IMP: Integrative Multi-species Prediction

Homo sapiens

8 known processes

HMBS

hydroxymethylbilane synthase

(Aliases: PORC,PBG-D,UPS,PBGD)

HPRD: 01440
MIM: 609806
Ensembl: ENSG00000149397
Ensembl: ENSG00000256269
HGNC: 4982
Entrez: 3145
UniProtKB: P08397

Process Predictions
Disease Predictions

HMBS biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
post embryonic development	GO:0009791	2	0.158
cellular amino acid metabolic process	GO:0006520	116	0.121
mitochondrion organization	GO:0007005	156	0.095
cofactor metabolic process	GO:0051186	87	0.084
carbohydrate derivative biosynthetic process	GO:1901137	207	0.058
cellular ketone metabolic process	GO:0042180	80	0.057
cytoplasmic transport	GO:0016482	379	0.049
multicellular organismal aging	GO:0010259	3	0.045
purine ribonucleoside metabolic process	GO:0046128	437	0.043
single organism cellular localization	GO:1902580	332	0.042
posttranscriptional regulation of gene expression	GO:0010608	213	0.041
nucleotide biosynthetic process	GO:0009165	109	0.040
regulation of cellular amino acid metabolic process	GO:0006521	6	0.039
regulation of cellular amine metabolic process	GO:0033238	11	0.039
organonitrogen compound biosynthetic process	GO:1901566	200	0.038
locomotory behavior	GO:0007626	1	0.038
protein processing	GO:0016485	226	0.038
cellular amine metabolic process	GO:0044106	41	0.036
protein maturation	GO:0051604	233	0.033
cellular macromolecule catabolic process	GO:0044265	380	0.031
small molecule biosynthetic process	GO:0044283	157	0.030
determination of adult lifespan	GO:0008340	2	0.030
organophosphate catabolic process	GO:0046434	430	0.030
regulation of proteolysis	GO:0030162	293	0.030
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.030
amine metabolic process	GO:0009308	44	0.030
cellular response to dna damage stimulus	GO:0006974	379	0.030
female gamete generation	GO:0007292	2	0.029
positive regulation of catabolic process	GO:0009896	310	0.029
negative regulation of cell proliferation	GO:0008285	228	0.028
single organism membrane organization	GO:0044802	268	0.028
organophosphate biosynthetic process	GO:0090407	163	0.027
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	281	0.026
cellular lipid metabolic process	GO:0044255	303	0.024
positive regulation of cellular amine metabolic process	GO:0033240	7	0.024
cellular response to oxygen containing compound	GO:1901701	276	0.024
regulation of cellular ketone metabolic process	GO:0010565	50	0.024
cellular macromolecular complex assembly	GO:0034622	324	0.024
alcohol metabolic process	GO:0006066	114	0.024
regulation of cellular response to stress	GO:0080135	244	0.024
defense response	GO:0006952	315	0.023
nucleoside phosphate biosynthetic process	GO:1901293	109	0.023
nucleoside triphosphate metabolic process	GO:0009141	422	0.023
ribonucleotide catabolic process	GO:0009261	405	0.023
negative regulation of cellular protein metabolic process	GO:0032269	353	0.023
mitotic cell cycle phase transition	GO:0044772	162	0.022
embryo development	GO:0009790	123	0.022
chemical homeostasis	GO:0048878	306	0.022
negative regulation of programmed cell death	GO:0043069	321	0.022
response to biotic stimulus	GO:0009607	276	0.022
cofactor biosynthetic process	GO:0051188	31	0.021
response to growth factor	GO:0070848	205	0.021
negative regulation of protein metabolic process	GO:0051248	391	0.021
protein homooligomerization	GO:0051260	100	0.021
response to oxygen containing compound	GO:1901700	369	0.020
protein localization to organelle	GO:0033365	280	0.020
regulation of transferase activity	GO:0051338	355	0.020
organelle assembly	GO:0070925	176	0.020
protein localization to membrane	GO:0072657	160	0.020
protein targeting	GO:0006605	187	0.019
nucleocytoplasmic transport	GO:0006913	176	0.019
positive regulation of hydrolase activity	GO:0051345	331	0.019
apoptotic signaling pathway	GO:0097190	268	0.019
oogenesis	GO:0048477	2	0.019
protein oligomerization	GO:0051259	173	0.018
negative regulation of protein maturation	GO:1903318	142	0.018
regulation of kinase activity	GO:0043549	314	0.018
regulation of endopeptidase activity	GO:0052548	170	0.018
neuromuscular junction development	GO:0007528	3	0.018
regulation of cell growth	GO:0001558	135	0.018
response to organic cyclic compound	GO:0014070	204	0.018
protein catabolic process	GO:0030163	325	0.018
positive regulation of developmental process	GO:0051094	314	0.018
negative regulation of phosphorylation	GO:0042326	174	0.017
regulation of peptidase activity	GO:0052547	180	0.017
positive regulation of cellular catabolic process	GO:0031331	284	0.017
response to abiotic stimulus	GO:0009628	336	0.017
negative regulation of catalytic activity	GO:0043086	335	0.017
negative regulation of protein phosphorylation	GO:0001933	140	0.017
immune response	GO:0006955	307	0.017
purine ribonucleoside triphosphate metabolic process	GO:0009205	411	0.017
amino acid activation	GO:0043038	12	0.017
histone modification	GO:0016570	251	0.016
negative regulation of peptidase activity	GO:0010466	91	0.016
establishment of protein localization to organelle	GO:0072594	172	0.016
actin filament based process	GO:0030029	224	0.016
adult locomotory behavior	GO:0008344	1	0.016
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	116	0.016
nucleoside phosphate catabolic process	GO:1901292	412	0.016
ribonucleoside triphosphate catabolic process	GO:0009203	391	0.016
regulation of defense response	GO:0031347	154	0.016
positive regulation of cellular component organization	GO:0051130	376	0.016
dna repair	GO:0006281	198	0.016
cell morphogenesis	GO:0000902	296	0.015
internal peptidyl lysine acetylation	GO:0018393	97	0.015
regulation of cell differentiation	GO:0045595	393	0.015
maintenance of location	GO:0051235	112	0.015
ribonucleoside triphosphate metabolic process	GO:0009199	412	0.015
positive regulation of proteolysis	GO:0045862	142	0.015
negative regulation of multicellular organismal process	GO:0051241	317	0.015
cell growth	GO:0016049	160	0.015
negative regulation of developmental process	GO:0051093	247	0.015
positive regulation of programmed cell death	GO:0043068	249	0.015
regulation of protein processing	GO:0070613	150	0.014
epithelium development	GO:0060429	227	0.014
negative regulation of organelle organization	GO:0010639	126	0.014
positive regulation of immune system process	GO:0002684	283	0.014
guanosine containing compound metabolic process	GO:1901068	244	0.014
response to external biotic stimulus	GO:0043207	261	0.014
microtubule based process	GO:0007017	210	0.014
negative regulation of cellular component organization	GO:0051129	235	0.014
protein import into mitochondrial inner membrane	GO:0045039	3	0.014
lipid metabolic process	GO:0006629	381	0.014
cellular homeostasis	GO:0019725	196	0.014
nucleoside monophosphate metabolic process	GO:0009123	191	0.014
carbohydrate metabolic process	GO:0005975	207	0.014
negative regulation of growth	GO:0045926	97	0.014
membrane organization	GO:0061024	292	0.014
purine ribonucleotide biosynthetic process	GO:0009152	79	0.014
cellular component morphogenesis	GO:0032989	314	0.014
cellular protein catabolic process	GO:0044257	261	0.014
trna aminoacylation for mitochondrial protein translation	GO:0070127	3	0.013
positive regulation of transport	GO:0051050	336	0.013
glycosylation	GO:0070085	71	0.013
cellular response to organic cyclic compound	GO:0071407	127	0.013
regulation of mitochondrion organization	GO:0010821	54	0.013
purine containing compound catabolic process	GO:0072523	411	0.013
regulation of cysteine type endopeptidase activity	GO:2000116	127	0.013
spermatid development	GO:0007286	4	0.013
internal protein amino acid acetylation	GO:0006475	101	0.013
anterior posterior axis specification	GO:0009948	2	0.013
cellular protein complex assembly	GO:0043623	188	0.013
regulation of immune response	GO:0050776	201	0.013
anatomical structure formation involved in morphogenesis	GO:0048646	284	0.013
rna interference	GO:0016246	4	0.013
purine nucleoside catabolic process	GO:0006152	398	0.013
mitotic cell cycle process	GO:1903047	286	0.013
negative regulation of phosphorus metabolic process	GO:0010563	267	0.013
glycosyl compound catabolic process	GO:1901658	413	0.013
mitotic cell cycle	GO:0000278	326	0.013
alpha amino acid metabolic process	GO:1901605	72	0.013
regulation of protein kinase activity	GO:0045859	289	0.013
negative regulation of hydrolase activity	GO:0051346	182	0.013
positive regulation of purine nucleotide metabolic process	GO:1900544	227	0.012
regulation of apoptotic signaling pathway	GO:2001233	175	0.012
nucleotide catabolic process	GO:0009166	408	0.012
dna conformation change	GO:0071103	113	0.012
regulation of nucleoside metabolic process	GO:0009118	209	0.012
negative regulation of protein modification process	GO:0031400	200	0.012
negative regulation of proteolysis	GO:0045861	132	0.012
segmentation	GO:0035282	4	0.012
defense response to other organism	GO:0098542	129	0.012
ion homeostasis	GO:0050801	230	0.012
purine nucleoside triphosphate metabolic process	GO:0009144	412	0.012
regulation of protein maturation	GO:1903317	150	0.012
spermatid differentiation	GO:0048515	4	0.012
vesicle mediated transport	GO:0016192	371	0.012
peptidyl serine modification	GO:0018209	106	0.011
positive regulation of nucleoside metabolic process	GO:0045979	186	0.011
microtubule organizing center organization	GO:0031023	62	0.011
peptidyl lysine modification	GO:0018205	144	0.011
negative regulation of cell cycle	GO:0045786	193	0.011
intracellular protein transport	GO:0006886	270	0.011
single organism carbohydrate metabolic process	GO:0044723	193	0.011
cell projection assembly	GO:0030031	126	0.011
myosin filament assembly	GO:0031034	2	0.011
regulation of translation	GO:0006417	89	0.011
negative regulation of phosphate metabolic process	GO:0045936	267	0.011
glutamine family amino acid metabolic process	GO:0009064	17	0.011
response to oxidative stress	GO:0006979	121	0.011
regulation of sequence specific dna binding transcription factor activity	GO:0051090	211	0.011
negative regulation of protein processing	GO:0010955	142	0.011
regulation of protein stability	GO:0031647	87	0.011
cell activation	GO:0001775	213	0.011
negative regulation of immune system process	GO:0002683	136	0.011
positive regulation of cell differentiation	GO:0045597	211	0.011
blastoderm segmentation	GO:0007350	2	0.011
cellular ion homeostasis	GO:0006873	168	0.011
regulation of cell cycle phase transition	GO:1901987	126	0.010
metal ion transport	GO:0030001	272	0.010
cytokine production	GO:0001816	247	0.010
protein tetramerization	GO:0051262	47	0.010
organic hydroxy compound metabolic process	GO:1901615	147	0.010
establishment of protein localization to membrane	GO:0090150	121	0.010
protein acylation	GO:0043543	138	0.010
cell type specific apoptotic process	GO:0097285	125	0.010
fatty acid metabolic process	GO:0006631	115	0.010
ribonucleoside monophosphate metabolic process	GO:0009161	187	0.010
protein acetylation	GO:0006473	116	0.010
sulfate transmembrane transport	GO:1902358	3	0.010
response to virus	GO:0009615	126	0.010
response to nitrogen compound	GO:1901698	184	0.010
growth	GO:0040007	202	0.010

HMBS disease predictions

Disease	DO term ID	Size	Probability
disease of metabolism	DOID:0014667	295	0.877
inherited metabolic disorder	DOID:655	242	0.877
amino acid metabolic disorder	DOID:9252	50	0.027
carbohydrate metabolic disorder	DOID:2978	55	0.018
central nervous system disease	DOID:331	186	0.013
nervous system disease	DOID:863	431	0.013
neurodegenerative disease	DOID:1289	102	0.013
cancer	DOID:162	167	0.011
disease of cellular proliferation	DOID:14566	174	0.011
porphyria	DOID:13268	8	0.001
acute porphyria	DOID:3133	7	0.001

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