IMP: Integrative Multi-species Prediction

Homo sapiens

5 known processes

HADH

hydroxyacyl-CoA dehydrogenase

(Aliases: SCHAD,HAD,HADHSC,HHF4,HCDH,MSCHAD,HADH1,MGC8392)

Entrez: 3033
Ensembl: ENSG00000138796
MIM: 601609
HGNC: 4799
UniProtKB: E9PF18
UniProtKB: Q16836

Process Predictions
Disease Predictions

HADH biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
oxidation reduction process	GO:0055114	396	1.000	Mouse Rat
small molecule catabolic process	GO:0044282	92	0.999	Rat
organic acid catabolic process	GO:0016054	71	0.995	Rat
carboxylic acid catabolic process	GO:0046395	71	0.993	Rat
lipid catabolic process	GO:0016042	84	0.992	Rat
monocarboxylic acid catabolic process	GO:0072329	37	0.979	Rat
lipid oxidation	GO:0034440	33	0.978	Rat
cellular amino acid catabolic process	GO:0009063	31	0.908
fatty acid metabolic process	GO:0006631	115	0.894	Rat
cellular lipid catabolic process	GO:0044242	65	0.887	Rat
lipid metabolic process	GO:0006629	381	0.846	Rat
monocarboxylic acid metabolic process	GO:0032787	185	0.846	Rat
lipid modification	GO:0030258	84	0.833	Rat
fatty acid oxidation	GO:0019395	31	0.826	Rat
cofactor metabolic process	GO:0051186	87	0.780
fatty acid catabolic process	GO:0009062	29	0.649	Rat
fatty acid beta oxidation	GO:0006635	22	0.373	Rat
cellular lipid metabolic process	GO:0044255	303	0.308	Rat
organic hydroxy compound metabolic process	GO:1901615	147	0.288
protein homooligomerization	GO:0051260	100	0.273
cellular amino acid metabolic process	GO:0006520	116	0.265
cellular ketone metabolic process	GO:0042180	80	0.250
small molecule biosynthetic process	GO:0044283	157	0.227
alcohol metabolic process	GO:0006066	114	0.215
branched chain amino acid catabolic process	GO:0009083	4	0.211
primary alcohol metabolic process	GO:0034308	17	0.194
response to oxygen containing compound	GO:1901700	369	0.191	Rat
protein homotetramerization	GO:0051289	28	0.188
alpha amino acid metabolic process	GO:1901605	72	0.179
post embryonic development	GO:0009791	2	0.173
ethanol metabolic process	GO:0006067	5	0.141
protein tetramerization	GO:0051262	47	0.140
protein oligomerization	GO:0051259	173	0.135
citrate metabolic process	GO:0006101	2	0.106
coenzyme metabolic process	GO:0006732	65	0.095
fatty acid beta oxidation using acyl coa dehydrogenase	GO:0033539	3	0.094
determination of adult lifespan	GO:0008340	2	0.093
organic acid biosynthetic process	GO:0016053	97	0.080
carbohydrate metabolic process	GO:0005975	207	0.074
response to organic cyclic compound	GO:0014070	204	0.074
response to inorganic substance	GO:0010035	127	0.070
alpha amino acid catabolic process	GO:1901606	26	0.070
multicellular organismal aging	GO:0010259	3	0.064
diterpenoid metabolic process	GO:0016101	20	0.063
response to metal ion	GO:0010038	84	0.061
ion transmembrane transport	GO:0034220	338	0.061
quinone metabolic process	GO:1901661	18	0.057
organonitrogen compound biosynthetic process	GO:1901566	200	0.057
response to nitrosative stress	GO:0051409	4	0.056
defense response	GO:0006952	315	0.052
thioester metabolic process	GO:0035383	23	0.052
monocarboxylic acid biosynthetic process	GO:0072330	67	0.049
response to bacterium	GO:0009617	144	0.046
ethanol oxidation	GO:0006069	5	0.044
cofactor biosynthetic process	GO:0051188	31	0.044
regulation of cellular ketone metabolic process	GO:0010565	50	0.044
anion transport	GO:0006820	161	0.042
response to external biotic stimulus	GO:0043207	261	0.042
single organism carbohydrate metabolic process	GO:0044723	193	0.041
response to other organism	GO:0051707	261	0.039
cellular response to reactive oxygen species	GO:0034614	50	0.039
response to biotic stimulus	GO:0009607	276	0.038
nucleoside phosphate biosynthetic process	GO:1901293	109	0.037
cellular amino acid biosynthetic process	GO:0008652	30	0.037
carboxylic acid biosynthetic process	GO:0046394	97	0.036
response to reactive oxygen species	GO:0000302	61	0.034
primary alcohol catabolic process	GO:0034310	3	0.033
dicarboxylic acid metabolic process	GO:0043648	29	0.033
protein processing	GO:0016485	226	0.033
response to lipid	GO:0033993	206	0.032
organic anion transport	GO:0015711	103	0.031
organic hydroxy compound biosynthetic process	GO:1901617	71	0.030
ribonucleoside monophosphate metabolic process	GO:0009161	187	0.026
reactive oxygen species metabolic process	GO:0072593	75	0.025
branched chain amino acid metabolic process	GO:0009081	4	0.024
glycoside metabolic process	GO:0016137	13	0.024
nervous system development	GO:0007399	293	0.024
tricarboxylic acid cycle	GO:0006099	4	0.023
nucleotide biosynthetic process	GO:0009165	109	0.023
response to hormone	GO:0009725	175	0.022	Rat
isoprenoid metabolic process	GO:0006720	39	0.022
ribonucleoside triphosphate metabolic process	GO:0009199	412	0.021
negative regulation of transferase activity	GO:0051348	124	0.021
sulfur compound metabolic process	GO:0006790	101	0.021
response to steroid hormone	GO:0048545	80	0.021
polyketide metabolic process	GO:0030638	8	0.021
alpha amino acid biosynthetic process	GO:1901607	23	0.021
amino acid betaine metabolic process	GO:0006577	6	0.020
response to extracellular stimulus	GO:0009991	85	0.020
carnitine metabolic process	GO:0009437	5	0.020
hexose metabolic process	GO:0019318	55	0.019
tricarboxylic acid metabolic process	GO:0072350	4	0.019
hydrogen peroxide metabolic process	GO:0042743	20	0.019
spinal cord development	GO:0021510	4	0.018
maintenance of location	GO:0051235	112	0.018
transmembrane transport	GO:0055085	399	0.018
response to abiotic stimulus	GO:0009628	336	0.018
aerobic respiration	GO:0009060	7	0.018
mitochondrion organization	GO:0007005	156	0.018
immune response	GO:0006955	307	0.017
regulation of endopeptidase activity	GO:0052548	170	0.017
glucose metabolic process	GO:0006006	45	0.017
multicellular organismal homeostasis	GO:0048871	67	0.017
hepaticobiliary system development	GO:0061008	10	0.016
cellular response to oxidative stress	GO:0034599	85	0.016
gland development	GO:0048732	48	0.016
response to hydrogen peroxide	GO:0042542	40	0.016
organophosphate catabolic process	GO:0046434	430	0.016
nucleoside monophosphate metabolic process	GO:0009123	191	0.016
cellular aldehyde metabolic process	GO:0006081	20	0.016
response to nutrient levels	GO:0031667	81	0.016
nucleoside triphosphate metabolic process	GO:0009141	422	0.016
response to nitrogen compound	GO:1901698	184	0.016	Rat
cellular response to oxygen containing compound	GO:1901701	276	0.016
secretion by cell	GO:0032940	226	0.016	Rat
fatty alcohol metabolic process	GO:1903173	2	0.015
methyl branched fatty acid metabolic process	GO:0097089	2	0.015
vesicle mediated transport	GO:0016192	371	0.015
cellular modified amino acid metabolic process	GO:0006575	64	0.015
response to starvation	GO:0042594	59	0.015
inorganic ion transmembrane transport	GO:0098660	231	0.014
cellular respiration	GO:0045333	21	0.014
acyl coa metabolic process	GO:0006637	23	0.014
response to lipopolysaccharide	GO:0032496	70	0.014
reactive oxygen species biosynthetic process	GO:1903409	4	0.014
regulation of transferase activity	GO:0051338	355	0.014
brain development	GO:0007420	97	0.013
cellular response to hydrogen peroxide	GO:0070301	37	0.013
regulation of cellular amino acid metabolic process	GO:0006521	6	0.013
glutamate metabolic process	GO:0006536	10	0.013
regulation of peptidase activity	GO:0052547	180	0.013
cell type specific apoptotic process	GO:0097285	125	0.012
response to oxidative stress	GO:0006979	121	0.012
immune system development	GO:0002520	195	0.012
ras protein signal transduction	GO:0007265	73	0.012
single organism membrane organization	GO:0044802	268	0.012
glutamine family amino acid metabolic process	GO:0009064	17	0.012
endocytosis	GO:0006897	159	0.012
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	116	0.012
dicarboxylic acid catabolic process	GO:0043649	9	0.012
purine nucleotide catabolic process	GO:0006195	405	0.012
regulation of intracellular transport	GO:0032386	195	0.012
embryo development	GO:0009790	123	0.011
cholesterol homeostasis	GO:0042632	28	0.011
cellular response to dna damage stimulus	GO:0006974	379	0.011
energy derivation by oxidation of organic compounds	GO:0015980	43	0.011
negative regulation of catalytic activity	GO:0043086	335	0.011
purine nucleoside triphosphate metabolic process	GO:0009144	412	0.011
lipid localization	GO:0010876	106	0.011
response to organophosphorus	GO:0046683	41	0.011
purine ribonucleoside triphosphate catabolic process	GO:0009207	391	0.011
mitochondrial membrane organization	GO:0007006	40	0.011
regulation of membrane potential	GO:0042391	95	0.011
purine ribonucleoside metabolic process	GO:0046128	437	0.011
regulation of mitochondrion organization	GO:0010821	54	0.010
innate immune response	GO:0045087	178	0.010
sterol homeostasis	GO:0055092	28	0.010
organophosphate biosynthetic process	GO:0090407	163	0.010
positive regulation of blood pressure	GO:0045777	3	0.010
ribonucleotide catabolic process	GO:0009261	405	0.010
regulation of proteolysis	GO:0030162	293	0.010
organic acid transport	GO:0015849	65	0.010
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.010
lipid biosynthetic process	GO:0008610	177	0.010
negative regulation of hydrolase activity	GO:0051346	182	0.010
carnitine metabolic process coa linked	GO:0019254	2	0.010
epithelial cell differentiation	GO:0030855	141	0.010

HADH disease predictions

Disease	DO term ID	Size	Probability
disease of metabolism	DOID:0014667	295	0.995
inherited metabolic disorder	DOID:655	242	0.995
amino acid metabolic disorder	DOID:9252	50	0.935
carbohydrate metabolic disorder	DOID:2978	55	0.042
glycogen storage disease	DOID:2747	10	0.042
glycogen metabolism disorder	DOID:0050728	10	0.042
immune system disease	DOID:2914	155	0.027
hematopoietic system disease	DOID:74	100	0.019
central nervous system disease	DOID:331	186	0.018
nervous system disease	DOID:863	431	0.018
kidney disease	DOID:557	36	0.017
urinary system disease	DOID:18	40	0.017
neurodegenerative disease	DOID:1289	102	0.016
cancer	DOID:162	167	0.012
disease of cellular proliferation	DOID:14566	174	0.012
hyperinsulinemic hypoglycemia	DOID:13317	7	0.000

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