IMP: Integrative Multi-species Prediction

Homo sapiens

0 known processes

LIAS

lipoic acid synthetase

(Aliases: LIP1,LS,MGC23245,LAS)

Entrez: 11019
HPRD: 09514
HGNC: 16429
MIM: 607031
Ensembl: ENSG00000121897
UniProtKB: B4E0L7
UniProtKB: Q6P5Q6
UniProtKB: A0A024R9W0
UniProtKB: O43766

Process Predictions
Disease Predictions

LIAS biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
mitochondrion organization	GO:0007005	156	0.145
post embryonic development	GO:0009791	2	0.086
cellular amino acid metabolic process	GO:0006520	116	0.053
transmembrane transport	GO:0055085	399	0.048
purine nucleoside triphosphate metabolic process	GO:0009144	412	0.044
purine nucleoside triphosphate catabolic process	GO:0009146	392	0.043
mitochondrial respiratory chain complex assembly	GO:0033108	23	0.042
cellular protein complex assembly	GO:0043623	188	0.034
purine ribonucleoside catabolic process	GO:0046130	398	0.033
mitochondrial translation	GO:0032543	17	0.033
protein localization to organelle	GO:0033365	280	0.032
cellular macromolecular complex assembly	GO:0034622	324	0.031
oxidation reduction process	GO:0055114	396	0.030
nucleotide catabolic process	GO:0009166	408	0.029
multicellular organismal aging	GO:0010259	3	0.029
purine ribonucleoside triphosphate catabolic process	GO:0009207	391	0.028
nucleoside phosphate catabolic process	GO:1901292	412	0.028
nadh dehydrogenase complex assembly	GO:0010257	16	0.028
ncrna metabolic process	GO:0034660	108	0.028
cellular ketone metabolic process	GO:0042180	80	0.027
negative regulation of catalytic activity	GO:0043086	335	0.027
locomotory behavior	GO:0007626	1	0.025
single organism cellular localization	GO:1902580	332	0.025
ribonucleoside triphosphate catabolic process	GO:0009203	391	0.024
response to abiotic stimulus	GO:0009628	336	0.024
purine ribonucleoside metabolic process	GO:0046128	437	0.024
regulation of cell cycle process	GO:0010564	266	0.023
regulation of cellular ketone metabolic process	GO:0010565	50	0.023
coenzyme metabolic process	GO:0006732	65	0.023
translation	GO:0006412	132	0.022
protein import	GO:0017038	130	0.022
nucleoside catabolic process	GO:0009164	408	0.022
purine ribonucleoside triphosphate metabolic process	GO:0009205	411	0.022
determination of adult lifespan	GO:0008340	2	0.022
regulation of cell cycle	GO:0051726	393	0.022
sulfur compound metabolic process	GO:0006790	101	0.021
regeneration	GO:0031099	4	0.021
nucleoside triphosphate catabolic process	GO:0009143	394	0.021
purine nucleoside catabolic process	GO:0006152	398	0.021
cation transmembrane transport	GO:0098655	238	0.021
cellular response to dna damage stimulus	GO:0006974	379	0.020
adult locomotory behavior	GO:0008344	1	0.020
oogenesis	GO:0048477	2	0.020
ribonucleotide catabolic process	GO:0009261	405	0.020
vesicle mediated transport	GO:0016192	371	0.019
intracellular protein transmembrane transport	GO:0065002	24	0.019
positive regulation of hydrolase activity	GO:0051345	331	0.019
cellular macromolecule catabolic process	GO:0044265	380	0.019
negative regulation of phosphorus metabolic process	GO:0010563	267	0.019
negative regulation of cell death	GO:0060548	345	0.019
cellular amine metabolic process	GO:0044106	41	0.018
organophosphate catabolic process	GO:0046434	430	0.018
intracellular protein transport	GO:0006886	270	0.018
carboxylic acid catabolic process	GO:0046395	71	0.018
protein secretion	GO:0009306	98	0.017
ribonucleoside triphosphate metabolic process	GO:0009199	412	0.017
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	281	0.017
nucleoside triphosphate metabolic process	GO:0009141	422	0.017
female gamete generation	GO:0007292	2	0.017
protein oligomerization	GO:0051259	173	0.017
regulation of cellular response to stress	GO:0080135	244	0.017
regulation of cellular amine metabolic process	GO:0033238	11	0.017
rna modification	GO:0009451	27	0.017
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.017
anterior posterior axis specification	GO:0009948	2	0.016
negative regulation of developmental process	GO:0051093	247	0.016
lipid metabolic process	GO:0006629	381	0.016
amine metabolic process	GO:0009308	44	0.016
protein transmembrane transport	GO:0071806	25	0.016
negative regulation of programmed cell death	GO:0043069	321	0.016
secretion	GO:0046903	254	0.016
purine nucleoside monophosphate metabolic process	GO:0009126	186	0.015
trna aminoacylation	GO:0043039	12	0.015
mitotic cell cycle process	GO:1903047	286	0.015
purine nucleotide catabolic process	GO:0006195	405	0.015
chemical homeostasis	GO:0048878	306	0.015
cofactor metabolic process	GO:0051186	87	0.015
negative regulation of cellular protein metabolic process	GO:0032269	353	0.015
regulation of anatomical structure morphogenesis	GO:0022603	286	0.015
purine containing compound catabolic process	GO:0072523	411	0.015
regulation of cellular amino acid metabolic process	GO:0006521	6	0.015
negative regulation of hydrolase activity	GO:0051346	182	0.015
segmentation	GO:0035282	4	0.015
protein targeting	GO:0006605	187	0.015
negative regulation of apoptotic process	GO:0043066	316	0.014
negative regulation of phosphate metabolic process	GO:0045936	267	0.014
negative regulation of cellular component organization	GO:0051129	235	0.014
cytoplasmic transport	GO:0016482	379	0.014
ribonucleoside catabolic process	GO:0042454	406	0.014
microtubule based process	GO:0007017	210	0.014
fatty acid metabolic process	GO:0006631	115	0.014
multicellular organismal homeostasis	GO:0048871	67	0.014
regulation of protein localization	GO:0032880	296	0.014
regulation of transferase activity	GO:0051338	355	0.014
glycosyl compound catabolic process	GO:1901658	413	0.014
tissue regeneration	GO:0042246	3	0.014
compound eye development	GO:0048749	1	0.014
rna processing	GO:0006396	255	0.014
positive regulation of transport	GO:0051050	336	0.014
positive regulation of cellular amine metabolic process	GO:0033240	7	0.013
cation transport	GO:0006812	331	0.013
single organism membrane organization	GO:0044802	268	0.013
regulation of membrane potential	GO:0042391	95	0.013
cellular lipid metabolic process	GO:0044255	303	0.013
secretion by cell	GO:0032940	226	0.013
amino acid activation	GO:0043038	12	0.013
response to oxygen containing compound	GO:1901700	369	0.013
neuromuscular junction development	GO:0007528	3	0.012
brain morphogenesis	GO:0048854	1	0.012
dna repair	GO:0006281	198	0.012
cell development	GO:0048468	328	0.012
trna metabolic process	GO:0006399	35	0.012
cell morphogenesis	GO:0000902	296	0.012
cell division	GO:0051301	168	0.012
carbohydrate metabolic process	GO:0005975	207	0.012
intracellular mrna localization	GO:0008298	1	0.012
negative regulation of multicellular organismal process	GO:0051241	317	0.012
positive regulation of cell death	GO:0010942	263	0.012
cellular response to endogenous stimulus	GO:0071495	336	0.012
mitochondrial respiratory chain complex i biogenesis	GO:0097031	16	0.012
gtp metabolic process	GO:0046039	239	0.012
blastoderm segmentation	GO:0007350	2	0.011
epithelial cell proliferation	GO:0050673	128	0.011
peripheral nervous system development	GO:0007422	2	0.011
anterior posterior axis specification embryo	GO:0008595	2	0.011
establishment of protein localization to organelle	GO:0072594	172	0.011
negative regulation of protein metabolic process	GO:0051248	391	0.011
regulation of cellular component movement	GO:0051270	334	0.011
negative regulation of cellular amino acid metabolic process	GO:0045763	2	0.011
inorganic cation transmembrane transport	GO:0098662	194	0.011
viral process	GO:0016032	146	0.011
positive regulation of programmed cell death	GO:0043068	249	0.011
cell projection organization	GO:0030030	252	0.011
regulation of establishment of protein localization	GO:0070201	242	0.011
macromolecule methylation	GO:0043414	97	0.011
positive regulation of cellular component organization	GO:0051130	376	0.011
guanosine containing compound catabolic process	GO:1901069	239	0.011
cellular component morphogenesis	GO:0032989	314	0.011
regulation of locomotion	GO:0040012	329	0.011
system process	GO:0003008	349	0.011
protein maturation	GO:0051604	233	0.011
regulation of secretion by cell	GO:1903530	177	0.010
monocarboxylic acid metabolic process	GO:0032787	185	0.010
purine ribonucleoside monophosphate catabolic process	GO:0009169	158	0.010
regulation of growth	GO:0040008	165	0.010
negative regulation of intracellular signal transduction	GO:1902532	183	0.010
regulation of cell division	GO:0051302	116	0.010
regulation of cell differentiation	GO:0045595	393	0.010
positive regulation of apoptotic process	GO:0043065	246	0.010
negative regulation of cellular amine metabolic process	GO:0033239	3	0.010
cellular cation homeostasis	GO:0030003	163	0.010
multi organism cellular process	GO:0044764	156	0.010
methylation	GO:0032259	106	0.010
rna splicing	GO:0008380	131	0.010
immune response	GO:0006955	307	0.010
regulation of neural precursor cell proliferation	GO:2000177	4	0.010

LIAS disease predictions

Disease	DO term ID	Size	Probability
nervous system disease	DOID:863	431	0.041
sensory system disease	DOID:0050155	203	0.041
eye and adnexa disease	DOID:1492	150	0.041
retinal disease	DOID:5679	118	0.025
eye disease	DOID:5614	149	0.025
disease of metabolism	DOID:0014667	295	0.024
musculoskeletal system disease	DOID:17	223	0.021
muscle tissue disease	DOID:66	113	0.019
muscular disease	DOID:0080000	114	0.019
myopathy	DOID:423	104	0.017
retinal degeneration	DOID:8466	89	0.016
immune system disease	DOID:2914	155	0.015
primary ciliary dyskinesia	DOID:9562	27	0.014
cancer	DOID:162	167	0.014
disease of cellular proliferation	DOID:14566	174	0.014
cardiovascular system disease	DOID:1287	106	0.010

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