IMP: Integrative Multi-species Prediction

Homo sapiens

30 known processes

MAP3K1

mitogen-activated protein kinase kinase kinase 1

(Aliases: MEKK,MEKK1,MAPKKK1)

MIM: 600982
Ensembl: ENSG00000095015
Entrez: 4214
HGNC: 6848
UniProtKB: Q13233

Process Predictions
Disease Predictions

MAP3K1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability	Func Analog Org
multicellular organismal aging	GO:0010259	3	0.967
positive regulation of mapk cascade	GO:0043410	190	0.895	Mouse Rat
regulation of mapk cascade	GO:0043408	262	0.830	Mouse Rat
determination of adult lifespan	GO:0008340	2	0.793
positive regulation of map kinase activity	GO:0043406	80	0.733	Mouse Rat
hippo signaling	GO:0035329	20	0.727
peptidyl serine modification	GO:0018209	106	0.712	Rat
response to abiotic stimulus	GO:0009628	336	0.694
determination of dorsal identity	GO:0048263	4	0.679
mapk cascade	GO:0000165	288	0.678	Mouse Rat
positive regulation of jnk cascade	GO:0046330	52	0.643	Mouse Rat
cell type specific apoptotic process	GO:0097285	125	0.612
regulation of cell differentiation	GO:0045595	393	0.578
negative regulation of transport	GO:0051051	176	0.574
determination of dorsal ventral asymmetry	GO:0048262	4	0.563
activation of protein kinase activity	GO:0032147	90	0.559	Mouse Rat
signal transduction by phosphorylation	GO:0023014	297	0.546	Mouse Rat
growth	GO:0040007	202	0.528
regulation of jun kinase activity	GO:0043506	27	0.511	Mouse Rat
cell development	GO:0048468	328	0.508	Mouse
embryonic morphogenesis	GO:0048598	85	0.505
regulation of cellular response to stress	GO:0080135	244	0.505	Mouse Rat
protein ubiquitination	GO:0016567	314	0.499	Rat
negative regulation of jun kinase activity	GO:0043508	4	0.497
stress activated mapk cascade	GO:0051403	93	0.493	Mouse Rat
neurotransmitter secretion	GO:0007269	4	0.486
cell morphogenesis involved in differentiation	GO:0000904	144	0.485	Mouse
positive regulation of transferase activity	GO:0051347	227	0.465	Mouse Rat
generation of neurons	GO:0048699	152	0.464
regulation of cellular component movement	GO:0051270	334	0.456	Mouse
purine containing compound catabolic process	GO:0072523	411	0.454
cellular component morphogenesis	GO:0032989	314	0.448	Mouse
response to nitric oxide	GO:0071731	4	0.442
neuron differentiation	GO:0030182	138	0.437
regulation of stress activated protein kinase signaling cascade	GO:0070302	85	0.436	Mouse Rat
positive regulation of jun kinase activity	GO:0043507	23	0.432	Mouse Rat
rho protein signal transduction	GO:0007266	26	0.432
activation of jun kinase activity	GO:0007257	7	0.425	Mouse Rat
regulation of small gtpase mediated signal transduction	GO:0051056	156	0.419
response to oxygen containing compound	GO:1901700	369	0.413
purine ribonucleotide catabolic process	GO:0009154	404	0.406
response to light stimulus	GO:0009416	87	0.402
neuron projection regeneration	GO:0031102	1	0.402
hyperosmotic response	GO:0006972	4	0.399
neurogenesis	GO:0022008	169	0.388
nervous system development	GO:0007399	293	0.385
gtp catabolic process	GO:0006184	237	0.382
regulation of stress activated mapk cascade	GO:0032872	84	0.377	Mouse Rat
negative regulation of apoptotic process	GO:0043066	316	0.374
positive regulation of protein kinase activity	GO:0045860	190	0.374	Mouse Rat
guanosine containing compound catabolic process	GO:1901069	239	0.373
cell projection organization	GO:0030030	252	0.371
cellular response to external stimulus	GO:0071496	111	0.370
cell morphogenesis	GO:0000902	296	0.366	Mouse
response to radiation	GO:0009314	151	0.362
metal ion transport	GO:0030001	272	0.359
response to tumor necrosis factor	GO:0034612	76	0.354
regulation of protein modification by small protein conjugation or removal	GO:1903320	107	0.353
regulation of cell development	GO:0060284	161	0.347
anatomical structure formation involved in morphogenesis	GO:0048646	284	0.347
positive regulation of phosphorylation	GO:0042327	394	0.346	Mouse Rat
negative regulation of phagocytosis engulfment	GO:0060101	1	0.345
ras protein signal transduction	GO:0007265	73	0.344
wound healing	GO:0042060	115	0.341	Mouse
positive regulation of stress activated protein kinase signaling cascade	GO:0070304	61	0.335	Mouse Rat
cellular response to abiotic stimulus	GO:0071214	117	0.332
intracellular receptor signaling pathway	GO:0030522	104	0.329
guanosine containing compound metabolic process	GO:1901068	244	0.321
regulation of apoptotic signaling pathway	GO:2001233	175	0.319
i kappab kinase nf kappab signaling	GO:0007249	166	0.316
defense response	GO:0006952	315	0.314
regulation of cell morphogenesis involved in differentiation	GO:0010769	83	0.314
membrane organization	GO:0061024	292	0.312
jun phosphorylation	GO:0007258	28	0.307	Mouse Rat
developmental cell growth	GO:0048588	18	0.305
regulation of cell motility	GO:2000145	299	0.304	Mouse
collateral sprouting	GO:0048668	2	0.298
positive regulation of nitric oxide synthase biosynthetic process	GO:0051770	3	0.295
protein catabolic process	GO:0030163	325	0.288	Rat
axon extension	GO:0048675	13	0.275
regulation of map kinase activity	GO:0043405	108	0.275	Mouse Rat
neuron apoptotic process	GO:0051402	39	0.272
morphogenesis of embryonic epithelium	GO:0016331	4	0.270
cellular component disassembly	GO:0022411	92	0.262
skeletal system development	GO:0001501	79	0.261
cell growth	GO:0016049	160	0.260
digestive tract development	GO:0048565	75	0.259
cellular protein catabolic process	GO:0044257	261	0.248	Rat
positive regulation of synaptic transmission	GO:0050806	4	0.248
axon regeneration	GO:0031103	1	0.247
cellular response to metal ion	GO:0071248	43	0.242
innate immune response	GO:0045087	178	0.240
regulation of autophagy	GO:0010506	52	0.239
actin filament based process	GO:0030029	224	0.239	Mouse Rat
regulation of ras protein signal transduction	GO:0046578	155	0.237
regionalization	GO:0003002	29	0.235
neuron projection extension	GO:1990138	14	0.235
regulation of phagocytosis engulfment	GO:0060099	2	0.228
positive regulation of programmed cell death	GO:0043068	249	0.226	Rat
positive regulation of stress activated mapk cascade	GO:0032874	60	0.218	Mouse Rat
regulation of nucleotide metabolic process	GO:0006140	269	0.215
nucleotide catabolic process	GO:0009166	408	0.214
regulation of cellular ketone metabolic process	GO:0010565	50	0.214
glycosyl compound catabolic process	GO:1901658	413	0.212
apoptotic signaling pathway	GO:0097190	268	0.210
regulation of locomotion	GO:0040012	329	0.203	Mouse
negative regulation of protein transport	GO:0051224	75	0.203
negative regulation of cellular component movement	GO:0051271	106	0.197
taxis	GO:0042330	157	0.196
muscle structure development	GO:0061061	98	0.196
regulation of kinase activity	GO:0043549	314	0.194	Mouse Rat
cell projection morphogenesis	GO:0048858	129	0.193
purine ribonucleoside triphosphate catabolic process	GO:0009207	391	0.193
proteolysis involved in cellular protein catabolic process	GO:0051603	244	0.192	Rat
negative regulation of cellular protein metabolic process	GO:0032269	353	0.190
jnk cascade	GO:0007254	80	0.188	Mouse Rat
response to temperature stimulus	GO:0009266	22	0.186
positive regulation of protein serine threonine kinase activity	GO:0071902	119	0.185	Mouse Rat
chromatin organization	GO:0006325	351	0.184
response to mechanical stimulus	GO:0009612	51	0.182
cellular response to heat	GO:0034605	14	0.182
positive regulation of erk1 and erk2 cascade	GO:0070374	75	0.181
cellular response to mechanical stimulus	GO:0071260	39	0.178
post embryonic development	GO:0009791	2	0.177
apoptotic mitochondrial changes	GO:0008637	57	0.177	Mouse
purine ribonucleoside metabolic process	GO:0046128	437	0.176
regulation of developmental pigmentation	GO:0048070	2	0.175
segmentation	GO:0035282	4	0.174
protein targeting to nucleus	GO:0044744	104	0.171
transmembrane transport	GO:0055085	399	0.171
muscle system process	GO:0003012	81	0.168
regulation of rho protein signal transduction	GO:0035023	79	0.167
epithelium development	GO:0060429	227	0.166	Mouse
neuron projection development	GO:0031175	106	0.163
regulation of protein binding	GO:0043393	66	0.163
cation transport	GO:0006812	331	0.162
response to cytokine	GO:0034097	232	0.160
ubiquitin dependent protein catabolic process	GO:0006511	206	0.159	Rat
regulation of synaptic vesicle transport	GO:1902803	3	0.157
ribonucleotide catabolic process	GO:0009261	405	0.156
negative regulation of developmental process	GO:0051093	247	0.154
regulation of reactive oxygen species metabolic process	GO:2000377	41	0.153
regulation of protein transport	GO:0051223	213	0.151
negative regulation of phagocytosis	GO:0050765	4	0.151
ribonucleoside triphosphate metabolic process	GO:0009199	412	0.150
modification dependent macromolecule catabolic process	GO:0043632	212	0.149	Rat
negative regulation of cell migration	GO:0030336	102	0.145
organophosphate catabolic process	GO:0046434	430	0.145
regulation of protein kinase activity	GO:0045859	289	0.144	Mouse Rat
response to uv	GO:0009411	73	0.142
engulfment of apoptotic cell	GO:0043652	2	0.139
proteasomal protein catabolic process	GO:0010498	176	0.138
positive regulation of catabolic process	GO:0009896	310	0.136
negative regulation of cellular component organization	GO:0051129	235	0.134	Rat
positive regulation of cytokine production	GO:0001819	167	0.133
positive regulation of i kappab kinase nf kappab signaling	GO:0043123	132	0.132
positive regulation of developmental process	GO:0051094	314	0.131
neuron projection morphogenesis	GO:0048812	50	0.130
cellular macromolecule catabolic process	GO:0044265	380	0.129	Rat
nucleoside triphosphate catabolic process	GO:0009143	394	0.129
negative regulation of locomotion	GO:0040013	118	0.127
regulation of determination of dorsal identity	GO:2000015	2	0.126
purine nucleotide catabolic process	GO:0006195	405	0.126
response to heat	GO:0009408	21	0.126
establishment of protein localization to organelle	GO:0072594	172	0.125
protein processing	GO:0016485	226	0.121
somitogenesis	GO:0001756	2	0.121
actin filament based movement	GO:0030048	17	0.121
regulation of cell morphogenesis	GO:0022604	153	0.120
regulation of growth	GO:0040008	165	0.118
regulation of neurotransmitter secretion	GO:0046928	3	0.117
response to lipid	GO:0033993	206	0.117
rna interference	GO:0016246	4	0.117
mitochondrion organization	GO:0007005	156	0.116	Mouse
protein deacetylation	GO:0006476	38	0.116
negative regulation of cell death	GO:0060548	345	0.116
positive regulation of organelle organization	GO:0010638	195	0.114	Mouse
purine ribonucleoside catabolic process	GO:0046130	398	0.114
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.114
cellular response to oxygen containing compound	GO:1901701	276	0.113
regulation of secretion	GO:0051046	194	0.113
rac protein signal transduction	GO:0016601	12	0.113
desensitization of g protein coupled receptor protein signaling pathway by arrestin	GO:0002032	2	0.112
negative regulation of protein metabolic process	GO:0051248	391	0.112
vesicle transport along actin filament	GO:0030050	2	0.111
nucleocytoplasmic transport	GO:0006913	176	0.111
system process	GO:0003008	349	0.110
positive regulation of cell proliferation	GO:0008284	301	0.109
regulation of i kappab kinase nf kappab signaling	GO:0043122	162	0.108
purine nucleoside catabolic process	GO:0006152	398	0.108
ribonucleoside triphosphate catabolic process	GO:0009203	391	0.107
neurological system process	GO:0050877	163	0.106
purine nucleoside triphosphate catabolic process	GO:0009146	392	0.105
cellular ketone metabolic process	GO:0042180	80	0.104
cell part morphogenesis	GO:0032990	137	0.103
regulation of transferase activity	GO:0051338	355	0.103	Mouse Rat
autophagy	GO:0006914	88	0.103
actin filament organization	GO:0007015	128	0.102	Mouse Rat
dna replication	GO:0006260	116	0.102
cellular response to molecule of bacterial origin	GO:0071219	62	0.102
tube development	GO:0035295	125	0.101
macromolecule deacylation	GO:0098732	41	0.101
neuron development	GO:0048666	113	0.099
cellular response to transforming growth factor beta stimulus	GO:0071560	94	0.097	Mouse
regulation of cell cycle	GO:0051726	393	0.097
response to nitrogen compound	GO:1901698	184	0.097
regulation of response to external stimulus	GO:0032101	222	0.096
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	281	0.096
regulation of anatomical structure morphogenesis	GO:0022603	286	0.096
regulation of cellular component biogenesis	GO:0044087	281	0.096	Mouse Rat
immune system development	GO:0002520	195	0.096
release of cytochrome c from mitochondria	GO:0001836	35	0.095
aging	GO:0007568	66	0.094
vesicle mediated transport	GO:0016192	371	0.092
monocarboxylic acid metabolic process	GO:0032787	185	0.091
nucleoside phosphate catabolic process	GO:1901292	412	0.091
positive regulation of transport	GO:0051050	336	0.091
positive regulation of neuron apoptotic process	GO:0043525	8	0.091
modification dependent protein catabolic process	GO:0019941	209	0.089	Rat
protein targeting	GO:0006605	187	0.088
regulation of neurogenesis	GO:0050767	82	0.088
melanin metabolic process	GO:0006582	1	0.088
regulation of neuron differentiation	GO:0045664	70	0.087
response to growth factor	GO:0070848	205	0.087	Mouse
immune response	GO:0006955	307	0.087
activation of jnkk activity	GO:0007256	1	0.086	Rat
positive regulation of reactive oxygen species metabolic process	GO:2000379	24	0.086
g protein coupled receptor signaling pathway	GO:0007186	207	0.086
protein maturation	GO:0051604	233	0.085
negative regulation of multicellular organismal process	GO:0051241	317	0.083
positive regulation of apoptotic process	GO:0043065	246	0.082	Rat
anion transport	GO:0006820	161	0.082
defense response to bacterium	GO:0042742	63	0.082
positive regulation of protein phosphorylation	GO:0001934	313	0.082	Mouse Rat
erk1 and erk2 cascade	GO:0070371	104	0.081
stress activated protein kinase signaling cascade	GO:0031098	94	0.081	Mouse Rat
embryonic camera type eye morphogenesis	GO:0048596	2	0.080
establishment of protein localization to mitochondrion	GO:0072655	22	0.080
cellular potassium ion transport	GO:0071804	60	0.079
regulation of purine nucleotide metabolic process	GO:1900542	264	0.079
histone modification	GO:0016570	251	0.078
single organism cellular localization	GO:1902580	332	0.078
embryonic digestive tract morphogenesis	GO:0048557	2	0.078
positive regulation of dna metabolic process	GO:0051054	73	0.078
endocytosis	GO:0006897	159	0.078
regulation of neuron death	GO:1901214	56	0.077
regulation of anatomical structure size	GO:0090066	101	0.077	Mouse
digestive system development	GO:0055123	75	0.076
cell morphogenesis involved in neuron differentiation	GO:0048667	44	0.076
response to organonitrogen compound	GO:0010243	156	0.076
activation of mapkk activity	GO:0000186	18	0.075	Rat
secretion	GO:0046903	254	0.074
regulation of cell growth	GO:0001558	135	0.072
cellular macromolecular complex assembly	GO:0034622	324	0.072	Mouse
regulation of neuron apoptotic process	GO:0043523	35	0.071
extrinsic apoptotic signaling pathway	GO:0097191	119	0.070
regulation of gtp catabolic process	GO:0033124	180	0.070
organic hydroxy compound metabolic process	GO:1901615	147	0.070
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	125	0.070	Mouse
ectodermal digestive tract development	GO:0007439	1	0.069
phagocytosis engulfment	GO:0006911	7	0.069
negative regulation of map kinase activity	GO:0043407	27	0.069
regulation of ion transport	GO:0043269	189	0.069
cytoplasmic transport	GO:0016482	379	0.069
regulation of protein ubiquitination	GO:0031396	95	0.068
cellular response to cytokine stimulus	GO:0071345	181	0.068
chromatin modification	GO:0016568	298	0.068
axonogenesis	GO:0007409	31	0.068
developmental growth involved in morphogenesis	GO:0060560	23	0.067
regulation of cytokine production	GO:0001817	232	0.066
negative regulation of protein phosphorylation	GO:0001933	140	0.066
secretion by cell	GO:0032940	226	0.066
retina layer formation	GO:0010842	3	0.066
peptidyl serine phosphorylation	GO:0018105	101	0.065	Rat
posttranscriptional regulation of gene expression	GO:0010608	213	0.065
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	156	0.064
basement membrane organization	GO:0071711	3	0.064
response to metal ion	GO:0010038	84	0.063
protein folding	GO:0006457	38	0.063
negative regulation of apoptotic signaling pathway	GO:2001234	97	0.063
negative regulation of protein processing	GO:0010955	142	0.063
regulation of vesicle mediated transport	GO:0060627	130	0.062
single organism nuclear import	GO:1902593	104	0.062
adult locomotory behavior	GO:0008344	1	0.062
negative regulation of phosphorus metabolic process	GO:0010563	267	0.062
negative regulation of intracellular signal transduction	GO:1902532	183	0.061
mrna metabolic process	GO:0016071	175	0.061
cellular lipid metabolic process	GO:0044255	303	0.061
humoral immune response	GO:0006959	49	0.061
antibacterial humoral response	GO:0019731	24	0.060
regulation of nucleotide catabolic process	GO:0030811	205	0.060
regulation of gtpase activity	GO:0043087	180	0.060
positive regulation of neuron death	GO:1901216	14	0.059
regulation of reactive oxygen species biosynthetic process	GO:1903426	3	0.059
hematopoietic or lymphoid organ development	GO:0048534	186	0.059
regulation of proteolysis	GO:0030162	293	0.059
muscle tissue development	GO:0060537	62	0.059
small gtpase mediated signal transduction	GO:0007264	78	0.058
regulation of chromatin modification	GO:1903308	51	0.058
actin filament bundle assembly	GO:0051017	54	0.057	Rat
divalent metal ion transport	GO:0070838	152	0.057
gastrulation	GO:0007369	51	0.057
embryonic camera type eye development	GO:0031076	2	0.057
covalent chromatin modification	GO:0016569	254	0.056
nucleoside triphosphate metabolic process	GO:0009141	422	0.056
regulation of peptidase activity	GO:0052547	180	0.056
negative regulation of sequence specific dna binding transcription factor activity	GO:0043433	89	0.056
cation transmembrane transport	GO:0098655	238	0.056
cellular response to lipid	GO:0071396	127	0.056
response to osmotic stress	GO:0006970	17	0.056	Rat
secondary metabolic process	GO:0019748	17	0.056
apoptotic cell clearance	GO:0043277	12	0.055
hindbrain development	GO:0030902	3	0.055
regulation of vasculature development	GO:1901342	97	0.055
embryonic eye morphogenesis	GO:0048048	2	0.055
regulation of jnk cascade	GO:0046328	73	0.055	Mouse Rat
positive regulation of immune response	GO:0050778	159	0.055
regulation of ion transmembrane transport	GO:0034765	132	0.054
intrinsic apoptotic signaling pathway	GO:0097193	127	0.054
intrinsic apoptotic signaling pathway in response to dna damage	GO:0008630	50	0.054
vasculature development	GO:0001944	181	0.053
activation of mapk activity	GO:0000187	45	0.053	Mouse Rat
regulation of erk1 and erk2 cascade	GO:0070372	99	0.053
negative regulation of phosphorylation	GO:0042326	174	0.052
negative regulation of jnk cascade	GO:0046329	16	0.051
response to external biotic stimulus	GO:0043207	261	0.051
calcium ion transport	GO:0006816	147	0.050
programmed necrotic cell death	GO:0097300	18	0.050
negative regulation of stress activated mapk cascade	GO:0032873	19	0.050
neuron death	GO:0070997	65	0.050
female gamete generation	GO:0007292	2	0.050
positive regulation of immune system process	GO:0002684	283	0.050
cardiovascular system development	GO:0072358	262	0.050
cellular amino acid metabolic process	GO:0006520	116	0.050
endothelial cell apoptotic process	GO:0072577	26	0.049
cell cell signaling	GO:0007267	155	0.049
cellular response to radiation	GO:0071478	65	0.049
blood vessel development	GO:0001568	172	0.049
signal release	GO:0023061	70	0.049
positive regulation of organic acid transport	GO:0032892	3	0.049
negative regulation of cell proliferation	GO:0008285	228	0.049
regulation of cellular amine metabolic process	GO:0033238	11	0.049
actin cytoskeleton organization	GO:0030036	207	0.048	Mouse Rat
dephosphorylation	GO:0016311	209	0.048
detection of stimulus	GO:0051606	85	0.048
chemotaxis	GO:0006935	157	0.048
regulation of cellular amino acid metabolic process	GO:0006521	6	0.048
muscle cell differentiation	GO:0042692	63	0.046
reactive nitrogen species metabolic process	GO:2001057	3	0.046
peptidyl threonine phosphorylation	GO:0018107	41	0.046
negative regulation of catalytic activity	GO:0043086	335	0.046
positive regulation of cellular amine metabolic process	GO:0033240	7	0.046
hemopoiesis	GO:0030097	180	0.046
regulation of protein complex assembly	GO:0043254	147	0.046	Mouse
regulation of endopeptidase activity	GO:0052548	170	0.046
regulation of ras gtpase activity	GO:0032318	128	0.045
negative regulation of synaptic transmission	GO:0050805	2	0.045
defense response to other organism	GO:0098542	129	0.045
cell projection assembly	GO:0030031	126	0.044
synaptic vesicle exocytosis	GO:0016079	3	0.044
muscle hypertrophy	GO:0014896	14	0.044
cellular response to tumor necrosis factor	GO:0071356	63	0.044
regulation of dna replication	GO:0006275	68	0.044
regulation of synaptic transmission dopaminergic	GO:0032225	4	0.044
nuclear transport	GO:0051169	179	0.043
cellular response to endogenous stimulus	GO:0071495	336	0.043	Mouse
positive regulation of rho protein signal transduction	GO:0035025	4	0.043
embryo development	GO:0009790	123	0.042
regulation of immune response	GO:0050776	201	0.042
positive regulation of small gtpase mediated signal transduction	GO:0051057	12	0.042
response to organic cyclic compound	GO:0014070	204	0.042
positive regulation of locomotion	GO:0040017	186	0.042
positive regulation of protein modification by small protein conjugation or removal	GO:1903322	61	0.042
intracellular steroid hormone receptor signaling pathway	GO:0030518	61	0.041
regulation of protein serine threonine kinase activity	GO:0071900	179	0.041	Mouse Rat
maintenance of location	GO:0051235	112	0.041
regulation of nucleoside metabolic process	GO:0009118	209	0.041
protein autophosphorylation	GO:0046777	123	0.040	Rat
gtp metabolic process	GO:0046039	239	0.040
positive regulation of kinase activity	GO:0033674	204	0.040	Mouse Rat
regulation of cellular component size	GO:0032535	82	0.040	Mouse
memory	GO:0007613	3	0.040
negative regulation of kinase activity	GO:0033673	106	0.040
negative regulation of protein serine threonine kinase activity	GO:0071901	57	0.040
cellular response to uv	GO:0034644	32	0.040
inorganic ion transmembrane transport	GO:0098660	231	0.040
protein import into nucleus	GO:0006606	104	0.040
reactive oxygen species metabolic process	GO:0072593	75	0.040
negative regulation of protein kinase activity	GO:0006469	98	0.039
actin filament bundle organization	GO:0061572	54	0.039	Rat
regulation of establishment of protein localization	GO:0070201	242	0.039
regulation of purine nucleotide catabolic process	GO:0033121	205	0.039
regulation of sodium ion transport	GO:0002028	24	0.038
single organism carbohydrate metabolic process	GO:0044723	193	0.038
positive regulation of cell development	GO:0010720	92	0.038
cellular protein complex assembly	GO:0043623	188	0.038	Mouse
positive regulation of cellular component movement	GO:0051272	181	0.038
pattern specification process	GO:0007389	43	0.038
positive regulation of sequence specific dna binding transcription factor activity	GO:0051091	131	0.038
regulation of metal ion transport	GO:0010959	120	0.037
regulation of sequence specific dna binding transcription factor activity	GO:0051090	211	0.037
purine nucleoside triphosphate metabolic process	GO:0009144	412	0.037
tripartite regional subdivision	GO:0007351	2	0.037
positive regulation of dna replication	GO:0045740	35	0.037
regulation of synaptic plasticity	GO:0048167	3	0.037
positive regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043280	69	0.037
regulation of extent of cell growth	GO:0061387	9	0.037
regulation of rac gtpase activity	GO:0032314	4	0.036
rna splicing via transesterification reactions with bulged adenosine as nucleophile	GO:0000377	89	0.036
cellular response to dna damage stimulus	GO:0006974	379	0.036
organic anion transport	GO:0015711	103	0.036
axon development	GO:0061564	34	0.036
myoblast fusion	GO:0007520	1	0.036
myeloid cell differentiation	GO:0030099	117	0.036
behavioral response to ethanol	GO:0048149	2	0.036
organ morphogenesis	GO:0009887	147	0.035
embryonic digestive tract development	GO:0048566	10	0.035
regulation of growth rate	GO:0040009	1	0.035
lipid metabolic process	GO:0006629	381	0.035
negative regulation of nf kappab transcription factor activity	GO:0032088	51	0.035
sodium ion transport	GO:0006814	61	0.035
negative regulation of phosphate metabolic process	GO:0045936	267	0.034
striated muscle hypertrophy	GO:0014897	14	0.034
developmental growth	GO:0048589	48	0.034
tube morphogenesis	GO:0035239	95	0.034
regulation of cytoskeleton organization	GO:0051493	177	0.034	Mouse Rat
regulation of secretion by cell	GO:1903530	177	0.034
positive regulation of determination of dorsal identity	GO:2000017	1	0.033
negative regulation of catabolic process	GO:0009895	104	0.033
positive regulation of cellular component organization	GO:0051130	376	0.033	Mouse
pigment metabolic process	GO:0042440	16	0.033
positive regulation of meiotic cell cycle	GO:0051446	2	0.033
melanocyte differentiation	GO:0030318	2	0.033
regulation of synaptic vesicle exocytosis	GO:2000300	2	0.033
negative regulation of immune system process	GO:0002683	136	0.033
regulation of cellular carbohydrate metabolic process	GO:0010675	47	0.033
activation of innate immune response	GO:0002218	55	0.033
muscle contraction	GO:0006936	73	0.033
cellular response to inorganic substance	GO:0071241	45	0.033
regulation of dna metabolic process	GO:0051052	153	0.033
regulation of cell adhesion	GO:0030155	166	0.032
response to inorganic substance	GO:0010035	127	0.032
positive regulation of cell migration	GO:0030335	172	0.032
negative regulation of programmed cell death	GO:0043069	321	0.032
phagocytosis	GO:0006909	42	0.032
regulation of hippo signaling	GO:0035330	8	0.032
long term memory	GO:0007616	2	0.032
negative regulation of cell cycle	GO:0045786	193	0.032
angiogenesis	GO:0001525	147	0.032
positive regulation of gtp catabolic process	GO:0033126	166	0.032
regulation of innate immune response	GO:0045088	97	0.032
ameboidal type cell migration	GO:0001667	135	0.032
cellular response to nitrogen compound	GO:1901699	144	0.032
cellular response to starvation	GO:0009267	58	0.032
blood vessel morphogenesis	GO:0048514	162	0.032
prostaglandin secretion	GO:0032310	2	0.032
multicellular organismal movement	GO:0050879	17	0.032
regulation of calcium ion transport	GO:0051924	79	0.032
somatic stem cell maintenance	GO:0035019	4	0.031
phenol containing compound metabolic process	GO:0018958	12	0.031
negative regulation of intracellular transport	GO:0032387	60	0.031
cytokine mediated signaling pathway	GO:0019221	109	0.031
long term synaptic potentiation	GO:0060291	1	0.031
regulation of actin filament based process	GO:0032970	141	0.031	Mouse Rat
posttranscriptional gene silencing	GO:0016441	25	0.031
leukocyte activation	GO:0045321	164	0.031
protein deacylation	GO:0035601	39	0.031
dna dependent dna replication	GO:0006261	44	0.031
endosomal transport	GO:0016197	129	0.031
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	181	0.031
negative regulation of response to external stimulus	GO:0032102	83	0.030
positive regulation of fatty acid transport	GO:2000193	3	0.030
carbohydrate metabolic process	GO:0005975	207	0.030
cell division	GO:0051301	168	0.030
mitotic cell cycle	GO:0000278	326	0.030
cerebellum development	GO:0021549	2	0.030
regulation of intrinsic apoptotic signaling pathway	GO:2001242	72	0.030
inorganic cation transmembrane transport	GO:0098662	194	0.030
regulation of mitotic cell cycle phase transition	GO:1901990	118	0.030
compound eye development	GO:0048749	1	0.030
cellular response to lipopolysaccharide	GO:0071222	57	0.030
regulation of meiotic cell cycle	GO:0051445	4	0.030
regulation of extrinsic apoptotic signaling pathway	GO:2001236	85	0.030
regulation of protein localization to nucleus	GO:1900180	85	0.029
heart growth	GO:0060419	6	0.029
signal transduction by p53 class mediator	GO:0072331	72	0.029
regulation of membrane potential	GO:0042391	95	0.029
small molecule biosynthetic process	GO:0044283	157	0.029
oxidation reduction process	GO:0055114	396	0.029
regulation of histone modification	GO:0031056	47	0.029

MAP3K1 disease predictions

Disease	DO term ID	Size	Probability
disease of mental health	DOID:150	70	0.084
cardiovascular system disease	DOID:1287	106	0.042
musculoskeletal system disease	DOID:17	223	0.035
connective tissue disease	DOID:65	109	0.035

Loading network...

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network