IMP: Integrative Multi-species Prediction

Homo sapiens

28 known processes

NDUFS7

NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase)

(Aliases: MGC120002,CI-20,CI-20KD,FLJ45860,FLJ46880,PSST,MY017)

MIM: 601825
Entrez: 374291
HGNC: 7714
HPRD: 03491
Ensembl: ENSG00000115286
UniProtKB: Q7LD69
UniProtKB: O75251

Process Predictions
Disease Predictions

NDUFS7 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
mitochondrial respiratory chain complex i biogenesis	GO:0097031	16	0.999
nadh dehydrogenase complex assembly	GO:0010257	16	0.960
mitochondrial respiratory chain complex i assembly	GO:0032981	16	0.936
oxidation reduction process	GO:0055114	396	0.923
post embryonic development	GO:0009791	2	0.871
mitochondrial electron transport nadh to ubiquinone	GO:0006120	2	0.863
mitochondrion organization	GO:0007005	156	0.845
atp synthesis coupled electron transport	GO:0042773	4	0.820
mitochondrial respiratory chain complex assembly	GO:0033108	23	0.813
mitochondrial atp synthesis coupled electron transport	GO:0042775	4	0.807
ribonucleoside monophosphate metabolic process	GO:0009161	187	0.721
energy derivation by oxidation of organic compounds	GO:0015980	43	0.717
atp metabolic process	GO:0046034	176	0.660
purine nucleoside triphosphate metabolic process	GO:0009144	412	0.634
nucleoside triphosphate metabolic process	GO:0009141	422	0.589
purine ribonucleoside monophosphate metabolic process	GO:0009167	186	0.588
purine ribonucleoside metabolic process	GO:0046128	437	0.538
purine nucleoside monophosphate metabolic process	GO:0009126	186	0.537
multicellular organismal aging	GO:0010259	3	0.535
respiratory electron transport chain	GO:0022904	7	0.517
nucleoside monophosphate metabolic process	GO:0009123	191	0.509
purine ribonucleoside triphosphate metabolic process	GO:0009205	411	0.488
ribonucleoside triphosphate metabolic process	GO:0009199	412	0.487
response to drug	GO:0042493	81	0.484
cellular respiration	GO:0045333	21	0.442
determination of adult lifespan	GO:0008340	2	0.340
generation of precursor metabolites and energy	GO:0006091	68	0.328
myosin filament assembly	GO:0031034	2	0.280
cellular protein complex assembly	GO:0043623	188	0.242
oxidative phosphorylation	GO:0006119	10	0.206
cellular component assembly involved in morphogenesis	GO:0010927	73	0.205
anatomical structure formation involved in morphogenesis	GO:0048646	284	0.172
electron transport chain	GO:0022900	8	0.172
actin filament based process	GO:0030029	224	0.154
muscle cell differentiation	GO:0042692	63	0.133
growth	GO:0040007	202	0.097
system process	GO:0003008	349	0.089
nucleoside phosphate biosynthetic process	GO:1901293	109	0.086
response to oxidative stress	GO:0006979	121	0.079
embryo development	GO:0009790	123	0.076
myosin filament organization	GO:0031033	2	0.074
striated muscle myosin thick filament assembly	GO:0071688	2	0.072
female gamete generation	GO:0007292	2	0.071
aging	GO:0007568	66	0.063
actomyosin structure organization	GO:0031032	59	0.060
organelle assembly	GO:0070925	176	0.058
reproductive system development	GO:0061458	56	0.058
oogenesis	GO:0048477	2	0.048
cell development	GO:0048468	328	0.044
muscle contraction	GO:0006936	73	0.044
cellular component morphogenesis	GO:0032989	314	0.040
behavior	GO:0007610	112	0.039
regulation of apoptotic signaling pathway	GO:2001233	175	0.039
regulation of growth	GO:0040008	165	0.035
inorganic ion transmembrane transport	GO:0098660	231	0.035
reactive oxygen species metabolic process	GO:0072593	75	0.035
reproductive process	GO:0022414	106	0.034
excretion	GO:0007588	9	0.032
negative regulation of apoptotic signaling pathway	GO:2001234	97	0.031
maintenance of location	GO:0051235	112	0.031
muscle system process	GO:0003012	81	0.031
embryonic morphogenesis	GO:0048598	85	0.031
negative regulation of intracellular signal transduction	GO:1902532	183	0.030
striated muscle cell development	GO:0055002	27	0.030
organophosphate biosynthetic process	GO:0090407	163	0.029
reproduction	GO:0000003	63	0.029
regulation of kinase activity	GO:0043549	314	0.029
cellular amine metabolic process	GO:0044106	41	0.028
neuroblast proliferation	GO:0007405	4	0.028
cellular macromolecular complex assembly	GO:0034622	324	0.028
cellular amino acid metabolic process	GO:0006520	116	0.027
single organism cellular localization	GO:1902580	332	0.026
lipid metabolic process	GO:0006629	381	0.026
cellular response to dna damage stimulus	GO:0006974	379	0.025
purine nucleoside monophosphate biosynthetic process	GO:0009127	16	0.025
cellular lipid metabolic process	GO:0044255	303	0.024
nervous system development	GO:0007399	293	0.024
regulation of cellular amino acid metabolic process	GO:0006521	6	0.023
intrinsic apoptotic signaling pathway	GO:0097193	127	0.023
organonitrogen compound biosynthetic process	GO:1901566	200	0.023
cell part morphogenesis	GO:0032990	137	0.023
lipid localization	GO:0010876	106	0.023
brain development	GO:0007420	97	0.022
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.022
vesicle mediated transport	GO:0016192	371	0.022
single organism reproductive process	GO:0044702	98	0.022
regulation of cellular amine metabolic process	GO:0033238	11	0.021
fatty acid metabolic process	GO:0006631	115	0.021
endocytosis	GO:0006897	159	0.021
head development	GO:0060322	108	0.021
positive regulation of phosphorylation	GO:0042327	394	0.020
regulation of cell growth	GO:0001558	135	0.020
neurogenesis	GO:0022008	169	0.020
negative regulation of cell death	GO:0060548	345	0.020
apoptotic signaling pathway	GO:0097190	268	0.020
response to cytokine	GO:0034097	232	0.020
cell cycle phase transition	GO:0044770	173	0.019
protein targeting	GO:0006605	187	0.019
protein ubiquitination	GO:0016567	314	0.019
regulation of proteolysis	GO:0030162	293	0.019
cellular ketone metabolic process	GO:0042180	80	0.019
response to abiotic stimulus	GO:0009628	336	0.019
purine containing compound biosynthetic process	GO:0072522	88	0.019
mitotic cell cycle process	GO:1903047	286	0.019
regulation of intrinsic apoptotic signaling pathway	GO:2001242	72	0.019
ribonucleotide biosynthetic process	GO:0009260	81	0.019
regulation of neural precursor cell proliferation	GO:2000177	4	0.018
coenzyme metabolic process	GO:0006732	65	0.018
development of primary sexual characteristics	GO:0045137	35	0.018
protein localization to organelle	GO:0033365	280	0.018
embryo development ending in birth or egg hatching	GO:0009792	34	0.018
negative regulation of apoptotic process	GO:0043066	316	0.017
protein homooligomerization	GO:0051260	100	0.017
negative regulation of programmed cell death	GO:0043069	321	0.017
cation transport	GO:0006812	331	0.017
receptor mediated endocytosis	GO:0006898	84	0.017
amine metabolic process	GO:0009308	44	0.017
protein oligomerization	GO:0051259	173	0.016
intracellular protein transport	GO:0006886	270	0.016
positive regulation of cellular amine metabolic process	GO:0033240	7	0.016
mitotic cell cycle	GO:0000278	326	0.016
substantia nigra development	GO:0021762	45	0.016
central nervous system development	GO:0007417	123	0.016
cell growth	GO:0016049	160	0.016
negative regulation of cellular protein metabolic process	GO:0032269	353	0.015
sex differentiation	GO:0007548	45	0.015
cellular macromolecule catabolic process	GO:0044265	380	0.015
neuromuscular junction development	GO:0007528	3	0.015
nadh metabolic process	GO:0006734	1	0.015
lymphocyte activation	GO:0046649	133	0.015
negative regulation of phosphate metabolic process	GO:0045936	267	0.015
response to oxygen containing compound	GO:1901700	369	0.015
positive regulation of programmed cell death	GO:0043068	249	0.015
positive regulation of catabolic process	GO:0009896	310	0.015
nucleoside catabolic process	GO:0009164	408	0.015
positive regulation of transferase activity	GO:0051347	227	0.014
small molecule biosynthetic process	GO:0044283	157	0.014
ribose phosphate biosynthetic process	GO:0046390	82	0.014
mapk cascade	GO:0000165	288	0.014
protein modification by small protein conjugation	GO:0032446	342	0.014
protein localization to membrane	GO:0072657	160	0.014
internal protein amino acid acetylation	GO:0006475	101	0.014
establishment of protein localization to organelle	GO:0072594	172	0.014
response to organic cyclic compound	GO:0014070	204	0.014
protein catabolic process	GO:0030163	325	0.014
regulation of cell cycle	GO:0051726	393	0.014
monocarboxylic acid metabolic process	GO:0032787	185	0.014
regulation of cellular component biogenesis	GO:0044087	281	0.014
circulatory system development	GO:0072359	262	0.014
reproductive structure development	GO:0048608	55	0.013
striated muscle cell differentiation	GO:0051146	43	0.013
regulation of cellular ketone metabolic process	GO:0010565	50	0.013
negative regulation of developmental process	GO:0051093	247	0.013
positive regulation of hydrolase activity	GO:0051345	331	0.013
positive regulation of protein phosphorylation	GO:0001934	313	0.013
cellular response to cytokine stimulus	GO:0071345	181	0.013
negative regulation of catalytic activity	GO:0043086	335	0.013
segmentation	GO:0035282	4	0.013
cytoplasmic transport	GO:0016482	379	0.013
regulation of transferase activity	GO:0051338	355	0.013
negative regulation of protein metabolic process	GO:0051248	391	0.013
regulation of mapk cascade	GO:0043408	262	0.013
cardiovascular system development	GO:0072358	262	0.013
response to lipid	GO:0033993	206	0.013
cellular protein catabolic process	GO:0044257	261	0.012
regulation of mitotic cell cycle phase transition	GO:1901990	118	0.012
positive regulation of apoptotic process	GO:0043065	246	0.012
positive regulation of organelle organization	GO:0010638	195	0.012
developmental process involved in reproduction	GO:0003006	66	0.012
regulation of cell differentiation	GO:0045595	393	0.012
positive regulation of cellular component organization	GO:0051130	376	0.012
negative regulation of cell cycle	GO:0045786	193	0.012
regulation of endopeptidase activity	GO:0052548	170	0.012
protein maturation	GO:0051604	233	0.012
negative regulation of phosphorus metabolic process	GO:0010563	267	0.011
transmembrane transport	GO:0055085	399	0.011
regulation of cell cycle process	GO:0010564	266	0.011
regulation of cell cycle phase transition	GO:1901987	126	0.011
negative regulation of hydrolase activity	GO:0051346	182	0.011
mitotic cell cycle phase transition	GO:0044772	162	0.011
sulfate transmembrane transport	GO:1902358	3	0.011
response to axon injury	GO:0048678	1	0.011
myofibril assembly	GO:0030239	10	0.011
biological adhesion	GO:0022610	331	0.011
positive regulation of developmental process	GO:0051094	314	0.011
purine nucleoside biosynthetic process	GO:0042451	23	0.010
regeneration	GO:0031099	4	0.010
regulation of protein kinase activity	GO:0045859	289	0.010
inorganic cation transmembrane transport	GO:0098662	194	0.010
carbohydrate metabolic process	GO:0005975	207	0.010
modification dependent protein catabolic process	GO:0019941	209	0.010
protein acetylation	GO:0006473	116	0.010

NDUFS7 disease predictions

Disease	DO term ID	Size	Probability
inherited metabolic disorder	DOID:655	242	0.998
disease of metabolism	DOID:0014667	295	0.998
leigh disease	DOID:3652	16	0.967
mitochondrial metabolism disease	DOID:700	29	0.967
disease of cellular proliferation	DOID:14566	174	0.124
cancer	DOID:162	167	0.124
nervous system disease	DOID:863	431	0.017
sensory system disease	DOID:0050155	203	0.017
eye disease	DOID:5614	149	0.017
eye and adnexa disease	DOID:1492	150	0.017
muscular disease	DOID:0080000	114	0.016
musculoskeletal system disease	DOID:17	223	0.016
muscle tissue disease	DOID:66	113	0.016
myopathy	DOID:423	104	0.015
retinal degeneration	DOID:8466	89	0.014
retinal disease	DOID:5679	118	0.014
amino acid metabolic disorder	DOID:9252	50	0.013
organ system cancer	DOID:0050686	164	0.011

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