IMP: Integrative Multi-species Prediction

Homo sapiens

12 known processes

HSPB8

heat shock 22kDa protein 8

(Aliases: E2IG1,HMN2,HMN2A,H11,CMT2L,DHMN2,HSP22)

MIM: 608014
Entrez: 26353
HGNC: 30171
HPRD: 06420
Ensembl: ENSG00000152137
UniProtKB: Q9UJY1

Process Predictions
Disease Predictions

HSPB8 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
positive regulation of endothelial cell chemotaxis	GO:2001028	5	1.000	Human
sensory perception of light stimulus	GO:0050953	35	1.000	Human
visual perception	GO:0007601	27	1.000	Human
positive regulation of cell migration by vascular endothelial growth factor signaling pathway	GO:0038089	5	0.990	Human
positive regulation of endothelial cell chemotaxis by vegf activated vascular endothelial growth factor receptor signaling pathway	GO:0038033	4	0.984	Human
response to heat	GO:0009408	21	0.982	Fly
determination of adult lifespan	GO:0008340	2	0.972	Fly
response to temperature stimulus	GO:0009266	22	0.959	Fly
regulation of muscle system process	GO:0090257	53	0.958
negative regulation of striated muscle cell apoptotic process	GO:0010664	2	0.949
cellular response to ionizing radiation	GO:0071479	32	0.940	Human
spinal cord development	GO:0021510	4	0.938
negative regulation of apoptotic process	GO:0043066	316	0.901	Human
regulation of endothelial cell chemotaxis	GO:2001026	9	0.884	Human
protein oligomerization	GO:0051259	173	0.875	Human
cellular response to abiotic stimulus	GO:0071214	117	0.858	Human
response to ionizing radiation	GO:0010212	65	0.854	Human
response to radiation	GO:0009314	151	0.853	Human
negative regulation of programmed cell death	GO:0043069	321	0.851	Human
endothelial cell migration	GO:0043542	86	0.830	Human
protein homooligomerization	GO:0051260	100	0.789	Human
positive regulation of endothelial cell migration	GO:0010595	39	0.788	Human
response to hypoxia	GO:0001666	96	0.788	Fly
retina homeostasis	GO:0001895	42	0.744	Human
response to abiotic stimulus	GO:0009628	336	0.737	Human Fly
system process	GO:0003008	349	0.725	Human
response to virus	GO:0009615	126	0.715	Human
neurological system process	GO:0050877	163	0.664	Human
tissue homeostasis	GO:0001894	63	0.628	Human
protein folding	GO:0006457	38	0.621
biological adhesion	GO:0022610	331	0.583	Human
negative regulation of cell death	GO:0060548	345	0.553	Human
regulation of vasculature development	GO:1901342	97	0.512	Human
response to gamma radiation	GO:0010332	14	0.503	Human
multicellular organismal aging	GO:0010259	3	0.500	Fly
regulation of intracellular transport	GO:0032386	195	0.482	Human
positive regulation of interleukin 1 beta production	GO:0032731	13	0.472
response to oxygen levels	GO:0070482	100	0.452	Fly
regulation of epithelial cell migration	GO:0010632	93	0.445	Human
sensory perception	GO:0007600	103	0.423	Human
negative regulation of intracellular transport	GO:0032387	60	0.408	Human
positive regulation of cell migration	GO:0030335	172	0.399	Human
cardiovascular system development	GO:0072358	262	0.398	Human
positive regulation of epithelial cell migration	GO:0010634	55	0.363	Human
reactive oxygen species metabolic process	GO:0072593	75	0.360
positive regulation of tumor necrosis factor biosynthetic process	GO:0042535	5	0.319
regulation of interleukin 1 production	GO:0032652	21	0.312
single organismal cell cell adhesion	GO:0016337	148	0.309	Human
negative regulation of reactive oxygen species metabolic process	GO:2000378	11	0.305
regulation of cell growth	GO:0001558	135	0.299
positive regulation of cellular component movement	GO:0051272	181	0.299	Human
angiogenesis	GO:0001525	147	0.262	Human
regulation of anatomical structure morphogenesis	GO:0022603	286	0.248	Human
regulation of behavior	GO:0050795	82	0.245	Human
cellular response to mechanical stimulus	GO:0071260	39	0.242
tissue migration	GO:0090130	119	0.230	Human
cell activation	GO:0001775	213	0.223	Human
interleukin 1 beta production	GO:0032611	22	0.222
negative regulation of transport	GO:0051051	176	0.220	Human
response to wounding	GO:0009611	168	0.215	Human
blood coagulation	GO:0007596	76	0.196	Human
cellular response to tumor necrosis factor	GO:0071356	63	0.190
cellular response to vascular endothelial growth factor stimulus	GO:0035924	26	0.184	Human
regulation of reactive oxygen species metabolic process	GO:2000377	41	0.183
negative regulation of cell proliferation	GO:0008285	228	0.177
blood vessel morphogenesis	GO:0048514	162	0.171	Human
negative regulation of oxidative stress induced cell death	GO:1903202	17	0.168
regulation of protein kinase activity	GO:0045859	289	0.168
platelet activation	GO:0030168	44	0.167	Human
negative regulation of catalytic activity	GO:0043086	335	0.165
regulation of angiogenesis	GO:0045765	92	0.152	Human
epithelial cell migration	GO:0010631	119	0.151	Human
cell type specific apoptotic process	GO:0097285	125	0.150
stress activated mapk cascade	GO:0051403	93	0.142
regulation of tumor necrosis factor biosynthetic process	GO:0042534	8	0.134
platelet aggregation	GO:0070527	32	0.132	Human
epithelium migration	GO:0090132	119	0.131	Human
signal transduction by phosphorylation	GO:0023014	297	0.131
regulation of response to external stimulus	GO:0032101	222	0.124	Human
anatomical structure homeostasis	GO:0060249	100	0.122	Human
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	181	0.122	Human
cellular response to radiation	GO:0071478	65	0.120	Human
wound healing	GO:0042060	115	0.119	Human
ameboidal type cell migration	GO:0001667	135	0.113	Human
endothelial cell chemotaxis	GO:0035767	13	0.112	Human
positive regulation of chemotaxis	GO:0050921	57	0.109	Human
aging	GO:0007568	66	0.109	Fly
intrinsic apoptotic signaling pathway in response to oxidative stress	GO:0008631	21	0.109
positive regulation of developmental process	GO:0051094	314	0.108	Human
response to biotic stimulus	GO:0009607	276	0.107	Human Fly
response to oxidative stress	GO:0006979	121	0.106	Fly
negative regulation of phosphate metabolic process	GO:0045936	267	0.103
response to external biotic stimulus	GO:0043207	261	0.096	Human Fly
regulation of cellular response to oxidative stress	GO:1900407	26	0.095
taxis	GO:0042330	157	0.094	Human
regulation of cell motility	GO:2000145	299	0.092	Human
negative regulation of cellular response to oxidative stress	GO:1900408	18	0.091
response to estradiol	GO:0032355	23	0.087
cellular response to oxidative stress	GO:0034599	85	0.086
response to hydrogen peroxide	GO:0042542	40	0.085
response to mechanical stimulus	GO:0009612	51	0.084
negative regulation of apoptotic signaling pathway	GO:2001234	97	0.084
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.084
regulation of apoptotic signaling pathway	GO:2001233	175	0.083
negative regulation of protein metabolic process	GO:0051248	391	0.082
cell death in response to oxidative stress	GO:0036473	29	0.078
positive regulation of cellular amine metabolic process	GO:0033240	7	0.077
regulation of body fluid levels	GO:0050878	99	0.076	Human
growth	GO:0040007	202	0.074
regulation of system process	GO:0044057	101	0.074
negative regulation of cell growth	GO:0030308	83	0.074
regulation of intrinsic apoptotic signaling pathway	GO:2001242	72	0.074
mapk cascade	GO:0000165	288	0.073
regulation of oxidative stress induced cell death	GO:1903201	24	0.072
cellular amino acid metabolic process	GO:0006520	116	0.072
regulation of cellular amine metabolic process	GO:0033238	11	0.071
hemostasis	GO:0007599	76	0.070	Human
vasculature development	GO:0001944	181	0.070	Human
positive regulation of locomotion	GO:0040017	186	0.069	Human
regulation of endothelial cell migration	GO:0010594	67	0.068	Human
sulfur compound metabolic process	GO:0006790	101	0.067
regulation of oxidative stress induced intrinsic apoptotic signaling pathway	GO:1902175	16	0.065
ribonucleoside triphosphate metabolic process	GO:0009199	412	0.064
muscle cell apoptotic process	GO:0010657	11	0.063
positive regulation of purine nucleotide metabolic process	GO:1900544	227	0.060
cellular response to gamma radiation	GO:0071480	8	0.060	Human
regulation of striated muscle cell apoptotic process	GO:0010662	3	0.059
regulation of cellular component movement	GO:0051270	334	0.058	Human
circulatory system development	GO:0072359	262	0.057	Human
ras protein signal transduction	GO:0007265	73	0.056
extrinsic apoptotic signaling pathway in absence of ligand	GO:0097192	22	0.055
amine metabolic process	GO:0009308	44	0.055
response to lipid	GO:0033993	206	0.054
blood vessel development	GO:0001568	172	0.054	Human
single organism cell adhesion	GO:0098602	179	0.054	Human
regulation of response to oxidative stress	GO:1902882	26	0.053
atp catabolic process	GO:0006200	157	0.053
protein stabilization	GO:0050821	64	0.053
ribonucleotide catabolic process	GO:0009261	405	0.052
stress activated protein kinase signaling cascade	GO:0031098	94	0.049
posttranscriptional regulation of gene expression	GO:0010608	213	0.049
inorganic ion transmembrane transport	GO:0098660	231	0.047
regulation of cytokine biosynthetic process	GO:0042035	35	0.047
purine ribonucleoside monophosphate metabolic process	GO:0009167	186	0.046
positive regulation of blood vessel endothelial cell migration	GO:0043536	16	0.046	Human
intrinsic apoptotic signaling pathway	GO:0097193	127	0.045
positive regulation of cytokine production	GO:0001819	167	0.044
protein refolding	GO:0042026	14	0.044
regulation of tumor necrosis factor production	GO:0032680	43	0.043
single organism membrane organization	GO:0044802	268	0.043
regulation of chemotaxis	GO:0050920	74	0.041	Human
defense response to bacterium	GO:0042742	63	0.041	Fly
mrna metabolic process	GO:0016071	175	0.041
response to growth factor	GO:0070848	205	0.041	Human
nucleoside monophosphate metabolic process	GO:0009123	191	0.040
regulation of cytokine production	GO:0001817	232	0.040
purine ribonucleotide catabolic process	GO:0009154	404	0.040
purine nucleoside triphosphate catabolic process	GO:0009146	392	0.039
immune response	GO:0006955	307	0.039
ribonucleoside catabolic process	GO:0042454	406	0.039
microtubule polymerization or depolymerization	GO:0031109	37	0.039
cellular amine metabolic process	GO:0044106	41	0.039
carbohydrate metabolic process	GO:0005975	207	0.039
cellular ketone metabolic process	GO:0042180	80	0.039
ribonucleoside monophosphate metabolic process	GO:0009161	187	0.038
negative regulation of phosphorus metabolic process	GO:0010563	267	0.038
purine containing compound catabolic process	GO:0072523	411	0.038
cellular response to external stimulus	GO:0071496	111	0.037
enzyme linked receptor protein signaling pathway	GO:0007167	303	0.036	Human
chemotaxis	GO:0006935	157	0.036	Human
regulation of synaptic plasticity	GO:0048167	3	0.036
purine nucleoside monophosphate metabolic process	GO:0009126	186	0.035
regulation of locomotion	GO:0040012	329	0.035	Human
vascular endothelial growth factor receptor signaling pathway	GO:0048010	19	0.035	Human
cellular response to growth factor stimulus	GO:0071363	197	0.035	Human
multicellular organismal homeostasis	GO:0048871	67	0.035	Human
positive regulation of transferase activity	GO:0051347	227	0.034
regulation of transferase activity	GO:0051338	355	0.034
cellular protein catabolic process	GO:0044257	261	0.034
regulation of cellular ketone metabolic process	GO:0010565	50	0.033
embryonic placenta development	GO:0001892	1	0.033
cellular lipid metabolic process	GO:0044255	303	0.033
ribonucleoside monophosphate catabolic process	GO:0009158	158	0.032
regulation of inclusion body assembly	GO:0090083	13	0.032
rna interference	GO:0016246	4	0.031
inclusion body assembly	GO:0070841	17	0.031
negative regulation of response to oxidative stress	GO:1902883	18	0.031
regulation of cell migration	GO:0030334	289	0.030	Human
myeloid cell differentiation	GO:0030099	117	0.030
negative regulation of growth	GO:0045926	97	0.029
actin filament organization	GO:0007015	128	0.029
regulation of protein stability	GO:0031647	87	0.029
cellular component morphogenesis	GO:0032989	314	0.029
interleukin 1 production	GO:0032612	26	0.029
regulation of muscle hypertrophy	GO:0014743	10	0.029
response to topologically incorrect protein	GO:0035966	29	0.028
oxidation reduction process	GO:0055114	396	0.028
peripheral nervous system development	GO:0007422	2	0.028
response to hormone	GO:0009725	175	0.027
lipid metabolic process	GO:0006629	381	0.027
small gtpase mediated signal transduction	GO:0007264	78	0.026
response to organic cyclic compound	GO:0014070	204	0.026
regulation of vesicle mediated transport	GO:0060627	130	0.026
cellular response to reactive oxygen species	GO:0034614	50	0.025
regulation of protein serine threonine kinase activity	GO:0071900	179	0.025
regulation of purine nucleotide catabolic process	GO:0033121	205	0.025
regulation of blood vessel endothelial cell migration	GO:0043535	30	0.025	Human
regulation of anatomical structure size	GO:0090066	101	0.025
extrinsic apoptotic signaling pathway via death domain receptors	GO:0008625	42	0.025
negative regulation of intrinsic apoptotic signaling pathway	GO:2001243	40	0.025
defense response	GO:0006952	315	0.025	Fly
inorganic cation transmembrane transport	GO:0098662	194	0.025
regulation of ion transmembrane transport	GO:0034765	132	0.024
striated muscle contraction	GO:0006941	52	0.024
wnt signaling pathway	GO:0016055	156	0.024
response to decreased oxygen levels	GO:0036293	96	0.024	Fly
ubiquitin dependent protein catabolic process	GO:0006511	206	0.024
negative regulation of protein modification process	GO:0031400	200	0.023
positive regulation of tumor necrosis factor superfamily cytokine production	GO:1903557	22	0.023
negative regulation of phosphorylation	GO:0042326	174	0.023
positive regulation of meiotic cell cycle	GO:0051446	2	0.023
negative regulation of intracellular signal transduction	GO:1902532	183	0.023
rho protein signal transduction	GO:0007266	26	0.023
positive regulation of angiogenesis	GO:0045766	51	0.023	Human
apoptotic signaling pathway	GO:0097190	268	0.023
metal ion homeostasis	GO:0055065	169	0.023
anatomical structure formation involved in morphogenesis	GO:0048646	284	0.023	Human
response to unfolded protein	GO:0006986	24	0.022
modification dependent protein catabolic process	GO:0019941	209	0.022
positive regulation of nucleotide catabolic process	GO:0030813	185	0.022
peptidyl tyrosine phosphorylation	GO:0018108	170	0.022
regulation of interleukin 1 beta production	GO:0032651	18	0.022
cytoplasmic transport	GO:0016482	379	0.021
cytokine biosynthetic process	GO:0042089	37	0.021
negative regulation of protein phosphorylation	GO:0001933	140	0.021
cell adhesion	GO:0007155	325	0.021	Human
locomotory behavior	GO:0007626	1	0.021
response to alcohol	GO:0097305	64	0.021
neurotransmitter secretion	GO:0007269	4	0.021
vasodilation	GO:0042311	4	0.021
regulation of actin filament based process	GO:0032970	141	0.020
response to steroid hormone	GO:0048545	80	0.020
negative regulation of protein kinase activity	GO:0006469	98	0.020
negative regulation of kinase activity	GO:0033673	106	0.020
tumor necrosis factor biosynthetic process	GO:0042533	8	0.020
cell chemotaxis	GO:0060326	112	0.020	Human
spermatid differentiation	GO:0048515	4	0.019
brain development	GO:0007420	97	0.019
organonitrogen compound biosynthetic process	GO:1901566	200	0.019
positive regulation of cell motility	GO:2000147	177	0.019	Human
microtubule cytoskeleton organization	GO:0000226	176	0.019
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway	GO:1902176	10	0.019
signal transduction in absence of ligand	GO:0038034	22	0.019
purine ribonucleoside triphosphate catabolic process	GO:0009207	391	0.019
cell morphogenesis	GO:0000902	296	0.019
regulation of cell development	GO:0060284	161	0.019
behavior	GO:0007610	112	0.019	Human
cardiac muscle cell contraction	GO:0086003	4	0.019
regulation of jnk cascade	GO:0046328	73	0.019
negative regulation of hydrolase activity	GO:0051346	182	0.018
positive regulation of cytokine biosynthetic process	GO:0042108	25	0.018
regulation of cellular amino acid metabolic process	GO:0006521	6	0.018
negative regulation of cellular amino acid metabolic process	GO:0045763	2	0.018
cellular response to dna damage stimulus	GO:0006974	379	0.018
regeneration	GO:0031099	4	0.018
sterol metabolic process	GO:0016125	28	0.018
purine nucleotide catabolic process	GO:0006195	405	0.018
membrane organization	GO:0061024	292	0.018
response to other organism	GO:0051707	261	0.018	Human Fly
head development	GO:0060322	108	0.018
regulation of kinase activity	GO:0043549	314	0.018
regulation of cardiac muscle cell proliferation	GO:0060043	4	0.017
neuromuscular junction development	GO:0007528	3	0.017
nucleoside phosphate biosynthetic process	GO:1901293	109	0.017
sequestering of metal ion	GO:0051238	24	0.017
regulation of striated muscle contraction	GO:0006942	37	0.017
positive regulation of insulin like growth factor receptor signaling pathway	GO:0043568	4	0.017
muscle system process	GO:0003012	81	0.017
oogenesis	GO:0048477	2	0.017
cell aging	GO:0007569	52	0.017
protein catabolic process	GO:0030163	325	0.017
regulation of mitotic cell cycle	GO:0007346	189	0.017
regulation of protein modification by small protein conjugation or removal	GO:1903320	107	0.017
homotypic cell cell adhesion	GO:0034109	47	0.017	Human
coenzyme metabolic process	GO:0006732	65	0.017
regulation of extrinsic apoptotic signaling pathway	GO:2001236	85	0.017
positive regulation of cell proliferation	GO:0008284	301	0.016
response to salt stress	GO:0009651	3	0.016
negative regulation of protein maturation	GO:1903318	142	0.016
neuron projection regeneration	GO:0031102	1	0.016
regulation of wnt signaling pathway	GO:0030111	123	0.016
cellular macromolecular complex assembly	GO:0034622	324	0.016
positive regulation of cellular component organization	GO:0051130	376	0.016
cellular component disassembly	GO:0022411	92	0.016
regulation of protein processing	GO:0070613	150	0.016
regulation of i kappab kinase nf kappab signaling	GO:0043122	162	0.016
positive regulation of immune system process	GO:0002684	283	0.016
morphogenesis of embryonic epithelium	GO:0016331	4	0.016
proteolysis involved in cellular protein catabolic process	GO:0051603	244	0.016
heat acclimation	GO:0010286	3	0.016
regulation of tube size	GO:0035150	18	0.016
organelle fission	GO:0048285	149	0.016
gtp catabolic process	GO:0006184	237	0.015
positive regulation of cellular catabolic process	GO:0031331	284	0.015
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	116	0.015
microtubule based process	GO:0007017	210	0.015
nitrogen compound transport	GO:0071705	191	0.015
positive regulation of nucleoside metabolic process	GO:0045979	186	0.015
cellular response to topologically incorrect protein	GO:0035967	19	0.015
muscle hypertrophy	GO:0014896	14	0.015
cellular response to heat	GO:0034605	14	0.015
sequestering of calcium ion	GO:0051208	17	0.015
protein processing	GO:0016485	226	0.015
blood vessel endothelial cell migration	GO:0043534	42	0.015	Human
negative regulation of multicellular organismal process	GO:0051241	317	0.015
regulation of small gtpase mediated signal transduction	GO:0051056	156	0.015
activation of innate immune response	GO:0002218	55	0.014
tumor necrosis factor superfamily cytokine production	GO:0071706	45	0.014
protein maturation	GO:0051604	233	0.014
nucleoside catabolic process	GO:0009164	408	0.014
regulation of cell adhesion	GO:0030155	166	0.014
regulation of nucleotide catabolic process	GO:0030811	205	0.014
ribonucleoprotein complex disassembly	GO:0032988	7	0.014
memory	GO:0007613	3	0.014
negative regulation of extrinsic apoptotic signaling pathway	GO:2001237	52	0.014
rna catabolic process	GO:0006401	71	0.014
nerve development	GO:0021675	4	0.014
negative regulation of cellular amine metabolic process	GO:0033239	3	0.014
regulation of growth	GO:0040008	165	0.014
mitotic cell cycle process	GO:1903047	286	0.014
establishment of protein localization to organelle	GO:0072594	172	0.014
midbrain development	GO:0030901	45	0.014
protein localization to organelle	GO:0033365	280	0.014
ion transmembrane transport	GO:0034220	338	0.014
female gamete generation	GO:0007292	2	0.013
positive regulation of gtpase activity	GO:0043547	166	0.013
regulation of muscle cell differentiation	GO:0051147	31	0.013
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	156	0.013
cell cell junction organization	GO:0045216	69	0.013
spermatid development	GO:0007286	4	0.013
regulation of ion homeostasis	GO:2000021	73	0.013
regulation of protein transport	GO:0051223	213	0.013
single organism nuclear import	GO:1902593	104	0.013
regulation of gtp catabolic process	GO:0033124	180	0.013
nuclear division	GO:0000280	128	0.013
extrinsic apoptotic signaling pathway	GO:0097191	119	0.013
regulation of protein localization	GO:0032880	296	0.013
sleep	GO:0030431	2	0.013
regulation of neural precursor cell proliferation	GO:2000177	4	0.013
positive regulation of kinase activity	GO:0033674	204	0.013
striated muscle cell apoptotic process	GO:0010658	3	0.013
myoblast fusion	GO:0007520	1	0.013
regulation of ras protein signal transduction	GO:0046578	155	0.013
segmentation	GO:0035282	4	0.013
metencephalon development	GO:0022037	2	0.013
cell growth	GO:0016049	160	0.013
positive regulation of mapk cascade	GO:0043410	190	0.012
response to molecule of bacterial origin	GO:0002237	82	0.012
response to cytokine	GO:0034097	232	0.012
regulation of protein catabolic process	GO:0042176	155	0.012
morphogenesis of an epithelium	GO:0002009	60	0.012
cytokinesis	GO:0000910	96	0.012
nucleotide biosynthetic process	GO:0009165	109	0.012
dephosphorylation	GO:0016311	209	0.012
regulation of immune response	GO:0050776	201	0.012
protein localization to plasma membrane	GO:0072659	93	0.012
response to inorganic substance	GO:0010035	127	0.012
maintenance of location	GO:0051235	112	0.012
regulation of neurotransmitter secretion	GO:0046928	3	0.012
regulation of cytoplasmic transport	GO:1903649	149	0.012
response to starvation	GO:0042594	59	0.012	Fly
nucleoside triphosphate metabolic process	GO:0009141	422	0.012
purine nucleoside triphosphate metabolic process	GO:0009144	412	0.012
regulation of reactive oxygen species biosynthetic process	GO:1903426	3	0.012
oocyte differentiation	GO:0009994	2	0.012
sensory perception of pain	GO:0019233	4	0.012
regulation of cell cycle phase transition	GO:1901987	126	0.012
cytokine production	GO:0001816	247	0.012
syncytium formation by plasma membrane fusion	GO:0000768	2	0.012
adult locomotory behavior	GO:0008344	1	0.012
cellular modified amino acid metabolic process	GO:0006575	64	0.012
regulation of cysteine type endopeptidase activity	GO:2000116	127	0.012
post embryonic development	GO:0009791	2	0.012	Fly
regulation of ras gtpase activity	GO:0032318	128	0.012
negative regulation of inclusion body assembly	GO:0090084	9	0.012
nucleocytoplasmic transport	GO:0006913	176	0.012
protein localization to membrane	GO:0072657	160	0.012
sodium ion transmembrane transport	GO:0035725	59	0.012
blastoderm segmentation	GO:0007350	2	0.012
negative regulation of cysteine type endopeptidase activity	GO:2000117	48	0.012
protein targeting	GO:0006605	187	0.012
negative regulation of blood pressure	GO:0045776	3	0.012
developmental programmed cell death	GO:0010623	3	0.011
positive regulation of cell death	GO:0010942	263	0.011
anterior posterior axis specification	GO:0009948	2	0.011
rna splicing	GO:0008380	131	0.011
positive regulation of reactive oxygen species metabolic process	GO:2000379	24	0.011
thymus development	GO:0048538	3	0.011
endosomal transport	GO:0016197	129	0.011
regulation of muscle cell apoptotic process	GO:0010660	10	0.011
lymphocyte activation	GO:0046649	133	0.011
ion homeostasis	GO:0050801	230	0.011
negative regulation of cellular component movement	GO:0051271	106	0.011
negative regulation of cell migration	GO:0030336	102	0.011
striated muscle myosin thick filament assembly	GO:0071688	2	0.011
cellular response to misfolded protein	GO:0071218	2	0.011
associative learning	GO:0008306	1	0.011
cellular response to oxygen containing compound	GO:1901701	276	0.011
negative regulation of cellular protein metabolic process	GO:0032269	353	0.011
negative regulation of cell cycle	GO:0045786	193	0.011
establishment of protein localization to plasma membrane	GO:0090002	68	0.011
stem cell division	GO:0017145	2	0.011
action potential	GO:0001508	34	0.011
monovalent inorganic cation transport	GO:0015672	128	0.011
intracellular protein transmembrane transport	GO:0065002	24	0.011
regulation of homeostatic process	GO:0032844	121	0.011
neural nucleus development	GO:0048857	47	0.011
central nervous system development	GO:0007417	123	0.011
cellular amide metabolic process	GO:0043603	69	0.011
alcohol biosynthetic process	GO:0046165	52	0.011
response to tumor necrosis factor	GO:0034612	76	0.011
negative regulation of homeostatic process	GO:0032845	59	0.011
cell cycle checkpoint	GO:0000075	117	0.011
regulation of cellular response to stress	GO:0080135	244	0.011
positive regulation of programmed cell death	GO:0043068	249	0.011
axon regeneration	GO:0031103	1	0.011
tripartite regional subdivision	GO:0007351	2	0.011
regulation of cardiac muscle tissue growth	GO:0055021	4	0.011
small molecule biosynthetic process	GO:0044283	157	0.010
cerebellum development	GO:0021549	2	0.010
positive regulation of phosphorylation	GO:0042327	394	0.010
startle response	GO:0001964	3	0.010
regulation of meiosis	GO:0040020	3	0.010
regulation of neuronal synaptic plasticity	GO:0048168	1	0.010
actin mediated cell contraction	GO:0070252	12	0.010
epithelium development	GO:0060429	227	0.010
astrocyte differentiation	GO:0048708	4	0.010
negative regulation of organelle organization	GO:0010639	126	0.010
divalent metal ion transport	GO:0070838	152	0.010
fatty acid metabolic process	GO:0006631	115	0.010
neuroblast proliferation	GO:0007405	4	0.010
tissue regeneration	GO:0042246	3	0.010
cellular macromolecule catabolic process	GO:0044265	380	0.010
glutathione metabolic process	GO:0006749	20	0.010
eye photoreceptor cell differentiation	GO:0001754	2	0.010

HSPB8 disease predictions

Disease	DO term ID	Size	Probability	Func Analog Org
muscular disease	DOID:0080000	114	0.999	Human
cardiomyopathy	DOID:0050700	50	0.999	Human
intrinsic cardiomyopathy	DOID:0060036	50	0.999	Human
heart disease	DOID:114	68	0.999	Human
cardiovascular system disease	DOID:1287	106	0.999	Human
myopathy	DOID:423	104	0.999	Human
muscle tissue disease	DOID:66	113	0.999	Human
musculoskeletal system disease	DOID:17	223	0.999	Human
dilated cardiomyopathy	DOID:12930	32	0.985	Human
nervous system disease	DOID:863	431	0.922
sensory system disease	DOID:0050155	203	0.922	Human
eye and adnexa disease	DOID:1492	150	0.922	Human
charcot marie tooth disease type 2	DOID:0050539	15	0.815
neuropathy	DOID:870	52	0.815
charcot marie tooth disease	DOID:10595	33	0.815
neuromuscular disease	DOID:440	38	0.815
central nervous system disease	DOID:331	186	0.481
eye disease	DOID:5614	149	0.141	Human
connective tissue disease	DOID:65	109	0.050
disease by infectious agent	DOID:0050117	34	0.045
disease of metabolism	DOID:0014667	295	0.033
distal hereditary motor neuropathy	DOID:0050582	5	0.028
motor neuron disease	DOID:231	27	0.028
neurodegenerative disease	DOID:1289	102	0.028
motor neuritis	DOID:683	5	0.028
bone disease	DOID:0080001	88	0.024
disease of cellular proliferation	DOID:14566	174	0.019
cancer	DOID:162	167	0.019
organ system cancer	DOID:0050686	164	0.019
inherited metabolic disorder	DOID:655	242	0.017
bone remodeling disease	DOID:0080005	26	0.015
lens disease	DOID:110	5	0.015	Human
immune system disease	DOID:2914	155	0.012
hematopoietic system disease	DOID:74	100	0.012

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