IMP: Integrative Multi-species Prediction

Homo sapiens

22 known processes

NFS1

NFS1 nitrogen fixation 1 homolog (S. cerevisiae)

(Aliases: NIFS,IscS)

Entrez: 9054
MIM: 603485
HPRD: 04597
HGNC: 15910
Ensembl: ENSG00000244005
UniProtKB: Q53FP3
UniProtKB: Q9Y697

Process Predictions
Disease Predictions

NFS1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
cellular macromolecular complex assembly	GO:0034622	324	0.063
cofactor metabolic process	GO:0051186	87	0.061
cellular lipid metabolic process	GO:0044255	303	0.061
lipid metabolic process	GO:0006629	381	0.057
carbohydrate derivative biosynthetic process	GO:1901137	207	0.057
post embryonic development	GO:0009791	2	0.056
cellular amino acid metabolic process	GO:0006520	116	0.049
cofactor biosynthetic process	GO:0051188	31	0.044
cellular protein complex assembly	GO:0043623	188	0.044
mitochondrial respiratory chain complex assembly	GO:0033108	23	0.043
oogenesis	GO:0048477	2	0.043
multicellular organismal aging	GO:0010259	3	0.043
monocarboxylic acid metabolic process	GO:0032787	185	0.042
citrate metabolic process	GO:0006101	2	0.037
vesicle mediated transport	GO:0016192	371	0.035
organophosphate biosynthetic process	GO:0090407	163	0.034
amine metabolic process	GO:0009308	44	0.033
determination of adult lifespan	GO:0008340	2	0.032
positive regulation of hydrolase activity	GO:0051345	331	0.032
glycerophospholipid metabolic process	GO:0006650	84	0.031
female gamete generation	GO:0007292	2	0.031
glycerolipid metabolic process	GO:0046486	107	0.030
small molecule biosynthetic process	GO:0044283	157	0.030
mitochondrion organization	GO:0007005	156	0.030
cellular amine metabolic process	GO:0044106	41	0.029
single organism carbohydrate metabolic process	GO:0044723	193	0.028
carbohydrate metabolic process	GO:0005975	207	0.028
glycerolipid biosynthetic process	GO:0045017	51	0.028
regulation of proteolysis	GO:0030162	293	0.027
regulation of cellular amino acid metabolic process	GO:0006521	6	0.027
negative regulation of phosphorus metabolic process	GO:0010563	267	0.027
cellular ketone metabolic process	GO:0042180	80	0.027
positive regulation of proteolysis	GO:0045862	142	0.026
neuromuscular junction development	GO:0007528	3	0.026
lipoprotein metabolic process	GO:0042157	42	0.026
single organism cellular localization	GO:1902580	332	0.026
translation	GO:0006412	132	0.026
tricarboxylic acid metabolic process	GO:0072350	4	0.026
positive regulation of cell death	GO:0010942	263	0.026
posttranscriptional regulation of gene expression	GO:0010608	213	0.025
tricarboxylic acid cycle	GO:0006099	4	0.025
positive regulation of apoptotic process	GO:0043065	246	0.025
regulation of endopeptidase activity	GO:0052548	170	0.025
phospholipid metabolic process	GO:0006644	99	0.025
protein lipidation	GO:0006497	33	0.024
regulation of cellular amine metabolic process	GO:0033238	11	0.024
protein maturation	GO:0051604	233	0.024
lipid biosynthetic process	GO:0008610	177	0.024
membrane organization	GO:0061024	292	0.024
negative regulation of protein metabolic process	GO:0051248	391	0.024
negative regulation of phosphate metabolic process	GO:0045936	267	0.024
mitochondrial membrane organization	GO:0007006	40	0.024
negative regulation of phosphorylation	GO:0042326	174	0.023
zymogen activation	GO:0031638	70	0.023
negative regulation of catalytic activity	GO:0043086	335	0.023
cytoplasmic transport	GO:0016482	379	0.022
negative regulation of cellular protein metabolic process	GO:0032269	353	0.022
regulation of cellular ketone metabolic process	GO:0010565	50	0.022
regulation of peptidase activity	GO:0052547	180	0.022
mitochondrial respiratory chain complex i biogenesis	GO:0097031	16	0.022
organic acid catabolic process	GO:0016054	71	0.021
negative regulation of protein modification process	GO:0031400	200	0.021
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.021
oxidation reduction process	GO:0055114	396	0.021
regulation of protein kinase activity	GO:0045859	289	0.021
membrane lipid metabolic process	GO:0006643	53	0.021
phosphatidylinositol metabolic process	GO:0046488	53	0.020
positive regulation of peptidase activity	GO:0010952	88	0.020
protein processing	GO:0016485	226	0.020
lipoprotein biosynthetic process	GO:0042158	33	0.020
regulation of transferase activity	GO:0051338	355	0.020
protein localization to organelle	GO:0033365	280	0.020
organonitrogen compound biosynthetic process	GO:1901566	200	0.020
negative regulation of protein phosphorylation	GO:0001933	140	0.019
negative regulation of intracellular signal transduction	GO:1902532	183	0.019
negative regulation of transferase activity	GO:0051348	124	0.019
actin filament based process	GO:0030029	224	0.019
defense response	GO:0006952	315	0.019
regulation of kinase activity	GO:0043549	314	0.019
glycerol metabolic process	GO:0006071	4	0.019
positive regulation of organelle organization	GO:0010638	195	0.018
response to oxygen containing compound	GO:1901700	369	0.018
cation transport	GO:0006812	331	0.018
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	116	0.018
locomotory behavior	GO:0007626	1	0.018
transmembrane transport	GO:0055085	399	0.018
cytochrome complex assembly	GO:0017004	13	0.018
cellular protein catabolic process	GO:0044257	261	0.018
coenzyme biosynthetic process	GO:0009108	24	0.017
cellular macromolecule catabolic process	GO:0044265	380	0.017
immune response	GO:0006955	307	0.017
innate immune response	GO:0045087	178	0.017
single organism membrane organization	GO:0044802	268	0.017
nadh dehydrogenase complex assembly	GO:0010257	16	0.017
positive regulation of cellular component organization	GO:0051130	376	0.017
protein localization to membrane	GO:0072657	160	0.017
positive regulation of cysteine type endopeptidase activity	GO:2001056	79	0.017
system process	GO:0003008	349	0.017
establishment of protein localization to membrane	GO:0090150	121	0.017
fatty acid metabolic process	GO:0006631	115	0.016
secretion	GO:0046903	254	0.016
covalent chromatin modification	GO:0016569	254	0.016
memory	GO:0007613	3	0.016
generation of precursor metabolites and energy	GO:0006091	68	0.016
positive regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043280	69	0.016
ras protein signal transduction	GO:0007265	73	0.016
intracellular protein transport	GO:0006886	270	0.016
regulation of cysteine type endopeptidase activity	GO:2000116	127	0.016
positive regulation of catabolic process	GO:0009896	310	0.016
response to abiotic stimulus	GO:0009628	336	0.015
histone modification	GO:0016570	251	0.015
rna interference	GO:0016246	4	0.015
mitochondrial translation	GO:0032543	17	0.015
positive regulation of programmed cell death	GO:0043068	249	0.015
purine nucleoside triphosphate metabolic process	GO:0009144	412	0.015
respiratory chain complex iv assembly	GO:0008535	9	0.015
oocyte development	GO:0048599	1	0.015
embryo development	GO:0009790	123	0.015
segmentation	GO:0035282	4	0.015
protein catabolic process	GO:0030163	325	0.015
establishment of protein localization to organelle	GO:0072594	172	0.015
positive regulation of endopeptidase activity	GO:0010950	84	0.015
purine ribonucleoside triphosphate metabolic process	GO:0009205	411	0.015
coenzyme metabolic process	GO:0006732	65	0.015
small molecule catabolic process	GO:0044282	92	0.015
organophosphate catabolic process	GO:0046434	430	0.015
cation transmembrane transport	GO:0098655	238	0.015
positive regulation of cellular amine metabolic process	GO:0033240	7	0.014
nervous system development	GO:0007399	293	0.014
regeneration	GO:0031099	4	0.014
sulfur compound metabolic process	GO:0006790	101	0.014
inorganic ion transmembrane transport	GO:0098660	231	0.014
dephosphorylation	GO:0016311	209	0.014
ribonucleoside triphosphate catabolic process	GO:0009203	391	0.014
endocytosis	GO:0006897	159	0.014
negative regulation of cellular amine metabolic process	GO:0033239	3	0.014
negative regulation of cellular amino acid metabolic process	GO:0045763	2	0.014
protein glycosylation	GO:0006486	62	0.014
spermatid differentiation	GO:0048515	4	0.014
glycosyl compound catabolic process	GO:1901658	413	0.014
mitotic cell cycle	GO:0000278	326	0.014
carboxylic acid biosynthetic process	GO:0046394	97	0.014
negative regulation of kinase activity	GO:0033673	106	0.013
negative regulation of cell death	GO:0060548	345	0.013
cellular response to oxygen containing compound	GO:1901701	276	0.013
secretion by cell	GO:0032940	226	0.013
positive regulation of cellular catabolic process	GO:0031331	284	0.013
activation of cysteine type endopeptidase activity involved in apoptotic process	GO:0006919	49	0.013
proteolysis involved in cellular protein catabolic process	GO:0051603	244	0.013
reactive oxygen species metabolic process	GO:0072593	75	0.013
purine nucleotide catabolic process	GO:0006195	405	0.013
negative regulation of programmed cell death	GO:0043069	321	0.013
protein modification by small protein conjugation	GO:0032446	342	0.013
oocyte differentiation	GO:0009994	2	0.013
activation of cysteine type endopeptidase activity	GO:0097202	57	0.013
spermatid development	GO:0007286	4	0.013
peripheral nervous system development	GO:0007422	2	0.013
organic acid biosynthetic process	GO:0016053	97	0.013
nucleotide catabolic process	GO:0009166	408	0.013
purine containing compound catabolic process	GO:0072523	411	0.013
anterior posterior axis specification	GO:0009948	2	0.012
actin cytoskeleton organization	GO:0030036	207	0.012
anion transport	GO:0006820	161	0.012
mitochondrial respiratory chain complex i assembly	GO:0032981	16	0.012
ribonucleoside catabolic process	GO:0042454	406	0.012
glycoprotein metabolic process	GO:0009100	110	0.012
protein targeting	GO:0006605	187	0.012
membrane lipid biosynthetic process	GO:0046467	27	0.012
negative regulation of cell proliferation	GO:0008285	228	0.012
blastoderm segmentation	GO:0007350	2	0.012
rho protein signal transduction	GO:0007266	26	0.012
cell morphogenesis	GO:0000902	296	0.012
alcohol metabolic process	GO:0006066	114	0.012
maintenance of location	GO:0051235	112	0.012
ion transmembrane transport	GO:0034220	338	0.012
hindbrain development	GO:0030902	3	0.012
purine ribonucleotide catabolic process	GO:0009154	404	0.012
regulation of cell cycle	GO:0051726	393	0.012
negative regulation of hydrolase activity	GO:0051346	182	0.012
microtubule based process	GO:0007017	210	0.012
regulation of cellular response to stress	GO:0080135	244	0.012
response to external biotic stimulus	GO:0043207	261	0.012
response to other organism	GO:0051707	261	0.012
glycoprotein biosynthetic process	GO:0009101	91	0.012
cellular response to dna damage stimulus	GO:0006974	379	0.012
ribonucleoside triphosphate metabolic process	GO:0009199	412	0.012
response to biotic stimulus	GO:0009607	276	0.012
protein acylation	GO:0043543	138	0.012
negative regulation of cellular component organization	GO:0051129	235	0.011
chromatin modification	GO:0016568	298	0.011
carboxylic acid catabolic process	GO:0046395	71	0.011
negative regulation of protein kinase activity	GO:0006469	98	0.011
regulation of anatomical structure morphogenesis	GO:0022603	286	0.011
cellular component morphogenesis	GO:0032989	314	0.011
reactive nitrogen species metabolic process	GO:2001057	3	0.011
regulation of establishment of protein localization	GO:0070201	242	0.011
biological adhesion	GO:0022610	331	0.011
purine ribonucleoside metabolic process	GO:0046128	437	0.011
growth	GO:0040007	202	0.011
associative learning	GO:0008306	1	0.011
regulation of protein processing	GO:0070613	150	0.011
chromatin organization	GO:0006325	351	0.011
alpha amino acid metabolic process	GO:1901605	72	0.011
cellular carbohydrate metabolic process	GO:0044262	84	0.011
response to axon injury	GO:0048678	1	0.011
regulation of response to external stimulus	GO:0032101	222	0.011
metencephalon development	GO:0022037	2	0.011
regulation of immune response	GO:0050776	201	0.011
nucleoside phosphate catabolic process	GO:1901292	412	0.011
guanosine containing compound catabolic process	GO:1901069	239	0.011
organelle assembly	GO:0070925	176	0.011
liposaccharide metabolic process	GO:1903509	27	0.011
regulation of small gtpase mediated signal transduction	GO:0051056	156	0.011
cell projection organization	GO:0030030	252	0.011
negative regulation of multicellular organismal process	GO:0051241	317	0.011
reactive oxygen species biosynthetic process	GO:1903409	4	0.011
ribonucleotide catabolic process	GO:0009261	405	0.011
cellular response to cytokine stimulus	GO:0071345	181	0.010
sulfur compound biosynthetic process	GO:0044272	38	0.010
regulation of purine nucleotide catabolic process	GO:0033121	205	0.010
lipid modification	GO:0030258	84	0.010
glycosylation	GO:0070085	71	0.010
organic hydroxy compound metabolic process	GO:1901615	147	0.010
nucleoside catabolic process	GO:0009164	408	0.010
regulation of dna metabolic process	GO:0051052	153	0.010
tripartite regional subdivision	GO:0007351	2	0.010
response to cytokine	GO:0034097	232	0.010
glycerophospholipid biosynthetic process	GO:0046474	40	0.010
striated muscle myosin thick filament assembly	GO:0071688	2	0.010
sensory perception of pain	GO:0019233	4	0.010
nerve development	GO:0021675	4	0.010
cell growth	GO:0016049	160	0.010
positive regulation of cell proliferation	GO:0008284	301	0.010
macromolecule glycosylation	GO:0043413	63	0.010
metal ion transport	GO:0030001	272	0.010

NFS1 disease predictions

Disease	DO term ID	Size	Probability
inherited metabolic disorder	DOID:655	242	0.516
disease of metabolism	DOID:0014667	295	0.516
mitochondrial metabolism disease	DOID:700	29	0.035
carbohydrate metabolic disorder	DOID:2978	55	0.030
nervous system disease	DOID:863	431	0.019
eye and adnexa disease	DOID:1492	150	0.019
sensory system disease	DOID:0050155	203	0.019
eye disease	DOID:5614	149	0.019
musculoskeletal system disease	DOID:17	223	0.017
neuropathy	DOID:870	52	0.016
disease of cellular proliferation	DOID:14566	174	0.015
muscular disease	DOID:0080000	114	0.014
cancer	DOID:162	167	0.014
cardiovascular system disease	DOID:1287	106	0.014
central nervous system disease	DOID:331	186	0.014
retinal disease	DOID:5679	118	0.013
immune system disease	DOID:2914	155	0.013
myopathy	DOID:423	104	0.013
muscle tissue disease	DOID:66	113	0.013
organ system cancer	DOID:0050686	164	0.012
amino acid metabolic disorder	DOID:9252	50	0.012
retinal degeneration	DOID:8466	89	0.010
neurodegenerative disease	DOID:1289	102	0.010

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