Fly
development of primary sexual characteristics	GO:0045137	35	0.014	Worm
cellular macromolecule catabolic process	GO:0044265	380	0.014
epithelial cell differentiation	GO:0030855	141	0.014
positive regulation of organelle organization	GO:0010638	195	0.014
nucleic acid transport	GO:0050657	39	0.014
rrna processing	GO:0006364	35	0.014
rrna metabolic process	GO:0016072	40	0.014
purine ribonucleoside metabolic process	GO:0046128	437	0.014
enzyme linked receptor protein signaling pathway	GO:0007167	303	0.013
single organism membrane organization	GO:0044802	268	0.013	Rat
regulation of mitochondrion organization	GO:0010821	54	0.013
response to virus	GO:0009615	126	0.013
negative regulation of protein metabolic process	GO:0051248	391	0.013
ribonucleoside triphosphate catabolic process	GO:0009203	391	0.013
regeneration	GO:0031099	4	0.012
ribosomal subunit export from nucleus	GO:0000054	4	0.012
chemotaxis	GO:0006935	157	0.012	Worm
midbrain development	GO:0030901	45	0.012
carbohydrate derivative transport	GO:1901264	20	0.012
purine nucleotide catabolic process	GO:0006195	405	0.012
cellular cation homeostasis	GO:0030003	163	0.012
sexual reproduction	GO:0019953	37	0.012	Fly
regulation of meiosis	GO:0040020	3	0.011
immune response	GO:0006955	307	0.011
i kappab kinase nf kappab signaling	GO:0007249	166	0.011
response to wounding	GO:0009611	168	0.011
actin filament based movement	GO:0030048	17	0.011
positive regulation of i kappab kinase nf kappab signaling	GO:0043123	132	0.011
nucleotide catabolic process	GO:0009166	408	0.011
rna localization	GO:0006403	41	0.011
centrosome duplication	GO:0051298	28	0.011
purine ribonucleotide catabolic process	GO:0009154	404	0.011
necrotic cell death	GO:0070265	21	0.010
pigment biosynthetic process	GO:0046148	10	0.010
myeloid cell differentiation	GO:0030099	117	0.010
actin cytoskeleton organization	GO:0030036	207	0.010
regulation of neuron death	GO:1901214	56	0.010

GNB2L1 disease predictions

Disease	DO term ID	Size	Probability
eye and adnexa disease	DOID:1492	150	0.021
nervous system disease	DOID:863	431	0.021
sensory system disease	DOID:0050155	203	0.021
cancer	DOID:162	167	0.012
kidney cancer	DOID:263	11	0.012
renal carcinoma	DOID:4451	8	0.012
urinary system cancer	DOID:3996	15	0.012
renal cell carcinoma	DOID:4450	8	0.012
nonpapillary renal cell carcinoma	DOID:0050387	6	0.012
hereditary renal cell carcinoma	DOID:4455	6	0.012
disease of cellular proliferation	DOID:14566	174	0.012
organ system cancer	DOID:0050686	164	0.012

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