IMP: Integrative Multi-species Prediction

Homo sapiens

55 known processes

GOT2

glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)

(Aliases: KATIV,mitAAT,KAT4,FLJ40994)

HPRD: 00684
HGNC: 4433
Ensembl: ENSG00000125166
Entrez: 2806
MIM: 138150
UniProtKB: P00505

Process Predictions
Disease Predictions

GOT2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
oxidation reduction process	GO:0055114	396	0.626
aspartate metabolic process	GO:0006531	4	0.544
glycerol metabolic process	GO:0006071	4	0.538
alditol metabolic process	GO:0019400	5	0.414
citrate metabolic process	GO:0006101	2	0.387
generation of precursor metabolites and energy	GO:0006091	68	0.306
dicarboxylic acid biosynthetic process	GO:0043650	4	0.293	Fly
carbohydrate metabolic process	GO:0005975	207	0.291
glutamate metabolic process	GO:0006536	10	0.274	Fly
purine nucleoside monophosphate metabolic process	GO:0009126	186	0.221
aspartate family amino acid catabolic process	GO:0009068	5	0.211
cofactor metabolic process	GO:0051186	87	0.189
cellular respiration	GO:0045333	21	0.188
protein processing	GO:0016485	226	0.188
cofactor biosynthetic process	GO:0051188	31	0.176
tricarboxylic acid cycle	GO:0006099	4	0.167
regulation of proteolysis	GO:0030162	293	0.166
post embryonic development	GO:0009791	2	0.148
single organism carbohydrate metabolic process	GO:0044723	193	0.133
regulation of peptidase activity	GO:0052547	180	0.132
polyol metabolic process	GO:0019751	32	0.124
ribonucleoside monophosphate catabolic process	GO:0009158	158	0.124
vesicle mediated transport	GO:0016192	371	0.109
activation of cysteine type endopeptidase activity involved in apoptotic process	GO:0006919	49	0.100
alcohol metabolic process	GO:0006066	114	0.100
coenzyme metabolic process	GO:0006732	65	0.098
nucleotide biosynthetic process	GO:0009165	109	0.090
cellular carbohydrate metabolic process	GO:0044262	84	0.085
purine ribonucleotide biosynthetic process	GO:0009152	79	0.081
determination of adult lifespan	GO:0008340	2	0.080
nucleocytoplasmic transport	GO:0006913	176	0.077
endocytosis	GO:0006897	159	0.075
cation transport	GO:0006812	331	0.074
cytoplasmic transport	GO:0016482	379	0.067
organic hydroxy compound metabolic process	GO:1901615	147	0.067
regulation of endopeptidase activity	GO:0052548	170	0.065
cation transmembrane transport	GO:0098655	238	0.065
inorganic ion transmembrane transport	GO:0098660	231	0.064
cell cell signaling	GO:0007267	155	0.064	Fly
cellular amino acid metabolic process	GO:0006520	116	0.064
dicarboxylic acid metabolic process	GO:0043648	29	0.063
anatomical structure formation involved in morphogenesis	GO:0048646	284	0.063
tricarboxylic acid metabolic process	GO:0072350	4	0.059
protein maturation	GO:0051604	233	0.059
inorganic cation transmembrane transport	GO:0098662	194	0.059
embryo development	GO:0009790	123	0.058
alpha amino acid metabolic process	GO:1901605	72	0.057
ribose phosphate biosynthetic process	GO:0046390	82	0.055
epithelium development	GO:0060429	227	0.055
carboxylic acid catabolic process	GO:0046395	71	0.055
purine ribonucleoside metabolic process	GO:0046128	437	0.055
fatty acid metabolic process	GO:0006631	115	0.054
dicarboxylic acid catabolic process	GO:0043649	9	0.054
positive regulation of peptidase activity	GO:0010952	88	0.053
nucleoside triphosphate metabolic process	GO:0009141	422	0.051
monocarboxylic acid metabolic process	GO:0032787	185	0.050
response to abiotic stimulus	GO:0009628	336	0.050
cellular amino acid biosynthetic process	GO:0008652	30	0.050	Fly
activation of cysteine type endopeptidase activity	GO:0097202	57	0.049
protein localization to organelle	GO:0033365	280	0.049
carbohydrate derivative biosynthetic process	GO:1901137	207	0.048
multicellular organismal aging	GO:0010259	3	0.047
ribonucleoside triphosphate metabolic process	GO:0009199	412	0.047
glycosyl compound biosynthetic process	GO:1901659	27	0.046
regulation of feeding behavior	GO:0060259	3	0.045
energy derivation by oxidation of organic compounds	GO:0015980	43	0.044
atp metabolic process	GO:0046034	176	0.043
growth	GO:0040007	202	0.043
ion transmembrane transport	GO:0034220	338	0.043
positive regulation of cysteine type endopeptidase activity	GO:2001056	79	0.043
protein targeting	GO:0006605	187	0.042
spermatid development	GO:0007286	4	0.041
positive regulation of developmental process	GO:0051094	314	0.041
positive regulation of proteolysis	GO:0045862	142	0.041
ribonucleotide biosynthetic process	GO:0009260	81	0.040
zymogen activation	GO:0031638	70	0.040
positive regulation of hydrolase activity	GO:0051345	331	0.040
single organism cellular localization	GO:1902580	332	0.039
coenzyme biosynthetic process	GO:0009108	24	0.039
actin filament based process	GO:0030029	224	0.039
dna catabolic process	GO:0006308	49	0.039
cellular protein complex assembly	GO:0043623	188	0.038
purine nucleoside triphosphate metabolic process	GO:0009144	412	0.038
system process	GO:0003008	349	0.038
spermatid differentiation	GO:0048515	4	0.037
intracellular protein transport	GO:0006886	270	0.036
positive regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043280	69	0.034
purine ribonucleoside triphosphate metabolic process	GO:0009205	411	0.033
cellular component morphogenesis	GO:0032989	314	0.032
translation	GO:0006412	132	0.032
maintenance of location	GO:0051235	112	0.031
neurological system process	GO:0050877	163	0.031
cell development	GO:0048468	328	0.031
actin cytoskeleton organization	GO:0030036	207	0.031
ribonucleoside monophosphate metabolic process	GO:0009161	187	0.030
small molecule catabolic process	GO:0044282	92	0.030
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	116	0.029
ion homeostasis	GO:0050801	230	0.029
establishment of protein localization to organelle	GO:0072594	172	0.029
carboxylic acid biosynthetic process	GO:0046394	97	0.028	Fly
oogenesis	GO:0048477	2	0.028
monovalent inorganic cation transport	GO:0015672	128	0.028
regulation of nucleotide metabolic process	GO:0006140	269	0.027
organic acid biosynthetic process	GO:0016053	97	0.027	Fly
biological adhesion	GO:0022610	331	0.027
receptor mediated endocytosis	GO:0006898	84	0.027
regulation of cellular amine metabolic process	GO:0033238	11	0.027
secretion by cell	GO:0032940	226	0.027
organonitrogen compound biosynthetic process	GO:1901566	200	0.026	Fly
adult locomotory behavior	GO:0008344	1	0.025
regulation of generation of precursor metabolites and energy	GO:0043467	27	0.025
cellular macromolecular complex assembly	GO:0034622	324	0.025
endoplasmic reticulum unfolded protein response	GO:0030968	16	0.025
cellular macromolecule catabolic process	GO:0044265	380	0.025
locomotory behavior	GO:0007626	1	0.025
nucleoside monophosphate catabolic process	GO:0009125	159	0.025
purine ribonucleoside monophosphate metabolic process	GO:0009167	186	0.024
myosin filament assembly	GO:0031034	2	0.023
female gamete generation	GO:0007292	2	0.023
cellular ion homeostasis	GO:0006873	168	0.023
regulation of cysteine type endopeptidase activity	GO:2000116	127	0.022
oxidoreduction coenzyme metabolic process	GO:0006733	19	0.022
glutamine family amino acid metabolic process	GO:0009064	17	0.021	Fly
sulfur compound metabolic process	GO:0006790	101	0.021
regulation of transferase activity	GO:0051338	355	0.021
organic hydroxy compound biosynthetic process	GO:1901617	71	0.021
small molecule biosynthetic process	GO:0044283	157	0.021	Fly
epithelial cell differentiation	GO:0030855	141	0.020
response to hormone	GO:0009725	175	0.020
regulation of ion transport	GO:0043269	189	0.020
intracellular receptor signaling pathway	GO:0030522	104	0.020
positive regulation of apoptotic process	GO:0043065	246	0.020
striated muscle myosin thick filament assembly	GO:0071688	2	0.020
purine nucleoside triphosphate catabolic process	GO:0009146	392	0.020
chemical homeostasis	GO:0048878	306	0.020
organelle assembly	GO:0070925	176	0.019
positive regulation of organelle organization	GO:0010638	195	0.019
tissue homeostasis	GO:0001894	63	0.019
behavior	GO:0007610	112	0.019
response to peptide	GO:1901652	65	0.019
mitochondrial membrane organization	GO:0007006	40	0.018
lipid homeostasis	GO:0055088	39	0.018
nuclear transport	GO:0051169	179	0.018
nucleoside monophosphate metabolic process	GO:0009123	191	0.018
cell adhesion	GO:0007155	325	0.018
protein tetramerization	GO:0051262	47	0.018
neuron differentiation	GO:0030182	138	0.018
negative regulation of proteolysis	GO:0045861	132	0.018
myosin filament organization	GO:0031033	2	0.017
nucleoside triphosphate biosynthetic process	GO:0009142	20	0.017
protein autoprocessing	GO:0016540	4	0.017
positive regulation of cellular component organization	GO:0051130	376	0.017
regulation of developmental growth	GO:0048638	30	0.017
detection of stimulus	GO:0051606	85	0.017
positive regulation of cell death	GO:0010942	263	0.017
microtubule based process	GO:0007017	210	0.017
phototransduction	GO:0007602	3	0.017
muscle cell differentiation	GO:0042692	63	0.017
ribonucleotide catabolic process	GO:0009261	405	0.017
cell projection organization	GO:0030030	252	0.017
2 oxoglutarate metabolic process	GO:0006103	4	0.016
cellular ketone metabolic process	GO:0042180	80	0.016
dephosphorylation	GO:0016311	209	0.016
amino acid activation	GO:0043038	12	0.016
regulation of cellular amino acid metabolic process	GO:0006521	6	0.016
cellular component disassembly	GO:0022411	92	0.016
protein homooligomerization	GO:0051260	100	0.016
regulation of behavior	GO:0050795	82	0.016
alcohol biosynthetic process	GO:0046165	52	0.016
hydrogen transport	GO:0006818	23	0.016
single organism membrane organization	GO:0044802	268	0.016
ventral spinal cord development	GO:0021517	1	0.015
negative regulation of multicellular organismal process	GO:0051241	317	0.015
negative regulation of protein modification process	GO:0031400	200	0.015
regulation of mitochondrial membrane permeability involved in apoptotic process	GO:1902108	18	0.015
reproductive structure development	GO:0048608	55	0.015
nucleoside triphosphate catabolic process	GO:0009143	394	0.015
regulation of membrane potential	GO:0042391	95	0.015
positive regulation of purine nucleotide metabolic process	GO:1900544	227	0.015
ribonucleoside biosynthetic process	GO:0042455	25	0.015
generation of neurons	GO:0048699	152	0.015
secretion	GO:0046903	254	0.015
metal ion transport	GO:0030001	272	0.015
cellular amine metabolic process	GO:0044106	41	0.015
regulation of nucleoside metabolic process	GO:0009118	209	0.015
nadh metabolic process	GO:0006734	1	0.015
transmembrane transport	GO:0055085	399	0.015
neuromuscular junction development	GO:0007528	3	0.015
reproduction	GO:0000003	63	0.015	Worm
cellular component assembly involved in morphogenesis	GO:0010927	73	0.015
embryo development ending in birth or egg hatching	GO:0009792	34	0.015
anion transport	GO:0006820	161	0.015
positive regulation of growth	GO:0045927	58	0.015
microtubule cytoskeleton organization	GO:0000226	176	0.014
protein homotetramerization	GO:0051289	28	0.014
cellular cation homeostasis	GO:0030003	163	0.014
response to nitrogen compound	GO:1901698	184	0.014
regulation of growth	GO:0040008	165	0.014
negative regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043154	46	0.014
response to other organism	GO:0051707	261	0.014
regulation of purine nucleotide metabolic process	GO:1900542	264	0.014
positive regulation of endopeptidase activity	GO:0010950	84	0.014
purine nucleotide catabolic process	GO:0006195	405	0.014
multi organism cellular process	GO:0044764	156	0.013
sodium ion transmembrane transport	GO:0035725	59	0.013
nucleoside biosynthetic process	GO:0009163	26	0.013
cellular lipid metabolic process	GO:0044255	303	0.013
cellular chemical homeostasis	GO:0055082	180	0.013
organophosphate biosynthetic process	GO:0090407	163	0.013
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.013
amine metabolic process	GO:0009308	44	0.013
nucleotide catabolic process	GO:0009166	408	0.013
regulation of kinase activity	GO:0043549	314	0.013
single organism nuclear import	GO:1902593	104	0.013
purine ribonucleoside biosynthetic process	GO:0046129	23	0.013
apoptotic nuclear changes	GO:0030262	13	0.013
coenzyme a metabolic process	GO:0015936	6	0.012
muscle structure development	GO:0061061	98	0.012
purine nucleoside catabolic process	GO:0006152	398	0.012
spinal cord development	GO:0021510	4	0.012
positive regulation of nucleoside metabolic process	GO:0045979	186	0.012
mitochondrion organization	GO:0007005	156	0.012
immune response	GO:0006955	307	0.012
purine nucleotide biosynthetic process	GO:0006164	84	0.012
regulation of oxidative phosphorylation	GO:0002082	3	0.012
defense response	GO:0006952	315	0.012
negative regulation of phosphorylation	GO:0042326	174	0.012
nucleoside catabolic process	GO:0009164	408	0.012
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	125	0.012
organophosphate catabolic process	GO:0046434	430	0.012
response to oxidative stress	GO:0006979	121	0.012
positive regulation of programmed cell death	GO:0043068	249	0.012
negative regulation of transferase activity	GO:0051348	124	0.012
negative regulation of catalytic activity	GO:0043086	335	0.011
single organism reproductive process	GO:0044702	98	0.011
nucleoside phosphate biosynthetic process	GO:1901293	109	0.011
mitochondrial atp synthesis coupled electron transport	GO:0042775	4	0.011
reproductive process	GO:0022414	106	0.011
negative regulation of intracellular signal transduction	GO:1902532	183	0.011
negative regulation of cellular component organization	GO:0051129	235	0.011
negative regulation of cell proliferation	GO:0008285	228	0.011
regulation of cytoskeleton organization	GO:0051493	177	0.011
ribonucleoside bisphosphate metabolic process	GO:0033875	7	0.011
negative regulation of cellular protein metabolic process	GO:0032269	353	0.011
muscle cell development	GO:0055001	29	0.011
response to oxygen containing compound	GO:1901700	369	0.011
negative regulation of programmed cell death	GO:0043069	321	0.011
response to hypoxia	GO:0001666	96	0.011
ribonucleoside triphosphate catabolic process	GO:0009203	391	0.011
cilium morphogenesis	GO:0060271	75	0.010
response to peptide hormone	GO:0043434	61	0.010
purine containing compound catabolic process	GO:0072523	411	0.010
regulation of neural precursor cell proliferation	GO:2000177	4	0.010
regulation of hormone levels	GO:0010817	125	0.010
actomyosin structure organization	GO:0031032	59	0.010
neuroblast proliferation	GO:0007405	4	0.010
negative regulation of phosphate metabolic process	GO:0045936	267	0.010
nucleobase containing compound transport	GO:0015931	51	0.010
nervous system development	GO:0007399	293	0.010	Fly
reproductive system development	GO:0061458	56	0.010
protein acylation	GO:0043543	138	0.010
negative regulation of cysteine type endopeptidase activity	GO:2000117	48	0.010

GOT2 disease predictions

Disease	DO term ID	Size	Probability
inherited metabolic disorder	DOID:655	242	0.787
disease of metabolism	DOID:0014667	295	0.787
carbohydrate metabolic disorder	DOID:2978	55	0.257
amino acid metabolic disorder	DOID:9252	50	0.074
sensory system disease	DOID:0050155	203	0.069
nervous system disease	DOID:863	431	0.069
eye and adnexa disease	DOID:1492	150	0.069
central nervous system disease	DOID:331	186	0.056
neurodegenerative disease	DOID:1289	102	0.053
immune system disease	DOID:2914	155	0.052
hematopoietic system disease	DOID:74	100	0.019
neuropathy	DOID:870	52	0.017
neuromuscular disease	DOID:440	38	0.017
retinal disease	DOID:5679	118	0.016
retinal degeneration	DOID:8466	89	0.016
eye disease	DOID:5614	149	0.016
retinitis pigmentosa	DOID:10584	51	0.015
disease of cellular proliferation	DOID:14566	174	0.015
cancer	DOID:162	167	0.015
organ system cancer	DOID:0050686	164	0.015

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