IMP: Integrative Multi-species Prediction

Homo sapiens

0 known processes

IRF3

interferon regulatory factor 3

HPRD: 04769
MIM: 603734
HGNC: 6118
Ensembl: ENSG00000126456
Entrez: 3661
UniProtKB: Q14653
UniProtKB: M0QYT9
UniProtKB: E2GIM5
UniProtKB: E2GIM6
UniProtKB: E2GIM7
UniProtKB: E2GIM8
UniProtKB: E2GIM9

Process Predictions
Disease Predictions

IRF3 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
regulation of interferon beta biosynthetic process	GO:0045357	4	0.779	Mouse
serine phosphorylation of stat protein	GO:0042501	4	0.527
regulation of interferon alpha production	GO:0032647	11	0.470	Human Mouse
positive regulation of interferon beta production	GO:0032728	17	0.378	Human Mouse
nervous system development	GO:0007399	293	0.355
interferon beta production	GO:0032608	23	0.286	Human Mouse
cellular amine metabolic process	GO:0044106	41	0.260
regulation of cellular ketone metabolic process	GO:0010565	50	0.256
positive regulation of interferon alpha production	GO:0032727	11	0.254	Human Mouse
positive regulation of apoptotic process	GO:0043065	246	0.247
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	281	0.244	Mouse
cellular response to dna damage stimulus	GO:0006974	379	0.224
blood vessel development	GO:0001568	172	0.210
positive regulation of immune system process	GO:0002684	283	0.209	Mouse
regulation of mapk cascade	GO:0043408	262	0.200
negative regulation of cell proliferation	GO:0008285	228	0.200
regulation of cytokine production	GO:0001817	232	0.184	Human Mouse
single organism cellular localization	GO:1902580	332	0.183
negative regulation of phosphate metabolic process	GO:0045936	267	0.180
regulation of cellular amine metabolic process	GO:0033238	11	0.179
regulation of i kappab kinase nf kappab signaling	GO:0043122	162	0.164
chemical homeostasis	GO:0048878	306	0.161
regulation of interferon beta production	GO:0032648	22	0.154	Human Mouse
response to external biotic stimulus	GO:0043207	261	0.154	Human Mouse
negative regulation of protein modification process	GO:0031400	200	0.151
enzyme linked receptor protein signaling pathway	GO:0007167	303	0.146
mapk cascade	GO:0000165	288	0.146
apoptotic signaling pathway	GO:0097190	268	0.145
locomotory behavior	GO:0007626	1	0.138
regulation of type i interferon production	GO:0032479	26	0.137	Human Mouse
negative regulation of phosphorylation	GO:0042326	174	0.133
negative regulation of protein metabolic process	GO:0051248	391	0.130	Mouse
response to cytokine	GO:0034097	232	0.130	Human Mouse
type i interferon production	GO:0032606	27	0.124	Human Mouse
response to other organism	GO:0051707	261	0.123	Human Mouse
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	181	0.123
defense response to bacterium	GO:0042742	63	0.114
hematopoietic or lymphoid organ development	GO:0048534	186	0.113
response to abiotic stimulus	GO:0009628	336	0.112	Human
cellular response to cytokine stimulus	GO:0071345	181	0.111	Human Mouse
positive regulation of nf kappab transcription factor activity	GO:0051092	81	0.109
defense response	GO:0006952	315	0.102	Human Mouse
positive regulation of programmed cell death	GO:0043068	249	0.102
somatic muscle development	GO:0007525	1	0.101
membrane organization	GO:0061024	292	0.100
negative regulation of catalytic activity	GO:0043086	335	0.098
rhythmic behavior	GO:0007622	2	0.095
negative regulation of intracellular signal transduction	GO:1902532	183	0.094
signal transduction by phosphorylation	GO:0023014	297	0.094
tube development	GO:0035295	125	0.091
vasculature development	GO:0001944	181	0.090
jak stat cascade	GO:0007259	46	0.090
transmembrane transport	GO:0055085	399	0.089
protein modification by small protein conjugation	GO:0032446	342	0.085
protein targeting	GO:0006605	187	0.083
peptidyl serine phosphorylation	GO:0018105	101	0.083
type i interferon signaling pathway	GO:0060337	11	0.082	Mouse
positive regulation of defense response	GO:0031349	87	0.082	Mouse
intracellular protein transport	GO:0006886	270	0.081
protein localization to membrane	GO:0072657	160	0.080
regulation of protein serine threonine kinase activity	GO:0071900	179	0.078
positive regulation of cytokine production	GO:0001819	167	0.074	Human Mouse
single organism membrane organization	GO:0044802	268	0.074
cellular cation homeostasis	GO:0030003	163	0.074
cellular response to oxidative stress	GO:0034599	85	0.073
positive regulation of cell differentiation	GO:0045597	211	0.073
establishment of protein localization to organelle	GO:0072594	172	0.072
cellular response to external stimulus	GO:0071496	111	0.072	Human
i kappab kinase nf kappab signaling	GO:0007249	166	0.072
response to nitrogen compound	GO:1901698	184	0.071	Mouse
regulation of homeostatic process	GO:0032844	121	0.070
brain development	GO:0007420	97	0.070
response to biotic stimulus	GO:0009607	276	0.070	Human Mouse
positive regulation of interferon beta biosynthetic process	GO:0045359	4	0.069
cytokine mediated signaling pathway	GO:0019221	109	0.068	Mouse
peptidyl lysine acetylation	GO:0018394	101	0.068
response to bacterium	GO:0009617	144	0.067	Mouse
amine metabolic process	GO:0009308	44	0.067
cardiovascular system development	GO:0072358	262	0.066
peptidyl tyrosine phosphorylation	GO:0018108	170	0.066
hemopoiesis	GO:0030097	180	0.065
microtubule based process	GO:0007017	210	0.065
positive regulation of developmental process	GO:0051094	314	0.065
negative regulation of phosphorus metabolic process	GO:0010563	267	0.065
immune system development	GO:0002520	195	0.064
cell activation	GO:0001775	213	0.063
positive regulation of i kappab kinase nf kappab signaling	GO:0043123	132	0.063
negative regulation of protein phosphorylation	GO:0001933	140	0.062
positive regulation of immune response	GO:0050778	159	0.062	Mouse
regulation of cell differentiation	GO:0045595	393	0.062
establishment of protein localization to membrane	GO:0090150	121	0.061
alcohol metabolic process	GO:0006066	114	0.061
immune response	GO:0006955	307	0.061	Human Mouse
circadian behavior	GO:0048512	2	0.061
embryo development	GO:0009790	123	0.060
positive regulation of innate immune response	GO:0045089	79	0.060	Mouse
rna splicing	GO:0008380	131	0.060
regulation of immune response	GO:0050776	201	0.059	Human Mouse
glycerolipid metabolic process	GO:0046486	107	0.059
positive regulation of cell death	GO:0010942	263	0.059
regulation of cellular amino acid metabolic process	GO:0006521	6	0.058
protein acetylation	GO:0006473	116	0.058
peptidyl serine modification	GO:0018209	106	0.057
defense response to virus	GO:0051607	71	0.056	Human Mouse
positive regulation of sequence specific dna binding transcription factor activity	GO:0051091	131	0.055
organonitrogen compound biosynthetic process	GO:1901566	200	0.054
negative regulation of homeostatic process	GO:0032845	59	0.053
internal peptidyl lysine acetylation	GO:0018393	97	0.053
negative regulation of developmental process	GO:0051093	247	0.053
regulation of sequence specific dna binding transcription factor activity	GO:0051090	211	0.053
negative regulation of cell differentiation	GO:0045596	171	0.053
positive regulation of type i interferon mediated signaling pathway	GO:0060340	4	0.051	Mouse
cellular amino acid metabolic process	GO:0006520	116	0.051
myeloid cell homeostasis	GO:0002262	34	0.050
cellular biogenic amine metabolic process	GO:0006576	34	0.050
endocytic recycling	GO:0032456	12	0.050
positive regulation of type i interferon production	GO:0032481	20	0.050	Human Mouse
nitrogen cycle metabolic process	GO:0071941	3	0.050
mrna metabolic process	GO:0016071	175	0.049
cation homeostasis	GO:0055080	189	0.049
oogenesis	GO:0048477	2	0.049
cellular homeostasis	GO:0019725	196	0.048
response to oxidative stress	GO:0006979	121	0.048
response to oxygen containing compound	GO:1901700	369	0.048	Mouse
cellular ketone metabolic process	GO:0042180	80	0.047
response to virus	GO:0009615	126	0.047	Human Mouse
organophosphate biosynthetic process	GO:0090407	163	0.046
endomembrane system organization	GO:0010256	196	0.045
internal protein amino acid acetylation	GO:0006475	101	0.045
response to mechanical stimulus	GO:0009612	51	0.045	Human
regulation of peptidase activity	GO:0052547	180	0.045
neurogenesis	GO:0022008	169	0.044
post embryonic development	GO:0009791	2	0.044
leukocyte differentiation	GO:0002521	98	0.044
negative regulation of cellular protein metabolic process	GO:0032269	353	0.043
oocyte development	GO:0048599	1	0.043
regulation of apoptotic signaling pathway	GO:2001233	175	0.043
cell aging	GO:0007569	52	0.042
defense response to other organism	GO:0098542	129	0.041	Human Mouse
female gamete generation	GO:0007292	2	0.041
positive regulation of peptidase activity	GO:0010952	88	0.040
microtubule cytoskeleton organization	GO:0000226	176	0.039
segmentation	GO:0035282	4	0.039
head development	GO:0060322	108	0.038
positive regulation of hydrolase activity	GO:0051345	331	0.038
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	116	0.038
central nervous system development	GO:0007417	123	0.037
positive regulation of cellular component organization	GO:0051130	376	0.037
cytoplasmic transport	GO:0016482	379	0.037
compound eye development	GO:0048749	1	0.036
cell division	GO:0051301	168	0.036
negative regulation of cell death	GO:0060548	345	0.036
histone modification	GO:0016570	251	0.035
cell cycle arrest	GO:0007050	71	0.035	Human
covalent chromatin modification	GO:0016569	254	0.035
regulation of endopeptidase activity	GO:0052548	170	0.034
lipid metabolic process	GO:0006629	381	0.034
post embryonic organ development	GO:0048569	1	0.034
mrna processing	GO:0006397	133	0.034
histone acetylation	GO:0016573	93	0.034
extrinsic apoptotic signaling pathway	GO:0097191	119	0.033
negative regulation of canonical wnt signaling pathway	GO:0090090	55	0.033
intrinsic apoptotic signaling pathway in response to dna damage	GO:0008630	50	0.033
blastoderm segmentation	GO:0007350	2	0.032
epithelium development	GO:0060429	227	0.032
nucleoside phosphate biosynthetic process	GO:1901293	109	0.032
negative regulation of sequence specific dna binding transcription factor activity	GO:0043433	89	0.032
determination of adult lifespan	GO:0008340	2	0.032
neuron development	GO:0048666	113	0.031
rna processing	GO:0006396	255	0.031
positive regulation of phosphorylation	GO:0042327	394	0.031
regulation of keratinocyte apoptotic process	GO:1902172	1	0.031
single organism carbohydrate metabolic process	GO:0044723	193	0.031
erythrocyte homeostasis	GO:0034101	31	0.031
positive regulation of chromatin modification	GO:1903310	30	0.031
oxidation reduction process	GO:0055114	396	0.030
positive regulation of triglyceride biosynthetic process	GO:0010867	4	0.030
innate immune response	GO:0045087	178	0.030	Mouse
metal ion transport	GO:0030001	272	0.030
response to inorganic substance	GO:0010035	127	0.030
regulation of protein kinase activity	GO:0045859	289	0.029
intrinsic apoptotic signaling pathway	GO:0097193	127	0.029
plasma membrane organization	GO:0007009	115	0.028
cellular response to type i interferon	GO:0071357	12	0.028	Mouse
myeloid cell differentiation	GO:0030099	117	0.028
mitotic cell cycle process	GO:1903047	286	0.028
angiogenesis	GO:0001525	147	0.028
negative regulation of apoptotic process	GO:0043066	316	0.028
regulation of autophagy	GO:0010506	52	0.028
positive regulation of cellular amine metabolic process	GO:0033240	7	0.028
cellular response to mechanical stimulus	GO:0071260	39	0.028	Human
positive regulation of dna metabolic process	GO:0051054	73	0.027
mitochondrial membrane organization	GO:0007006	40	0.027
monovalent inorganic cation homeostasis	GO:0055067	37	0.027
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.027
negative regulation of programmed cell death	GO:0043069	321	0.027
positive regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043280	69	0.026
memory	GO:0007613	3	0.026
anion transport	GO:0006820	161	0.026
negative regulation of cell cycle	GO:0045786	193	0.026	Human
cell development	GO:0048468	328	0.026
mrna 3 end processing	GO:0031124	24	0.026
g protein coupled receptor signaling pathway	GO:0007186	207	0.026
peptide transport	GO:0015833	74	0.026
protein localization to organelle	GO:0033365	280	0.025
axon cargo transport	GO:0008088	2	0.025
regulation of jak stat cascade	GO:0046425	44	0.025
regulation of establishment of protein localization	GO:0070201	242	0.025
regulation of cysteine type endopeptidase activity	GO:2000116	127	0.025
response to nitric oxide	GO:0071731	4	0.025
positive regulation of cellular catabolic process	GO:0031331	284	0.025
cell type specific apoptotic process	GO:0097285	125	0.025
cellular response to nitrogen compound	GO:1901699	144	0.024
cellular ion homeostasis	GO:0006873	168	0.024
regulation of type i interferon mediated signaling pathway	GO:0060338	9	0.024	Mouse
multicellular organismal aging	GO:0010259	3	0.024
keratinocyte apoptotic process	GO:0097283	1	0.024
vesicle mediated transport	GO:0016192	371	0.024
oocyte differentiation	GO:0009994	2	0.024
cell morphogenesis	GO:0000902	296	0.024
anatomical structure formation involved in morphogenesis	GO:0048646	284	0.023
response to organonitrogen compound	GO:0010243	156	0.023
response to glucagon	GO:0033762	1	0.023
regulation of response to dna damage stimulus	GO:2001020	94	0.023
dna biosynthetic process	GO:0071897	40	0.023
positive regulation of autophagy	GO:0010508	24	0.023
negative regulation of cellular amino acid metabolic process	GO:0045763	2	0.022
microtubule bundle formation	GO:0001578	15	0.022
immune response regulating signaling pathway	GO:0002764	97	0.022
interferon alpha production	GO:0032607	11	0.022	Human Mouse
ion transmembrane transport	GO:0034220	338	0.022
cellular response to endogenous stimulus	GO:0071495	336	0.022
negative regulation of kinase activity	GO:0033673	106	0.022
positive regulation of endopeptidase activity	GO:0010950	84	0.022
regulation of protein localization	GO:0032880	296	0.022
regulation of cell cycle	GO:0051726	393	0.022	Human
response to radiation	GO:0009314	151	0.021
neuron death	GO:0070997	65	0.021
hormone transport	GO:0009914	68	0.021
response to toxic substance	GO:0009636	37	0.021
sensory organ development	GO:0007423	52	0.021
epithelial cell differentiation	GO:0030855	141	0.020
regulation of innate immune response	GO:0045088	97	0.020	Mouse
negative regulation of mapk cascade	GO:0043409	56	0.020
regulation of mitotic cell cycle	GO:0007346	189	0.020
glycerolipid biosynthetic process	GO:0045017	51	0.020
positive regulation of cytokine mediated signaling pathway	GO:0001961	12	0.020	Mouse
phospholipid metabolic process	GO:0006644	99	0.020
regulation of secretion	GO:0051046	194	0.020
spermatid differentiation	GO:0048515	4	0.020
purine nucleotide biosynthetic process	GO:0006164	84	0.020
osteoblast differentiation	GO:0001649	92	0.020
organic hydroxy compound metabolic process	GO:1901615	147	0.019
regulation of cytokine mediated signaling pathway	GO:0001959	41	0.019	Mouse
muscle structure development	GO:0061061	98	0.019
regulation of myeloid cell differentiation	GO:0045637	81	0.019
positive regulation of transport	GO:0051050	336	0.019
cation transport	GO:0006812	331	0.019
establishment of protein localization to plasma membrane	GO:0090002	68	0.019
protein localization to plasma membrane	GO:0072659	93	0.019
leukocyte activation	GO:0045321	164	0.019
regulation of kinase activity	GO:0043549	314	0.019
protein deubiquitination	GO:0016579	79	0.019
chloride transmembrane transport	GO:1902476	38	0.019
neurological system process	GO:0050877	163	0.019
regulation of lipid biosynthetic process	GO:0046890	47	0.019
hindbrain development	GO:0030902	3	0.019
hexose metabolic process	GO:0019318	55	0.019
embryonic morphogenesis	GO:0048598	85	0.019
immune response activating cell surface receptor signaling pathway	GO:0002429	45	0.019
nuclear import	GO:0051170	106	0.019
innate immune response activating signal transduction	GO:0002758	48	0.019
generation of neurons	GO:0048699	152	0.018
glycerophospholipid metabolic process	GO:0006650	84	0.018
lymphocyte homeostasis	GO:0002260	4	0.018
adaptive immune response	GO:0002250	49	0.018	Human
positive regulation of homeostatic process	GO:0032846	47	0.018
cell projection organization	GO:0030030	252	0.018
negative regulation of wnt signaling pathway	GO:0030178	69	0.018
regulation of neural precursor cell proliferation	GO:2000177	4	0.018
cellular carbohydrate metabolic process	GO:0044262	84	0.018
response to uv	GO:0009411	73	0.018
nucleic acid phosphodiester bond hydrolysis	GO:0090305	102	0.018
neuron differentiation	GO:0030182	138	0.017
regulation of cell growth	GO:0001558	135	0.017
protein ubiquitination	GO:0016567	314	0.017
mitochondrial transport	GO:0006839	60	0.017
regulation of angiogenesis	GO:0045765	92	0.017
renal system development	GO:0072001	63	0.017
histone serine phosphorylation	GO:0035404	4	0.017
positive regulation of histone deacetylase activity	GO:1901727	3	0.016
negative regulation of transferase activity	GO:0051348	124	0.016
response to light stimulus	GO:0009416	87	0.016
regulation of lymphocyte activation	GO:0051249	103	0.016
positive regulation of cytokine biosynthetic process	GO:0042108	25	0.016
positive regulation of myeloid cell differentiation	GO:0045639	39	0.016
secretion by cell	GO:0032940	226	0.016
neuroblast proliferation	GO:0007405	4	0.016
lymphocyte activation	GO:0046649	133	0.016
negative regulation of g0 to g1 transition	GO:0070317	2	0.016
mitotic cell cycle	GO:0000278	326	0.016
regulation of hormone levels	GO:0010817	125	0.016
activation of immune response	GO:0002253	114	0.016
spermatid development	GO:0007286	4	0.016
negative regulation of protein kinase activity	GO:0006469	98	0.016
system process	GO:0003008	349	0.016
actin filament bundle organization	GO:0061572	54	0.016
stem cell development	GO:0048864	69	0.016
regulation of erythrocyte differentiation	GO:0045646	17	0.016
positive regulation of lipid biosynthetic process	GO:0046889	22	0.016
lymphocyte mediated immunity	GO:0002449	48	0.015
immune response activating signal transduction	GO:0002757	90	0.015
response to hormone	GO:0009725	175	0.015
erythrocyte differentiation	GO:0030218	28	0.015
monovalent inorganic cation transport	GO:0015672	128	0.015
peptide hormone secretion	GO:0030072	50	0.015
regulation of cellular ketone metabolic process by positive regulation of transcription from rna polymerase ii promoter	GO:0072366	1	0.015
epidermis development	GO:0008544	59	0.015
visual learning	GO:0008542	1	0.015
rna polyadenylation	GO:0043631	14	0.015
protein processing	GO:0016485	226	0.015
regulation of plasma lipoprotein particle levels	GO:0097006	32	0.015
regeneration	GO:0031099	4	0.015
protein import	GO:0017038	130	0.015
response to peptide hormone	GO:0043434	61	0.015
embryonic placenta development	GO:0001892	1	0.015
regulation of proteolysis	GO:0030162	293	0.015
cellular response to insulin stimulus	GO:0032869	41	0.015
protein autophosphorylation	GO:0046777	123	0.014
skin development	GO:0043588	76	0.014
gland development	GO:0048732	48	0.014
positive regulation of erythrocyte differentiation	GO:0045648	11	0.014
carbohydrate derivative biosynthetic process	GO:1901137	207	0.014
cellular response to growth factor stimulus	GO:0071363	197	0.014
carbon catabolite activation of transcription from rna polymerase ii promoter	GO:0000436	3	0.014
positive regulation of interleukin 4 biosynthetic process	GO:0045404	1	0.014
cellular lipid metabolic process	GO:0044255	303	0.014
morphogenesis of embryonic epithelium	GO:0016331	4	0.014
nuclear transport	GO:0051169	179	0.014
regulation of cell activation	GO:0050865	125	0.014
blood vessel morphogenesis	GO:0048514	162	0.014
regulation of growth	GO:0040008	165	0.014
response to tumor necrosis factor	GO:0034612	76	0.014
response to drug	GO:0042493	81	0.013
chromatin modification	GO:0016568	298	0.013
positive regulation of keratinocyte apoptotic process	GO:1902174	1	0.013
stem cell differentiation	GO:0048863	93	0.013
neuron remodeling	GO:0016322	2	0.013
defense response to gram negative bacterium	GO:0050829	14	0.013
dephosphorylation	GO:0016311	209	0.013
positive regulation of secretion	GO:0051047	116	0.013
amino acid import	GO:0043090	4	0.013
positive regulation of mitochondrial membrane permeability	GO:0035794	17	0.013
apoptotic process involved in morphogenesis	GO:0060561	3	0.013
regulation of transporter activity	GO:0032409	82	0.013
carbohydrate metabolic process	GO:0005975	207	0.013
regulation of intrinsic apoptotic signaling pathway	GO:2001242	72	0.013
cellular component morphogenesis	GO:0032989	314	0.013
regulation of dna metabolic process	GO:0051052	153	0.013
positive regulation of ion transmembrane transport	GO:0034767	40	0.013
cell death in response to oxidative stress	GO:0036473	29	0.013
endoplasmic reticulum organization	GO:0007029	20	0.013
regulation of neuron apoptotic process	GO:0043523	35	0.013
regulation of protein catabolic process	GO:0042176	155	0.013
visual behavior	GO:0007632	2	0.012
response to growth factor	GO:0070848	205	0.012
cellular response to oxygen containing compound	GO:1901701	276	0.012	Mouse
positive regulation of mapk cascade	GO:0043410	190	0.012
regulation of adaptive immune response	GO:0002819	33	0.012	Human
response to type i interferon	GO:0034340	14	0.012	Mouse
regulation of map kinase activity	GO:0043405	108	0.012
positive regulation of cell proliferation	GO:0008284	301	0.012
regulation of intracellular transport	GO:0032386	195	0.012
urea metabolic process	GO:0019627	3	0.012
mitotic cell cycle checkpoint	GO:0007093	68	0.012
regulation of cholesterol homeostasis	GO:2000188	2	0.012
maintenance of location	GO:0051235	112	0.012
generation of precursor metabolites and energy	GO:0006091	68	0.012
regulation of secretion by cell	GO:1903530	177	0.012
peptidyl lysine modification	GO:0018205	144	0.012
positive regulation of protein complex assembly	GO:0031334	86	0.012
digestive tract development	GO:0048565	75	0.012
cellular response to peptide hormone stimulus	GO:0071375	56	0.012
peptidyl tyrosine modification	GO:0018212	170	0.012
mammary gland morphogenesis	GO:0060443	2	0.012
regulation of membrane permeability	GO:0090559	25	0.012
histone h4 acetylation	GO:0043967	47	0.011
striated muscle cell differentiation	GO:0051146	43	0.011
regulation of extrinsic apoptotic signaling pathway	GO:2001236	85	0.011
cytokine production	GO:0001816	247	0.011	Human Mouse
cellular macromolecular complex assembly	GO:0034622	324	0.011
response to decreased oxygen levels	GO:0036293	96	0.011
endosomal transport	GO:0016197	129	0.011
regulation of lipid metabolic process	GO:0019216	96	0.011
organic hydroxy compound transport	GO:0015850	63	0.011
regulation of cellular response to stress	GO:0080135	244	0.011
cellular response to reactive nitrogen species	GO:1902170	2	0.011
b cell homeostasis	GO:0001782	1	0.011
tripartite regional subdivision	GO:0007351	2	0.011
homeostasis of number of cells	GO:0048872	40	0.011
golgi vesicle transport	GO:0048193	80	0.011
regulation of peptidyl serine phosphorylation	GO:0033135	50	0.011
sensory perception	GO:0007600	103	0.011
anatomical structure homeostasis	GO:0060249	100	0.011
regulation of cell cycle phase transition	GO:1901987	126	0.011
mitochondrion organization	GO:0007005	156	0.011
positive regulation of binding	GO:0051099	45	0.011
inorganic anion transport	GO:0015698	60	0.011
phosphatidylcholine metabolic process	GO:0046470	19	0.011
cellular response to radiation	GO:0071478	65	0.011
regulation of transferase activity	GO:0051338	355	0.011
pyridine containing compound biosynthetic process	GO:0072525	3	0.011
regulation of neuron death	GO:1901214	56	0.011
cellular response to extracellular stimulus	GO:0031668	72	0.011
positive regulation of interleukin 2 production	GO:0032743	11	0.011
camp biosynthetic process	GO:0006171	47	0.011
response to cocaine	GO:0042220	1	0.011
regulation of anatomical structure size	GO:0090066	101	0.011
protein maturation	GO:0051604	233	0.010
negative regulation of developmental growth	GO:0048640	10	0.010
regulation of receptor activity	GO:0010469	47	0.010
response to hyperoxia	GO:0055093	4	0.010
cytokine metabolic process	GO:0042107	38	0.010	Mouse
neuron projection development	GO:0031175	106	0.010
positive regulation of neuron death	GO:1901216	14	0.010
interleukin 8 production	GO:0032637	51	0.010
negative regulation of hydrolase activity	GO:0051346	182	0.010
chromosome segregation	GO:0007059	114	0.010
regulation of protein complex assembly	GO:0043254	147	0.010
regulation of wnt signaling pathway	GO:0030111	123	0.010

IRF3 disease predictions

Disease	DO term ID	Size	Probability	Func Analog Org
disease of cellular proliferation	DOID:14566	174	0.115	Human
cancer	DOID:162	167	0.112	Human
organ system cancer	DOID:0050686	164	0.105	Human
central nervous system disease	DOID:331	186	0.084
nervous system disease	DOID:863	431	0.084
disease of metabolism	DOID:0014667	295	0.043
neurodegenerative disease	DOID:1289	102	0.040
synucleinopathy	DOID:0050890	22	0.040
musculoskeletal system disease	DOID:17	223	0.014
connective tissue disease	DOID:65	109	0.014
gastrointestinal system cancer	DOID:3119	52	0.013	Human
brain disease	DOID:936	73	0.013
epilepsy syndrome	DOID:1826	41	0.013
large intestine cancer	DOID:5672	29	0.011
intestinal cancer	DOID:10155	29	0.011
colorectal cancer	DOID:9256	29	0.011

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