IMP: Integrative Multi-species Prediction

Homo sapiens

67 known processes

LMNA

lamin A/C

(Aliases: HGPS,LDP1,FPL,LMN1,CDCD1,LMNL1,CDDC,PRO1,EMD2,CMT2B1,LFP,LMNC,LGMD1B,IDC,FPLD,CMD1A)

Entrez: 4000
Ensembl: ENSG00000160789
MIM: 150330
HGNC: 6636
HPRD: 01035
UniProtKB: Q5TCI8
UniProtKB: P02545

Process Predictions
Disease Predictions

LMNA biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
actin filament based process	GO:0030029	224	0.987	Worm Fly
actin cytoskeleton organization	GO:0030036	207	0.957	Worm Fly
actin filament organization	GO:0007015	128	0.955	Fly
cell projection organization	GO:0030030	252	0.844
circulatory system development	GO:0072359	262	0.830	Mouse
regulation of actin cytoskeleton organization	GO:0032956	116	0.810	Fly
biological adhesion	GO:0022610	331	0.801
cell adhesion	GO:0007155	325	0.793
positive regulation of cellular component organization	GO:0051130	376	0.789
post embryonic development	GO:0009791	2	0.787	Worm
cell matrix adhesion	GO:0007160	85	0.765
regulation of cytoskeleton organization	GO:0051493	177	0.751	Fly
regulation of protein localization	GO:0032880	296	0.723	Mouse
nucleoside catabolic process	GO:0009164	408	0.698
endothelial cell migration	GO:0043542	86	0.676
regulation of cellular ketone metabolic process	GO:0010565	50	0.654
nucleoside phosphate catabolic process	GO:1901292	412	0.640
purine nucleotide catabolic process	GO:0006195	405	0.613
single organism cellular localization	GO:1902580	332	0.611	Mouse Worm Fly
regulation of cell differentiation	GO:0045595	393	0.590
purine nucleoside catabolic process	GO:0006152	398	0.588
glycosyl compound catabolic process	GO:1901658	413	0.569
cell substrate adhesion	GO:0031589	132	0.568
regulation of rho protein signal transduction	GO:0035023	79	0.568
single organismal cell cell adhesion	GO:0016337	148	0.566
regulation of anatomical structure morphogenesis	GO:0022603	286	0.565
organophosphate catabolic process	GO:0046434	430	0.545
purine nucleoside triphosphate metabolic process	GO:0009144	412	0.539
positive regulation of gtpase activity	GO:0043547	166	0.534
guanosine containing compound metabolic process	GO:1901068	244	0.503
cell activation	GO:0001775	213	0.500
cell development	GO:0048468	328	0.498	Mouse Worm
regulation of protein localization to nucleus	GO:1900180	85	0.492	Mouse
regulation of actin filament based process	GO:0032970	141	0.491	Fly
nucleoside triphosphate catabolic process	GO:0009143	394	0.491
purine ribonucleoside triphosphate catabolic process	GO:0009207	391	0.490
regulation of nucleoside metabolic process	GO:0009118	209	0.484
single organism membrane organization	GO:0044802	268	0.483	Mouse Fly
regulation of gtpase activity	GO:0043087	180	0.478
establishment of protein localization to membrane	GO:0090150	121	0.477
purine containing compound catabolic process	GO:0072523	411	0.469
cellular response to growth factor stimulus	GO:0071363	197	0.465
single organism cell adhesion	GO:0098602	179	0.464
regulation of cellular amine metabolic process	GO:0033238	11	0.464
chemotaxis	GO:0006935	157	0.456
cellular amine metabolic process	GO:0044106	41	0.450
positive regulation of gtp catabolic process	GO:0033126	166	0.447
nucleoside triphosphate metabolic process	GO:0009141	422	0.439
cell morphogenesis	GO:0000902	296	0.432
regulation of purine nucleotide metabolic process	GO:1900542	264	0.431
actin filament bundle organization	GO:0061572	54	0.415
positive regulation of cell adhesion	GO:0045785	84	0.410
purine nucleoside triphosphate catabolic process	GO:0009146	392	0.405
ameboidal type cell migration	GO:0001667	135	0.405
blood circulation	GO:0008015	113	0.403	Zebrafish
regulation of cell morphogenesis	GO:0022604	153	0.397
cellular component morphogenesis	GO:0032989	314	0.389	Worm
cell chemotaxis	GO:0060326	112	0.388
regulation of cell migration	GO:0030334	289	0.386	Mouse
ribonucleoside triphosphate metabolic process	GO:0009199	412	0.386
negative regulation of organelle organization	GO:0010639	126	0.379	Mouse
transforming growth factor beta receptor signaling pathway	GO:0007179	76	0.377
ribonucleotide catabolic process	GO:0009261	405	0.371
leukocyte migration	GO:0050900	107	0.364
protein catabolic process	GO:0030163	325	0.360	Worm
nucleotide catabolic process	GO:0009166	408	0.357
rho protein signal transduction	GO:0007266	26	0.357
nervous system development	GO:0007399	293	0.347	Fly
positive regulation of cellular catabolic process	GO:0031331	284	0.344
regulation of cellular component biogenesis	GO:0044087	281	0.334	Fly
i kappab kinase nf kappab signaling	GO:0007249	166	0.332
positive regulation of i kappab kinase nf kappab signaling	GO:0043123	132	0.330
regulation of actin filament bundle assembly	GO:0032231	36	0.330
establishment of protein localization to plasma membrane	GO:0090002	68	0.329
regulation of gtp catabolic process	GO:0033124	180	0.324
guanosine containing compound catabolic process	GO:1901069	239	0.322
regulation of nucleotide catabolic process	GO:0030811	205	0.315
protein localization to membrane	GO:0072657	160	0.309
cellular macromolecular complex assembly	GO:0034622	324	0.307	Worm Fly
cell morphogenesis involved in differentiation	GO:0000904	144	0.301
regulation of establishment of protein localization	GO:0070201	242	0.300
purine ribonucleoside metabolic process	GO:0046128	437	0.299
positive regulation of nucleotide catabolic process	GO:0030813	185	0.298
ribonucleoside triphosphate catabolic process	GO:0009203	391	0.292
regulation of cellular amino acid metabolic process	GO:0006521	6	0.292
positive regulation of programmed cell death	GO:0043068	249	0.288
plasma membrane organization	GO:0007009	115	0.285
wound healing	GO:0042060	115	0.283
positive regulation of intracellular protein transport	GO:0090316	76	0.281
positive regulation of transport	GO:0051050	336	0.278
positive regulation of hydrolase activity	GO:0051345	331	0.275
epithelial cell differentiation	GO:0030855	141	0.269
response to growth factor	GO:0070848	205	0.261
positive regulation of nucleoside metabolic process	GO:0045979	186	0.257
enzyme linked receptor protein signaling pathway	GO:0007167	303	0.254
positive regulation of cell proliferation	GO:0008284	301	0.253	Worm
cellular response to endogenous stimulus	GO:0071495	336	0.249
positive regulation of cytoplasmic transport	GO:1903651	82	0.246
regulation of stress fiber assembly	GO:0051492	32	0.245
regulation of cell substrate adhesion	GO:0010810	68	0.244
positive regulation of purine nucleotide catabolic process	GO:0033123	185	0.242
small gtpase mediated signal transduction	GO:0007264	78	0.242
regulation of nucleotide metabolic process	GO:0006140	269	0.241
ribonucleoside catabolic process	GO:0042454	406	0.238
gtp catabolic process	GO:0006184	237	0.236
protein oligomerization	GO:0051259	173	0.233
secretion	GO:0046903	254	0.233
anatomical structure formation involved in morphogenesis	GO:0048646	284	0.232	Worm
secretion by cell	GO:0032940	226	0.231
regulation of cell morphogenesis involved in differentiation	GO:0010769	83	0.230
positive regulation of cell death	GO:0010942	263	0.229
epithelial cell migration	GO:0010631	119	0.229
purine ribonucleoside catabolic process	GO:0046130	398	0.229
regulation of rho gtpase activity	GO:0032319	66	0.223
endomembrane system organization	GO:0010256	196	0.222	Mouse Fly
protein targeting	GO:0006605	187	0.220	Mouse
cell junction organization	GO:0034330	79	0.219
protein localization to plasma membrane	GO:0072659	93	0.218
growth	GO:0040007	202	0.218	Worm
neuron differentiation	GO:0030182	138	0.216
protein import	GO:0017038	130	0.212	Mouse
response to inorganic substance	GO:0010035	127	0.212
amine metabolic process	GO:0009308	44	0.210
regulation of locomotion	GO:0040012	329	0.208	Mouse
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	116	0.208
positive regulation of protein transport	GO:0051222	135	0.207
purine ribonucleotide catabolic process	GO:0009154	404	0.206
intracellular protein transport	GO:0006886	270	0.204	Mouse
actin filament bundle assembly	GO:0051017	54	0.201
inorganic cation transmembrane transport	GO:0098662	194	0.200
cytoplasmic transport	GO:0016482	379	0.194	Mouse
regulation of intracellular transport	GO:0032386	195	0.193
protein localization to nucleus	GO:0034504	136	0.192	Mouse Fly
response to wounding	GO:0009611	168	0.190
mitotic nuclear division	GO:0007067	119	0.189	Worm
stress fiber assembly	GO:0043149	40	0.188
positive regulation of apoptotic process	GO:0043065	246	0.175
positive regulation of ras gtpase activity	GO:0032320	117	0.170
blood vessel endothelial cell migration	GO:0043534	42	0.169
ras protein signal transduction	GO:0007265	73	0.168
cell part morphogenesis	GO:0032990	137	0.167
vasculature development	GO:0001944	181	0.164
regulation of cell motility	GO:2000145	299	0.161	Mouse
leukotriene a4 metabolic process	GO:1901751	1	0.161
response to abiotic stimulus	GO:0009628	336	0.160
response to lipid	GO:0033993	206	0.160
organelle assembly	GO:0070925	176	0.157	Worm
circulatory system process	GO:0003013	113	0.154	Zebrafish
regulation of ras gtpase activity	GO:0032318	128	0.151
gtp metabolic process	GO:0046039	239	0.150
myeloid cell differentiation	GO:0030099	117	0.150
homotypic cell cell adhesion	GO:0034109	47	0.149
taxis	GO:0042330	157	0.149
cellular ketone metabolic process	GO:0042180	80	0.148
cell junction assembly	GO:0034329	67	0.148
negative regulation of cellular component movement	GO:0051271	106	0.148
cellular response to transforming growth factor beta stimulus	GO:0071560	94	0.144
locomotory behavior	GO:0007626	1	0.143	Fly
regulation of protein import into nucleus	GO:0042306	78	0.143
cellular component assembly involved in morphogenesis	GO:0010927	73	0.142	Worm
system process	GO:0003008	349	0.142	Zebrafish
negative regulation of multicellular organismal process	GO:0051241	317	0.142
regulation of peptidase activity	GO:0052547	180	0.140
positive regulation of cell substrate adhesion	GO:0010811	37	0.140
positive regulation of protein localization to nucleus	GO:1900182	48	0.139
positive regulation of cell migration	GO:0030335	172	0.139
mitotic cell cycle process	GO:1903047	286	0.139	Worm Fly
positive regulation of intracellular transport	GO:0032388	104	0.138
cardiovascular system development	GO:0072358	262	0.138	Mouse
regulation of i kappab kinase nf kappab signaling	GO:0043122	162	0.138
muscle structure development	GO:0061061	98	0.137
platelet aggregation	GO:0070527	32	0.135
regulation of protein transport	GO:0051223	213	0.134
regulation of microtubule cytoskeleton organization	GO:0070507	61	0.133
response to oxygen containing compound	GO:1901700	369	0.133
nucleocytoplasmic transport	GO:0006913	176	0.133	Mouse
regulation of proteolysis	GO:0030162	293	0.133
positive regulation of catabolic process	GO:0009896	310	0.131
vesicle mediated transport	GO:0016192	371	0.131	Worm
nuclear division	GO:0000280	128	0.130	Worm
positive regulation of cellular component movement	GO:0051272	181	0.125
negative regulation of apoptotic process	GO:0043066	316	0.125	Mouse
substrate adhesion dependent cell spreading	GO:0034446	41	0.125
cellular response to abiotic stimulus	GO:0071214	117	0.124
cellular amino acid metabolic process	GO:0006520	116	0.123
regulation of cardiac muscle cell membrane potential	GO:0086036	1	0.122
positive regulation of cell differentiation	GO:0045597	211	0.119
regulation of small gtpase mediated signal transduction	GO:0051056	156	0.118
multicellular organismal aging	GO:0010259	3	0.117	Worm
regulation of endopeptidase activity	GO:0052548	170	0.116
positive regulation of nucleotide metabolic process	GO:0045981	230	0.116
peptidyl tyrosine phosphorylation	GO:0018108	170	0.116
membrane organization	GO:0061024	292	0.115	Mouse Fly
positive regulation of axon extension	GO:0045773	4	0.114
positive regulation of cellular amine metabolic process	GO:0033240	7	0.114
positive regulation of cell development	GO:0010720	92	0.114
negative regulation of cellular protein metabolic process	GO:0032269	353	0.113
autophagy	GO:0006914	88	0.113
organ morphogenesis	GO:0009887	147	0.112	Fly
positive regulation of cell motility	GO:2000147	177	0.111
negative regulation of transport	GO:0051051	176	0.110
negative regulation of protein catabolic process	GO:0042177	59	0.110
protein processing	GO:0016485	226	0.110
generation of neurons	GO:0048699	152	0.108
cellular response to external stimulus	GO:0071496	111	0.106
motor neuron axon guidance	GO:0008045	2	0.105
regulation of purine nucleotide catabolic process	GO:0033121	205	0.105
cation transmembrane transport	GO:0098655	238	0.104
metal ion transport	GO:0030001	272	0.101
female gamete generation	GO:0007292	2	0.101
regulation of anatomical structure size	GO:0090066	101	0.100	Fly
regulation of cell adhesion	GO:0030155	166	0.100
leukocyte chemotaxis	GO:0030595	76	0.099
response to biotic stimulus	GO:0009607	276	0.099
positive regulation of defense response	GO:0031349	87	0.099
positive regulation of rho gtpase activity	GO:0032321	56	0.098
muscle contraction	GO:0006936	73	0.098
negative regulation of cell migration	GO:0030336	102	0.097
muscle organ development	GO:0007517	56	0.096
cell substrate adherens junction assembly	GO:0007045	30	0.095
positive regulation of nucleocytoplasmic transport	GO:0046824	54	0.095
microtubule based process	GO:0007017	210	0.095	Mouse Fly
positive regulation of purine nucleotide metabolic process	GO:1900544	227	0.094
regulation of cellular component movement	GO:0051270	334	0.094	Mouse
positive regulation of actin filament bundle assembly	GO:0032233	25	0.094
regulation of protein targeting	GO:1903533	91	0.093
positive regulation of rac gtpase activity	GO:0032855	31	0.093
determination of adult lifespan	GO:0008340	2	0.092	Worm
embryo development	GO:0009790	123	0.091	Worm
negative regulation of protein metabolic process	GO:0051248	391	0.091
protein localization to cell surface	GO:0034394	28	0.091
organic hydroxy compound metabolic process	GO:1901615	147	0.090
innate immune response	GO:0045087	178	0.090
hepoxilin metabolic process	GO:0051121	1	0.090
regulation of membrane potential	GO:0042391	95	0.090
regulation of neurogenesis	GO:0050767	82	0.089
angiogenesis	GO:0001525	147	0.088
regulation of cell growth	GO:0001558	135	0.087
regulation of mitotic cell cycle	GO:0007346	189	0.087	Worm
cell projection morphogenesis	GO:0048858	129	0.086
neuron projection development	GO:0031175	106	0.084
coagulation	GO:0050817	78	0.083
myeloid leukocyte migration	GO:0097529	62	0.081
positive regulation of phosphorylation	GO:0042327	394	0.081
blood vessel morphogenesis	GO:0048514	162	0.080
neuron projection regeneration	GO:0031102	1	0.079
response to other organism	GO:0051707	261	0.079
regulation of protein complex assembly	GO:0043254	147	0.078	Fly
interleukin 1 production	GO:0032612	26	0.078
regulation of epithelial cell migration	GO:0010632	93	0.078
nucleoside monophosphate metabolic process	GO:0009123	191	0.077
neurological system process	GO:0050877	163	0.076
regulation of defense response	GO:0031347	154	0.076
negative regulation of catabolic process	GO:0009895	104	0.076
muscle cell development	GO:0055001	29	0.076	Mouse Worm
cell growth	GO:0016049	160	0.075
positive regulation of developmental process	GO:0051094	314	0.075
regulation of cell development	GO:0060284	161	0.074
endocytosis	GO:0006897	159	0.074	Worm
purine ribonucleoside triphosphate metabolic process	GO:0009205	411	0.073
intrinsic apoptotic signaling pathway	GO:0097193	127	0.073
regulation of cell matrix adhesion	GO:0001952	42	0.072
positive regulation of cell growth	GO:0030307	48	0.072
regulation of metal ion transport	GO:0010959	120	0.072
positive regulation of cholesterol storage	GO:0010886	4	0.071
tissue migration	GO:0090130	119	0.071
response to external biotic stimulus	GO:0043207	261	0.071
blood vessel development	GO:0001568	172	0.071
regulation of apoptotic signaling pathway	GO:2001233	175	0.070	Mouse
organelle fission	GO:0048285	149	0.069	Worm
modification dependent protein catabolic process	GO:0019941	209	0.068
protein targeting to nucleus	GO:0044744	104	0.067	Mouse
nuclear transport	GO:0051169	179	0.067	Mouse
dna replication dependent nucleosome assembly	GO:0006335	32	0.066
cell projection assembly	GO:0030031	126	0.066
protein localization to organelle	GO:0033365	280	0.066	Mouse Fly
positive regulation of locomotion	GO:0040017	186	0.066
cell aging	GO:0007569	52	0.065
regulation of cellular component size	GO:0032535	82	0.065	Fly
cellular response to oxygen containing compound	GO:1901701	276	0.063
protein maturation	GO:0051604	233	0.063
regulation of response to wounding	GO:1903034	101	0.062
response to radiation	GO:0009314	151	0.062
transmembrane transport	GO:0055085	399	0.061
histone modification	GO:0016570	251	0.061
negative regulation of programmed cell death	GO:0043069	321	0.061	Mouse
negative regulation of cytoskeleton organization	GO:0051494	45	0.060
memory	GO:0007613	3	0.060
negative regulation of protein maturation	GO:1903318	142	0.060
associative learning	GO:0008306	1	0.060
positive regulation of cellular component biogenesis	GO:0044089	158	0.060
response to light stimulus	GO:0009416	87	0.058
renal system development	GO:0072001	63	0.058
calcium ion transmembrane transport	GO:0070588	76	0.057
regulation of intracellular protein transport	GO:0033157	123	0.057
thiamine transport	GO:0015888	3	0.056
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	156	0.056
inflammatory response	GO:0006954	79	0.056
cytokine production	GO:0001816	247	0.055
cell morphogenesis involved in neuron differentiation	GO:0048667	44	0.054
negative regulation of cellular component organization	GO:0051129	235	0.054	Mouse
cell substrate junction assembly	GO:0007044	35	0.054
establishment of protein localization to organelle	GO:0072594	172	0.054	Mouse
single organism nuclear import	GO:1902593	104	0.053	Mouse
neurogenesis	GO:0022008	169	0.053
positive regulation of cell matrix adhesion	GO:0001954	23	0.053
dna repair	GO:0006281	198	0.053
nitrogen compound transport	GO:0071705	191	0.052
cellular lipid metabolic process	GO:0044255	303	0.052
positive regulation of organelle organization	GO:0010638	195	0.052
response to transforming growth factor beta	GO:0071559	94	0.052
response to decreased oxygen levels	GO:0036293	96	0.052
thiamine transmembrane transport	GO:0071934	2	0.052
post embryonic organ development	GO:0048569	1	0.051
actomyosin structure organization	GO:0031032	59	0.051	Worm
regulation of growth	GO:0040008	165	0.051	Worm
cilium morphogenesis	GO:0060271	75	0.051
protein depolymerization	GO:0051261	30	0.051
regulation of actin polymerization or depolymerization	GO:0008064	56	0.050	Fly
negative regulation of response to external stimulus	GO:0032102	83	0.050
protein homooligomerization	GO:0051260	100	0.050
regulation of response to external stimulus	GO:0032101	222	0.049
regulation of vasculature development	GO:1901342	97	0.049
regulation of blood vessel size	GO:0050880	18	0.048
bleb assembly	GO:0032060	6	0.048
cellular response to nutrient levels	GO:0031669	69	0.048
covalent chromatin modification	GO:0016569	254	0.047
proteolysis involved in cellular protein catabolic process	GO:0051603	244	0.047
positive regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043280	69	0.047
actin polymerization or depolymerization	GO:0008154	56	0.047	Fly
cellular macromolecule catabolic process	GO:0044265	380	0.047
hemopoiesis	GO:0030097	180	0.047
sensory perception of smell	GO:0007608	2	0.047
positive regulation of cell morphogenesis involved in differentiation	GO:0010770	50	0.046
hematopoietic or lymphoid organ development	GO:0048534	186	0.046
regulation of protein catabolic process	GO:0042176	155	0.046
regulation of ras protein signal transduction	GO:0046578	155	0.045
chromosome segregation	GO:0007059	114	0.045	Worm
regulation of body fluid levels	GO:0050878	99	0.045
leukocyte migration involved in inflammatory response	GO:0002523	2	0.045
ubiquitin dependent protein catabolic process	GO:0006511	206	0.045
regulation of nucleocytoplasmic transport	GO:0046822	98	0.045
regulation of ion transport	GO:0043269	189	0.045
regulation of microtubule based process	GO:0032886	74	0.045
neuron projection morphogenesis	GO:0048812	50	0.045
nucleotide excision repair	GO:0006289	31	0.045
epithelium migration	GO:0090132	119	0.045
negative regulation of protein transport	GO:0051224	75	0.045
anterior posterior axis specification	GO:0009948	2	0.045
proteasomal protein catabolic process	GO:0010498	176	0.044
negative regulation of proteolysis	GO:0045861	132	0.043
calcium ion transport	GO:0006816	147	0.043
peptidyl lysine acetylation	GO:0018394	101	0.043
neuron development	GO:0048666	113	0.042
negative regulation of extrinsic apoptotic signaling pathway	GO:2001237	52	0.042	Mouse
cellular response to mechanical stimulus	GO:0071260	39	0.042
cellular response to oxidative stress	GO:0034599	85	0.042
response to lipopolysaccharide	GO:0032496	70	0.041
regulation of cytoplasmic transport	GO:1903649	149	0.041
mitotic cell cycle phase transition	GO:0044772	162	0.041
nucleosome assembly	GO:0006334	50	0.041
regulation of protein stability	GO:0031647	87	0.040
mitotic cell cycle checkpoint	GO:0007093	68	0.040
adherens junction assembly	GO:0034333	34	0.040
lipoxin b4 metabolic process	GO:2001304	1	0.040
central nervous system development	GO:0007417	123	0.040	Fly
regulation of transcription factor import into nucleus	GO:0042990	39	0.040
regulation of wnt signaling pathway	GO:0030111	123	0.040
peripheral nervous system development	GO:0007422	2	0.039
response to nutrient levels	GO:0031667	81	0.039
divalent inorganic cation transport	GO:0072511	158	0.039
cell cycle phase transition	GO:0044770	173	0.039
cell division	GO:0051301	168	0.039
regulation of angiogenesis	GO:0045765	92	0.039
fatty acid metabolic process	GO:0006631	115	0.038
cellular protein catabolic process	GO:0044257	261	0.038
behavior	GO:0007610	112	0.038	Worm Fly
protein tetramerization	GO:0051262	47	0.038
platelet activation	GO:0030168	44	0.038
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	91	0.038
adenylate cyclase inhibiting dopamine receptor signaling pathway	GO:0007195	4	0.037
regulation of chromosome segregation	GO:0051983	44	0.037	Worm
regulation of microtubule polymerization or depolymerization	GO:0031110	27	0.037
regulation of secretion by cell	GO:1903530	177	0.037
lipid localization	GO:0010876	106	0.036
hemostasis	GO:0007599	76	0.036
regulation of proteasomal protein catabolic process	GO:0061136	87	0.036
response to hypoxia	GO:0001666	96	0.036
adherens junction organization	GO:0034332	36	0.036
cellular protein complex assembly	GO:0043623	188	0.036	Worm Fly
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	71	0.035
positive regulation of response to external stimulus	GO:0032103	88	0.035
gastrulation	GO:0007369	51	0.035
cell cell junction organization	GO:0045216	69	0.035
negative regulation of protein modification process	GO:0031400	200	0.035
oogenesis	GO:0048477	2	0.035
regulation of calcium ion transport	GO:0051924	79	0.035
release of cytoplasmic sequestered nf kappab	GO:0008588	4	0.034
regulation of cell projection organization	GO:0031344	107	0.034
atp catabolic process	GO:0006200	157	0.034
aging	GO:0007568	66	0.034
regulation of immune response	GO:0050776	201	0.034
dna replication independent nucleosome organization	GO:0034724	27	0.034
actin filament based movement	GO:0030048	17	0.034
positive regulation of protein import into nucleus	GO:0042307	46	0.034
negative regulation of cellular catabolic process	GO:0031330	83	0.034
vitamin transmembrane transport	GO:0035461	4	0.034
negative regulation of locomotion	GO:0040013	118	0.033
chronological cell aging	GO:0001300	2	0.033
sprouting angiogenesis	GO:0002040	29	0.033
protein acetylation	GO:0006473	116	0.033
regulation of system process	GO:0044057	101	0.033
negative regulation of hydrolase activity	GO:0051346	182	0.033
regulation of gene silencing	GO:0060968	24	0.033
reproductive process	GO:0022414	106	0.033	Rat Worm Fly
sister chromatid segregation	GO:0000819	54	0.033
negative regulation of chromosome organization	GO:2001251	48	0.033
cell cycle checkpoint	GO:0000075	117	0.033
mapk cascade	GO:0000165	288	0.033
cilium assembly	GO:0042384	63	0.033
response to oxidative stress	GO:0006979	121	0.032
dna replication independent nucleosome assembly	GO:0006336	27	0.032
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	125	0.032
regulation of chromosome organization	GO:0033044	103	0.032
spindle checkpoint	GO:0031577	26	0.032
regulation of protein processing	GO:0070613	150	0.031
g2 m transition of mitotic cell cycle	GO:0000086	41	0.031
regulation of actin filament polymerization	GO:0030833	50	0.031	Fly
negative regulation of catalytic activity	GO:0043086	335	0.031
peptidyl tyrosine modification	GO:0018212	170	0.031
protein secretion	GO:0009306	98	0.031
regulation of cell junction assembly	GO:1901888	29	0.031
single organism reproductive process	GO:0044702	98	0.031	Rat Worm Fly
apoptotic signaling pathway	GO:0097190	268	0.031	Mouse
skin development	GO:0043588	76	0.031
negative regulation of proteasomal protein catabolic process	GO:1901799	32	0.031
maintenance of location	GO:0051235	112	0.031
posttranscriptional regulation of gene expression	GO:0010608	213	0.031
regulation of endothelial cell migration	GO:0010594	67	0.030
negative regulation of cellular protein catabolic process	GO:1903363	38	0.030
negative regulation of protein complex disassembly	GO:0043242	20	0.030
protein heterotetramerization	GO:0051290	3	0.030
modification dependent macromolecule catabolic process	GO:0043632	212	0.030
axon development	GO:0061564	34	0.030
regulation of transferase activity	GO:0051338	355	0.030
morphogenesis of embryonic epithelium	GO:0016331	4	0.030
immune response	GO:0006955	307	0.030
negative regulation of sequence specific dna binding transcription factor activity	GO:0043433	89	0.029
purine ribonucleoside monophosphate metabolic process	GO:0009167	186	0.029
neurotransmitter secretion	GO:0007269	4	0.029
establishment of planar polarity	GO:0001736	3	0.029
response to extracellular stimulus	GO:0009991	85	0.029
regulation of protein kinase activity	GO:0045859	289	0.029
negative regulation of cell cycle phase transition	GO:1901988	89	0.029
positive regulation of proteolysis	GO:0045862	142	0.028
regulation of cytokine production	GO:0001817	232	0.028
macromolecular complex disassembly	GO:0032984	60	0.028
nuclear import	GO:0051170	106	0.028	Mouse
regulation of cell division	GO:0051302	116	0.028
spindle organization	GO:0007051	53	0.028
positive regulation of cytoskeleton organization	GO:0051495	83	0.028
regulation of nervous system development	GO:0051960	88	0.028
protein acylation	GO:0043543	138	0.028
response to hormone	GO:0009725	175	0.028
interleukin 1 secretion	GO:0050701	18	0.027
regulation of cell cell adhesion	GO:0022407	57	0.027
cell adhesion mediated by integrin	GO:0033627	27	0.027
negative regulation of cellular amino acid metabolic process	GO:0045763	2	0.027
positive regulation of endopeptidase activity	GO:0010950	84	0.027
positive regulation of peptidase activity	GO:0010952	88	0.026
mitotic cell cycle	GO:0000278	326	0.026	Worm Fly
dna replication dependent nucleosome organization	GO:0034723	32	0.026
regulation of cellular protein catabolic process	GO:1903362	96	0.026
neutrophil chemotaxis	GO:0030593	24	0.026
positive regulation of nervous system development	GO:0051962	54	0.026
regulation of protein localization to plasma membrane	GO:1903076	40	0.026
regulation of ion homeostasis	GO:2000021	73	0.026
regulation of protein localization to cell surface	GO:2000008	15	0.025
brain development	GO:0007420	97	0.025
adult locomotory behavior	GO:0008344	1	0.025	Fly
purine ribonucleoside monophosphate catabolic process	GO:0009169	158	0.025
viral life cycle	GO:0019058	132	0.025
cell fate determination	GO:0001709	3	0.025
negative regulation of phosphate metabolic process	GO:0045936	267	0.025
cellular response to dna damage stimulus	GO:0006974	379	0.025

LMNA disease predictions

Disease	DO term ID	Size	Probability
muscular disease	DOID:0080000	114	0.448
musculoskeletal system disease	DOID:17	223	0.448
muscle tissue disease	DOID:66	113	0.313
muscular dystrophy	DOID:9884	51	0.313
myopathy	DOID:423	104	0.313
kidney disease	DOID:557	36	0.302
urinary system disease	DOID:18	40	0.302
connective tissue disease	DOID:65	109	0.033
bone disease	DOID:0080001	88	0.033
central nervous system disease	DOID:331	186	0.031
neurodegenerative disease	DOID:1289	102	0.031
nervous system disease	DOID:863	431	0.031
bone development disease	DOID:0080006	55	0.026

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